科研日报 2026-11-02

2026-11-02

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📅 Daily Report - 2026-11-02

今日筛选出 88 条内容，来自 2 个来源

🤖 今日AI智能总结

🧬 数据前沿

今日焦点：单细胞测序技术在肿瘤免疫逃逸机制（如结直肠癌、黑色素瘤）和神经系统发育研究中取得重要进展。

主要方向：

肿瘤免疫与耐药机制：揭示线粒体复合物I在结直肠癌免疫逃逸和耐药中的作用；探讨单细胞RNA测序在 oral squamous cell carcinoma (OSCC) 中的应用。
神经系统发育调控：利用ChIP-Seq、ATAC-Seq和RNA-seq研究哺乳动物神经系统发育中的染色质重塑因子。
免疫疾病与治疗：分析单细胞RNA测序揭示冰毒对肝脏免疫反应的影响；研究TCR-T细胞在肿瘤治疗中的作用；评估化疗、病毒疗法对肿瘤免疫环境的影响。

技术亮点：

多组学整合分析：结合TCGA数据、CRISPR筛选、单细胞RNA测序等技术，深入解析复杂生物学过程。
新型单细胞技术应用：单细胞多组学分析（染色质状态与转录组）用于研究基底神经节。

🧪 博客更新

今日焦点：一项突破性研究揭示了常见肠道细菌引发结直肠癌的机制，另一项研究则开发出能在症状出现前十年预测阿尔茨海默病风险的血液检测方法。

主要方向：

肠道菌群与结直肠癌的关联机制
阿尔茨海默病早期风险预测
新型细菌防御系统机制

技术亮点：

发现肠道细菌导致结直肠癌的关键分子通路。
开发出基于血液标志物的阿尔茨海默病风险评估方法。
揭示一种与已知机制完全相反的细菌防御系统。

📚 分类浏览

🧬 数据前沿 (85条)

详细内容（前10条）

1. ⭐ GSE316410 线粒体复合物 I 通过赋予微卫星稳定型结直肠癌铁死亡抵抗力来促进免疫逃逸 [scRNA-seq]

✍️ 作者：未知作者
🏷️ 关键词：cancer、immune、resistance、scRNA
📝 描述：Contributors : Xiaojun Zhou ; Xiang ZhaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe discovered, through mining TCGA data and conducting CRISPR screens, that mitochondrial complex I promotes immune evasion in microsatellite stable colorectal cancer. To explore the role of mitochondrial complex I in regulating the immune microenvironment, we treated subcutaneous CT26 Cell transplant tumour with targeted mitochondrial complex I inhibitor IACS-010759 and performed scRNA-Seq
🔗 查看原文

2. ⭐ GSE247842 单细胞 RNA 测序揭示甲基苯丙胺对肝脏免疫反应的抑制作用，其中 DRD1 参与其中 [scRNA-Seq]

✍️ 作者：未知作者
🏷️ 关键词：immune、sequencing、single-cell、scRNA
📝 描述：Contributors : Jin-ting Zhou ; Yungang Xu ; Xiao-Huan Liu ; Cheng Cheng ; Jing-na FanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMethamphetamine (METH) has been found to induce various physical and psychological changes, as well as damage to the immune system. The liver, which houses a significant number of immune cells, is particularly susceptible to the toxic effects of METH. Dopamine, an important neurotransmitter in both METH addiction and immune regulation, plays a crucial role in this process. In our study, we developed a chronic METH administration model and conducted single-cell RNA sequencing to investigate the impact of METH on liver immune cells and the involvement of the dopamine receptor D1 (DRD1) in this process.
🔗 查看原文

3. ⭐ GSE352390 人类口腔鳞状细胞癌肿瘤的单细胞RNA测序

✍️ 作者：未知作者
🏷️ 关键词：carcinoma、sequencing、single-cell
📝 描述：Contributor : Minh Phuong DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell RNA sequencing was performed on tumor tissues from two patients with oral squamous cell carcinoma to characterize the tumor microenvironment and identify cell populations expressing IL10 and TNF-α.
🔗 查看原文

4. ⭐ GSE347840 巨噬细胞向肌成纤维细胞的转化可能是IgA肾病早期肾纤维化的潜在驱动因素：来自单细胞RNA测序分析的启示

✍️ 作者：未知作者
🏷️ 关键词：macrophage、sequencing、single-cell
📝 描述：Contributors : Guo Jing ; Luo Chenggong ; Adele Yelizha ; Tang Yuyan ; He Haidong ; Yu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: IgA nephropathy (IgAN) is a leading cause of chronic kidney disease (CKD) and renal failure. Renal tubulointerstitial fibrosis is a predictor of a poor kidney outcome, and macrophages are involved into this process. However, the precise phenotyping mechanisms of macrophages at the early stage of IgAN, particularly how they initiate fibrogenesis, remain largely unknown. Methods: Single-cell RNA sequencing analysis was conduct on renal biopsy specimens from IgAN patients, as well as membranous nephropathy (MN) control samples and adjacent healthy kidney control samples from the public GEO database. After quality control and batch correction, unsupervised clustering, differential expression analysis and pathway enrichment analysis were carried out. Subsequently, an IgAN mouse model was established to investigate the fibrosis severity and potential mechanism. Results: Single-cell transcriptomic analysis revealed changes in the renal immune microenvironment in IgAN, characterized by an increase in macrophages and fibroblasts and a decrease in proximal tubular cells. Macrophages in IgAN exhibit M2 phenotyping, with high expression of CD163 and low expression of Fc gamma receptor IIIa (FCGR3A). In the IgAN mouse model, histological staining confirmed interstitial extracellular matrix (ECM) deposition. Immunostaining for F4/80 and α-SMA found a substantial population of F4/80+α-SMA+ cells in lesions of interstitial fibrosis in IgAN mouse model kidneys, whereas few or no such cells were seen in control groups. Furthermore, transcriptomic analysis revealed significant upregulation of the cytoskeletal protein Septin7 in IgAN macrophages, and Septin7 co-localized with α-SMA⁺ cells. Conclusions: Patients with early-stage renal fibrosis in IgA nephropathy exhibit prominent infiltration of M2-polarized macrophages, consistent with a macrophage-to-myofibroblast transition (MMT) process. Here, we identified Septin7 as a potential biomarker that is upregulated in IgAN kidneys and spatially associated with fibrotic severity, suggesting a potential role in the initial of fibrotic process.
🔗 查看原文

5. ⭐ GSE346656 肿瘤浸润性 NY-ESO-1 TCR-T 细胞的单细胞 RNA 测序，这些细胞具有 WT 或 ITAM M3 CD3ζ

✍️ 作者：未知作者
🏷️ 关键词：tumor、sequencing、single-cell
📝 描述：Contributors : Haopeng Wang ; Kun Wang ; Wen HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed single-cell RNA sequencing to characterize the transcriptional states of tumor-infiltrating NY-ESO-1-specific TCR-T cells expressing wild-type (WT) CD3ζ or the ITAM M3 CD3ζ variant. Human primary T cells were engineered to express the NY-ESO-1 TCR together with WT or ITAM M3 CD3ζ and adoptively transferred into NSG mice bearing A375 human melanoma xenografts. Tumor-infiltrating lymphocytes (TILs) were isolated 10 days after TCR-T cell infusion. For each condition, TILs from three mice were pooled before single-cell RNA sequencing using the BD Rhapsody platform. The dataset was generated to investigate how ITAM M3-mediated recalibration of TCR signaling affects TCR-T cell functional state, including activation, cytotoxicity, exhaustion, proliferation, and stemness within the tumor microenvironment.
🔗 查看原文

6. ⭐ GSE330794 胶质瘤病毒疗法的临床反应与免疫组织和 T 细胞多样性有关。

✍️ 作者：未知作者
🏷️ 关键词：immune、T cell、glioma
📝 描述：Series Type : OtherOrganism : Homo sapiens ; Mesocricetus auratusThis SuperSeries is composed of the SubSeries listed below.
🔗 查看原文

7. ⭐ GSE317206 哺乳动物神经系统发育中的神经元染色质重塑因子 [ChIP-Seq]

✍️ 作者：未知作者
🏷️ 关键词：nervous、Neuronal、ChIP-seq
📝 描述：Contributors : Alyssa Ialongo ; Ssu-Yu Yeh ; Kaitlin Montanera ; Ho Sung RheeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusNeuronal differentiation requires the precise regulation of neural lineage commitment genes, whose expression can be regulated through various epigenetic mechanisms such as chromatin remodeling. Integration of neuron-specific subunits of the mammalian Brg1-associated factor (BAF) chromatin remodeling complex enables the transcriptional regulation of neural lineage commitment genes, which is required for proper neurodevelopment. Here, we demonstrate that neuron-specific BAF chromatin remodling subunits are required for the transcriptional regulation of neuronal genes during nervous system development.
🔗 查看原文

8. ⭐ GSE315848 哺乳动物神经系统发育中的神经元染色质重塑因子 [ATAC-Seq]

✍️ 作者：未知作者
🏷️ 关键词：nervous、Neuronal、ATAC-seq
📝 描述：Contributors : Alyssa Ialongo ; Ho Sung RheeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusNeuronal differentiation requires the precise regulation of neural lineage commitment genes, whose expression can be regulated through various epigenetic mechanisms such as chromatin remodeling. Integration of neuron-specific subunits of the mammalian Brg1-associated factor (BAF) chromatin remodeling complex enables the transcriptional regulation of neural lineage commitment genes, which is required for proper neurodevelopment. Here, we demonstrate that neuron-specific BAF chromatin remodling subunits are required for the transcriptional regulation of neuronal genes during nervous system development.
🔗 查看原文

9. ⭐ GSE315747 哺乳动物神经系统发育中的神经元染色质重塑因子 [RNA-seq]

✍️ 作者：未知作者
🏷️ 关键词：nervous、Neuronal、RNA-seq
📝 描述：Contributors : Alyssa Ialongo ; Ssu-Yu Yeh ; Ho Sung RheeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuronal differentiation requires the precise regulation of neural lineage commitment genes, whose expression can be regulated through various epigenetic mechanisms such as chromatin remodeling. Integration of neuron-specific subunits of the mammalian Brg1-associated factor (BAF) chromatin remodeling complex enables the transcriptional regulation of neural lineage commitment genes, which is required for proper neurodevelopment. Here, we demonstrate that neuron-specific BAF chromatin remodling subunits are required for the transcriptional regulation of neuronal genes during nervous system development.
🔗 查看原文

10. ⭐ GSE313934 线粒体复合物 I 通过赋予微卫星稳定型结直肠癌铁死亡抵抗力来促进免疫逃逸

✍️ 作者：未知作者
🏷️ 关键词：cancer、immune、resistance
📝 描述：Contributors : Xiaojun Zhou ; Xiang ZhaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe discovered, through mining TCGA data and conducting CRISPR screens, that mitochondrial complex I promotes immune evasion in microsatellite stable colorectal cancer. To explore the role of mitochondrial complex I in regulating the immune microenvironment, we treated CT26 cell line with targeted mitochondrial complex I inhibitor IACS-010759 and performed RNA-Seq
🔗 查看原文

💡 该来源还有 75 条内容，详见文末

🧪 博客更新 (3条)

详细内容（全部3条）

1. ⭐ 科学家最终发现一种常见的肠道细菌如何引发结肠癌

✍️ 作者：未知作者
🏷️ 关键词：cancer、regex:bacter(ia|ial|ium)、gut、regex:gut(-?microbiome)?
📝 描述：Scientists at Johns Hopkins have uncovered a crucial missing link between a common gut bacterium and colorectal cancer, solving a mystery that has puzzled researchers for nearly two decades. The bacterium, Bacteroides fragilis, produces a toxin that damages the colon’s protective lining, triggers chronic inflammation, and promotes tumor formation.
🔗 查看原文

2. 简单的血液检测可以在症状出现前10年揭示患阿尔茨海默病的风险。

✍️ 作者：未知作者
🏷️ 关键词：Alzheimer
📝 描述：A major international study found that a simple blood test could help predict Alzheimer’s-related cognitive decline years before symptoms appear, with the highest-risk individuals facing a 38% chance of impairment within five years and an estimated 78% chance within 10 years. Scientists believe the discovery could pave the way for earlier intervention and future treatments designed to prevent Alzheimer’s before memory problems begin.
🔗 查看原文

3. 科学家发现了一种极其奇特的细菌防御机制，他们一度以为这种机制已经失效。

✍️ 作者：未知作者
🏷️ 关键词：regex:bacter(ia|ial|ium)
📝 描述：Scientists have discovered a bizarre bacterial defense system that works almost completely backward from anything seen before. Unlike typical bacterial immune systems that keep a deadly toxin under control until a virus attacks, this unusual mechanism waits until an infection begins before producing the DNA that switches on its lethal weapon. The infected bacterium then destroys itself, preventing the virus from multiplying and spreading to neighboring cells.
🔗 查看原文

📊 关键词统计

关键词	出现次数
sequencing	18
RNA-seq	14
single-cell	13
immune	10
transcriptome	6
methylation	6
cancer	5
macrophage	5
resistance	5
epigenetic	4
nervous	4
genome	4
regex:bacter(ia	ial
carcinoma	3
tumor	3
immunity	3
Neuronal	3
Alzheimer	2
cardiac	2
spatial	2

📎 更多内容

🧬 数据前沿其他内容 (75条)

📅 报告生成时间：2026-11-02 00:54
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