详细内容（前10条）

1. ⭐ GSE276212 空间基因组和转录组共定位揭示肿瘤组织中的克隆异质性 [DNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、DNA-seq、spatial、genome、transcriptome
• 📝 描述：Contributors : Yang Liu ; Dejiang Wang ; Xiangjun Di ; Shenjie WangSeries Type : OtherOrganism : Homo sapiens ; Mus musculusTumor heterogeneity arises from the sequential acquisition of somatic mutations and the selection of fitter clones, leading to distinct genotypes and phenotypes. Joint mapping of genome and transcriptome in the same tumor tissue can directly link clonoal relation to transcriptional state enabling a more in-depth understanding of intrinsic and extrinct tumor heterogeneity in the tissue context. Here, we introduce Spatial-GT-seq, a spatial multi-omic technology capable of genome-wide co-profiling of the genome and transcriptome at near single-cell resolution. We demonstrated in situ identification of tumor subclones in a mouse model of lung metastasis, with parallel transcriptomic profiles indicating that the gene expression profile of the same tumor clone is altered by the tumor microenvironment. Furthermore, analysis of primary and recurrent human pancreatic neuroendocrine tumors reveals both persistent and newly emerging tumor subclones, exhibiting transcriptional changes in both the original and recurrence sites. These findings highlight Spatial-GT-seq as a valuable platform for studying genotype-phenotype-microenvironment associations, providing new insights into cancer evolution and heterogeneity.
• 🔗 查看原文

2. ⭐ GSE276211 空间基因组和转录组共定位揭示肿瘤组织中的克隆异质性 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、RNA-seq、spatial、genome、transcriptome
• 📝 描述：Contributors : Yang Liu ; Dejiang Wang ; Xiangjun Di ; Shenjie WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusTumor heterogeneity arises from the sequential acquisition of somatic mutations and the selection of fitter clones, leading to distinct genotypes and phenotypes. Joint mapping of genome and transcriptome in the same tumor tissue can directly link clonoal relation to transcriptional state enabling a more in-depth understanding of intrinsic and extrinct tumor heterogeneity in the tissue context. Here, we introduce Spatial-GT-seq, a spatial multi-omic technology capable of genome-wide co-profiling of the genome and transcriptome at near single-cell resolution. We demonstrated in situ identification of tumor subclones in a mouse model of lung metastasis, with parallel transcriptomic profiles indicating that the gene expression profile of the same tumor clone is altered by the tumor microenvironment. Furthermore, analysis of primary and recurrent human pancreatic neuroendocrine tumors reveals both persistent and newly emerging tumor subclones, exhibiting transcriptional changes in both the original and recurrence sites. These findings highlight Spatial-GT-seq as a valuable platform for studying genotype-phenotype-microenvironment associations, providing new insights into cancer evolution and heterogeneity.
• 🔗 查看原文

3. ⭐ GSE352702 阑尾腺癌单细胞RNA测序显示上皮细胞比例低，且肿瘤微环境富含成纤维细胞

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、tumor microenvironment、sequencing、single-cell
• 📝 描述：Contributors : Betul B Gunes ; Nicholas Hornstein ; Mingshuang Wang ; Mahmoud Yousef ; Mohammad M Fanaeian ; Abdelrahman Yousef ; Saikat Chowdhury ; Mohammad A Zeineddine ; Cara Haymaker ; Beth Helmink ; Keith Fournier ; John P ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAppendiceal adenocarcinoma (AA) is an understudied gastrointestinal malignancy. Treatment is guided by its proximal counterpart, colorectal cancer (CRC), despite recent studies demonstrating AA’s unique mutational landscape and poor response to CRC chemotherapy. As the first application of single-cell technology to AA these data provide insight into the intratumor heterogeneity of AA and highlight the important contribution of the tumor microenvironment in this orphan disease. These results also reinforce multiple observations that AA is a unique disease entity from CRC and targeting the tumor microenvironment should be considered as a therapeutic strategy.
• 🔗 查看原文

4. ⭐ GSE276213 空间基因组和转录组共定位揭示肿瘤组织中的克隆异质性

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、spatial、genome、transcriptome
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

5. ⭐ GSE346548 透明细胞肾细胞癌肿瘤和邻近正常肾组织样本的 RNA 测序。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、carcinoma、RNA-seq
• 📝 描述：Contributors : Mengwei Li ; Congyi Zhang ; Wenqiu Cai ; Feng Ren ; Xintong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRenal cell carcinoma (RCC) is among the most common urological malignancies, yet the transcriptomic landscape underlying its pathogenesis remains incompletely characterized, particularly for non-coding regions that may harbor functional non-canonical open reading frames (ncORFs). Here we performed whole-transcriptome RNA-seq on 5 clear cell RCC tumor tissues and 5 adjacent normal kidney tissues to systematically profile mRNA, lncRNA, and circRNA expression. This dataset serves as the transcriptomic layer of an integrative multi-omics study aimed at identifying dysregulated ncORF-encoded micropeptides in RCC, with lncRNAs representing a predominant source of tumor-associated cryptic peptides. The data provide a reference for translational activity assessment when combined with matchedribosome profiling and immunopeptidomics datasets.
• 🔗 查看原文

6. ⭐ GSE345263 成人骨髓中的 CD4 谱系红系髓系祖细胞定义了巨噬细胞生成的替代途径 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、RNA-seq、pathway
• 📝 描述：Contributors : Tikoo Shweta ; Jain Rohit ; Weninger Wolfgang ; Wielscher Matthias ; Farlik MatthiasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages originate from distinct developmental sources, but in adulthood, their replenishment is thought to depend exclusively on circulating monocytes. Here, we identify a previously unrecognized CD4-lineage erythro-myeloid progenitor, termed EMPROR (Erythro-Myeloid Progenitor), that resides in the adult bone marrow and defines an alternative pathway for generating macrophages. EMPROR cells are phenotypically and transcriptionally distinct from hematopoietic stem cells, common myeloid progenitors, and monocyte precursors. They lack expression of Csf1r and Ccr2 while expressing Cd4 and c-Kit. Single-cell RNA sequencing, RNA velocity analysis, and in vitro and in vivo lineage assays demonstrate a multilineage potential encompassing macrophage, neutrophil, megakaryocytic, and erythroid fates. In vivo, EMPROR cells efficiently generate perivascular and tumor-associated macrophages independently of CCR2-mediated monocyte recruitment, and also contribute to erythroid and granulocytic lineages under inflammatory and neoplastic conditions. Transcriptomic comparisons position EMPROR cells closest to embryonic erythro-myeloid progenitors, indicating that an embryonic-like erythro-myeloid program persists within the adult bone marrow. These findings expand current models of adult myelopoiesis and highlight a previously unappreciated developmental pathway that sustains macrophage diversity beyond the classical monocyte lineage.
• 🔗 查看原文

7. ⭐ GSE345262 成人骨髓中的 CD4 谱系红系-髓系祖细胞定义了巨噬细胞生成的替代途径 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、scRNA、pathway
• 📝 描述：Contributors : Tikoo Shweta ; Jain Rohit ; Weninger Wolfgang ; Wielscher Matthias ; Farlik Matthias ; Shaw LisaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages originate from distinct developmental sources, but in adulthood, their replenishment is thought to depend exclusively on circulating monocytes. Here, we identify a previously unrecognized CD4-lineage erythro-myeloid progenitor, termed EMPROR (Erythro-Myeloid Progenitor), that resides in the adult bone marrow and defines an alternative pathway for generating macrophages. EMPROR cells are phenotypically and transcriptionally distinct from hematopoietic stem cells, common myeloid progenitors, and monocyte precursors. They lack expression of Csf1r and Ccr2 while expressing Cd4 and c-Kit. Single-cell RNA sequencing, RNA velocity analysis, and in vitro and in vivo lineage assays demonstrate a multilineage potential encompassing macrophage, neutrophil, megakaryocytic, and erythroid fates. In vivo, EMPROR cells efficiently generate perivascular and tumor-associated macrophages independently of CCR2-mediated monocyte recruitment, and also contribute to erythroid and granulocytic lineages under inflammatory and neoplastic conditions. Transcriptomic comparisons position EMPROR cells closest to embryonic erythro-myeloid progenitors, indicating that an embryonic-like erythro-myeloid program persists within the adult bone marrow. These findings expand current models of adult myelopoiesis and highlight a previously unappreciated developmental pathway that sustains macrophage diversity beyond the classical monocyte lineage.
• 🔗 查看原文

8. ⭐ GSE303722：经基因工程改造表达IL12的iPSC衍生抗原呈递细胞可刺激肿瘤组织重编程和抗肿瘤免疫

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity、antigen
• 📝 描述：Contributors : Masateru Yamamoto ; Kyoko Fukuda ; Yasushi UemuraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusActivation of cancer-reactive T cells by dendritic cells (DCs) is important for cancer elimination by host immunity. One type of cancer immunotherapy in which DCs loaded with “cancer antigens” are administered has not been able to achieve stable efficacy due to heterogeneity in cell quality dependent on patient DC status. We constructed IL12-producing antigen-presenting cells from mouse induced pluripotent stem cells (iPSC). These cells can be controlled to proliferate using cytokines, allowing for the mass production of cells with stable performance. When these cells were loaded with a model cancer antigen and administered to cancer-bearing mice, cancer-reactive T cells rapidly acquired effector functions and propagated an interferon (IFN)-stimulated gene signature to cancer tissue distant from the site of administration. This was accompanied by infiltration of effector cells into the cancer tissue, while associated with a decrease in myeloid-derived suppressor cells. These were extremely more potent than immune checkpoint inhibitors (ICIs) and were further amplified in combination with ICIs and correlated with antitumor effects. Based on these observations, we constructed IL12-producing antigen-presenting cells from human iPSCs that express only HLA molecules involved in cancer antigen presentation and exclude other HLA molecules for improved versatility. These human cells, like their mouse counterparts, were capable of cytokine-regulated proliferation and induced antigen-specific activation and IFN-γ production of cancer antigen-specific T cells. Thus, these cells may become an alternative antigen-presenting cell platform for patient DCs to overcome HLA polymorphisms and ensure stable supply and quality.
• 🔗 查看原文

9. ⭐ GSE301083 HOXA9 重编程 3D 基因组结构以调节急性髓系白血病中的致癌转录 [CUT&RUN]

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、regex:onco(logy|logist|gene|genic)、genome
• 📝 描述：Contributors : Xueqing Wang ; Wentao Yang ; Fan Fang ; Yali DouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe hierarchical three-dimensional (3D) organization of chromatin underpins the spatial and temporal control of gene expression during development. This principle is exemplified by the Hox gene clusters, where dynamic topological architecture governs precise transcriptional activation. While disruption of chromatin organization at Hox genes is increasingly recognized in various human malignancies, the extent to which Hox genes themselves contribute to shaping 3D genome architecture remains poorly understood. In particular, it is unknown whether oncogenic overexpression of HOXA9—a highly conserved transcription factor and common downstream effector of diverse genetic alterations in acute myeloid leukemia (AML)—can actively reprogram chromatin topology. Here, we uncover a pivotal role for HOXA9 as a master regulator of 3D chromatin architecture in human AML. We demonstrate that HOXA9 orchestrates a leukemia-specific reconfiguration of chromatin topology. HOXA9 promotes the formation of leukemia specific topologically associating domains (TADs) and establishes long-range enhancer–promoter interactions essential for maintaining the leukemic transcriptional program. Perturbation of HOXA9 leads to widespread architectural collapse, marked by the dissolution of chromatin loops, disrupted enhancer communication, and silencing of critical leukemogenic genes. Furthermore, HOXA9-mediated chromatin looping occurs independently of CTCF. Instead, HOXA9 functions through the cohesin complex to facilitate higher-order genome organization, thereby functioning as a non-canonical architectural factor. Among its targets, we identify NHLRC2 as a HOXA9-associated loop gene essential for leukemic cell survival and proliferation. Collectively, these findings uncover a previously unappreciated architectural function of HOXA9 in modulating 3D genome organization and sustaining oncogenic gene expression in AML. More broadly, they suggest a mechanistic paradigm in which HOX transcription factors actively reprogram nuclear architecture to enforce lineage-specific or malignant gene expression programs.
• 🔗 查看原文

10. ⭐ GSE246620 探索与口腔鳞状细胞癌颈部淋巴结转移相关的microRNA

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、lymph、regex:lymph(o|atic)?
• 📝 描述：Contributors : Ryoji Yoshida ; Junki InoueSeries Type : Expression profiling by arrayOrganism : Homo sapiensExploring biomarkers involved in lymph node metastasis in oral cancer
• 🔗 查看原文

💡 该来源还有 127 条内容，详见 文末

详细内容（全部1条）

1. Tempus公司获得体外诊断医疗器械法规（IVDR）认证，其xR RNA测序技术可用于实体瘤分析。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、sequencing
• 📝 描述：Tempus AI receives European IVDR certification for its xR assay, expanding access to RNA sequencing for detecting actionable gene fusions and splice variants in solid tumors…
• 🔗 查看原文

• GSE352662 皮肤黑色素瘤转移灶电化学治疗后肿瘤免疫微环境的纵向空间映射
• GSE352509 肠道微生物雌马酚的产生与认知轨迹相关并抑制NLRP3炎症小体的激活
• GSE337795 靶向 ERO1α 触发三阴性乳腺癌中的肿瘤免疫监视 [RNA-seq]
• GSE336881 靶向 ERO1α 触发三阴性乳腺癌中的肿瘤免疫监视 [scRNA-seq]
• GSE324592 体细胞 TP53 突变驱动 T 细胞和 NK 细胞功能障碍，并在急性髓系白血病中形成炎症免疫微环境
• GSE280112 单细胞中 5-甲基胞嘧啶、5-羟甲基胞嘧啶和转录组的联合分析揭示了导致人类原始生殖细胞成熟过程中全基因组 DNA 甲基化擦除的因素
• GSE159670 结直肠肿瘤和正常组织中的全基因组DNA甲基化分析
• GSE352065 癌细胞对KRAS(G12C)抑制的适应性转录反应
• GSE351967 T细胞反应可区分进展为癌症的口腔发育不良亚群
• GSE351631：PKM2-WT 和 PKM2-K89R 细胞来源的混合原位胰腺肿瘤的单细胞 RNA 测序
• GSE346551 透明细胞肾细胞癌肿瘤及其邻近正常肾组织样本的核糖体谱分析
• GSE345108 成人骨髓中的CD4谱系红系-髓系祖细胞定义了巨噬细胞生成的一条替代途径
• GSE341556 小 RNA 测序揭示了食蟹猴肝脏 miRNA 特征与代谢功能障碍相关的脂肪性肝炎
• GSE329186 利多卡因通过转录组重编程和抑制NF-κB/STAT1信号通路来减轻LPS诱导的巨噬细胞炎症
• GSE327375 T细胞来源的IL-17A在胰岛素抵抗条件下会恶化牙周组织
• GSE314679 免疫细胞适应不同的干细胞微环境以控制组织稳态 [scRNA-seq]
• GSE301086 HOXA9 将转录控制与急性髓系白血病中的高级染色质结构联系起来 [RNA-seq]
• GSE277638 体外培养 6 天后 PBMC 对 EBV 的反应的基因表达谱和 TCR 测序（单细胞水平）。
• GSE246433 对晚期着床期间子宫肌层的表观基因组分析揭示了猪细胞锌稳态通路相关基因中的调控元件（ChIP-Seq）
• GSE246432 对晚期着床期间子宫肌层的表观基因组分析揭示了猪细胞锌稳态通路相关基因中的调控元件（RNA-Seq）
• GSE352613 Foxp3 和 STAT5 的协同作用通过调节 IL-2 诱导的基因表达赋予调节性 T 细胞适应性 [ATAC-Seq]
• GSE351587 肝激酶B1耗竭破坏星形胶质细胞中的泛酸：辅酶A通路
• GSE350656 单细胞分析揭示了在阿尔茨海默病 AppNL-G-F 小鼠模型中，ERβ 对神经血管保护的性别特异性调控
• GSE350427 SARS-CoV-2 Nsp2 重编程宿主免疫以驱动致病性炎症
• GSE348509 单细胞调控基因组学揭示肝硬化中髓系和T细胞重编程的协同作用
• GSE344612 Id2 调控致病性 Th2 细胞中 IL-33 驱动的代谢重编程（RNA-seq）
• GSE344609 干预后对照前，广谱中和抗体介导的HIV抑制期间的免疫激活
• GSE337796 靶向 ERO1α 触发三阴性乳腺癌的肿瘤免疫监视
• GSE335166 MORC2A 是雄性生殖细胞逆转录转座子 DNA 甲基化和 H3K9me3 所必需的 [RNA-seq]
• GSE334899 TREX1通过降解胞质短DNA分子来限制抗肿瘤免疫
• GSE331089 单细胞分析揭示了活性巨噬细胞活化综合征的转录组模式以及白蛋白融合的白细胞介素-10在小鼠模型中的治疗潜力
• GSE326633 内源性PD-L1阻断抗体驱动强效抗肿瘤免疫
• GSE326149：TNBS诱导小鼠纤维化肠道组织的小RNA测序
• GSE311182 Foxp3 和 STAT5 的协同作用通过调节 IL-2 诱导的基因表达赋予调节性 T 细胞适应性 [RNA-Seq]
• GSE307646 跨物种转录组对应关系的几何推断 [RNA-Seq]
• GSE307645 跨物种转录组对应关系的几何推断 [scRNA-Seq]
• GSE281560 SND1的SUMO化促进癌细胞中新型抑癌miRNA的降解
• GSE280233 习惯性咀嚼槟榔通过抑制正常口腔黏膜的整体甲基化促进口腔鳞状细胞癌的发生
• GSE352552 T细胞代谢重编程控制重症哮喘的气道重塑
• GSE348752 HFpEF HMDP：扩展的 BXD 品系中心室 RNA 测序
• GSE346752：Slc1a1内皮细胞条件性敲除小鼠和对照组脑内皮细胞的RNA测序
• GSE346246 妊娠晚期热应激诱导出生和断奶时乳腺实质中的基因表达和持续性DNA甲基化改变
• GSE345863 妊娠晚期热应激诱导出生和断奶时乳腺实质基因表达变化 [RNA-Seq]
• GSE345861 妊娠晚期热应激诱导出生和断奶时乳腺实质中持续的 DNA 甲基化改变 [亚硫酸氢盐测序]
• GSE341289 坎氏弧菌中的分解代谢激活蛋白和群体感应交叉控制群体行为 [ChIP-Seq]
• GSE339401 坎氏弧菌中的分解代谢激活蛋白和群体感应交叉控制群体行为 [RNA-seq]
• GSE335104 RNA结合的MYBL2与致癌转录因子MAFG和FRA1相互作用，促进黑色素瘤的发生发展
• GSE333673 丙型肝炎病毒清除后诱导染色质重塑的可变印迹 [ChIP-Seq]
• GSE332591 一组血清外泌体miRNA作为胰腺癌潜在生物标志物的诊断价值
• 来自犬正常脑组织的GSE330017 RNA测序数据
• GSE327329 m6A 阅读蛋白 IGF2BP3 的异常稳定驱动 FBXW7 突变型结直肠癌的转移进展和 5-FU 耐药性
• GSE326794 m6A 阅读蛋白 IGF2BP3 的异常稳定驱动 FBXW7 突变型结直肠癌的转移进展和 5-FU 耐药性
• GSE326531 CRYAB驱动的线粒体分裂诱导衰老，从而促进LUAD脑转移瘤对EGFR-TKI的适应性耐药
• GSE321659 建立多阶段体外筛选平台以鉴定炎症性肠病肠黏膜损伤的候选化合物
• GSE319838 CAR-DC1s驱动多克隆新抗原特异性免疫
• GSE317047 跨尺度因果映射框架揭示巨噬细胞在平衡动脉发育中的调控作用
• GSE314678 免疫细胞适应不同的干细胞微环境以控制组织稳态 [bulkRNA-seq]
• GSE314299 RNA-seq 和 CRISPR 筛选在 AML 细胞中维奈托克和阿扎胞苷治疗后的应用
• GSE311931 p38α MAPK-MK2轴驱动化疗介导的核肌动蛋白重塑，从而促进卵巢癌进展
• GSE310694 Pumilio蛋白的急性降解揭示了胚胎干细胞命运决定中的双相转录后调控层级[RNA-Seq]
• GSE308616 BUD23 的核糖体修饰驱动对能量状态和代谢健康的选择性翻译控制 [Ribo-seq]
• GSE308532 BUD23介导的核糖体修饰驱动对能量状态和代谢健康的选择性翻译调控
• GSE308207 BUD23介导的核糖体修饰驱动对能量状态和代谢健康的选择性翻译调控
• GSE306939 RHOX12L 拮抗 TRIM28-SETDB1 抑制以激活胚胎 IAP/MERVK 逆转录转座子 [ATAC-Seq]
• GSE306376 HOXA9 将转录控制与急性髓系白血病中的高级染色质结构联系起来 [HiC]
• GSE303284 EGFR突变型非小细胞肺癌中通过角蛋白17+异常基底样耐药持续细胞群实现耐药性的多谱系进化
• GSE297937 核共抑制因子 NCOR1 和 NCOR2 调控胸腺细胞信号传导、选择和迁移 [scATAC-seq]
• GSE292445 AR-V7 凝聚体驱动去势抵抗性前列腺癌中的雄激素非依赖性转录
• GSE285323 淋巴内皮限制性合成回路疗法增强手术淋巴水肿模型中的修复和化疗免疫疗法反应
• GSE273623 物种依赖性 WNT/β-catenin 信号传导在早期着床过程中协调上胚层形态发生 [RNA-Seq]
• GSE246434 对晚期着床期间子宫肌层的表观基因组分析揭示了猪细胞锌稳态通路相关基因中的调控元件
• GSE188194 mRNA和前体mRNA上2’-O-甲基化位点的鉴定
• GSE352692 局部染色质、3D基因组折叠和转座子货物形状 Sleeping Beauty 转座
• GSE352606：吉西他滨-miR-15a治疗对亲代和耐药HCT116结直肠癌细胞的转录组分析
• GSE352602 Foxp3 和 STAT5 的协同作用通过调节 IL-2 诱导的基因表达赋予调节性 T 细胞适应性 [Myc_RNA]
• GSE352343 靶向 Alk4 通路可预防与年龄相关的骨质流失。
• GSE352331 基线免疫转录状态可预测有性感染风险个体未来感染 HIV-1 的情况
• GSE352288 局部染色质、3D 基因组折叠和转座子货物塑造 Sleeping Beauty 转座 [tagmap]
• GSE352286 局部染色质、3D 基因组折叠和转座子货物塑造睡美人转座 [pADam]
• GSE351871 年龄相关的 hsa_piR_020485 抑制骨髓基质细胞的成骨分化并促进巨噬细胞迁移
• GSE351755 细胞外囊泡中的蛋白酶体介导受体结直肠癌细胞的大部分转录效应
• GSE351178 平行转录组学揭示了红腹刺桐（Quadrastichus erythrinae）和花斑刺桐（Erythrina variegata）的昆虫发育转变和与虫瘿相关的宿主转录差异
• GSE350895 胶原蛋白/PMMA治疗人类皮肤成纤维细胞的空间转录组分析[Xenium]
• GSE349688 磁性纳米粒子 (MNPQ) 处理后胶质母细胞瘤细胞系 (GL261) 转录组的基因表达
• GSE349627 不同浓度NPY处理的小鼠骨髓间充质干细胞的RNA测序
• GSE349296 KLF16 和 SIN3A 与 CTD-2377D24.6 细胞相关，促进子宫内膜癌细胞增殖。
• GSE349203 靶向 EGR1 可减弱炎症性角质形成细胞和过敏性皮肤炎症中 CCL2 的表达
• GSE348876 PERSIST-On 实现可遗传和可微调的人类基因激活 [RNA-seq]
• GSE348705 基底外侧杏仁核恐惧记忆痕迹中睡眠依赖性 DNA 甲基化重塑 [PIP-Seq]
• GSE348542 睡眠依赖性基底外侧杏仁核恐惧记忆痕迹的DNA甲基化重塑
• GSE348488 基底外侧杏仁核恐惧记忆痕迹中睡眠依赖性 DNA 甲基化重塑 [第 1 批 WGBS]
• GSE348480 基底外侧杏仁核恐惧记忆痕迹中睡眠依赖性 DNA 甲基化重塑 [第 2 批 WGBS]
• GSE348103 周细胞在小鼠社会压力和人类抑郁症中调节脑血管完整性[培养细胞RNA测序]
• GSE344220 硬蜱TNFBP基因沉默对小鼠咬伤皮肤转录组的局部影响
• GSE342465 PODXL 调控 α-突触核蛋白聚集体的神经元进入
• GSE341759 HIV-1感染的小胶质细胞中病毒复制水平依赖性的转录和microRNA重编程连续体将有效感染与神经认知相关基因网络联系起来[RNA-seq]
• GSE341758 HIV-1感染的小胶质细胞中病毒复制水平依赖性的转录和microRNA重编程连续体将有效感染与神经认知相关基因网络联系起来[scRNA-seq]
• GSE341398 GOLDEN：基于基因表达和等位基因信息的分解方法用于分析空间转录组数据中的遗传异质性
• GSE338308 NLRP3炎症小体介导的细胞焦亡在暴露于具有不同表面化学性质的纳米塑料后加剧胰岛素抵抗
• GSE335170 MORC2A 是雄性生殖细胞系中逆转录转座子 DNA 甲基化和 H3K9me3 所必需的
• GSE335167 MORC2A 是雄性生殖细胞中逆转录转座子 DNA 甲基化和 H3K9me3 所必需的 [smallRNA-seq]
• GSE335165 MORC2A 是雄性生殖细胞中逆转录转座子 DNA 甲基化和 H3K9me3 所必需的 [EM-seq]
• GSE335164 MORC2A 是雄性生殖细胞中逆转录转座子 DNA 甲基化和 H3K9me3 所必需的 [CUT&RUN]
• GSE333790 早期心肌梗死中巨噬细胞亚型和行为的转录组学特征
• GSE332854 Sarm1 控制神经损伤后雪旺细胞从保护状态向修复状态的转变 [RNA-seq]
• GSE332811 常见动脉粥样硬化小鼠模型中的单细胞转录组测序
• GSE329876 MUC13 增强鼻上皮细胞中 IL-17 信号通路活性
• GSE327909 单细胞图谱揭示结直肠息肉发生早期微环境重塑的共同特征
• GSE327337 正畸牙齿移动过程中人牙周膜的单细胞图谱
• GSE326147 mRNA表达谱分析TNBS诱导小鼠肠道纤维化
• GSE323388 RNA-seq 对经 CDCA 处理的小鼠 2 细胞胚胎（野生型与 Tcl1 KO）进行分析
• GSE318452 PIF7 中的 PolyQ 重复序列在拟南芥中作为可调温度传感器发挥作用 [RNA-seq]
• GSE315602 补体C3介导的海马CA2突触损伤是母体免疫激活中Srpx2缺陷导致社交缺陷的基础
• GSE311555 核内 Argonaute HRDE-1 通过跨代小 RNA 反馈环维持染色质非依赖性转录沉默 [小 RNA 测序]
• GSE311553 核 Argonaute HRDE-1 通过跨代小 RNA 反馈环维持染色质非依赖性转录沉默 [核 RNA 测序]
• GSE311522 核内 Argonaute HRDE-1 通过跨代小 RNA 反馈环维持染色质非依赖性转录沉默 [bulk RNA-seq]
• GSE311192 Foxp3 和 STAT5 的协同作用通过调节 IL-2 诱导的基因表达赋予调节性 T 细胞适应性
• GSE311187 Foxp3 和 STAT5 的协同作用通过调节 IL-2 诱导的基因表达赋予调节性 T 细胞适应性 [Cut & Run]
• GSE309777 RNA测序用于比较SAIPS-PAI0组和VIPS-PAI组
• GSE307647 跨物种转录组对应关系的几何推断
• GSE299141 系统性硬化症患者和健康对照者的皮肤和外周血单核细胞 (PBMC) 样本的单细胞 RNA 测序
• GSE290169 RNA免疫沉淀测序（RIP-seq）在大肠杆菌J53或CFT073中进行，用于分析与FopA蛋白在体内结合的RNA。
• GSE287634 社会压力对雄性和雌性小鼠的行为和 adBNST 转录组的影响存在差异。
• GSE280419 BL-Hi-C，解析人类胚胎干细胞中CTCF和CTCF-s的多样性
• GSE280302 解读人类胚胎干细胞中 CTCF 和 CTCF-s 的多样性 [ChIP-seq]
• GSE279425 Krüppel样因子5重塑运动骨骼肌中的脂质代谢
• GSE246329 ISL1 和 AQP5 相互协同作用，通过调节 CD44 表达增强胃癌细胞干性。