详细内容（前10条）

1. ⭐ GSE343505 纵向单细胞和空间转录组学揭示犬边缘区淋巴瘤的肿瘤内异质性、治疗反应和比较价值

• ✍️ 作者：未知作者
• 🏷️ 关键词：lymphoma、single-cell、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Canis lupus familiarisThis SuperSeries is composed of the SubSeries listed below.
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2. ⭐ GSE343503 纵向单细胞和空间转录组学揭示犬边缘区淋巴瘤的肿瘤内异质性、治疗反应和比较价值 [scRNAseq 数据]

• ✍️ 作者：未知作者
• 🏷️ 关键词：lymphoma、single-cell、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Grace E Walker ; Marissa Macchietto ; Kelly Reid ; Lauren E Burt ; Amber Winter ; Sara Pracht ; Michelle Buettner ; Velia Penza ; Caitlin Yung ; Rose Dicovitsky ; Alana Kuzmik ; Daniel A Vallera ; Kim Demos-Davies ; Davis M Seelig ; Antonella Borgatti ; Mike Henson ; Caitlin Feiock ; Jaime F Modiano ; Shruthi Naik ; Aaron L Sarver ; Amy E TreefulSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisDiffuse B-cell lymphomas are the most prevalent canine hematologic malignancies, and their clinical presentation resembles that of human B-cell non-Hodgkin lymphomas (NHLs). However, a lack of a clear subtyping framework perpetuates imprecise treatment approaches that fail to address mechanisms of therapy resistance. Here, we employed deep phenotyping via serial sampling and longitudinal transcriptomics to evaluate intratumoral composition and therapy response in a 6-year-old neutered male goldendoodle with stage 5A marginal zone lymphoma (MZL). Following sequential treatment consisting of a single IV dose of oncolytic vesicular stomatitis virotherapy (VSV) and standard CHOP chemotherapy 30 days later, we performed scRNAseq on seven serial lymph node biopsies and spatial sequencing on a resection taken 10 days post-VSV treatment. B cells (>90%) comprised three transcriptionally distinct and temporally stable subpopulations, with specific copy number profiles and robust spatial organization despite disrupted lymph node architecture. Analysis across subpopulations revealed downregulation of the quiescence program including KLF2, suggesting similarity to KLF2-deficient human MZL. While VSV successfully reached target B cells, downstream transcriptional responses were predominantly localized to the T-cell compartment. T cells (≤6%) showed increased proliferation and upregulation of cytotoxicity markers post-VSV administration, enriching for leukocyte-mediated cytotoxicity pathways consistent with an anti-viral immune response. Ultimately, these results provide an in vivo proof-of-concept for the treatment paradigm in canine lymphoma, while emphasizing the need for improved subtyping frameworks and multidimensional treatment strategies targeting intratumoral heterogeneity.
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3. ⭐ GSE308275 卵巢免疫图谱的整合单细胞和空间转录组学揭示了不同巨噬细胞在与卵巢早衰相关的经典半乳糖血症中的作用

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、single-cell、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Raghuveer Kavarthapu ; Son Vo ; Natalie Hanby ; Thang Pham ; Christophe Vanpouille ; Margaret Brunette ; Hong Lou ; Maria Sierra ; Jacqueline C Yano ; Veronica Gomez-LoboSeries Type : OtherOrganism : Homo sapiensPremature ovarian insufficiency (POI) is a complication that affects 80% of females with classic galactosemia (CG), caused by mutations in the GALT gene. Immune system regulates normal physiological processes and pathological aspects of the ovarian function. While previous animal studies have shown that accumulation of toxic galactose metabolites trigger cellular stress pathways, contribute to the disease’s complications, it remains unclear how these influence the immune landscape in CG patients. Here, we investigated the molecular and cellular changes in the ovarian immune environment that may impact the ovarian function contributing to early onset of POI in prepubteral girls with CG. We noticed a marked increase in both monocyte and tissue derived macrophages, and expression of pro-inflammatory cytokines in the CG ovary. Furthermore, we noticed oxidative stress induced activation of NLRP3 inflammasome, which contributed to recruitment of macrophages, induction of pyroptotic cell-death, and overall exacerbation of the inflammatory response.
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4. ⭐ GSE320096 T细胞抗原识别测序（TAR-seq）能够对疫苗诱导的细胞免疫进行体外和体内精确表征。

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、vaccine、T cell、sequencing
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaThis project contains T cell single-cell RNA/TCR-seq data from rhesus macaques, including antigen-stimulated T cells. These data were used to generate a probalistic model for detection of TCR-stimulation.
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5. ⭐ GSE265811 NNMT 缺失通过表观遗传和代谢重编程驱动前列腺癌进展（scRNA-seq）

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、metabolic、scRNA、epigenetic
• 📝 描述：Contributors : Qu Deng ; Erick Mitchell-Velasquez ; Sharan Venkatesh ; Irfan AsanganiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMethionine metabolism plays a pivotal role in cancer, with methionine serving as the primary precursor for S-adenosylmethionine (SAM), a critical methyl donor in various methylation processes, including DNA and histone methylation. This study delves into the genetic deletion and silencing of Nicotinamide N-Methyltransferase (NNMT) in prostate cancer (PCa) and its impact on methionine metabolism and cancer progression. We identify significant loss of NNMT expression in PCa and metastatic castration-resistant prostate cancer (CRPC) compared to healthy prostate tissue. Functional experiments reveal a potential tumor-suppressive role of NNMT in PCa, supported by reduced cell proliferation, colony formation, and sphere formation upon NNMT overexpression. Moreover, we explore the sensitivity of NNMT-positive and NNMT-negative PCa to dietary methionine restriction (MR). NNMT-negative PCa exhibits resistance to MR, which is associated with increased mTORC1 activity. This resistance is characterized by elevated protein synthesis and reduced apoptosis, suggesting a complex interplay between dietary methionine and NNMT expression in cancer. In summary, this study sheds light on NNMT’s multifaceted role in PCa progression, methionine metabolism, and epigenetic regulation. It also highlights potential therapeutic strategies for managing NNMT-negative tumors, offering new avenues for prostate cancer treatment.
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6. ⭐ GSE254506 NNMT 缺失通过表观遗传和代谢重编程驱动前列腺癌进展（RNA-Seq）

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、metabolic、RNA-seq、epigenetic
• 📝 描述：Contributors : Qu Deng ; Erick Mitchell-Velasquez ; Mohammed Alhusayan ; Ramakrishman Natesan ; Sharan Venkatesh ; Priti Lal ; Rahul Mannan ; Irfan A AsanganiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMethionine metabolism plays a pivotal role in cancer, with methionine serving as the primary precursor for S-adenosylmethionine (SAM), a critical methyl donor in various methylation processes, including DNA and histone methylation. This study delves into the genetic deletion and silencing of Nicotinamide N-Methyltransferase (NNMT) in prostate cancer (PCa) and its impact on methionine metabolism and cancer progression. We identify significant loss of NNMT expression in PCa and metastatic castration-resistant prostate cancer (CRPC) compared to healthy prostate tissue. Functional experiments reveal a potential tumor-suppressive role of NNMT in PCa, supported by reduced cell proliferation, colony formation, and sphere formation upon NNMT overexpression. Moreover, we explore the sensitivity of NNMT-positive and NNMT-negative PCa to dietary methionine restriction (MR). NNMT-negative PCa exhibits resistance to MR, which is associated with increased mTORC1 activity. This resistance is characterized by elevated protein synthesis and reduced apoptosis, suggesting a complex interplay between dietary methionine and NNMT expression in cancer. In summary, this study sheds light on NNMT’s multifaceted role in PCa progression, methionine metabolism, and epigenetic regulation. It also highlights potential therapeutic strategies for managing NNMT-negative tumors, offering new avenues for prostate cancer treatment.
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7. ⭐ GSE254505 NNMT 缺失通过表观遗传和代谢重编程驱动前列腺癌进展（ChIP-Seq）

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、metabolic、ChIP-seq、epigenetic
• 📝 描述：Contributors : Qu Deng ; Erick Mitchell-Velasquez ; Mohammed Alhusayan ; Ramakrishman Natesan ; Sharan Venkatesh ; Priti Lal ; Rahul Mannan ; Irfan A AsanganiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMethionine metabolism plays a pivotal role in cancer, with methionine serving as the primary precursor for S-adenosylmethionine (SAM), a critical methyl donor in various methylation processes, including DNA and histone methylation. This study delves into the genetic deletion and silencing of Nicotinamide N-Methyltransferase (NNMT) in prostate cancer (PCa) and its impact on methionine metabolism and cancer progression. We identify significant loss of NNMT expression in PCa and metastatic castration-resistant prostate cancer (CRPC) compared to healthy prostate tissue. Functional experiments reveal a potential tumor-suppressive role of NNMT in PCa, supported by reduced cell proliferation, colony formation, and sphere formation upon NNMT overexpression. Moreover, we explore the sensitivity of NNMT-positive and NNMT-negative PCa to dietary methionine restriction (MR). NNMT-negative PCa exhibits resistance to MR, which is associated with increased mTORC1 activity. This resistance is characterized by elevated protein synthesis and reduced apoptosis, suggesting a complex interplay between dietary methionine and NNMT expression in cancer. In summary, this study sheds light on NNMT’s multifaceted role in PCa progression, methionine metabolism, and epigenetic regulation. It also highlights potential therapeutic strategies for managing NNMT-negative tumors, offering new avenues for prostate cancer treatment.
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8. ⭐ GSE285539 ​​NNMT缺失通过表观遗传和代谢重编程驱动前列腺癌进展

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、metabolic、epigenetic
• 📝 描述：Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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9. ⭐ GSE339161 巨噬细胞 NPM1 通过 STAT3-CCRL2 轴驱动抗肿瘤免疫

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity、macrophage
• 📝 描述：Contributor : Rongchuan ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlthough nucleophosmin (NPM1) is a well-characterized oncogene in acute myeloid leukemia, much less is known about its role in solid tumor immunity. Here, we examined the function of NPM1 in regulating anti-tumor immunity within the tumor microenvironment.
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10. ⭐ GSE336709 CpG 高甲基化和 WNT/AP-1 协同作用定义了高危儿童肾上腺皮质癌的表观遗传图谱和临床亚组 [甲基化芯片]

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、epigenetic、methylation
• 📝 描述：Contributors : Victoria E Fincke ; Mauice Loßner ; Marina Kunstreich ; Nic G Reitsam ; Irmengard Sax ; Marlena Mucha ; Felix Dorn ; Lorenz C Helmschrott ; Maria D Hernandez Ramirez ; Sebastian Dintner ; Konstantin Okonechnikov ; Martin Sill ; Ina Oehme ; Heike Peterziel ; Enrique Blanco-Carmona ; Eva Sipos ; Stefan Wudy ; Christoph Slavetinsky ; Jörg Fuchs ; Bruno Märkl ; Eva Jüttner ; Christian Vokuhl ; Michael C Frühwald ; Antje Redlich ; Stefan Pfister ; Matthias Schlesner ; Rainer Claus ; Michaela Kuhlen ; Pascal D JohannSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensTreatment of three adult ACC cell lines (H295R and ACC1, ACC2) with entinostat and decitbaine led to consistent dose-dependent changes in DNA methylation patterns. These findings support entinostat’s potential to reverse high-risk epigenetic programs in pACT and highlight HDAC inhibition as a promising therapeutic avenue, particularly when combined with established treatments.
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1. 机器学习改进了活性基因的RNA测序注释

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：Machine learning improves interpretation of RNA sequencing data, helping researchers accurately identify active genes, non-coding RNAs, and other transcription units…
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2. RNA测序有助于预测干细胞移植对儿童急性髓系白血病（AML）的疗效。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：RNA sequencing powers the HSCT-64 framework to predict which children with acute myeloid leukemia are most likely to benefit from hematopoietic stem cell transplantation…
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3. 运动或许有助于衰老的大脑“清理垃圾”。

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging
• 📝 描述：Regular exercise may help the brain clear away harmful waste that can build up with age. Researchers found that physical activity supports several processes linked to the brain’s glymphatic cleanup system, including better sleep, lower inflammation, and healthier blood vessels. Because this waste-removal system becomes increasingly important as we get older, exercise could play a meaningful role in protecting against cognitive decline.
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• GSE308221 CpG 高甲基化和 WNT/AP-1 协同作用定义了高危儿童肾上腺皮质癌的表观遗传图谱和临床亚组 [甲基化芯片]
• GSE287499 Slc16a1-Col2a1CreERT2 小鼠脊柱运动节段的空间转录组学分析揭示了椎间盘中不同区域的差异。
• GSE342714 表观遗传抑制因子 TRIM28 协调心肌小梁形成和致密化以促进心腔形成 [RNA-Seq]
• GSE305335 致癌超级增强子激活TKT调控前列腺癌中的代谢重编程和免疫抑制重塑
• GSE335590 对 GPP 进行系统性单细胞分析，揭示治疗反应性和持续性免疫特征
• GSE325223 硬脑膜转移模型中脑膜淋巴管的RNA测序
• GSE317987 埃塞俄比亚皮肤利什曼病病变的空间分布图揭示了患者定义的免疫特征
• GSE317208 无机砷暴露后前列腺肿瘤微环境的免疫调节
• GSE297732 一种基于单细胞RNA测序的抗氧化粘合水凝胶，用于无疤痕且功能性地修复声带
• GSE284617 DNMT1 促进代谢功能障碍相关脂肪肝疾病的进展 [ChIP-seq]
• GSE284446 DNMT1 促进代谢功能障碍相关脂肪肝疾病的进展 [RNA-seq]
• GSE343489 CpG 高甲基化和 WNT/AP-1 协同作用定义了高危儿童肾上腺皮质癌的表观遗传图谱和临床亚组
• GSE336546 CpG 高甲基化和 WNT/AP-1 协同作用定义了高危儿童肾上腺皮质癌的表观遗传图谱和临床亚组 [细胞系]
• GSE302010 独特的表观遗传改变和加速的有丝分裂衰老定义了第二原发性乳腺癌
• GSE293400 RNA-seq 数据用于研究 NCI-H23 对 KRAS 抑制剂的反应
• GSE277200 MicroRNA155 在阿尔茨海默病海马神经发生和 GABA 能信号传导中的作用 [MIR155 过表达 RNA 测序数据]
• GSE277199 MicroRNA155 在阿尔茨海默病海马神经发生和 GABA 能信号传导中的作用 [MIR155 敲除 RNA 测序数据]
• GSE272774 通过单细胞测序定义人类软组织对种植体周围炎的异质性
• GSE242936 DNA复制应激诱导的人类伯基特淋巴瘤细胞转录组鉴定出MBD1是生发中心来源B淋巴瘤发生的新型抑制因子
• GSE242935 DNA复制应激诱导的人类伯基特淋巴瘤细胞转录组鉴定出MBD1是生发中心衍生B淋巴瘤发生的新型抑制因子[ChIP]
• GSE242375 DNA复制应激诱导的人类伯基特淋巴瘤细胞转录组鉴定出MBD1是生发中心衍生B淋巴瘤发生的新型抑制因子[RNA]
• GSE343103 RNA-seq 分析 LNCaP 前列腺癌细胞中 FOXA1 和 TRIM28 敲低的影响
• GSE342713 表观遗传抑制因子 TRIM28 协调心肌小梁形成和致密化以促进心腔形成 [CUT&Tag]
• GSE310682 转录因子 BLIMP1 通过调节巨噬细胞对营养挑战的适应来促进肥胖和动脉粥样硬化 [scRNA-Seq]
• GSE305381 BET 抑制剂与高卡度胺通过抑制弥漫性大 B 细胞淋巴瘤中的 MYC 和 E2F 通路产生协同作用 [ATAC-Seq]
• GSE305380 BET 抑制剂与高卡度胺通过抑制弥漫性大 B 细胞淋巴瘤中的 MYC 和 E2F 通路产生协同作用 [ChIP-Seq]
• GSE305378 BET 抑制剂与高卡胺通过抑制弥漫性大 B 细胞淋巴瘤中的 MYC 和 E2F 通路产生协同作用 [RNA-Seq]
• GSE303245 NSUN6敲低HepG2细胞中全转录组M5C甲基化谱分析
• GSE286430 KSR2 是 TAL1 阳性 T 细胞急性淋巴细胞白血病中的一种新型候选癌基因，具有潜在的临床意义。
• GSE283283 衰老和感染中补体途径和丝氨酸蛋白酶抑制剂激活的时空转录组学微环境
• GSE343455 VEGFR1阻断抗体改善糖尿病小鼠的内皮结构、肾功能和肾小球滤过率
• GSE331211 小鼠肝脏急性乙醇诱导肝损伤的RNA测序分析
• GSE328129 肾小管上皮细胞通过PANX1-胞外ATP-P2X7信号通路促进醛固酮依赖性肾损伤中的巨噬细胞焦亡
• GSE327695 产肠毒素脆弱拟杆菌在小鼠中诱导宿主基因型特异性结肠上皮和免疫反应，样本集#2：富含白细胞的结肠制备
• GSE327693 产肠毒素脆弱拟杆菌在小鼠中诱导宿主基因型特异性结肠上皮和免疫反应，样本集#1
• GSE327633 抑制性转录因子的系统性降解控制基因表达和细胞命运决定 [delWD40TLE1 RNAseq]
• GSE327631 系统性降解抑制性转录因子控制基因表达和细胞命运决定 [RNAseq R610S-TLE1]
• GSE324141 PTPN13 通过 IRF3 和 PI3K-p85 的去磷酸化促进埃博拉病毒诱导的免疫失调
• GSE323095 MiaA介导的tRNA修饰将色氨酸衰减和tRNA丰度的变化与铜绿假单胞菌的复杂表型联系起来[RNA-seq]
• GSE322960 D2-mdx小鼠骨骼肌和心肌纤维脂肪生成祖细胞的纤维化分化谱
• GSE310369 天然产物 Corramycin 作为 DNA 回旋酶抑制剂，可克服结核分枝杆菌的氟喹诺酮类耐药性
• GSE309037 人类原代单核细胞在I型干扰素刺激或与胶质母细胞瘤细胞共培养后的转录组变化
• GSE293914 耐药持续细胞释放的 CCL20 会损害 EGFR 突变型肺腺癌的免疫治疗
• GSE288182 局部脑重编程可缓解阿尔茨海默病及相关骨质流失
• GSE285014 DNMT1 促进代谢功能障碍相关脂肪肝疾病的进展 [snRNA-Seq]
• GSE284281 硬脑膜转移模型硬脑膜的单细胞测序
• GSE283953 DNMT1促进代谢功能障碍相关脂肪肝疾病的进展
• GSE343611 全基因组解旋酶生成的单链DNA图谱揭示了RNA聚合酶III转录基因处的Hrq1活性
• GSE335328 全氟辛酸暴露加速果蝇幼体发育并扰乱线粒体代谢
• GSE325415 癌症和化疗引起的恶病质的不同影响：基于生物性别的结直肠癌临床前模型比较分析
• GSE318634 西伯利亚披碱草（Elymus sibiricus）中NAC转录因子的全基因组鉴定及EsANAC029在光响应中的功能表征
• GSE313391 研究表明，BCAP31 或 POLR1E 的缺失会加速秀丽隐杆线虫的衰老，并与血管内皮细胞的衰老有关。
• GSE312222 METTL1 的药理学抑制作为治疗实体瘤和血液肿瘤的疗法 [RNA-Seq]
• GSE310599 小鼠新皮层深部兴奋性神经元类型的时空发育
• GSE305910 USP7 测序在未经处理的 MDA-MB-231 细胞中
• GSE305729 DNA折纸疫苗程序化抗原聚焦生发中心
• GSE305228 TDP2介导的DNA修复调控神经元早期反应基因转录和皮层神经元连接的动态变化
• GSE303272 靶向 S100A9 以抑制急性髓系白血病的恶性进展
• GSE280829 对高蛋氨酸饮食诱导的高同型半胱氨酸血症小鼠（接受或未接受甜菜碱治疗）的海马组织进行 RNA 测序。
• GSE280828 高蛋氨酸饮食后 C57BL/6 小鼠皮层的 RNA 测序。
• GSE280827 C57BL/6 小鼠高蛋氨酸喂养 8 周以上后海马中 H3K27ac 和 H3K27me3 的 ChIP-seq。
• GSE233871 “数字染色体显带”：一种基于单细胞RNA测序的染色体显带方法可区分真实性别和假性性别
• GSE343158 甲硫氨酸驱动的PPARγ N⁶-甲基腺苷修饰在浸润巨噬细胞中促进胶质母细胞瘤的免疫抑制
• GSE339052 肝细胞来源的 sIL1RAP 在饮食条件下抑制慢性炎症
• GSE310681 转录因子BLIMP1通过调节巨噬细胞对营养挑战的适应性来促进肥胖和动脉粥样硬化
• GSE305382 BET抑制剂通过抑制弥漫性大B细胞淋巴瘤中的MYC和E2F通路与高尔卡度胺产生协同作用
• GSE297473 利用mRNA递送对人类造血干细胞进行体内基因组编辑以治疗血液疾病
• GSE292825 甲基化的eEF1A选择性解码mRNA以塑造癌症蛋白质组