详细内容（前10条）

1. ⭐ GSE313353 肠道 BMP SMADs 通过直接靶向绒毛分区基因和控制转录因子层级来赋予绒毛中部模式 [空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Contributors : Alexandra Logerfo ; Jahangir Iqbal ; Rachel Ofer ; Sneha Kandalgaonkar ; Rahma Rizly ; Kiranmayi Vemuri ; Lei Chen ; Martin Matzuk ; Michael VerziSeries Type : OtherOrganism : Mus musculusIntestinal villus enterocytes exist in spatially restricted cell states, called zones, and continuously transdifferentiate as they migrate toward the villus tip. Bone morphogenetic protein (BMP) signaling through the BMPR1A receptor is required for zonation of enterocytes; however, the molecular mechanisms and transcriptional regulators downstream of BMP ligands/receptors are unclear. Using compound genetic mouse models and epigenomic techniques, we find that SMAD1 and SMAD5 are necessary for activation of middle villus zone genes via direct binding and control of a transcription factor hierarchy. Spatial transcriptomics reveal a homeotic-like shift in the villus pattern of SMAD1/SMAD5 double mutants, with the villus bottom and tip domains expanding at the expense of the middle. Surprisingly, SMAD1 and SMAD5 are not required for regulation of villus tip identity, which is dependent on SMAD4. Epigenomics approaches identify a mechanism for villus patterning in which SMAD1/5 directly activate some mid-villus genes and control others via a transcription factor hierarchy, including a SMAD-regulated transcription factor, TBX3, as a downstream effector of villus zonation.
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2. ⭐ GSE341921 PGK1 兼具 NF-κB/p65 激酶的功能，在三阴性乳腺癌中协调 M2 样巨噬细胞介导的免疫抑制

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、macrophage、regex:immuno(logy|therapy|suppression)、kinase
• 📝 描述：Contributors : Wenhui Li ; Tinglin Yang ; Chaocong Xu ; Anwen Ren ; Yiyang Shen ; Pengfei Yi ; Tao HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTriple-negative breast cancer (TNBC) is the most aggressive molecular subtype with limited therapeutic options. Metabolic reprogramming is a hallmark of cancer, and emerging evidence indicates metabolic enzymes possess non-canonical moonlighting functions. We identified phosphoglycerate kinase 1 (PGK1) as a key link between glycolysis and immunosuppression in TNBC. To investigate the role of PGK1 in shaping the tumor immune microenvironment, we performed single-cell RNA sequencing (scRNA-seq) on TNBC cells (4T1) with PGK1 knockdown (shPgk1) and negative control (shNC), each with three biological replicates. Single-cell libraries were prepared on the TaiM4 scRNA platform and sequenced on the BGI DNBSEQ platform using paired-end sequencing. A total of 33,138 high-quality cells were retained after quality filtering. Our analysis revealed that PGK1 knockdown significantly altered the transcriptional landscape and immune signaling pathways in TNBC cells.
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3. ⭐ GSE339365 全基因组 H3K4me3 分析揭示了 COVID-19 急性危重期循环免疫细胞的动态表观遗传重编程

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、genome、epigenetic
• 📝 描述：Contributors : Dominik Schaack ; Benedikt H Siegler ; Jan Niklas Thon ; Markus A WeigandSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSevere COVID-19 is associated with innate immune dysregulation resembling sepsis-induced immunoparalysis. Epigenetic mechanisms, particularly changes in H3K4me3 enrichment at gene promoters, have been observed in immune tolerance and monocyte dysfunction in sepsis. Whether comparable H3K4me3 alterations occur during acute critical COVID-19 illness has not been investigated. Among 706 differentially bound consensus peaks with promoter association between ICU and non-ICU groups, 704 showed increased H3K4me3 occupancy in ICU patients, predominantly at neutrophil effector gene loci, supported by pathway enrichment of neutrophil degranulation and innate immune activation. Monocyte HLA-DR expression and ex vivo TLR-stimulated IL-6 secretion were persistently reduced throughout the first week of ICU treatment. Longitudinal profiling in the ICU group revealed a shift from an interferon-driven chromatin signature at admission toward sustained innate immune activation and ECM remodelling at day seven. This study provides the first genome-wide H3K4me3 characterization of circulating immune cells during acute critical COVID-19, demonstrating that epigenetic reprogramming is an active and dynamic process that mirrors the functional immune dysregulation observed in these patients.
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4. ⭐ GSE327915 膳食中的猪殃酸A通过靶向肠道菌群-免疫轴缓解抑郁样行为

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、gut、regex:gut(-?microbiome)?
• 📝 描述：Contributors : Jiangwei Yang ; Yun Ma ; Zixin Liang ; Shuihong Wang ; Heqiu WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated whether dietary poricoic acid A (PAA) alleviates chronic unpredictable stress (CUS)-induced depressive-like behaviors in mice by modulating the gut microbiota-immune axis. Male C57BL/6J mice were subjected to CUS and treated with PAA. Results showed that PAA alleviated depressive- and anxiety-like behaviors, reduced hippocampal neuronal damage, and restored gut microbiota composition by suppressing harmful bacteria like Ligilactobacillus murinus while promoting beneficial taxa such as Akkermansia muciniphila and Lactobacillus reuteri. Hippocampal transcriptomics revealed that PAA modulated immune cell infiltration by reducing M1 and restoring M2 macrophages, with significant correlations between gut microbial taxa and hippocampal immune gene expression. Functional analyses indicated that PAA regulated pathways related to synaptic plasticity and neuroinflammation, which was confirmed by qPCR and Western blot showing restored expression of HSP90B1, RPS6KB2, IGF2BP2, and COL4A5. In conclusion, dietary PAA alleviates depressive-like behaviors in CUS mice by remodeling the gut microbiota and modulating the hippocampal M1/M2 macrophage balance via the gut-brain axis, supporting its potential as a prebiotic-like nutritional agent for major depressive disorder.
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5. ⭐ GSE337374 前列腺干细胞抗原 (PSCA) 在结直肠癌中的致癌作用：对靶向治疗的启示

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、antigen、regex:onco(logy|logist|gene|genic)
• 📝 描述：Contributors : Jinyue Duan ; Yi Wang ; Qisen Li ; Yujue Wang ; Jinrui Liu ; Yi Qi ; Yichi Zhang ; Changhao Fu ; Zhongyi Cong ; Can Wang ; Manman SuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProstate stem cell antigen (PSCA), a pivotal member of the lymphocyte antigen-6 (Ly6) protein family, has been implicated in the tumorigenesis and neoplastic progression of diverse cancer types. In this study, we conducted a thorough investigation into the role of PSCA in the development of colorectal cancer (CRC). Survival analysis based on The Cancer Genome Atlas (TCGA) dataset demonstrated that elevated expression of PSCA was tightly correlated with unfavorable overall survival, inferior relapse-free survival and worse post-progression survival among CRC patients.Additionally, PSCA exhibited significantly higher expression levels in colorectal cancer stem cell (CRC-SCs) rel-ative to CRC cell lines.Loss-of-function assaysusing small interfering RNA (siRNA)-mediated silencing were performed to evaluate the effects of PSCA downregula-tion on the stemness properties of CRC-SCs, including proliferative capacity, invasive potential and apoptotic rate, which were assessed by MTS assay, transwell invasion assay and flow cytometry analysis, respectively. The results showed that silencing PSCA markedly suppressed the proliferation and invasion of CRC-SCs, while significantly promoting cellular apoptosis. RNA sequencing was performed to identify differentially expressed genes (DEGs) in the PSCA knockdown group compared to the negative control group.
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6. ⭐ GSE319762 CD47阻断重编程单核细胞-巨噬细胞轴以促进动脉粥样硬化中的炎症消退

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、monocyte、inflammation
• 📝 描述：Contributors : Murat Kirtay ; Kai-Uwe JarrSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTargeting the CD47-SIRPα axis, a dominant “don’t-eat-me” signal, via innate immune checkpoint inhibition limits atherosclerosis in preclinical models and early clinical studies. However, how this pro-efferocytic intervention reshapes the immune landscape of atherosclerotic lesions remains incompletely understood. Using single-cell transcriptomics, we comprehensively characterized the transcriptomic profile of mouse CD45+ aortic leukocytes by CD47 blockade.
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7. ⭐ GSE313530 非人灵长类动物空间转录组学数据集

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Jayden A O’Brien ; Nishka Kuttanna ; Khadijah Mazhar ; Marisol Mancilla Moreno ; Asta Arendt-Tranholm ; Joseph B Lesnak ; Michael A Wilde ; Rainer V Haberberger ; Jane M Brandon ; Katherin A Gabriel ; Seph M Palomino ; Theodore J PriceSeries Type : OtherOrganism : Macaca fascicularis ; Macaca mulatta ; Papio anubis10X genomics Visium spatial RNA sequencing was performed on 18 non-human primate dorsal root ganglia (16 Macaca fascicularis, 1 Macaca mulatta, Papio anubis)
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8. ⭐ GSE311831 百日咳毒素诱导的淋巴细胞增多症增强了抗肿瘤免疫环境，并改善了鳞状细胞癌模型中的抗PD1治疗反应。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、carcinoma、immune
• 📝 描述：Contributors : Jae-Keun Cho ; Kyungmin Lee ; Da-Yong Shin ; Truc D Nguyen ; Woong-Yang Park ; Se jin Im ; Han-Sin JeongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusElevation of the neutrophil-to-lymphocyte ratio (NLR) in cancer patients predicts a worse prognosis, and NLR is a good discriminator in response to anti-tumor immune checkpoint inhibitors. However, the therapeutic potential of NLR normalization to enhance the efficacy of anti-tumor immunotherapy has not been investigated. In this study, we chose pertussis toxin (PTX) as an agent to induce lymphocytosis and lower NLR. PTX decreased NLR in squamous cell carcinoma (SCC)-tumor-bearing mice and shifted the tumors from low to high immune scores. PTX-induced elevation of CXCL9 led to lymphocytosis and increased immune cell infiltration in tumor tissues. The combination treatment with PTX and anti-PD1 antibody significantly suppressed in vivo SCC tumor growth, compared to anti-PD1 treatment alone. The combination treatment induced a larger proportion of T cells in the tumor microenvironment, and these findings were associated with an increase in terminally differentiated CD8 T cells and their augmented Ki-67 expression. In addition, tumor-specific IFN-γ production was augmented in animals treated with anti-PD1 antibody and combination treatments, but not with PTX alone. In summary, PTX can induce high lymphocyte infiltration into tumor tissue, leading to the NLR normalization and a favorable immune environment for immune checkpoint inhibitors.
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9. ⭐ GSE306702 恒河猴睾丸单细胞图谱揭示了衰老和季节依赖性的精子发生和微环境稳态调控 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging、RNA-seq、single-cell
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaSpermatogenesis is a highly orchestrated process that depends on precise coordination between germ cells and the testicular microenvironment. However, how aging and seasonal shifts jointly regulate this process in nonhuman primates remains largely unexplored. Here, we generated a comprehensive single-cell transcriptomic atlas of the rhesus monkey testis across different ages and reproductive seasons. Our analyses reveal that Sertoli cells actively regulate the blood–testis barrier (BTB) by dynamically remodeling tight and adherens junctions, thereby mediating seasonal fluctuations in meiotic germ cells. We further identified a previously uncharacterized SSC subpopulation (U3) enriched in the non-breeding season, defined by PDGF pathway activation. By integrating this pathway into a three-dimensional collagen–PDGF scaffold, we successfully established an in vitro rhesus SSC culture system with enhanced clonogenicity and long-term propagation. In parallel, testicular immunosenescence emerged as a key determinant of age-related reproductive decline. We provide the first evidence that double-negative T cells (DNTs) markedly accumulate in aged testes, while pro-inflammatory macrophages (Mφ_SPAG16, M1-like) aberrantly expand during the non-breeding season, together disrupting immune homeostasis and niche support. Collectively, this study delineates the age- and season-dependent regulation of spermatogenesis in rhesus monkeys by integrating Sertoli–BTB dynamics, SSC niche signaling, and immune remodeling, thereby providing new mechanistic insights into testicular aging and reproductive homeostasis. experimental design：Following the manufacturer’s protocol, cells were isolated from rhesus monkey testicular tissue for single-cell RNA sequencing, with results validated via immunocytochemistry and qPCR.
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10. ⭐ GSE306699 恒河猴睾丸单细胞图谱揭示了衰老和季节依赖性的精子发生和微环境稳态调控 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging、single-cell、scRNA
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaSpermatogenesis is a highly orchestrated process that depends on precise coordination between germ cells and the testicular microenvironment. However, how aging and seasonal shifts jointly regulate this process in nonhuman primates remains largely unexplored. Here, we generated a comprehensive single-cell transcriptomic atlas of the rhesus monkey testis across different ages and reproductive seasons. Our analyses reveal that Sertoli cells actively regulate the blood–testis barrier (BTB) by dynamically remodeling tight and adherens junctions, thereby mediating seasonal fluctuations in meiotic germ cells. We further identified a previously uncharacterized SSC subpopulation (U3) enriched in the non-breeding season, defined by PDGF pathway activation. By integrating this pathway into a three-dimensional collagen–PDGF scaffold, we successfully established an in vitro rhesus SSC culture system with enhanced clonogenicity and long-term propagation. In parallel, testicular immunosenescence emerged as a key determinant of age-related reproductive decline. We provide the first evidence that double-negative T cells (DNTs) markedly accumulate in aged testes, while pro-inflammatory macrophages (Mφ_SPAG16, M1-like) aberrantly expand during the non-breeding season, together disrupting immune homeostasis and niche support. Collectively, this study delineates the age- and season-dependent regulation of spermatogenesis in rhesus monkeys by integrating Sertoli–BTB dynamics, SSC niche signaling, and immune remodeling, thereby providing new mechanistic insights into testicular aging and reproductive homeostasis. experimental design：Following the manufacturer’s protocol, cells were isolated from rhesus monkey testicular tissue for single-cell RNA sequencing, with results validated via immunocytochemistry and qPCR.
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1. ⭐ 对用于单细胞和空间转录组学的长读长RNA测序工具进行基准测试

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：RNA sequencing benchmark compares long-read bioinformatics tools for single-cell and spatial transcriptomics, helping researchers improve isoform detection and gene…
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2. 斯坦福大学科学家发现免疫细胞会像微型炸弹一样爆炸

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune
• 📝 描述：Stanford researchers discovered immune cells in flatworms that explode within minutes, killing nearby bacteria and foreign cells before vanishing completely. Their unusually fast and localized attack could offer clues for developing targeted treatments against infections and cancer.
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• 利用ATAC-seq技术对小鼠外周淋巴结和派氏淋巴集结中的高内皮细胞（HEC）进行染色质可及性分析（GSE342565）。
• GSE313450 心脏收缩通过抑制静脉淋巴命运来塑造心内膜特性。
• GSE313352 肠道 BMP SMADs 通过直接靶向绒毛分区基因和控制转录因子层级来赋予绒毛中部模式 [ATAC-seq]
• GSE313351 肠道 BMP SMADs 通过直接靶向绒毛分区基因和控制转录因子层级结构来赋予绒毛中部模式 [RNA-seq]
• GSE336341 IGF2BP2 通过 PI3K/AKT 信号通路促进食管鳞状细胞癌的进展
• GSE329207 靶向磷脂酰丝氨酸抑制肿瘤细胞 [RNA-seq]
• GSE327289 脑血管单核 RNA 测序揭示阿尔茨海默病和原发性 tau 蛋白病中的热休克激活和血管重塑
• GSE314062 血浆cfDNA中细胞特异性DNA甲基化标记揭示头颈癌的诊断潜力
• GSE313808 利用集成的单细胞、空间和原位分析对人类皮肤慢性伤口组织生物膜感染进行高分辨率映射 [Xenium]
• GSE305287 调节性T细胞在肿瘤免疫逃逸早期阶段抑制CD8+ TRM样细胞
• GSE295392 PIKfyve调控的脂质代谢是神经内分泌前列腺癌的治疗靶点
• GSE293600 多梳蛋白 EED 限制小细胞肺癌神经内分泌表型并驱动肺癌组织学转化 [ATAC-seq]
• GSE293599 多梳蛋白 EED 限制小细胞肺癌神经内分泌表型并驱动肺癌组织学转化 [批量 RNA 测序]
• GSE293598 多梳蛋白 EED 限制小细胞肺癌神经内分泌表型并驱动肺癌组织学转化 [ChIP-seq]
• GSE293597 多梳蛋白 EED 限制小细胞肺癌神经内分泌表型并驱动肺癌组织学转化 [scRNA-seq]
• GSE288076 不同年龄段幼稚CD4+ T细胞的全基因组DNA甲基化
• GSE342584 肿瘤靶向IL-10联合IL-2可增强抗肿瘤免疫力
• GSE342177 REMODEL：用于纵向ctDNA甲基化谱分析的模块化框架揭示了治疗反应和复发相关的表观遗传重塑
• GSE316081 SLF2 和 SMC5 功能障碍驱动 HSC 衰老并易患 MDS，定义了一种新的遗传性骨髓衰竭综合征 [RNA-seq]
• GSE316079 SLF2 和 SMC5 功能障碍驱动 HSC 衰老并易患 MDS，定义了一种新的遗传性骨髓衰竭综合征 [ATAC-seq]
• GSE304710 泛ERBB抑制剂与KRAS抑制剂在直肠癌中具有协同作用
• GSE274081 ILC3 需要一种独特的顺式调控元件来通过放大 RORγt 表达来维持肠道耐受性 [scRNA-seq]
• GSE314239 氟伐他汀联合双嘧达莫通过乳酸脱氢酶相关的胆固醇/脂质代谢抑制犬血管肉瘤在患者来源异种移植模型中的生长
• GSE313354 肠道 BMP SMADs 通过直接靶向绒毛分区基因和控制转录因子层级来赋予绒毛中部模式 [CUT&Run]
• GSE310573 外周神经胶质细胞驱动皮肤鳞状细胞癌的发生
• GSE310323 抑制两条p53通路通过MTHFD1L-RNA m6A诱导的自主细胞生长和免疫逃逸促进HCC的发生
• GSE280574 mChIP-seq 高通量表观基因组分析揭示了癌症中 H2A.Z 和 H3K4me3 的解耦现象
• GSE337651 墨西哥中部人群骨肉瘤和健康骨样本的 RNA-seq 分析
• GSE336982 肥胖通过气道免疫功能障碍促进肺癌发生
• GSE332750 miR-206转染肺腺癌细胞系的转录组分析
• GSE330633 术后复发患者原发性EGFR突变肺腺癌组织的小RNA测序
• GSE330103 核纤层蛋白调控心肌细胞成熟基因的核和染色质结构。(Hi-C)
• GSE330100 核纤层蛋白调控心肌细胞成熟基因的核和染色质结构。(P0.5 scRNA-seq)
• GSE330099 核纤层蛋白调控心肌细胞成熟基因的核和染色质结构。(P0.5 ATAC-seq)
• GSE330013 核纤层蛋白调控心肌细胞成熟基因的核和染色质结构。(P7.5 批量 RNA 测序)
• GSE328683 可编程合成细胞因子受体使巨噬细胞极化为用户定义的功能状态
• GSE326385 岩藻黄素通过抑制 CD36 驱动的脂肪酸摄取来改善代谢功能障碍相关的脂肪性肝炎
• GSE326115 代谢和骨骼肌功能障碍与多发性硬化症动物模型中的疲劳样行为相关
• GSE323384 对照组和 LACTB KO iPSC 衍生小胶质细胞的批量 RNA 测序
• GSE323383 对照组和 LACTB KD 人 THP1 巨噬细胞的批量 RNA 测序
• GSE319390 哺乳动物循环释放的miRNA（乳腺癌高发和低发病率）作为人类乳腺癌风险的指标
• GSE315656 高危骨髓增生异常综合征中阿扎胞苷反应的RNA表观遗传学和线粒体特征
• GSE313272 原子级 TCR-配体相互作用指导记忆 T 细胞分化和交叉反应性 [RNA-seq]
• GSE309979 GeoMx GeoMx-DSP 毒性脂质诱导的肝窦内皮细胞ICAM1表观遗传激活调节MASH中髓系驱动的纤维炎症反应
• GSE309841 前列腺癌男性患者的整合组织分析 VIII
• GSE308157 抗逆转录病毒治疗后HTLV-1无症状携带者和HAM/TSP患者免疫细胞的转录重编程
• GSE303895 糖尿病引起的听力损失：基于下一代测序的研究模型
• GSE299128 尼达尼布和免疫抑制剂治疗自身免疫性炎症性肌病和进行性肺纤维化的耐受性和安全性
• GSE297438 靶向 CPSF73（mRNA 3’ 末端加工核酸内切酶）可逆转癌细胞的上皮-间质转化
• GSE293596 多梳蛋白 EED 限制小细胞肺癌神经内分泌表型并驱动肺癌组织学转化 [snRNA-seq]
• GSE286453 电场诱导释放和测量正常及高危妊娠妇女尿液转录组学和关键蛋白的液体活检
• GSE277942 果蝇（Drosophila melanogaster）中肠中未交配和已交配雌蝇的差异表达分析
• GSE274031 HepG2 ChIP-seq
• GSE266964 肥胖破坏了下丘脑摄食回路中 CtBP2 介导的转录平衡维持 [ChIP-seq]
• GSE263716 静息幼稚（rN）和过渡（T1T2）B细胞中SLE疾病活动的表观遗传学分析
• GSE242392 拟南芥叶绿体基因组在发育和环境刺激过程中的断裂
• GSE242391 拟南芥叶绿体基因组在发育和环境刺激下的断裂（ssDRIP-Seq）
• GSE242390 拟南芥叶绿体基因组在发育和环境刺激过程中的断裂（DEtail-Seq）
• GSE236955 外周神经胶质细胞驱动皮肤鳞状细胞癌的发生
• GSE186351 机器学习方法利用全基因组血液中5-羟甲基胞嘧啶识别多发性骨髓瘤生存预后模型
• GSE342329：伊立替康治疗的野生型和Gsdme缺陷型小鼠小肠转录组分析
• GSE342273 全基因组转录组分析揭示了三室甘蓝（Brassica rapa var. trilocularis）中茉莉酸介导的防御重编程和硫代葡萄糖苷积累
• GSE333484 MDM2 结合并抑制 RNA 聚合酶 III，从而抑制针对胞质 DNA 的先天免疫反应
• GSE304808 鸡先天性抗病毒免疫反应中IRF9的功能分析
• GSE304294 一项研究发现，靶向 TROP2 的抗体药物偶联物 (ADC) 与氧化磷酸化抑制剂协同作用，通过抑制 PI3K-AKT-mTOR 信号通路增强食管鳞状细胞癌 (ESCC) 细胞凋亡。
• GSE299996 WT1 通过改变细胞外硫酸乙酰肝素状态来调控 Sulf1 的转录，从而启动心外膜信号传导和命运 [scRNA-Seq]
• GSE299995 WT1 对 Sulf1 的转录控制通过改变细胞外硫酸乙酰肝素状态启动心外膜信号传导和命运 [ATAC-Seq]
• GSE342035 对 SNCA-GR 人源化敲入小鼠的四个脑区进行批量长读长 RNA 测序，以表征 SNCA 同工型
• GSE342034：SNCA-GR人源化敲入小鼠黑质/腹侧被盖区和嗅球的匹配短读长和长读长单核RNA测序
• GSE314478 高通量测序数据，来自经15轮筛选后通过捕获-SELEX法获得的雌马酚适体。