详细内容（前10条）

1. ⭐ GSE305176 细胞类型分辨的空间蛋白质组学和转录组学整合揭示早期卵巢癌的新机制

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、spatial、transcriptomics、proteomics
• 📝 描述：Contributors : Andreas Metousis ; Hilary A Kenny ; Aasa Shimizu ; Lisa Schweizer ; Shani Ben-moshe ; Agnes Bilecz ; Rahul Krishnan ; Jingwen Zhang ; Isabel Alcazar ; Lucy Kelliher ; Mallika Ravi ; Tejas Samantarey ; Sabrina Richter ; Yan Li ; Jiying Wang ; Sophia Steigerwald ; Fabian J Theis ; Florian A Rosenberger ; Thierry M Nordmann ; Seiko D Yamada ; Ricardo Lastra ; Matthias Mann ; Ernst LengyelSeries Type : OtherOrganism : Homo sapiensHigh-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for early-stage cancer detection and development of effective treatment stategies. We performed and integrated spatial cell-type resolved proteomics and paired transcriptomics across 25 women with precursor lesions of the fallopian tube and/or HGSC. Epithelial cell signatures revealed early activation of SUMOylation machinery, increased ATR and Wnt signaling, and enhanced MHC-I antigen presentation along the disease trajectory. The stroma exhibited extracellular matrix (ECM) remodeling and interferon-mediated inflammation. Serous tubal intraepithelial carcinomas (STICs) in cancer patients contained a pro-coagulative signature and reduced APOA1/2 compared to STICs in individuals without cancer. Functional studies confirmed the role of epithelial-derived TRIP13 and SUMOylation, and cancer-associated fibroblast-derived SULF1 and BGN in HGSC progression. These findings provide unique molecular insights into HGSC pathogenesis and identify potential new therapeutic targets for intervention.
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2. ⭐ GSE301933 CD36介导的反应性小胶质细胞脂质积累通过Nlrp3-IL-1β通路驱动视网膜变性[空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、pathway
• 📝 描述：Contributors : Tian Zhou ; Ziqi Yang ; Biyan Ni ; Hong Zhou ; Yang Zhou ; Jingpeng Li ; Minglu Ma ; Huaicheng Wang ; Peng An ; Huiyi Xu ; Xiaojing Lin ; Shiya Lin ; Shida Chen ; Lixia Lin ; Wei Yi ; Xialin Liu ; Chang HeSeries Type : OtherOrganism : Mus musculusLipid accumulation in microglia through CD36 enhances Nlrp3 inflammasome activation, contributing to retinal neurodegeneration.
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3. ⭐ GSE300717 RNA-seq 和 ATAC-seq 分析 5-氮杂胞苷处理的 HepG2 细胞揭示了肝细胞癌中 BFL-1 和 SQOR 的表观遗传学重新激活

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、RNA-seq、ATAC-seq、epigenetic
• 📝 描述：Contributors : Wonjin Woo ; Lark Kyun KimSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) remains a major therapeutic challenge with poor prognosis due to treatment resistance. Epigenetic silencing of tumor suppressor genes through promoter hypermethylation contributes to oncogenesis and resistance to cell death stimuli. We employed low-concentration 5-azacytidine (5-AZA) treatment to identify epigenetically silenced genes that modulate cell death susceptibility in HepG2 hepatocellular carcinoma cells without inducing baseline cytotoxicity. HepG2 cells were treated with 0, 2, and 10 μM 5-azacytidine for 4 days, followed by integrative RNA-seq and ATAC-seq analysis to characterize transcriptomic changes and chromatin accessibility patterns. This approach revealed coordinated promoter opening and transcriptional reactivation of methylation-silenced genes, particularly BFL-1 (BCL2A1) and SQOR, whose reactivation enhanced cell death susceptibility to TNF-α/CHX and sorafenib treatments. Our findings provide mechanistic insights into epigenetic vulnerabilities in HCC and demonstrate the utility of multi-omics approaches for identifying therapeutically tractable targets for precision epigenetic editing strategies.
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4. ⭐ GSE296517 探究吉西他滨联合聚焦超声热消融治疗乳腺癌的协同潜力：基于空间转录组学的BR54试验研究

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Awndre Gamache ; Ana Oliveira ; Timothy N BullockSeries Type : OtherOrganism : Homo sapiensBreast tumors frequently exhibit resistance to immunotherapy due to their immunosuppressive tumor microenvironment (TME). Preclinical evidence indicates that combining thermal high-intensity focused ultrasound (T-FUS) with the chemotherapeutic gemcitabine (GEM) can significantly alter this TME, promoting recruitment and activation of antitumor immune cells and facilitating durable, T cell–mediated tumor control. We hypothesize that GEM preconditioning enhances T-FUS-induced inflammatory responses by reducing anti-inflammatory cell abundance in the transition zone, thereby amplifying the infiltration and activation of effector immune cells.Leveraging the ongoing BR54 clinical trial (NCT04796220), we analyzed resected breast cancer specimens, collected approximately 14 days post-T FUS treatment, with or without prior GEM pretreatment. Using NanoString’s CosMx Spatial Molecular Imager and 1000-plex RNA panel, we performed spatially-resolved gene transcription profiling within histologically defined regions, including FUS-induced thermal lesions and adjacent tumor areas. Our analysis focused on quantifying myeloid cell, T cell, and NK cell signatures, evaluating effector molecule gene expression, and assessing immunosuppressive-to-effector cell ratios.Comparative analyses between FUS-treated patient samples (with or without GEM pretreatment) and archival untreated controls, as well as pre- to post-treatment biopsy comparisons, were conducted to evaluate therapy-induced remodeling of the TME. This project aims to elucidate the potential synergistic effects of GEM combined with T-FUS in breast cancer and establish the CosMx platform as a robust tool for integrated spatial multiomics analysis in clinical oncology research.
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5. ⭐ GSE326618 人体单细胞三维基因组组织和DNA甲基化图谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、genome、methylation
• 📝 描述：Contributors : Jingtian Zhou ; May Wu ; Rosa G Castanon ; Anna Bartlett ; Ben Clock ; Samantha Marcotte ; Joseph R Nery ; Michelle Liem ; Naomi Claffey ; Lara Boggeman ; Cesar Barragan ; Rafael Arrojo e Drigo ; Annika Weimer ; Johnathan Cooper-Knock ; Sai Zhang ; Michael P Snyder ; Carolyn O’Connor ; Chongyuan Luo ; Jesse R Dixon ; Joseph R EckerSeries Type : Methylation profiling by high throughput sequencing ; OtherOrganism : Homo sapiensHigher-order chromatin structure and DNA methylation are critical for gene regulation, but how these vary across the human body remains unclear. We performed multiomic profiling of three-dimensional (3D) genome structure and DNA methylation for 86,689 single nuclei across 16 tissues, identifying 35 major and 206 cell subtypes. We revealed extensive changes in CG and non-CG methylation across cell types and characterized 3D chromatin structure at an unprecedented cellular resolution. Extensive discrepancies exist between cell types delineated by DNA methylation and genome structure, which indicates that the role of distinct epigenomic features in maintaining cell identity may vary by lineage. This study expands our understanding of the diversity of DNA methylation and chromatin structure and offers a reference for exploring gene regulation in human health and disease.
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6. ⭐ GSE341526 苍术内酯III通过抑制ACT1/TRAF6/NF-κB介导的IL-17通路调节肠-肝轴，从而减轻顺铂诱导的急性肝损伤

• ✍️ 作者：未知作者
• 🏷️ 关键词：pathway、gut、regex:gut(-?microbiome)?
• 📝 描述：Contributor : Guoyin KaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Cisplatin (DDP) is a highly effective and broad-spectrum chemotherapeutic agent. However, its clinical application is limited by severe hepatotoxicity. Currently available hepatoprotective agents are often associated with insufficient efficacy or side effects. Therefore, developing new hepatoprotective agents that are highly efficient and low in toxicity is urgent. Objectives: Atractylodes macrocephala Koidz. is a well-known traditional Chinese medicine for strengthening the spleen function. According to the theory of traditional Chinese medicine, “When liver disease occurred, the spleen should be strengthened first” suggests that A. macrocephala Koidz. might possess hepatoprotective properties. Therefore, this study focuses on the molecular mechanism by which the active factors of A. macrocephala Koidz. exert their liver-protective effects. Methods: Animal experiments were adopted to screen the active factors of A. macrocephala Koidz. Multi-omics integrated analysis, including gut microbial diversity, transcriptomics, and metabolomics, combined with fecal microbiota transplantation (FMT) experiments were performed to clarify the mechanism of liver-protective effects of atractylenolide III (AT-III). Results: We found that AT-III-derived from A. macrocephala Koidz. significant decreased ALT, AST levels and hepatic pathological symptoms in DDP-induced acute liver injury (ALI). AT-III alleviated DDP-induced ALI via the “gut-liver axis” by inhibiting the ACT1/TRAF6/NF-κB-mediated IL-17 signaling pathway. Eight distinct microbial species, including Parabacteroides and Alloprevotella, were identified with significant differences. Besides, metabolite N6-(1,2-dicarboxyethyl)-AMP was identified as a novel biomarker for hepatotoxicity. Meanwhile, the FMT results indicated that the intestinal microbiota has a better alleviating effect on ALI than the metabolites of the intestinal microbiota.
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7. ⭐ GSE338463 成人发病型肠道神经节细胞减少症的临床和单细胞测序特征

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell、regex:intestin(e|al)
• 📝 描述：Contributors : Ran Zhen ; Zhang Yuanchuan ; Chen Quanyu ; Wang Xinping ; Feng SiyuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypoganglionosisis a rare motility disorder characterized by a significant reduction in enteric ganglion cells.scRNA-seq indicated immune microenvironment remodeling in the lesioned bowel segment, characterized by an increased proportion of plasma cells. These plasma cells exhibited features of endoplasmic reticulum stress, activation of the unfolded protein response pathway, and enrichment in immune regulatory functions. B cells and T cells also showed enrichment in immune-related pathways.
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8. ⭐ GSE338333 巨噬细胞 VISTA 在同种免疫组织损伤期间抑制炎症和抗原呈递程序 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、antigen、RNA-seq
• 📝 描述：Contributors : Lifei Liang ; Rui Shi ; Cuidi Xu ; Xiaohan Yu ; Maoxin Liao ; Tongyu Zhu ; Ruiming Rong ; Jiangang Hou ; Dong Zhu ; Cheng YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMacrophage inflammatory plasticity is a central determinant of immune-mediated tissue injury, yet the intrinsic checkpoint mechanisms that restrain inflammatory macrophage programming remain incompletely defined. Here, using acute cardiac allograft rejection as an alloimmune tissue-injury model, we found that Vsir, encoding V-domain Ig suppressor of T-cell activation (VISTA), was preferentially expressed in graft macrophages but declined as macrophages acquired inflammatory and antigen-presenting states. Single-cell RNA sequencing and pseudotime analysis revealed that VISTA downregulation accompanied macrophage progression from reparative/resident-like states toward inflammatory programs. In vitro, VISTA overexpression intrinsically restrained pro-inflammatory macrophage polarization, reduced inflammatory cytokine expression, and limited the induction of antigen-presenting molecules including MHC-II and CD80, thereby attenuating macrophage-driven CD4⁺ T-cell proliferation. Integrative CUT&Tag and RNA-seq analyses further showed that VISTA overexpression was associated with reduced H3K4me3 enrichment at inflammatory regulatory loci, including TRAF5 and CHDH, together with transcriptional repression of NF-κB-, TNF-, MAPK-, and IL-17-associated inflammatory programs. In vivo F4/80 promoter-directed Vsir restoration shifted intragraft macrophages away from inflammatory polarization, reduced T-cell accumulation, and attenuated early rejection-associated tissue injury. Together, these findings identify VISTA as an intrinsic regulator of macrophage inflammatory programming and point to H3K4me3-associated chromatin remodeling as a regulatory layer linked to VISTA-mediated inflammatory restraint.
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9. ⭐ GSE336699 肥大细胞 St8sia1-GD3 轴作为糖表观遗传检查点驱动心脏适应不良性重塑 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cardiac、RNA-seq、epigenetic
• 📝 描述：Contributors : Changzuan Zhou ; Lisheng Fu ; Tianyou Yuan ; Fangfang Li ; Fanhuan Tang ; Songwen Chen ; Jun LiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPathogenical immune-cardiac crosstalk underlies maladaptive remodeling in chronic heart failure, yet therapies directly targeting this axis are lacking. Glycoconjugates, which are crucial for signal transduction and extracellular matrix integrity, represent an underexploited therapeutic avenue. This study sought to define the role of glycoconjugate-metabolizing enzymes at the immune-cardiac interface and evaluate their translational potential. We performed integrative analyses of bulk and single-cell RNA sequencing data from failing human and mouse hearts. Employing mouse models of pressure overload (transverse aortic constriction, TAC) and ischemia-reperfusion (IR), we utilized global and mast cell (MC)-specific gene deletion, bone-marrow chimeras, and pharmacologic neutralization. Mechanistic insights were gained through multi-omics profiling, including RNA-seq, ATAC-seq, and CUT&Tag.
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10. ⭐ GSE316779 CpG 高甲基化和 WNT/AP-1 协同作用定义了高危儿童肾上腺皮质癌的表观遗传图谱和临床亚组 [Visium HD]

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、Visium、epigenetic
• 📝 描述：Contributors : Victoria E Fincke ; Mauice Loßner ; Marina Kunstreich ; Nic G Reitsam ; Irmengard Sax ; Marlena Mucha ; Felix Dorn ; Lorenz C Helmschrott ; Maria D Hernandez Ramirez ; Sebastian Dintner ; Konstantin Okonechnikov ; Martin Sill ; Ina Oehme ; Heike Peterziel ; Enrique Blanco-Carmona ; Eva Sipos ; Stefan Wudy ; Christoph Slavetinsky ; Jörg Fuchs ; Bruno Märkl ; Eva Jüttner ; Christian Vokuhl ; Michael C Frühwald ; Antje Redlich ; Stefan Pfister ; Matthias Schlesner ; Rainer Claus ; Michaela Kuhlen ; Pascal D JohannSeries Type : OtherOrganism : Homo sapiensTo investiagte the cellular heterogenity one sample from each DNA methylation-based subgroup was investiagted using the Visium HD platform by 10x Genomics.
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1. MIRACLE 通过持续学习使单细胞图谱保持最新状态。

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell
• 📝 描述：RNA sequencing datasets can now be continually integrated using MIRACLE, enabling cell atlases to grow efficiently as new multimodal data become available…
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• GSE316541 α2,6-唾液酸糖蛋白调节肿瘤微环境中肿瘤浸润 CD8+ T 细胞的抗肿瘤免疫 [CD8+T]
• GSE316540 α2,6-唾液酸糖蛋白调控肿瘤微环境中肿瘤浸润CD8+ T细胞的抗肿瘤免疫
• GSE312933 揭示多发性骨髓瘤中硼替佐米耐药性的奥秘：来自 RNA-Seq 和 PI3K/mTOR 通路分析的启示
• GSE305218 单细胞 RNA 测序揭示白血病来源外泌体对造血干细胞的影响
• GSE335921 RNA-seq分析不同微环境下的分子通路变化
• GSE325868 整合转录组分析揭示了居住在波多黎各的西班牙裔人群结直肠癌的免疫和分子分期特异性特征
• GSE319384 代谢可塑性是胰腺导管腺癌中突变型p53驱动的铁死亡抵抗的基础
• GSE342115 多个 Argonaute 复合物协调拟南芥种系中的表观遗传沉默 [RNA-Seq]
• GSE341753 黏连蛋白在调控元件上的加载塑造红细胞生成过程中的 3D 基因组折叠 [RNA-Seq]
• GSE310938 DUSP2 抑制染色质重塑 BAF 复合物以协调 CD8+ T 细胞效应程序化 [ATAC-seq]
• GSE310053 DUSP2 抑制染色质重塑 BAF 复合物以协调 CD8+ T 细胞效应编程 [ChIP-Seq]
• GSE310048 DUSP2 抑制染色质重塑 BAF 复合物以协调 CD8+ T 细胞效应程序化 [RNA-seq]
• GSE341321 核受体 AhR 对维生素 B2 的感知重编程肝脏代谢 [RNA-Seq]
• GSE341320 核受体 AhR 对维生素 B2 的感知重编程肝脏代谢 [ChIP-Seq]
• GSE341319 核受体 AhR 对维生素 B2 的感知重编程肝脏代谢 [ATAC-Seq]
• GSE341191：局限性前列腺癌患者不可逆电穿孔术前和术后7天采集的配对外周血单核细胞的单细胞转录组分析
• GSE338979 α7 整合素是 HPV 阴性头颈癌中染色质可及性和基因表达的关键共调节因子 [ATAC-seq]
• GSE338332 巨噬细胞 VISTA 在同种免疫组织损伤期间抑制炎症和抗原呈递程序 [Cut&Tag]
• GSE338267 巨噬细胞 VISTA 在同种免疫组织损伤期间抑制炎症和抗原呈递程序
• GSE334187 RNA-seq 分析 FBXO8 敲低在 HONE-1 鼻咽癌细胞中的表达谱
• GSE326123 编辑的造血干细胞可挽救弗里德赖希共济失调中的弗拉塔辛缺乏症以及炎症驱动的神经系统、心脏和胰腺病变
• GSE325503 Gpt2 KO 和 Gpt2 WT 小鼠脑组织中的组蛋白甲基化
• GSE305720 多组学研究揭示 GTSE1 通过 Hippo 信号通路促进食管鳞状细胞癌干性
• GSE305113 免疫肽组指导的个性化肽疫苗在慢性淋巴细胞白血病中诱导强效的T细胞反应
• GSE305014 RSK1 重编程泛素通路以促进免疫抑制
• GSE304640 解码 SOS：eIF2B 作为突变 KRAS 信号传导和肿瘤发生的关键驱动因素 [RNA-seq]
• GSE304309 健康人外周血双阳性 T 细胞的单细胞转录组和 TCR 分析 [scRNA-seq]
• GSE303504 ATGL驱动的脂肪分解定义了PSMA高表达前列腺癌中可靶向的代谢脆弱性
• GSE303181 STC-1 通过 PI3K/AKT 通路激活和免疫调节减弱瘢痕形成
• GSE284237 对三种蜡样芽孢杆菌菌株进行了转录组分析，比较了未经处理的培养基（nk）和经处理的培养基（k；预先与CaCo-2细胞孵育），该分析采用RNA测序技术完成。
• GSE284162 新辅助化疗联合抗PD-1单克隆抗体治疗局部晚期可切除口腔鳞状细胞癌的疗效：一项单臂II期临床试验
• GSE282433 微重力通过 Piezo1 介导的钙离子稳态和自噬途径的调节抑制口腔鳞状细胞癌的生长
• GSE279489 高脂饮食触发趋化因子依赖性免疫重编程，加剧急性肾损伤[scRNA-seq]
• GSE275649 癌症相关成纤维细胞通过与内皮细胞和恶性上皮细胞相互作用在晚期胃癌预后分层中的作用 [细胞系 RNA-seq]
• GSE275647 癌症相关成纤维细胞通过与内皮细胞和恶性上皮细胞相互作用在晚期胃癌预后分层中的作用 [AGC RNA-seq]
• GSE262925 表达IL-21的效应CD8+ T细胞亚群对感染和癌症具有更强的控制作用
• GSE341885 催化失活的KDM5B-NTT亚型与染色质结合，并增加乳腺癌细胞中H3K4三甲基化水平
• GSE330974 两波激活驱动系统性先天免疫反应对抗甲病毒感染
• GSE312626 ASCL1 C 端磷酸化降解子调控小细胞肺癌中 ASCL1 蛋白的稳定性
• GSE309943 免疫代谢内型定义了 2 型糖尿病的不同临床轨迹 [scRNA-seq II]
• GSE309942 免疫代谢内型定义了 2 型糖尿病的不同临床轨迹 [scRNA-seq I]
• GSE309941 免疫代谢内型定义了 2 型糖尿病的不同临床轨迹 [bulk RNA-seq]
• GSE301924 EFHD1 通过触发 Ca2+ 依赖性线粒体分裂导致代谢性肝损伤
• GSE342117 多个 Argonaute 复合物协调拟南芥种系中的表观遗传沉默 [亚硫酸氢盐测序]
• GSE342116 多个 Argonaute 复合物协调拟南芥种系中的表观遗传沉默 [RIP-Seq]
• GSE341988 连续病原体暴露可使大脑神经免疫微环境正常化，并揭示组织驻留记忆性 CD8 T 细胞-小胶质细胞轴塑造成年神经发生
• GSE341752 黏连蛋白在调控元件上的加载塑造红细胞生成过程中的 3D 基因组折叠 [Micro-C U937]
• GSE341565 黏连蛋白在调控元件上的加载塑造红细胞生成过程中的 3D 基因组折叠 [Micro-C]
• GSE341414 黏连蛋白在调控元件上的加载塑造红细胞生成过程中的三维基因组折叠
• GSE326240 研究表明，在接受高剂量辐射前预防性抑制 LATS1/2 可通过 Yap 依赖性和非依赖性机制促进受损肠上皮的再生。
• GSE311350 DUSP2抑制染色质重塑BAF复合物以调控CD8+ T细胞效应程序
• GSE278713 囊性与实性前庭神经鞘瘤患者的全转录组分析揭示候选长链非编码RNA分子特征
• GSE269908 小胶质细胞与脑移植单核细胞衍生巨噬细胞的转录组分析
• GSE341447 左氧氟沙星对SW48结直肠癌细胞凋亡通路的影响
• GSE341385 胆固醇依赖性代谢通过限制能量紊乱促进结核分枝杆菌对贝达喹啉的耐受性
• GSE341190 假手术或不可逆电穿孔后7天收集的皮下和原位RM-1小鼠前列腺肿瘤的单细胞转录组
• GSE338805 α7整合素是HPV阴性头颈癌中染色质可及性和基因表达的关键共调节因子
• GSE338317 免疫检查点抑制剂介导的结肠炎与溃疡性结肠炎的结肠免疫结构比较
• GSE338255 更年期过渡时间反映了系统性生物衰老
• GSE337985 DNA甲基化热点揭示了断奶前奶牛犊生长和疾病抵抗力的关键易感窗口
• GSE335839 双向基因对中的 RNA 非依赖性顺式自调控回路控制代谢
• GSE330265 RM1股骨内接种小鼠骨髓单细胞测序
• GSE330264 假股内接种小鼠骨髓单细胞测序
• GSE330263 RM1股内接种小鼠背根神经节单细胞测序
• GSE330229 RNA聚合酶II延伸加速驱动内皮细胞转化和斑块易损性：超延伸复合物的药理学靶向[RNA-seq]
• GSE330210 RNA聚合酶II延伸加速驱动内皮细胞转化和斑块易损性：超延伸复合物的药理学靶向[ChIP-seq]
• GSE324494 研究发现，髓系细胞中 LACTB 表达降低与琥珀酰肉碱水平升高和阿尔茨海默病风险降低相关。
• GSE318970 髓母细胞瘤的代谢依赖性反映了其潜在的细胞起源
• GSE318208 RNA-seq 检测了接受 Omaveloxolone 治疗的 Leigh 综合征患者的血液样本。
• GSE316382 CIS 调节巨噬细胞功能
• GSE308106 衰老前期和siDUSP4处理的结肠成纤维细胞的批量RNA测序
• GSE308105 用年轻或衰老前原代结肠成纤维细胞的条件培养基处理原代结肠上皮细胞的批量 RNA 测序
• GSE307006 干扰素-γ介导的巨噬细胞对结核分枝杆菌的物种特异性免疫反应
• GSE306650 靶向 TNFα/TNFR1 轴以减轻实验性急性胰腺炎的炎症
• GSE306316 RNA-seq 样本来自接受奥马维洛酮治疗的莱氏综合征患者血液样本
• GSE306153 RNA-seq 携带 Leigh 综合征导致 SURF1 基因复合杂合突变的患者来源谷氨酸能神经元，经 Omaveloxolone 治疗。
• GSE306145 合成材料植入物纤维化中野生型和 Foxp3-DTR 小鼠股四头肌的批量 RNA 测序
• GSE305761：FTO过表达小鼠慢性阻塞性肺疾病模型肺组织RNA测序
• GSE305282 野生型秀丽隐杆线虫和表达野生型或 G2019S 突变型人 LRRK2 的品系的转录组分析
• GSE305138 侧隔小胶质细胞TIA1通过调节NF-κB信号通路促进慢性炎症性疼痛
• GSE305099 小激活 RNA AW1-51 (CEBPA-51) 引发靶向 DNA 去甲基化以促进基因激活 [RNA-seq]
• GSE305021 TRIP13 通过维持 HAT1 稳定性促进 CD4+Foxp3+ 调节性 T 细胞的扩增和免疫抑制
• GSE304639 解码 SOS：eIF2B 作为突变 KRAS 信号传导和肿瘤发生的关键驱动因素 [核糖体测序]
• GSE304498 对感染SIV的恒河猴进行的纵向转录组分析揭示了未经治疗的SIV感染和长期抗逆转录病毒治疗期间外周免疫动态的变化
• GSE304447 肽处理的人 IPS 衍生运动神经元的批量 RNA 测序
• GSE304257 全结肠切除术后小肠适应性的多组学研究。
• GSE303422 VPS72 拷贝数增加通过 ATF3/mTORC1/SREBP1 轴驱动从头脂肪生成和肝癌发生 [RNA-seq]
• GSE303421 VPS72 拷贝数增加通过 ATF3/mTORC1/SREBP1 轴驱动从头脂肪生成和肝癌发生 [ChIP-Seq]
• GSE303420 VPS72 拷贝数增加通过 ATF3/mTORC1/SREBP1 轴驱动从头脂肪生成和肝癌发生 [ATAC-seq]
• GSE300969 细胞周期蛋白依赖性激酶 8 选择性剪接的拟议模型：高血压继发性心力衰竭的潜在机制。
• GSE297242 乳酸积累对MDA-MB-231乳腺癌细胞翻译和转录的影响
• GSE294136 RAD21 通过激活 ERK1/2 信号重塑 H3K4me3 修饰以驱动肺腺癌进展 [ChIP-seq]
• GSE289986 脊椎动物嗅觉上皮的跨物种单细胞图谱
• GSE282319 长读长 RNA 测序揭示了一种新的长链非编码 RNA，该 RNA 调控体细胞重编程和多能性
• GSE279530 PHLDA2 通过增加细胞外基质沉积和血管通透性促进乳腺癌转移
• GSE275034 根瘤菌 exoX 缺失菌株的转录组分析。
• GSE273786 CYCS基因的一种新变异通过肿瘤坏死因子信号传导失调导致血小板减少症
• GSE248270 低盐度不会影响暴露于弧菌属的幼年佛罗里达鲳鱼（Trachinotus carolinus）的免疫相关基因表达或脂肪酸生物合成。
• GSE241680 S期诱导的RNA许可DNA复制控制ORC1在早期DNA复制起始位点的结合[RNA-seq]
• GSE241677 S期诱导的RNA许可DNA复制控制ORC1在早期DNA复制起始位点的结合[ChIP-seq]
• GSE240701 小鼠体外循环手术中心肌缺血再灌注损伤的lncRNA-miRNA-mRNA相互作用网络的综合分析[RNA-seq]
• GSE339020 肥大细胞花生四烯酸5-脂氧合酶缺乏通过限制肥大细胞白三烯来减轻小鼠缺血/再灌注诱导的心脏纤维化重塑