详细内容（前10条）

1. ⭐ GSE341436 在单细胞水平上表征肿瘤微环境揭示了骨巨细胞瘤中潜在的免疫逃逸机制

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immune、tumor microenvironment、single-cell
• 📝 描述：Contributor : Dongyang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGiant cell tumor of bone (GCTB) is intermediate, locally aggressive primary bone tumor that are usually occur in long bones and typically present as lytic lesions, leading to cortical expansion or destruction with a soft-tissue component. At present, the main treatment of GCTB is surgical curettage and bone cement filling, but the recurrence rate is more than 20%. It is known that tumor recurrence and immune escape are closely related to the microenvironment. We need a deeper understanding of the complex tumor microenvironment, as well as the role of various immune cells in the development of GCTB, in order to achieve a comprehensive treatment of GCTB.
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2. ⭐ GSE304098 组蛋白修饰分析揭示肿瘤微环境获得的超级增强子调控食管鳞状细胞癌的进展

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、carcinoma、tumor microenvironment、histone
• 📝 描述：Contributors : Liu Peng ; Yi-Meng Zhang ; Xiong-xing HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenomic and proteomic studies have advanced our understanding of esophageal squamous cell carcinoma (ESCC) biology and pathogenesisGenomic and proteomic studies of esophageal squamous cell carcinoma (ESCC) have advanced our understanding of the biology and pathogenesis of the disease. However, the histone modification landscape inprofile of ESCC remains poorly characterized, especially from human clinical samplesunderstood. Here, we performed comprehensive histone modification profiling of paired samples from 122 ESCC patients, identifying numerous aberrantly expressed histone modification sitesand identified a number of modification sites that are aberrantly expressed in ESCC. Most of these alterations correlate with patient survivalMost of these differentially expressed histone modification sites are associated with survival in ESCC patients. In particular, H3K27ac is aberrantly expressed in tumor tissue and stroma and its high expression is significantly correlated with poor prognosis of ESCC patients. We analyzed the H3K27ac ChIP-seq data for primary ESCC tumor tissues and ESCC cell lines and identified hundreds of altered putative super-enhancers (SEs) in ESCC tissues respectively relative to ESCC cell lines. Moreover, these differential SEs contribute to the transcriptomic aberrations in ESCC tissues. Genes regulated by ESCC tissue- gained SEs are highly expressed in ESCC tissues compared to ESCCthan in cell lines and are mostly enriched in microenvironment-related pathways. We definerefer to these SEs as tumor microenvironment-acquired super-enhancers (TMEA-SEs). Through integrative analysis of ChIP-seq, RNA-seq, scRNA-seq and ATAC-seq data, we identified a TMEA-SE activated in cancer-associated fibroblasts (CAFs) and found that IL1R1 is directly regulated by this TMEA-SE. We demonstrated that IL1R1 activation can affect CAFs to promotes ESCC cells migration and invasion via CAFs. Collectively, our findings these observations reveal that a critical oncogenic mechanism in ESCC whereby TMEA-SE drive malignancy by activating IL1R1 in CAFs.
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3. ⭐ GSE276797 野生型 (WT) 和阿尔茨海默病 (AD) 转基因动物 (5xFAD) 的深颈淋巴结 (dCLNs)、浅颈淋巴结 (sCLNs) 和腹股沟淋巴结 (iLNs) 免疫细胞的单细胞水平基因表达谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?、Alzheimer
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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4. ⭐ GSE276796 野生型和阿尔茨海默病 (AD) 转基因动物 (5xFAD)vdj_t 的深颈淋巴结 (dCLNs)、浅颈淋巴结 (sCLNs) 和腹股沟淋巴结 (iLNs) 免疫细胞的单细胞水平基因表达谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?、Alzheimer
• 📝 描述：Contributors : Castellani Giulia ; Michal SchwartzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe dCLNs are lymph nodes specialized in draining cerebrospinal fluid (CSF). We used single cell RNA sequencing (scRNA-seq) to characterize the immune cell populations in the dCLNs compared to other draining lymph nodes. We compared the immune landscape of the dCLNs between healthy WT mice and 5xFAD mice to investigate the role of dCLNs immunity in AD progression. Additionaly, we sequenced the TCR and BCR transcripts to analyze the clonal distribution of T-cells and B-cells in each lymph node.
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5. ⭐ GSE276795 野生型和阿尔茨海默病转基因动物 (5xFAD)vdjb 的深颈淋巴结 (dCLNs)、浅颈淋巴结 (sCLNs) 和腹股沟淋巴结 (iLNs) 免疫细胞的单细胞水平基因表达谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?、Alzheimer
• 📝 描述：Contributors : Castellani Giulia ; Michal SchwartzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe dCLNs are lymph nodes specialized in draining cerebrospinal fluid (CSF). We used single cell RNA sequencing (scRNA-seq) to characterize the immune cell populations in the dCLNs compared to other draining lymph nodes. We compared the immune landscape of the dCLNs between healthy WT mice and 5xFAD mice to investigate the role of dCLNs immunity in AD progression. Additionaly, we sequenced the TCR and BCR transcripts to analyze the clonal distribution of T-cells and B-cells in each lymph node.
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6. ⭐ GSE276794 野生型 (WT) 和阿尔茨海默病 (AD) 转基因动物 (5xFAD)GEX 的深颈淋巴结 (dCLN)、浅颈淋巴结 (sCLN) 和腹股沟淋巴结 (iLN) 中免疫细胞的单细胞水平基因表达谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?、Alzheimer
• 📝 描述：Contributors : Castellani Giulia ; Michal SchwartzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe dCLNs are lymph nodes specialized in draining cerebrospinal fluid (CSF). We used single cell RNA sequencing (scRNA-seq) to characterize the immune cell populations in the dCLNs compared to other draining lymph nodes. We compared the immune landscape of the dCLNs between healthy WT mice and 5xFAD mice to investigate the role of dCLNs immunity in AD progression. Additionaly, we sequenced the TCR and BCR transcripts to analyze the clonal distribution of T-cells and B-cells in each lymph node.
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7. ⭐ GSE276793 野生型 (WT) 和阿尔茨海默病 (AD) 转基因动物 (5xFAD) 的深颈淋巴结 (dCLNs)、浅颈淋巴结 (sCLNs) 和腹股沟淋巴结 (iLNs) 免疫细胞的单细胞水平基因表达谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?、Alzheimer
• 📝 描述：Contributors : Castellani Giulia ; Michal SchwartzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe dCLNs are lymph nodes specialized in draining cerebrospinal fluid (CSF). We used single cell RNA sequencing (scRNA-seq) to characterize the immune cell populations in the dCLNs compared to other draining lymph nodes. We compared the immune landscape of the dCLNs between healthy WT mice and 5xFAD mice to investigate the role of dCLNs immunity in AD progression. Additionaly, we sequenced the TCR and BCR transcripts to analyze the clonal distribution of T-cells and B-cells in each lymph node.
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8. ⭐ GSE302677 空间转录组学揭示了ANCA相关性肾血管炎中损伤反应区室和协调的免疫-纤维化信号传导

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Yucheng Tang ; Chunhua Zhu ; Aihua Zhang ; Enrico PetrettoSeries Type : OtherOrganism : Homo sapiensImmune dysregulation is a hallmark of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), particularly in the kidney; however, the spatial organization of renal microenvironments remains poorly understood. Here, we applied spatial transcriptomics to renal biopsies from pediatric patients with AAV representing distinct histological classes defined by the Berden classification (4 control, 2 focal, and 3 non-focal cases), generating an in situ map of localized disease programs. Four disease-associated compartments—immune/interstitial fibroblasts (IM/Fib), glomeruli, myofibroblasts, and vascular compartments—showed distinct compartment-specific signatures that correlated with patient-level histopathology. We further identified coordinated immune–fibrotic signaling associated with different histopathological classes. Within IM/Fib, the CXCR4–CD74 receptor complex co-localized with IgM⁺ cells, and lumican (LUM) co-localized with collagen I/III; both were validated by immunofluorescence and associated with fibrotic injury. These tissue-anchored signatures represent potential disease-associated molecular features with possible diagnostic relevance, and highlight the value of this foundational spatial transcriptomics map for generating testable hypotheses to be further evaluated in larger, stratified, treatment-annotated cohorts.
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9. ⭐ GSE315487 CD73抑制可克服前列腺癌模型中PARP抑制引起的适应性免疫抵抗

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、resistance
• 📝 描述：Contributors : Ping Xie ; Renqiang Ma ; Minghui Zhang ; Jie Fan ; Longzhen Song ; Yong Wan ; Bin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetastatic castration-resistant prostate cancer (mCRPC) remains a major cause of cancer-related mortality in the male population. While poly(ADP-ribose) polymeraseinhibitors (PARPi) are approved for selected mCRPC patients with homologous recombination repair (HRR) deficiencies, combinations with PD-1/PD-L1 inhibitors immunotherapy have demonstrated limited efficacy in unselected populations. To investigate the immunomodulatory effects of PARPi in an unbiased manner, we performed bulk RNA sequencing on HRR-proficient MyC-CaP cells treated with PARPi Olaparib or control vehicle. Pathway enrichment analysis revealed a marked upregulation of CD73 (NT5E), an emerging immune checkpoint ectoenzyme that generates extracellular adenosine, suggesting an adaptive mechanism that undermines PARPi efficacy and enables unwanted immunosuppression. CD73 induction by PARPi was confirmed in both human and mouse prostate cancer cell lines, with more pronounced effects in the HRR-compromised PTEN knock-out (KO) cells. Mechanistically, Olaparib-driven CD73 expression was mediated through the DNA damage-activated ATR-CHEK1-IRF1 and TGF-β1-ΑΚΤ signaling pathways. Concurrently, PARPi enhanced tumor cell immunogenicity by activating the type I interferon pathway and antigen presentation machinery. In vivo, combining Olaparib with CD73 blockade therapy delayed tumor growth, improved T-cell infiltration, and augmented antigen-specific CD8⁺ T-cell effector function across HRR-proficient and PTEN KO prostate cancer models. These findings highlight PARPi-induced CD73 upregulation as a novel resistance mechanism and support PARPi plus CD73 blockade as a promising therapeutic strategy for mCRPC, irrespective of HRR status.
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10. ⭐ GSE311644 癌胚 RNA 结合蛋白 IGF2BP 抑制白血病干细胞中的先天免疫信号通路 [ATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、immune、ATAC-seq
• 📝 描述：Contributors : Irina Elcheva ; Karamveer Karamveer ; Yasin Uzun ; Alexis Morrissey ; Shaun MahonySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensActivation of innate inflammatory signaling and tumor-specific antigen presentation in cancer cells provides a foundation for anti-cancer immunotherapies. Here, we show that Insulin-like Growth Factor 2 mRNA-Binding Proteins (IGF2BP1, IGF2BP2, and IGF2BP3), which are upregulated across various human malignancies, including acute myeloid leukemia (AML), suppress the activity of RNA-sensing pattern recognition receptors and downstream ISRE- and NF-κB-driven transcription. IGF2BPs exert a strong inhibitory effect on RIG-I signaling. This suppression is most pronounced when all three paralogs are co-expressed, particularly in embryonic-like hematoendothelial and leukemia stem cells and is at least partly mediated through IGF2BP-dependent regulation of negative regulators of immune signaling. Genetic and pharmacological inhibition of IGF2BPs activates innate immune signaling and induces MHC class I gene expression in AML, highlighting a promising strategy for RIG-I- and TLR-based cancer immunotherapies.
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💡 该来源还有 110 条内容，详见 文末

• GSE311641 癌胚 RNA 结合蛋白 IGF2BP 抑制白血病干细胞中的先天免疫信号通路 [RNA-seq]
• GSE330902 单细胞分析鉴定出与肉瘤样尿路上皮癌相关的罕见正常间充质样尿路上皮细胞[批量RNA测序]
• GSE302818 SPEN 是一种雄激素受体依赖性肿瘤抑制因子，介导前列腺癌的激素治疗耐药性。
• GSE341410 胶原蛋白和抗体诱导关节炎 (C&AIA) 小鼠膝关节滑膜的单细胞 RNA 测序
• GSE315019 DTMB 通过靶向炎症和脂质代谢来减轻饮食诱导的代谢功能障碍相关的脂肪性肝炎
• GSE302014 对妊娠晚期单细胞免疫谱分析揭示了趋化因子受体的重要性以及巨细胞病毒诱导的NK细胞在血液和蜕膜中的普遍性
• GSE299321 TEAD4 在胃癌代谢过程中的作用 [RNA-Seq]
• GSE275919 Nup153 通过 HDAC1 介导的表观遗传修饰调节神经元反应性 [RNA-seq]
• GSE275917 Nup153 通过 HDAC1 介导的表观遗传修饰调节神经元反应性 [ChIP-seq]
• GSE275916 Nup153 通过 HDAC1 介导的表观遗传修饰调节神经元反应性 [ATAC-seq]
• GSE273558 阿帕替尼联合替莫唑胺治疗复发性胶质母细胞瘤后肿瘤微环境 (TME) 的改变
• GSE271690 结直肠癌肿瘤边缘的整合单细胞和空间转录组图谱
• GSE336637 配对结直肠癌和邻近非肿瘤组织的 miRNA 测序分析
• GSE338165 单细胞分析揭示白塞氏病疾病活动性和临床亚型的单核细胞特征
• GSE330518 酪氨酸降解酶 FAH 的非经典功能驱动乳腺癌 CDK4/6 抑制剂耐药性 II
• GSE330516 酪氨酸降解酶 FAH 的非经典功能驱动乳腺癌 CDK4/6 抑制剂耐药性 I
• GSE315090 RNA-seq 检测 PAPRi 耐药的 BRCA2 缺陷型癌细胞
• GSE338670 Pandion PT-101 单细胞 RNA 测序：IL-2 突变体处理后 CD122+ 非髓系细胞的变化
• GSE330882 单细胞分析鉴定出与肉瘤样尿路上皮癌相关的罕见正常间质样尿路上皮细胞
• GSE341101 源自8个炎症型和8个沙漠型肿瘤的胃组织单细胞RNA测序
• GSE338899 体内 CRISPR 筛选揭示 DNMT3A 在介导肿瘤免疫逃逸中的双重功能
• GSE338506 人类胃癌 FFPE 标本的空间转录组分析
• GSE338065 可视化衰老和细胞重编程的表观遗传图谱：针对细胞和组织的优化ATAC-see
• GSE337271 单细胞 RNA 测序结果显示，SLC31A1 依赖的铜摄取调控小鼠骨髓基质细胞的成骨分化。
• GSE333739 RNA-seq 人类 HN-SCC-151 HPV 阴性头颈部鳞状细胞癌细胞经 DMSO 或 SUV420H1 抑制剂 A-196/siNC（对照）或 siSUV420H1 siRNA 处理。
• GSE333738 对用 DMSO 或 SUV420H1 抑制剂 A-196/siNC（对照）或 siSUV420H1 siRNA 处理的 HN-SCC-151 HPV 阴性头颈部鳞状细胞癌细胞中的人类 H4K20me3 进行全基因组定位。
• GSE333596 单细胞 RNA 测序鉴定出肺腺癌进展中的干细胞样亚群及其基因特征
• GSE329871 单细胞转录组学揭示 RARS2 相关脑桥小脑发育不全中的神经命运重编程
• GSE315023 环境丰富化通过表观遗传调控增强野生小鼠（Mus booduga）的适应能力，缓解社会压力诱发的焦虑样行为和记忆障碍。
• GSE313883 髓系 PINK1 抑制线粒体 DNA 释放和免疫信号传导，从而影响患者来源的特发性帕金森病模型中的神经元病理
• GSE312474 明尼利德对病毒-肿瘤-基质相互作用的调节增强了BRAF突变型结直肠癌中系统性双靶向麻疹病毒疗法的疗效
• GSE304156 产前酒精暴露选择性地诱导雄性青少年 C57Bl/6 小鼠肠道菌群改变
• GSE304134 FOSB-IGFBP5-IGF-1轴：抑制前列腺癌生长的新型调控通路
• GSE303886 SETDB2 通过表观遗传沉默 SMAD3 来减轻糖尿病肾病中的足细胞功能障碍 [MPC5-RNA-Seq]
• GSE303885 SETDB2 通过表观遗传沉默 SMAD3 减轻糖尿病肾病中的足细胞功能障碍 [条件性敲除小鼠-肾小球-RNA-Seq]
• GSE303884 SETDB2 通过表观遗传沉默 SMAD3 来减轻糖尿病肾病中的足细胞功能障碍 [肾小球 RNA-Seq]
• GSE303883 SETDB2 通过表观遗传沉默 SMAD3 来减轻糖尿病肾病中的足细胞功能障碍 [肾脏 RNA-Seq]
• GSE303244 PARP抑制剂他拉唑帕尼可有效抑制去势抵抗性前列腺癌的肿瘤生长
• GSE300192 Nup153 通过 HDAC1 介导的表观遗传修饰调节神经元反应性 [DamID-seq]
• GSE299322 TEAD4 在胃癌代谢过程中的作用 [亚硫酸氢盐测序]
• GSE296888 DDX21 敲除胎儿造血干细胞和祖细胞的转录变化和表观遗传图谱 [ATAC-seq]
• GSE285672 RNA-seq 数据（TGF-β 诱导的 A549 细胞）与 H3K4me3 ChIP-seq 数据进行比较
• GSE282103 SOWAHA 作为抑癌基因影响代谢重编程
• GSE339157 前列腺癌 (PCa) 原发肿瘤和转移灶的批量 RNA 测序：Epworth 临床队列
• GSE333169 瞬时 CB2R 调控促进管腔样分化并限制乳腺癌可塑性
• GSE331033 RhoA野生型等位基因缺失释放RhoA E40Q的癌症驱动功能
• GSE327324 基于核转录组分析的荧光激活核分选 (FANS) 分离的浦肯野细胞核的样本纯度验证。
• GSE313683 野生型和 Cry1/2 双敲除小鼠肺泡 II 型上皮细胞的批量 RNA 测序，有或无诺比列汀治疗。
• GSE313652 RNA-seq 来自用野生型或 Cry1/2 双敲除骨髓重建的野生型小鼠的支气管肺泡灌洗细胞。
• GSE295644 小鼠慢性贫血脾细胞单细胞转录组分析
• GSE338789 GLS1和MPC2在生发中心B细胞调控中的作用
• GSE338655 来自健康成年人单次递增剂量 IL-2 突变体 MK-6194（以前称为 PT-101）临床试验中分选的 Treg 细胞的批量 RNA 测序
• GSE336280 小鼠胰腺肿瘤诱导咀嚼和吞咽关键肌肉的病理性重塑 [RNA-seq]
• GSE318669 吸烟对人类血细胞类型DNA甲基化的影响（1）
• GSE314196 IgA、IgG 和 IgM ASC 的独特 DNA 甲基化图谱 [ASC.RRBS]
• GSE314192 IgA、IgG 和 IgM ASC 的独特转录图谱 [RNA-Seq]
• GSE306031 单核转录组学揭示细胞类型特异性重塑和癫痫相关小胶质细胞
• GSE302864 DNMT3B驱动神经内分泌谱系可塑性和前列腺癌的侵袭性进展
• GSE301584 CRISPR 数据，用于前列腺癌细胞系 (LNCaP)，从第 0 天开始，分别用 DMSO、恩扎卢胺或合成雄激素 (R1881) 处理。
• GSE301583 用恩扎卢胺处理和未处理（DMSO）的前列腺癌细胞系（含 SPEN 野生型和 SPEN 敲除型）的多聚核糖体测序
• GSE292286 层粘蛋白相关多肽 2 α 的缺失导致染色质重组和 A 型层粘蛋白重新分布到开放的基因组区域 [RNA-seq]
• GSE292285 层粘蛋白相关多肽 2 α 的耗竭导致染色质重组和 A 型层粘蛋白重新分布到开放的基因组区域 [ChIP-seq]
• GSE292284 层粘蛋白相关多肽 2 α 的耗竭导致染色质重组和 A 型层粘蛋白重新分布到开放的基因组区域 [ATAC-seq]
• GSE341455 骨骼肌代谢、核糖体和发育途径的重编程有助于女性接受 Roux-en-Y 胃旁路手术后的适应性改变
• GSE341378 SMALS-329 处理对 ACHN 肾癌细胞基因表达的影响
• GSE341192 骨骼肌代谢、核糖体和发育途径的重编程有助于女性Roux-en-Y胃旁路手术引起的适应性改变
• GSE338495 单细胞分辨率下尾索动物幼虫的转录组解剖 [scRNA-seq]
• GSE338266 DNA甲基化调控青春期延迟患者下丘脑-垂体-性腺轴的激活
• GSE338021 新型染料木素异黄酮生物碱 (GIA) 在缺氧条件下对 HCT116 结直肠癌细胞基因表达的影响
• GSE337269 H3K9ac ChIP-seq 分析野生型和 Slc31a1 条件性敲除小鼠骨髓基质细胞
• 利用ATAC-seq技术对野生型和Slc31a1条件性敲除小鼠骨髓基质细胞进行染色质可及性分析（GSE337266）。
• GSE336782 抑制Hippo通路可通过Müller胶质细胞衍生的光感受器再生恢复盲鼠的视觉功能
• GSE335898 人类脑血管空间图谱揭示了特化的细胞群
• GSE334387 微纳米塑料 (MNP) 与接受肺部手术切除的儿童肺部炎症
• GSE333740 人类 HN-SCC-151 HPV 阴性头颈部鳞状细胞癌细胞用 DMSO 或 SUV420H1 抑制剂 A-196/siNC（对照）或 siSUV420H1 siRNA 处理。
• GSE333434 大口黑鲈（Micropterus nigricans）鳃和脾脏对细菌混合感染的转录组反应
• GSE329742 机械缺氧在人鼻软骨细胞和骨髓间充质干细胞共培养中调控软骨生成-骨软骨转录组
• GSE329138 溴己新和京尼平处理的秀丽隐杆线虫的 RNA-seq 分析
• GSE329137 秀丽隐杆线虫在衰老过程中以及 daf-16(mu86) 突变体中的基因表达变化
• GSE327766 对感染白锈菌的抗性和感病芥菜品系进行比较转录组分析，揭示了其白锈病防御机制。
• GSE327272 斑马鱼幼体四个发育阶段内皮细胞的单细胞转录组分析
• GSE326899 ZFPOBI1/TRIM28 的全基因组结合及其相关的 H3K9me3 动态变化
• GSE312232 HT-29 人结直肠癌细胞的体外处理及 NanoString nCounter 分析
• GSE308363 邻苯二甲酸二乙酯 (DEP) 对代谢相关疾病的影响
• GSE305291 沙利度胺逆转中枢神经系统散发性动静脉畸形
• GSE303915 SETDB2 通过表观遗传沉默 SMAD3 来减轻糖尿病肾病中的足细胞功能障碍
• GSE303586 Vγ9Vδ2 T 细胞体外耗竭模型：表征和再激活策略以推进免疫疗法开发
• GSE301734 帕里米法索是一种新型广谱抗肿瘤药物
• GSE299405 miR-29a-3p 影响胎鼠肝脏 DNA 甲基化水平
• GSE299346 Mecp2 稳定活性染色质区域的糖皮质激素系统 [scRNA-Seq]
• GSE298162 Mecp2 稳定活性染色质区域的糖皮质激素系统 [scATAC-Seq]
• GSE296783 DDX21敲除胎儿造血干细胞和祖细胞的转录变化和表观遗传图谱
• GSE296646 视网膜色素变性多种模型的单细胞比较分析揭示了光感受器中激活的共同促生存机制
• GSE295756 sEV/miR-29a-3p 对胎鼠肝脏葡萄糖代谢的影响
• GSE295530 Mecp2 稳定活性染色质区域的糖皮质激素系统 [RNA-seq]
• GSE291638 多组学网络鉴定出α1-抗胰蛋白酶缺乏个体血浆中中性粒细胞弹性蛋白酶阳性细胞外囊泡是肺部炎症的加速因子
• GSE285671 H3K4me3 ChIP-seq 鉴定 TGF-β 诱导的 A549 细胞中的 EMT 转录因子
• GSE276725 单细胞转录组比较分析揭示了人类成年大脑皮层细胞类型的区域多样性
• GSE273090 玉味地黄汤与棕榈味地黄汤的比较分析：在衰老模型中延长寿命和改善肾功能
• GSE272241 Luhmes 来源多巴胺能神经元线粒体应激反应的特征分析；分化的 Luhmes 细胞经抗霉素 + 寡霉素处理 8 小时后，利用 RNA 测序比较表达谱
• GSE272218 ADAT2/3介导的tRNA编辑促进癌细胞生长和肿瘤发生
• GSE271917 鉴定血浆外泌体 miRNA 作为预测胃癌患者程序性死亡受体 1 (PD-1) 阻断联合化疗疗效的生物标志物
• GSE239689 慢性应激通过促进腺泡诱导的神经中Slc6a2的增加来加速胰腺癌的肿瘤发生
• GSE223062 GATA3 的早期活性介导人类原肠胚形成中的模式形成和谱系特化 [scRNA-Seq]
• GSE222947 GATA3 的早期活性介导人类原肠胚形成中的模式形成和谱系特化 [ChIP-seq]
• GSE222946 GATA3 的早期活性介导人类原肠胚形成中的模式形成和谱系特化 [ATAC-seq]
• GSE222945 GATA3 的早期活性介导人类原肠胚形成中的模式形成和谱系特化 [RNA-seq]
• GSE155577 基因表达数据来自在免疫缺陷和免疫功能正常小鼠体内生长的E-A14小鼠乳腺肿瘤中分离的上皮和间质肿瘤细胞
• GSE155173 拟南芥中过表达 Topless 相关基因 1 (TPR1) 的全基因组 EDS1 依赖性 H3K9 乙酰化模式
• GSE145420 RNA-seq 对 Klf5-KO 胆管上皮细胞体外三维结构的研究