科研日报 2026-07-26

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📅 Daily Report - 2026-07-26

今日筛选出 1280 条内容,来自 2 个来源

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🤖 今日AI智能总结

🧬 数据前沿

今日焦点: 利用工程细菌模拟细胞器修复肿瘤抑制功能,以及空间转录组学解码胰腺癌神经侵袭中的施万细胞激活机制,展现了癌症治疗与精准诊断的新突破。

主要方向

  • 肿瘤抑制基因功能恢复与癌症治疗(工程细菌模拟细胞器)
  • 肿瘤神经侵袭机制解析(施万细胞、空间转录组学)
  • 免疫细胞在肿瘤微环境中的作用(TNBC、NK细胞、CD8+ T细胞)
  • 组织纤维化与修复研究(瘢痕、成纤维细胞)

技术亮点

  • 工程细菌作为外源性细胞器模拟物用于癌症治疗。
  • Xenium空间转录组学在定义细胞群体和纤维化程序中的应用。
  • 单细胞RNA测序揭示TNBC外泌体对NK细胞的免疫抑制效应。

🧪 博客更新

今日焦点: APOE2基因有望延缓大脑衰老并预防阿尔茨海默病;新型RNA测序技术显著提升肺癌突变检测能力。

主要方向

  • 探索APOE2基因延缓大脑衰老、保护神经元的机制。
  • 识别驱动肺癌的基因突变,为靶向治疗提供依据。
  • 开发促进肌肉修复的新型化合物。

技术亮点

  • 利用RNA测序技术,精确检测MET exon 14跳跃事件,指导肺癌靶向治疗。
  • 发现一种硫基化合物(LASSS),能保护并增强肌肉修复蛋白功能。

📚 分类浏览

🧬 数据前沿 (1277条)

详细内容(前10条)

1.GSE322551 Engineered bacteria as exogenous organelle mimics restore PTEN and p53 tumor suppressor functions for cancer therapy

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:tumor、cancer、bacteria、regex:bacter(ia|ial|ium)
  • 📝 描述:Contributors : Shijie Bi ; Maoqin Wang ; Qing Guan ; Yaxin Wang ; Runchang Liu ; Jiaying Zhang ; Meng Li ; Quan Liu ; Peng Wang ; Youming Zhang ; Jun Fu ; Ruijuan Li ; Jun LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis work establishes a novel paradigm for using engineered intracellular bacteria asexogenous organelle-like systems to restore tumor suppressor functions and offers a promising strategy for cancer therapy
  • 🔗 查看原文

2.GSE303707 通过模拟神经损伤反应和利用空间转录组学解码胰腺癌神经侵袭中雪旺细胞的激活

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:cancer、spatial、spatial transcriptomics、transcriptomics
  • 📝 描述:Contributors : Luju Jiang ; Shuqi Cai ; Zheqi Weng ; Zhiwei Cai ; Shan Zhang ; Shu-Heng JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPerineural invasion (PNI) is a critical neuropathic change in pancreatic cancer, driven by cancer-nerve interactions, where Schwann cells (SC) undergo reprogramming similar to nerve injury, promoting tumor spread. Despite this, the molecular mechanisms underlying SC activation and their involvement in extrapancreatic PNI remain poorly understood. In this study, we drew an analogy between the process of PNI and nerve injury, identifying six nerve injury-related genes (ARRDC4, ATF3, CBFB, NAV2, SNTB1, and TOX) that are highly expressed in SC and implicated in PNI. To certify the role of the selected six genes in neural invasion, the expression of these genes in N008 were knockdown by siRNA.After knocking down the expression of these six genes in N008 cells and performing RNA sequencing, it was found that the knockdown of these genes was associated with the activation of neural pathways, such as axon regeneration, Schwann cell differentiation, axonogenesis, and neurogenesis ,suggesting that these genes likely influence the functions of periphery nervous system.
  • 🔗 查看原文

3.GSE303346 单细胞 RNA 测序揭示三阴性乳腺癌来源外泌体对 NK 细胞反应的免疫抑制作用

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:cancer、NK cell、RNA-seq、single-cell
  • 📝 描述:Contributors : Reza Shahbazi ; Samaneh Maleknia ; Sanam Rezaei BenamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple-negative breast cancer (TNBC) is a highly aggressive and immunogenic subtype that lacks effective targeted therapies. Although tumor-derived exosomes are known to influence immune responses, their direct role in shaping human NK cell plasticity remains insufficiently characterized. In this study, we performed an integrative single-cell multiomic analysis of primary human NK cells following exposure to exosomes isolated from 17 genomically distinct TNBC cell lines. By combining single-cell transcriptomics, we identified conserved and subtype-specific immunoregulatory programs elicited by TNBC-derived exosomes.
  • 🔗 查看原文

4.GSE341250 Xenium空间转录组学分析揭示瘢痕疙瘩中间充质成纤维细胞的扩增和保守的纤维化细胞外基质(ECM)程序

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:spatial、spatial transcriptomics、transcriptomics
  • 📝 描述:Contributor : Min DengSeries Type : OtherOrganism : Homo sapiensIn this study, we applied single-cell-resolution targeted Xenium spatial transcriptomics (Xenium ST) to define keloid-associated cellular and molecular programs within intact tissue architecture, with a focus on fibroblast populations and conserved pro-fibrotic gene programs linked to ECM remodeling across diverse ancestry.
  • 🔗 查看原文

5.GSE337898 ATAC-seq profiling of lineage-traced exhausted and memory-like CD8+ T cell subsets during tumor progression

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:tumor、T cell、ATAC-seq
  • 📝 描述:Contributors : Vaishali Aggarwal ; Jian Cui ; Creg J Workman ; Dario A A VignaliSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo investigate the epigenetic landscape of tumor-reactive exhausted CD8+ T cells, ATAC-seq was performed on fluorescence-activated cell sorted CD8+ T cell subsets isolated from Lag3^iCreERT2^ Rosa26^LSL-tdTomato^ mice bearing B16-F10 melanoma tumors. Chromatin accessibility profiles were generated for lineage-traced LAG3^+tdTomato^+, LAG3^-tdTomato^+, and corresponding control CD8+ T cell populations isolated from tumors and draining lymphoid tissues. These data were used to characterize chromatin accessibility changes associated with exhausted, progenitor-like, and memory-like CD8+ T cell states and to define epigenetic relationships among lineage-traced T cell populations.
  • 🔗 查看原文

6.GSE330798 Oncogenic Modulation of MAPK Signaling in Leukemia via SPNS2-Mediated Sphingosine Metabolism Rewiring

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:leukemia、metabolism、regex:onco(logy|logist|gene|genic)
  • 📝 描述:Contributors : Gaetano Sodaro ; Khansa Saadallah ; Alexandre Puissant ; Camille LobrySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLipid metabolism rewiring is an essential determinant of cancer transformation and progression, yet metabolic checkpoints that act as key switches in this process remain poorly defined. Using functional genomics in a mouse model of acute myeloid leukemia (AML), we identified the sphingosine-1-phosphate transporter SPNS2 as a sphingolipid checkpoint protein critical for leukemia development. SPNS2 expression is regulated by MYC and progressively decreases with AML differentiation, highlighting its tumor-suppressive role in a subset of Core Binding Factor AMLs. Integrating lipidomic profiling, RNA-seq, flow cytometry, and microscopy with gain- and loss-of-function approaches, we showed that SPNS2 modulation rewires sphingolipid metabolism by altering sphingomyelin levels, thereby affecting membrane nanodomain formation, active RAS localization and MAPK signaling. Exogenous reintroduction of SPNS2 decreases sphingomyelin levels, disrupts nanodomain organization, and limits leukemic progression in AML mouse models. Our data revealed an unrecognized mechanism by which sphingolipid transport dynamics intersect with oncogenic signaling to control cancer progression.
  • 🔗 查看原文

7.GSE319327 A Pan-Cancer Single-Cell Atlas to Evaluate Tumor Identity, Cell Line Concordance, and Dependency Mapping

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:tumor、cancer、single-cell
  • 📝 描述:Contributors : Rosyli F Reveron-Thornton ; James P Agolia ; Daniel D DelittoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBulk RNA sequencing enables pan-cancer transcriptional analyses, but obscures cancer cell-specific programs due to admixture with nonmalignant cells, limiting direct comparison between experimental models and human tumors. Single-cell RNA sequencing (scRNA-seq) overcomes these limitations, yet biological interpretability of public datasets is often compromised by variable data quality, inconsistent annotation, and atlas-scale aggregation strategies that favor data volume over biological coherence. We therefore developed a stringent integration framework that prioritizes representative malignant transcriptional states. Using Mahalanobis distance-based selection in batch-corrected latent space, we constructed a pan-cancer atlas of 135,441 high-quality malignant cells from 494 samples spanning 36 adult and pediatric cancer types. Atlas-derived signatures were used to assess tumor–cell line concordance and project ElasticNet models trained on DepMap CRISPR screens to infer cancer-specific gene dependencies. Together, the scTumor Atlas provides a scalable framework for tumor identity inference, cancer cell line benchmarking, and systematic identification of genetic vulnerabilities.
  • 🔗 查看原文

8.GSE316703 Microbiota-Derived Isovalerate Ameliorates Sex-Specific Gut Barrier Dysfunction in Malnutrition [RNA-seq colon epithelium]

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:RNA-seq、gut、regex:gut(-?microbiome)?
  • 📝 描述:Contributors : Lauren E Lynch ; Krishnakant G Soni ; Jennifer K Spinler ; Abu Hena Mostafa Kamal ; Nagireddy Putluri ; Stephanie W Fowler ; Margaret E Conner ; Hoa Nguyen-Phuc ; Xi-Lei Zeng ; Mary K Estes ; Sarah E Blutt ; Geoffrey A PreidisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMalnutrition is a major global health challenge that increases intestinal permeability and susceptibility to sepsis, yet the mechanisms driving barrier dysfunction remain poorly defined. We aimed to identify how the gut microbiome and microbiota-derived metabolites regulate intestinal barrier integrity during malnutrition. We used a low-protein, low-fat diet (LPLFD) to induce malnutrition in specific pathogen-free (SPF) and germ-free (GF) mice. Colonic permeability and mucus thickness were quantified. Metabolomics identified microbiota-derived metabolites altered by malnutrition. Human colonoids were used to test mechanistic effects of candidate metabolites. Barrier restoration was evaluated following colonic administration of isovalerate or oral supplementation with its precursor amino acid, leucine. LPLFD-induced malnutrition increased colonic permeability and reduced mucus thickness in male, but not female, SPF mice. These defects were absent in malnourished GF mice, indicating a microbiota-dependent and sexually dimorphic mechanism of barrier disruption. Metabolomic analysis revealed reduced colonic levels of branched-chain fatty acids (BCFAs) in malnourished mice. Supplementation of human colonoids with the BCFA isovalerate improved barrier function and altered expression of genes associated with epithelial junctional complexes. Restoring isovalerate levels, either directly via colonic administration or indirectly through oral leucine supplementation, partially rescued barrier defects in malnourished male mice. These findings identify BCFAs, particularly isovalerate, as essential microbiota-derived regulators of intestinal barrier integrity during malnutrition. This work reveals a sex-specific, microbiota-dependent pathway of barrier dysfunction and highlights microbial metabolites as promising therapeutic targets for mitigating sepsis risk in undernourished populations.
  • 🔗 查看原文

9. GSE340534 CD4阳性αβ T细胞总RNA测序(ENCSR615FXW)

10. GSE340533 CD4阳性αβ T细胞(ENCSR614CXA)的总RNA测序

💡 该来源还有 1267 条内容,详见 文末

🧪 博客更新 (3条)

详细内容(全部3条)

1. APOE2 may protect the brain from Alzheimer’s and aging

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:aging、Alzheimer
  • 📝 描述:The longevity-linked APOE2 gene appears to protect brain cells by reducing DNA damage and helping neurons recover from stress. The finding could open a new path toward treatments that mimic APOE2’s defenses in people at higher genetic risk for Alzheimer’s.
  • 🔗 查看原文

2. 基于RNA的检测揭示了驱动肺癌的突变具有非凡的多样性

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:cancer
  • 📝 描述:RNA sequencing improved detection of clinically important MET exon 14 skipping events, helping identify lung cancer patients who may benefit from targeted therapies…
  • 🔗 查看原文

3. Scientists discover a compound that could supercharge aging muscle repair

  • ✍️ 作者:未知作者
  • 🏷️ 关键词:aging
  • 📝 描述:A sulfur-based compound called LASSS appears to protect and supercharge a key protein involved in repairing damaged muscle. The discovery could eventually lead to new ways to slow muscle loss and preserve strength as people age.
  • 🔗 查看原文

📊 关键词统计

关键词出现次数
RNA-seq1210
T cell290
macrophage35
ChIP-seq21
regex:intestin(eal)
monocyte13
cancer9
cardiac5
leukemia5
tumor4
ATAC-seq3
immune3
aging3
B cell2
bacteria2
regex:bacter(iaial
spatial2
spatial transcriptomics2
transcriptomics2
Hi-C2

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🧬 数据前沿 其他内容 (1267条)

📅 报告生成时间:2026-07-25 22:14
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