详细内容（全部6条）

1. ⭐ GSE329027 Menin-RelA复合物拮抗癌细胞内在和肿瘤微环境诱导的NF-κB过度激活，从而抑制胰腺神经内分泌肿瘤的发生

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、tumor microenvironment
• 📝 描述：Contributors : Claire Wen Ying Neo ; Jun Wei Chan ; Elhadi Iich ; Tomomi Taguchi ; Nikita Bora ; Gokce Oguz ; Si Rong Heng ; Xinyi Zhang ; Jet Yee Ng ; Alvin Wei Tian Ng ; Kally Sze Mien Tan ; Wei Xuan Tan ; Adaikalavan Ramasamy ; Takeshi Miyatsuka ; Tatsuya Kin ; James Shapiro ; Khek-Yu Ho ; Joanne Yuen Yie Ngeow ; Adrian Kee Keong TeoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPancreatic neuroendocrine tumors (PNETs) are rare neuroendocrine cancers with high mortality rates and an immense unmet medical need. While the genetic and immune landscape of PNETs is defined, the molecular mechanisms linking these factors to tumorigenesis remain poorly understood. Here, we identify NF-κB signaling as a key effector pathway that contributes to PNET tumorigenesis, regulated through both cancer cell extrinsic and intrinsic mechanisms. CellChat analysis identifies M2-like macrophages as the dominant source of NF-κB-activating cytokines, and co-culture of PNET cancer cells with THP-1-derived M2-macrophages significantly enhances RelA phosphorylation and colony-forming capacity in vitro. Concurrently, we uncovered a cancer cell intrinsic safeguard mechanism wherein the tumor suppressor menin physically associates with RelA to suppress PNET growth in vitro and in vivo. Molecular docking identified key residues mediating the menin-RelA interaction and revealed three clinically relevant menin mutants (P320R, R415P, W423R) that destabilize this complex, compromising menin’s ability to restrain PNET growth. Mechanistically, menin and RelA co-bind κB sites on promoters of proliferation-associated NF-κB target genes, including NR4A1, and epigenetically silence their expression through reduced H3K27ac. Crucially, NR4A1 depletion or small-molecule inhibition suppresses PNET growth in vitro and in vivo. Together, our findings reveal a novel menin-RelA-NR4A1 axis that regulates PNET growth and demonstrates how extrinsic and intrinsic factors converge on NF-κB signaling, highlighting potential therapeutic avenues.
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2. GSE303490 新型纳米硒补充剂通过维持钙稳态调节 Sik1 通路，从而延长寿命并延缓多器官衰老

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging、pathway
• 📝 描述：Contributors : Yang Yu ; Jintao Song ; Mengjiao GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging involves progressive physiological decline and increased disease susceptibility, creating demand for effective interventions. While selenium regulates redox homeostasis and aging, its therapeutic use is limited by bioavailability and toxicity. We developed diselenide-bridged mesoporous silica nanoparticles (SeMSNs) as a novel delivery system. SeMSNs delayed cellular senescence in fibroblasts and H₂O₂-induced models by reducing oxidative stress and senescence markers (p16, p21). In aged mice, SeMSNs extended lifespan, reduced frailty, and improved multiple age-related conditions including muscle atrophy, renal dysfunction, cognitive decline, and hepatic steatosis while restoring metabolic balance. Mechanistically, SeMSNs upregulated selenoproteins (GPx1, SelK), restored calcium homeostasis, attenuated ER stress, and inhibited NFATc2-mediated Sik1 transcription. Clinical data showed inverse correlations between selenium levels and aging biomarkers. SeMSNs also rejuvenated human adipose progenitor cells via calcium-NFATc2-Sik1 modulation. These findings reveal SeMSNs surpass conventional antioxidants by targeting selenium-calcium crosstalk, providing a translatable nanotherapeutic strategy for multi-organs aging intervention and healthy longevity through selenium’s molecular mechanisms.
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3. GSE326578 Menin-RelA复合物拮抗癌细胞内在和肿瘤微环境诱导的NF-κB过度激活，从而抑制胰腺神经内分泌肿瘤的发生

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Contributors : Claire Wen Ying Neo ; Jun Wei Chan ; Gokce Oguz ; Adaikalavan Ramasamy ; Adrian Kee Keong TeoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic neuroendocrine tumours (PNETs) are rare neuroendocrine cancers with high mortality rates and an immense unmet medical need. While the genetic and immune landscape of PNETs is defined, the molecular mechanisms linking these factors to tumorigenesis remain poorly understood. Here, we identify NF-κB signaling as a key effector pathway that contributes to PNET tumorigenesis, regulated through both cancer cell extrinsic and intrinsic mechanisms. CellChat analysis identifies M2-like macrophages as the dominant source of NF-κB-activating cytokines, and co-culture of PNET cancer cells with THP-1-derived M2-macrophages significantly enhances RelA phosphorylation and colony-forming capacity in vitro. Concurrently, we uncovered a cancer cell intrinsic safeguard mechanism wherein the tumour suppressor menin physically associates with RelA to suppress PNET growth in vitro and in vivo. Molecular docking identified key residues mediating the menin-RelA interaction and revealed three clinically relevant menin mutants (P320R, R415P, W423R) that destabilize this complex, compromising menin’s ability to restrain PNET growth. Mechanistically, menin and RelA co-bind κB sites on promoters of proliferation-associated NF-κB target genes, including NR4A1, and epigenetically silence their expression through reduced H3K27ac. Crucially, NR4A1 depletion or small-molecule inhibition suppresses PNET growth in vitro and in vivo. Together, our findings reveal a novel menin-RelA-NR4A1 axis that regulates PNET growth and demonstrates how extrinsic and intrinsic factors converge on NF-κB signaling, highlighting potential therapeutic avenues.
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4. GSE337832 STING 通过 JAK-STAT 信号通路驱动大疱性类天疱疮中 CD4+T 细胞分化

• ✍️ 作者：未知作者
• 🏷️ 关键词：T cell
• 📝 描述：Contributors : Weiwei Jiang ; Mengke Sun ; Junchen He ; Tianxue Wang ; Tao Guo ; Lizhi HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBullous pemphigoid (BP) is an autoimmune blistering disease with an increasing incidence in recent years; however, the underlying immune regulatory mechanisms remain largely unclear. As a critical signaling hub linking innate and adaptive immunity, stimulator of interferon genes (STING) has recently been implicated in the pathogenesis of various autoimmune diseases and may regulate tissue inflammation and immune homeostasis through modulation of CD4+ T cell responses. In this study, transcriptomic analysis revealed that differentially expressed genes in peripheral blood CD4+ T cells from BP patients were primarily enriched in the JAK-STAT signaling pathway, T cell activation and differentiation, and type I interferon (IFN-I)-related pathways. Pharmacological inhibition of STING markedly attenuated the aberrant activation of these signaling pathways. Our findings suggest that STING may contribute to BP immunopathogenesis by regulating the JAK-STAT signaling axis and promoting abnormal CD4+ T cell activation and differentiation, providing new insights into the molecular mechanisms underlying BP and identifying potential therapeutic targets.
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5. GSE337830 小鼠肾脏在对比剂诱导的急性肾损伤中的单细胞转录组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell
• 📝 描述：Contributors : Mengqing Ma ; Hao Zhang ; Weijuan Deng ; Xia Du ; Ting Chen ; Zhaowei Wang ; Chuxian Chen ; Mengxing Chen ; Binbin Pan ; Dawei Chen ; Qing Sun ; Mengting Lu ; Yimin Li ; Wenjuan Huang ; Rui Tang ; Zhibin Qiu ; Xin Wan ; Changchun CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study generated single-cell RNA sequencing profiles from four mouse kidneys with contrast-induced acute kidney injury (CIAKI) using the 10x Genomics Chromium platform. The dataset was generated to characterize renal cell populations, cell type-specific transcriptional alterations, and immune responses associated with CIAKI. It provides a comprehensive resource for investigating the molecular mechanisms underlying kidney injury and related cellular responses.
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6. GSE237112 下一代测序有助于对临床菌株白色念珠菌 CA10 进行转录谱定量分析，该菌株单独或联合使用盐酸伊拉环素和氟康唑治疗。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：Contributors : Shicun zheng ; Xiuyun liSeries Type : Expression profiling by high throughput sequencingOrganism : Candida albicansmRNA profiles of Candida albicans clinical strain CA10, which treated with iravacycline hydrochloride and fluconazole alone or in combination, were generated by deep sequencing, in triplicate, using Illumina NovaSeq 6000 . The sequence reads that passed quality filters were analyzed at the transcript isoform level. qRT–PCR validation was performed using SYBR Green assay.We found that the gene expression related to purine nucleotide synthesis was significantly down-regulated in the combination group of iravacycline hydrochloride and fluconazole, which suggested that we might have DNA damage.
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详细内容（全部3条）

1. 实验性药物通过修复肠道逆转严重脂肪肝疾病

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?
• 📝 描述：An experimental drug called DT-109 reversed severe fatty liver disease in animal studies by repairing the gut and preventing harmful toxins from damaging the liver. The discovery could open the door to a new class of treatments for MASH and potentially other diseases tied to gut health.
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2. 研究人员警告：大量吸食大麻可能增加患癌风险

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Heavy marijuana smoking may raise the risk of lung cancer and several head and neck cancers, according to growing research, but many important questions remain unanswered. Scientists are still trying to determine how much marijuana use is enough to significantly increase cancer risk. Edibles have not been linked to lung cancer so far, while the long-term effects of vaping marijuana and secondhand marijuana smoke are still being investigated.
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3. 一种常用降压药或许能显著增强癌症治疗的效果。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Researchers found that the common blood pressure drug telmisartan can significantly improve the performance of the cancer drug olaparib, potentially expanding its benefits beyond patients with BRCA-related tumors. The combination is already being tested in human clinical trials after showing strong immune-boosting and anticancer effects in preclinical studies.
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