详细内容（前10条）

1. ⭐ GSE336887 IGF2BP1 在高危神经母细胞瘤中促进免疫抑制性肿瘤微环境，导致其对免疫疗法产生耐药性。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、tumor microenvironment、regex:immuno(logy|therapy|suppression)、resistance
• 📝 描述：Contributors : Mayura R Dhamdhere ; Chethana P Gowda ; Yuka Imamura ; Hong-Gang Wang ; Todd S Schell ; Vladimir S SpiegelmanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIncorporation of the current immunotherapy, GD2-targeting monoclonal antibody into the standard of care has moderately improved clinical outcomes in children with high-risk neuroblastoma (HR-NB), however, the overall survival remains low. More than 50% of patients with HR-NBs are refractory to or eventually develop resistance towards anti-GD2 treatment. HR-NBs in general are known to exhibit low tumor-mutational burden, are immunologically cold and possess an immunosuppressive tumor microenvironment. Understanding the mechanisms of immune evasion may provide novel targets for improving the efficacy of immunotherapies for these immunologically cold HR-NBs. Here, utilizing immunocompetent mouse models of immunologically cold HR-NB, we uncovered a novel function of IGF2BP1 in promoting immune escape of neuroblastoma tumors. We demonstrate that neuroblastoma cell-specific knockdown of IGF2BP1 favorably alters the tumor microenvironment of HR-NBs, turning these “immunologically cold” tumors to an immunogenic type, thereby priming them for anti-GD2 therapy-induced immune responses. Downregulation of IGF2BP1 in NB cells decreased the immunosuppressive T-regulatory and dysfunctional/exhausted CD8 T cells; and promoted the accumulation of effector MHCII+ macrophages at the tumor site. Importantly, knockdown of IGF2BP1 along with anti-GD2 immunotherapy induced a synergistic immunogenic effect and achieved a potent anti-tumor response in HR-NB mouse model, with increased accumulation of effector CD8+ T cells and CD86+ macrophages, but decreased MDSCs in the tumor microenvironment. Thus, disrupting NB cancer cell IGF2BP1-mediated immunosuppression is a potential approach for improving the efficacy of anti-GD2 immunotherapy towards HR-NBs.
• 🔗 查看原文

2. ⭐ GSE311200 对晚期或复发性非小细胞肺癌患者在不同治疗方案（包括免疫疗法、EGFR-TKI 和化疗）下循环生物标志物与肿瘤免疫微环境的相关性进行了综合分析。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immune、regex:immuno(logy|therapy|suppression)
• 📝 描述：Contributors : Chanida Vinayanuwattikun ; Piyada Sitthideatphaiboon ; Krittiya KorphaisarnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe prospective cohort of advanced or recurrence non-small cell lung cancer in 2 academic centers in Bangkok, Thailand. We enrolled participants who received systemic treatment based on biomarker results, for example, EGFR TKI for sensitizing EGFR mutations. Pretreatment specimens and blood were collected and analyzed for circulating biomarkers, including TIME, i.e., CD8, Treg/FOXP3, and PD-L1 (22C3). Advanced omics platforms, such as RNA sequencing and whole-exome sequencing, are also employed to explain biologic meaningful.
• 🔗 查看原文

3. ⭐ GSE324769 空间转录组学揭示与口腔上皮发育不良恶性转化相关的分子差异

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Naren Raja ; Harsh B Pathak ; Amrita Mitra ; Sufi Mary Thomas ; Yong Wang ; Tanya Gibson ; Rong WangSeries Type : OtherOrganism : Homo sapiensBackgroundOral epithelial dysplasia (OED) is a precancerous oral lesion with an increased risk of progression to oral squamous cell carcinoma (OSCC). The molecular mechanisms driving OED progression are still poorly understood. To address this gap, we applied spatial transcriptomics to benign, OED and OSCC samples to uncover molecular drivers of oral carcinogenesis, with a focus on OED transformation.MethodsWe performed spatial transcriptomics on 13 benign, 15 OED (8 with transformation, 7 without), and 14 OSCC biopsies using the NanoString GeoMx Digital Spatial Profiler. Regions of interest were segmented into epithelial and stromal compartments with morphological markers. Gene expression was profiled using the GeoMx cancer transcriptome atlas assay for ~1,800 tumor related genes. Differentially expressed genes (DEGs) from next-generation sequencing were subject to bioinformatic analyses.ResultsDifferentially gene expression analysis between OED with and without transformation revealed eight upregulated and three downregulated genes in epithelial cells, with no significant changes in immune cells. Protein-protein interaction network analysis identified B2M, STAT1, and CD74 as central hub genes. Pathway enrichment analysis suggested interferon and cytokine-mediated immune pathways, along with myeloid and amyloid formation-related pathways, as important contributors to OED transformation. Transcription factor analysis highlighted RELA and RFX as key upstream regulators.ConclusionsMalignant transformation of OED appears to be primarily driven by epithelial-intrinsic activation of interferon and inflammatory signaling pathways rather than overt transcriptional reprogramming of immune cells. These findings suggest that early immune-related alterations in oral carcinogenesis are tumor cell centered and may precede significant changes in immune cell composition.
• 🔗 查看原文

4. ⭐ GSE332958 靶向治疗诱导肿瘤消退和靶向治疗耐受性残留黑色素瘤期间免疫细胞的单细胞RNA测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immune、scRNA
• 📝 描述：Contributors : Chia-Hsin Hsu ; Keng-Jung Lee ; Jingyi Chen ; Leanne R. Donahue ; Jianping Lin ; Danielle Kacaj ; Richard M. White ; Zhong-Yin Zhang ; Andrew C. WhiteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell RNA sequencing (scRNA-seq) was performed to profile immune cell states in BRAF-mutant melanoma during targeted therapy-induced tumor regression and therapy-tolerant residual disease. CD45⁺ tumor-infiltrating immune cells were isolated from immunocompetent melanoma models treated with BRAF/MEK inhibitors and analyzed by scRNA-seq using the 10x Genomics Chromium platform. Comparative single-cell transcriptomic analysis revealed dynamic remodeling of the tumor immune microenvironment during treatment, including distinct macrophage and NK cell populations associated with therapeutic response and tolerance. Macrophage–NK cell crosstalk and cytokine signaling pathways were found to orchestrate immune activation during tumor regression, whereas immunosuppressive macrophage subsets and reduced NK effector signatures characterized the tolerant state. This dataset provides a comprehensive immune cell–level resource to investigate innate immune dynamics and intercellular communication mechanisms underlying targeted therapy efficacy and resistance in melanoma.
• 🔗 查看原文

5. ⭐ GSE332731 利用无线植入式光电子技术在体内对 Cre 调控的基因建模进行局部控制 [空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Trisha Bansal ; Varsha Sreekanth ; Jalees Rehman ; Andrei V KarginovSeries Type : OtherOrganism : Mus musculusEffective modeling of chronic human diseases in vivo requires precise spatiotemporal regulation of molecular processes at defined tissue locations. Optogenetic and optoelectronic tools can provide such control but targeting internal organs such as the lungs remain challenging. To address this, we developed E-LightR-Cre recombinase, enabling precise, spatially restricted gene activation with no dark-state activity and robust blue-light responsiveness. To achieve local activation of E-LightR-Cre in specific organ sites, we engineered wireless, fully implantable optoelectronic devices enabling focal illumination of murine lungs with no discernible organ damage. The size of activated area is controlled by modulating light intensity and duration. Using implanted optoelectronic devices, we activated E-LightR-Cre in a selected area of mouse lungs and achieved local regulation of targeted genes. Light-regulated expression of oncogenic KRas-G12D mutant in mouse lungs induced local formation of oncogenic lesions. These results show that our protein engineering and adaptable optoelectronic approaches enable facile application of optogenetic tools for locally controlled disease modeling in vivo.
• 🔗 查看原文

6. ⭐ GSE304087 DNA甲基化谱分析发现簇状原钙黏蛋白的长程表观遗传沉默是脑膜瘤进展的关键决定因素[RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、epigenetic、methylation
• 📝 描述：Contributors : Daniel J Merk ; Ghazaleh TabatabaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMeningioma is the most common primary brain tumor in adults, but molecular drivers of progression occurring in a subset of meningiomas are poorly understood. We hypothesized that epigenomic variations are causal for the clinical heterogeneity of meningiomas and may be functionally relevant for disease progression. To test this hypothesis, we performed global DNA methylation profiling of a large cross-sectional cohort and a longitudinal cohort of human meningiomas. Our analysis identifies a DNA hypermethylation signature that is correlated with clinical outcomes and enables more accurate prognostication in intermediate-risk meningiomas than previous classification systems. Analyses of longitudinal high-grade meningioma samples in comparison to clinically benign meningiomas and normal meningeal tissue show convergent contributions, but differing plasticity of copy number variations and DNA hypermethylation along the trajectory of meningioma progression. Systematic analysis of DNA hypermethylation in high-grade meningiomas unravel a tumor suppressive role of clustered protocadherins by regulating b-catenin signaling. Together, our study provides fundamental insights into the molecular mechanisms underlying the heterogeneity of clinically benign and aggressive meningiomas and the microevolutionary adaptation during disease progression.
• 🔗 查看原文

7. ⭐ GSE302988 PGAM5通过丙酮酸代谢途径调节乳酸生成以促进非小细胞肺癌进展的机制

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、metabolism、pathway
• 📝 描述：Contributors : Jianxin Wang ; Guodong HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensStudy on the regulation of pyruvate and its metabolites by knocking down PGAM5 through transcriptome analysis
• 🔗 查看原文

8. ⭐ GSE280330 体内单细胞核糖体谱分析揭示衰老过程中细胞类型特异性翻译程序 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging、single-cell、scRNA
• 📝 描述：Contributors : Clara Duré ; Umesh Ghoshdastider ; Ramona Weber ; Peter F Renz ; Fabiola Valdivia-Francia ; Ameya Khandekar ; Federica Sella ; Katie Hyams ; Yigit Merve ; Mark Ormiston ; Homare Yamahachi ; Mitchell Levesque ; Stephanie Ellis ; Ataman SendoelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSomatic stem cells are characterized by their low overall protein synthesis rates, a feature implicated in driving their stemness. Yet, how aging reshapes the translational landscape of stem cells and how these changes impact their regenerative capacity remains poorly understood. Here, we present an in vivo single-cell ribosome profiling strategy to monitor tissue-wide translational landscapes of the young and aged mouse skin. By implementing efficient in vivo cell isolation and switching to RNAse I-based ribonuclease for generating ribosomal footprints, we enhance the accessibility of single-cell ribosome profiling and facilitate the evaluation of triplet periodicity, a hallmark of high-quality data. Leveraging this strategy and integrating single-cell RNA sequencing with ribosome profiling, we document the translational landscapes of the major epidermal cell types, outline cell-type-specific translational efficiencies and capture heterogeneity in differentiation commitment among stem cell populations. Notably, we identify a pronounced translational reprogramming of AP-1 subunits specifically in aged epidermal stem cells. Our proof-of-concept study illustrates the power of in vivo single-cell ribosome profiling to map cell-type-specific translational landscapes and offers a scalable strategy for tissue-wide interrogation of translational landscapes at single-cell resolution.
• 🔗 查看原文

9. ⭐ GSE271705 MCF10A衍生细胞系中乳腺癌进展过程中组蛋白修饰的整合ChIP-seq和转录组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、ChIP-seq、histone
• 📝 描述：Contributors : Seth Frietze ; Cong GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer arises from complex epigenetic mechanisms that drive tumorigenesis. Gene regulatory elements play a pivotal role in reprogramming gene expression patterns, facilitating tumor initiation, progression, and metastasis. However, a comprehensive characterization of epigenetic alterations across cancer development remains incomplete, particularly for the spectrum of post-translational histone modifications in the evolution of breast tumors. In this study, we explored the dynamic landscape of epigenetic changes using a breast cancer progression model based on the MCF10A cell line. We integrated ChIP-seq and transcriptomic profiling to investigate the epigenetic heterogeneity across four MCF10A-derived cancer cell lines: normal (MCF10A), HRAS G12V transformed, ductal carcinoma in situ (DCIS), and metastatic (CA1a). Our analysis revealed significant changes in chromatin patterns at regulatory elements, including stage-specific variability in H3K27me3 and H3K9me3-marked heterochromatin domains. These profiles underly the epigenomic changes in each of these cell states to provide insights into human breast cancer progression.
• 🔗 查看原文

10. ⭐ GSE271438 癌症相关成纤维细胞通过表观遗传沉默 Decorin 促进结直肠癌的血管生成模拟 [甲基化阵列]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、epigenetic、methylation
• 📝 描述：Contributors : Yin Zhu ; Yurui LiuSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensTo investigate the DNA methylation landscape differences between CAFs and NFs in colorectal cancer, we extracted primary fibroblasts from colorectal cancer tissue and para-cancerous tissue for 850K chip analysis.
• 🔗 查看原文

💡 该来源还有 124 条内容，详见 文末

详细内容（全部2条）

1. 图论人工智能和Mamba模型改进了单细胞RNA测序细胞分类

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell
• 📝 描述：RNA sequencing combined with graph neural networks and Mamba models improves cell type classification, enabling more accurate analysis of complex single-cell datasets… The post Graph AI and Mamba models improve single-cell RNA sequencing cell classification appeared first on RNA-Seq Blog.
• 🔗 查看原文

2. Transformer AI 模型如何推进单细胞 RNA 测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell
• 📝 描述：RNA sequencing is benefiting from Transformer-based AI models that improve analysis of complex single-cell datasets while supporting more accurate and scalable biological discovery… The post How transformer AI models are advancing single-cell RNA sequencing appeared first on RNA-Seq Blog.
• 🔗 查看原文

• GSE267729 单细胞转录组学揭示小鼠雌激素更年期转变过程中卵巢衰老和衰老细胞积累的基础
• GSE179812 Macrophage Heterogeneity in Progression and Regression Phases of Cisplatin Induced AKI Mice Model - A single-cell RNA sequencing study
• GSE320080 对造血细胞和非造血细胞进行单细胞 RNA 测序，揭示了特应性皮炎和 NRG1 小鼠肺组织中独特的特征。
• GSE336140 mTORC2-HIF-1β 信号通路在肺癌中产生可靶向的鞘脂脆弱性 [RNA-Seq]
• GSE335944转录组分析揭示围产期心肌病中蛋白质稳态和细胞存活通路紊乱，最终导致心力衰竭
• GSE334737 绵羊肥胖诱导瘦素抵抗期间血浆小RNA测序
• GSE327733 Galectin-1 促进单核细胞驱动的过度炎症反应，并代表骨髓增生性肿瘤的新型治疗靶点 [RNA-Seq]
• GSE327732 Galectin-1 促进单核细胞驱动的过度炎症反应，并代表骨髓增生性肿瘤的新型治疗靶点 [scRNA-Seq]
• GSE323168 基因组测序剖析 SVA 逆转录转座子疾病 X 连锁肌张力障碍帕金森综合征的后果 [DNA-seq]
• GSE322966 基因组测序解析 SVA 逆转录转座子疾病 X 连锁肌张力障碍帕金森综合征的后果 [RNA-Seq]
• GSE322527 狼疮性肾炎发作期患者外周血或尿液中 CD4 或 CD8 单阳性 T 淋巴细胞的单细胞转录组和 T 细胞受体序列。
• GSE315214 肠系膜炎症相关成纤维细胞促进肠上皮功能障碍和克罗恩病进展
• GSE315154 CRISPR/Cas9筛选揭示PRKCB介导的YBX1磷酸化促进结直肠癌的奥沙利铂耐药性
• GSE314573 CD44拮抗oHSV促进三级淋巴结构的形成并增强抗肿瘤免疫力
• GSE313917 补体蛋白酶 C1s 通过重塑小胶质细胞代谢驱动间充质胶质母细胞瘤的免疫抑制
• GSE309747 PRMT7 特异性 PROTAC 降解剂通过 NF-kB 激活增强 CD8+ T 效应功能，从而改善过继性癌症免疫疗法。
• GSE308369 缺血性中风通过 FTO 介导的表观遗传修饰加速动脉粥样硬化进展 [RNA-Seq]
• GSE304097 DNA甲基化谱分析表明，簇状原钙黏蛋白的长程表观遗传沉默是脑膜瘤进展的关键决定因素。
• GSE304096 DNA甲基化谱分析发现簇状原钙黏蛋白的长程表观遗传沉默是脑膜瘤进展的关键决定因素[纵向]
• GSE304094 DNA甲基化谱分析发现簇状原钙黏蛋白的长程表观遗传沉默是脑膜瘤进展的关键决定因素[发现]
• GSE304093 DNA甲基化谱分析发现簇状原钙黏蛋白的长程表观遗传沉默是脑膜瘤进展的关键决定因素[细胞系]
• GSE303384 Mtg16肿瘤抑制因子维持和建立抑制的机制[CUT&RUN, ChIP-Seq]
• GSE303336 药理学抑制CXCR4可增强B细胞淋巴瘤模型中传统疗法和靶向疗法的抗肿瘤活性
• GSE302992 核PTK7与DNA-PK相互作用驱动三阴性乳腺癌的DNA修复和免疫逃逸
• GSE301871 SFB 驱动的派氏淋巴集结重塑增强 IgA 和 IgG2b 类别转换和非典型记忆 B 细胞生成 [scRNA-Seq]
• GSE301372 条件性Vhlh基因敲除小鼠模型肾脏组织的单细胞RNA测序。[sc-RNA_Seq]
• GSE301357 2型细胞因子生物标志物高表达和低表达的重度哮喘患者的气道转录组
• GSE299610 亚临床新生儿 HSV-1 感染触发免疫反应并调节神经通路，导致长期后遗症 [Visium]
• GSE289496 颗粒酶K CD8⁺ T细胞具有组织驻留特征，可促进克罗恩病患者的肠道炎症
• GSE284956 克服雌激素受体阳性（ER+）乳腺癌细胞周期抑制剂耐药的内在机制
• GSE280255 体内单细胞核糖体谱分析揭示衰老过程中细胞类型特异性翻译程序
• GSE271741 染色体 7 异常急性髓系白血病 (AML) 患者的单细胞转录组和蛋白质组分析
• GSE271516 Erianin 诱导 GSDMD 依赖性细胞焦亡，并通过 PI3K/AKT 信号通路协同增强弥漫性大 B 细胞淋巴瘤中阿霉素的疗效
• GSE233489：沙门氏菌感染后结肠和硬脑膜CD45+细胞的单细胞RNA测序
• GSE179807 Single-cell RNA Sequencing of Wild Type and Cisplatin Induced AKI (3d and 7d groups) Mouse Kidney
• GSE335811 巨噬细胞诱导的衰老癌相关成纤维细胞促进SASP介导的结直肠癌化疗耐药性
• GSE335881 可逆性上胚层区域化决定人类PSC的分化潜能[RNA-Seq]
• GSE334112 可逆的上胚层区域化决定人类PSC的分化潜能[ATAC-seq]
• GSE318840 单细胞固定 RNA 分析揭示骨肉瘤演化过程中驱动转移的协调多细胞网络
• GSE317471 对早衰症血管壁的单细胞分析揭示了进行性细胞类型特异性功能障碍和体细胞突变的积累
• GSE313258 增塑剂邻苯二甲酸二异壬酯通过代谢物驱动肝脏脂质代谢重塑
• GSE295107 剪接因子的翻译控制决定造血干细胞命运 [scRNA-seq]
• GSE294393 剪接因子的翻译控制决定造血干细胞命运 [RNA-Seq]
• GSE334972 心内膜 Tie2 通过将 FOXO1 隔离在细胞质内并刺激 versican 裂解来调控心肌小梁形成
• GSE292307 ARID1A 终止胃再生以预防癌症
• GSE276621 互惠遗传筛选鉴定出控制表皮细胞活化的表观遗传因子。[ChIP-Seq]
• GSE269658 免疫检查点分子作为金黄色葡萄球菌骨感染预后的生物标志物
• GSE336922 硫氧还蛋白-Serinc2-脂质信号轴调节小鼠的情绪相关行为 [ATAC-Seq]
• GSE336792 干细胞因子 248 调控 ILC2 转录程序并促进过敏性哮喘中的黏膜炎症
• GSE336720 DNMT3B 与 SMARCB1 发挥拮抗作用，是横纹肌样瘤的可靶向脆弱点 [RNA-seq]
• GSE336715 PM2.5诱导的野生型小鼠乳腺上皮细胞转录反应的比较RNA测序分析
• GSE336713：对小鼠骨髓纤维化脾脏进行全面的单细胞RNA分析，鉴定出可靶向的免疫-基质相互作用。
• GSE336474 LEF1 和微环境决定因素定义了慢性疾病中的 T 细胞干性 [scMultiome]
• GSE336436 LEF1 和微环境决定因素定义了慢性疾病中的 T 细胞干性
• GSE336137 mTORC2-HIF-1β 信号通路在肺癌中产生可靶向的鞘脂脆弱性 [多聚体测序]
• GSE335708 吗啡急性戒断与长期戒断时间点VTA转录组的性别特异性紊乱
• GSE334560 MYCN驱动儿童神经胶质瘤从神经祖细胞转化，并造成独特的治疗弱点
• GSE334160 心肌细胞分泌的靶向小胶质细胞活化和下丘脑炎症的小型细胞外囊泡加重射血分数保留型心力衰竭
• GSE331228 CLP小鼠肝脏和肺脏的RNA测序分析(6h)
• GSE329353 利用动态磁驱动技术构建肠绒毛芯片，用于识别 EGR1 作为 IBD 治疗靶点
• GSE329226 水螅（Hydra viridissima）的ATAC-seq染色质可及性分析
• GSE329225 共生和无共生水螅的总RNA测序
• GSE328345 从工业副产品中提取的富含多酚的提取物能够调节肠道菌群并抑制肠道寄生虫感染
• GSE325933 心脏、肺和尾尖成纤维细胞中 GATA4 敲除的转录组分析
• GSE325467 4-1BBL 信号传导促进 B 细胞活化，但在实验性疟疾期间限制其增殖
• GSE325279 ALDH1抑制剂DIMATE在AML中诱导免疫原性重塑的同时，还能维持免疫功能
• GSE324743 肝细胞通过提供外源性丝氨酸促进胰腺癌肝转移
• GSE324601 人类iPSC衍生的类人血管瘤在第16天和第28天的空间转录组分析
• GSE322968 基因组测序剖析 SVA 逆转录转座子疾病 X 连锁肌张力障碍帕金森综合征的后果 [CUT&Run]
• GSE320454 发育调控的长程增强子-启动子接触介导人类神经发育 [scRNA-seq]
• GSE320169 甘蔗杂交种 (ZZ1) 叶片响应镰刀菌感染的时间进程转录组分析
• GSE318999 发育调控的长程增强子-启动子接触介导人类神经发育 [ATAC-Seq]
• GSE317900 ZDHHC8介导的β-catenin棕榈酰化促进WNT信号通路激活并驱动骨肉瘤的顺铂耐药性
• GSE317299 儿童肾病综合征类固醇反应的独特免疫特征
• GSE317076 家蚕（Bombyx mori）蜕皮变异的转录组分析
• GSE316205 白花苷通过Rap1a/ERK信号通路抑制破骨细胞线粒体自噬来缓解骨质疏松症
• GSE311302 NUDT21 敲低 RNA-seq 在神经母细胞瘤 II 中
• GSE309741 小鼠胰腺导管腺癌细胞系（有/无 C1galt1c1 敲除）的批量 RNA 测序
• GSE307081 缺血性卒中通过FTO介导的表观遗传修饰加速动脉粥样硬化进展
• GSE307034 缺血性中风通过 FTO 介导的表观遗传修饰加速动脉粥样硬化进展 [Ribo-Seq]
• GSE307033 缺血性中风通过 FTO 介导的表观遗传修饰加速动脉粥样硬化进展 [MeRIP-Seq]
• GSE307032 缺血性中风通过 FTO 介导的表观遗传修饰加速动脉粥样硬化进展 [CUT&Tag]
• GSE305397 原代小鼠心脏内皮细胞在尿毒症条件下表现出 Lcn2 上调。
• GSE304874 研究发现，不同的表观遗传特征是低级别和高级别非肌层浸润性膀胱癌分子分型的基础。
• GSE304119 SARS-CoV-2 S蛋白假型慢病毒对3D皮肤模型转录组的影响
• GSE303982 Mettl3 敲除基底细胞衍生类器官的 RNA-seq 和 MeRIP-seq 比较
• GSE303720 直肠癌术前放化疗疗效预测的生物标志物
• GSE303354 Mtg16肿瘤抑制因子维持和建立抑制的机制
• GSE302795 磷酸化泛素是一种介导线粒体-细胞核相互作用的第二信使和表观遗传标记
• GSE302714 用锰 (Mn) 或胰岛素处理的原代小鼠肝细胞的 RNA 测序
• GSE301577 SFB驱动的派氏淋巴集结重塑增强IgA和IgG2b类别转换以及非典型记忆B细胞生成II
• GSE301463 Smoothened介导的信号传导参与小胶质细胞的免疫和非免疫功能
• GSE301432 SFB驱动的派氏淋巴集结重塑增强IgA和IgG2b类别转换以及非典型记忆B细胞生成
• GSE301422 人类巨噬细胞对 13 种聚合物材料反应的转录组分析。
• GSE300338 RNA-seq 分析 U937 细胞中 BRD4 敲低的情况
• GSE299510 与奥沙利铂联合治疗通过重组肿瘤内巨噬细胞改善溶瘤病毒疗法的远隔效应[scRNA-seq]
• GSE299495 母体蠕虫通过吲哚-3-丙酸重塑微生物群以促进后代抗病毒免疫
• GSE299440 亚临床新生儿HSV-1感染触发免疫反应并调节神经通路，导致长期后遗症
• GSE297336 猪子宫内膜容受前期和容受期单细胞转录组分析
• GSE296076 ARP-1野生型和ARP-1卡非佐米耐药细胞RNA测序分析
• GSE295453 干扰素诱导的免疫特征与猪细胞培养模型中戊型肝炎病毒感染的抑制相关
• GSE294257 ALDH1A1+ 细胞是子宫内膜祖细胞，有助于子宫内膜再生和子宫内膜异位症 [小鼠单细胞RNA测序]
• GSE291439 C57BL6 Substrain Differences in Hippocampal-Dependent Learning and Transcriptome
• GSE290288 解读早期妊娠期驴（Equus asinus）胎儿性腺发育的单细胞图谱
• GSE289033 阻断骨细胞中的脂质信使：预防和治疗代谢相关脂肪肝疾病的新策略
• GSE284430 人类效应和记忆 CD8 T 细胞分化过程中 CD45 亚型的调控：对 T 细胞命名法的影响
• GSE284032 利用 DIRAC 对空间多组学数据进行整合和注释，突显了淋巴器官的空间组织结构
• GSE272604 一项针对恒河猴的新型表观遗传时钟研究揭示了早期生活逆境与表观遗传年龄加速之间的关联
• GSE271766 大鼠辐射诱导食管损伤的单细胞RNA测序
• GSE271429 丙氨酸代谢对小鼠精原干细胞生物能量平衡的调控
• GSE271004 腺泡细胞和导管细胞来源的胰腺癌的转录组分析
• GSE270897 β-catenin 相关转录特征预测肝细胞癌患者的生存结果。
• GSE261306 基于胎盘转座元件失调的先兆子痫早期预测 [RNA-Seq]
• GSE252704 疟原虫操纵红细胞膜以实现细胞内适应：RNA测序
• GSE246617 脑血管转录组分析揭示间歇性禁食调节慢性脑低灌注诱发的疾病通路。
• GSE233544 研究硬脑膜中 T 细胞对全身感染的反应
• GSE233491 对用 2% DSS 或 H2O 对照处理的小鼠的各种组织进行批量 TCR 测序。
• GSE233490 全硬脑膜组织批量RNA测序
• GSE227209 小鼠树突状细胞在有或无 Il13ra1 存在下的单细胞 RNA 测序
• GSE207819 Leukemia impose cell autonomous defects in long-term stem cell function.
• GSE179806 Bulk RNA Sequencing of Wild Type and Cisplatin Induced AKI (3d and 7d groups) Mouse Kidney
• GSE151789 Gene expression profiling of EMT-associated breast cancer models
• GSE336870 单核 RNA 测序揭示索拉非尼诱导心脏毒性的病理过程和关键转录因子
• GSE334065 PRMT1 敲低在 MDA-MB-231 M3 细胞中的转录组分析