详细内容（前10条）

1. ⭐ GSE325817 中风通过重塑肿瘤微环境驱动胶质瘤进展 [空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、tumor microenvironment、glioma、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Qi Ye ; Hari Krishna Yalamanchili ; Hyun Kyoung LeeSeries Type : OtherOrganism : Mus musculusEpidemiological studies suggest increased brain tumor risk in patients with prior stroke. Comparative transcriptomic analyses reveal enrichment of stroke-associated gene signatures in high-grade gliomas; nevertheless, the mechanisms that unify these conditions remains unclear. Here we show that stroke promotes tumor infiltration towards the site of stroke injury in human and mouse glioma models, accompanied by reduced overall survival. Stroke induces remodeling of the tumor microenvironment (TME), including the emergence of a unique population of tumor-associated astrocytes (TAAs) that exhibit reduced Ca2+ activity at the infiltrative edge, and enrichment of tumor-associated microglia and macrophages (TAMs). Chemogenetic stimulation of Ca2+ signaling in TAAs or depletion of TAMs reverses stroke-induced glioma progression. We further identify the sodium–bicarbonate cotransporter Slc4a4 as a key regulator of Ca2+ activity in TAAs and associated TAM recruitment. Collectively, our findings demonstrate that stroke accelerates glioma progression through remodeling of astrocytic and immune compartments of the TME.
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2. ⭐ GSE283729 组蛋白 3 赖氨酸 36 甲基化塑造肠道干细胞的表观遗传景观，从而调控脂质代谢并防止细胞衰老 [ATAC-seq 2]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolism、ATAC-seq、epigenetic、methylation、histone、regex:intestin(e|al)
• 📝 描述：Contributors : Yue Xu ; Ziyi WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe self-renewal capacity and differentiation potential of intestinal stem cells (ISCs) decline with age, leading to a loss of homeostasis and increased susceptibility to intestinal diseases. Despite the established importance of lipid metabolism and epigenetic regulation in ISC function, the molecular mechanisms linking these processes to aging-associated ISC dysfunction remain elusive. Here, we demonstrate that H3K36 methylation, caused by NSD2 or SETD2, is critical to ISC fate. We found that the deficiency of H3K36 methylation results in reduced ISC proliferation and differentiation, disturbs fatty acid metabolism, and induces ISC senescence. This loss leads to increased chromatin accessibility and enhancer activation, impairing the function of the SWI/SNF chromatin remodeling complex and affecting genes expression. Importantly, we find that metabolic intervention can rescue the decline in ISC numbers due to H3K36 methylation deficiency. Our findings reveal a critical role for H3K36 methylation in maintaining epigenetic landscape to orchestrate lipid metabolism and determine intestinal stem cell fate.
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3. ⭐ GSE283728 组蛋白 3 赖氨酸 36 甲基化塑造肠道干细胞的表观遗传景观，从而调控脂质代谢并防止细胞衰老 [ATAC-seq 1]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolism、ATAC-seq、epigenetic、methylation、histone、regex:intestin(e|al)
• 📝 描述：Contributors : Yue Xu ; Ziyi WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe self-renewal capacity and differentiation potential of intestinal stem cells (ISCs) decline with age, leading to a loss of homeostasis and increased susceptibility to intestinal diseases. Despite the established importance of lipid metabolism and epigenetic regulation in ISC function, the molecular mechanisms linking these processes to aging-associated ISC dysfunction remain elusive. Here, we demonstrate that H3K36 methylation, caused by NSD2 or SETD2, is critical to ISC fate. We found that the deficiency of H3K36 methylation results in reduced ISC proliferation and differentiation, disturbs fatty acid metabolism, and induces ISC senescence. This loss leads to increased chromatin accessibility and enhancer activation, impairing the function of the SWI/SNF chromatin remodeling complex and affecting genes expression. Importantly, we find that metabolic intervention can rescue the decline in ISC numbers due to H3K36 methylation deficiency. Our findings reveal a critical role for H3K36 methylation in maintaining epigenetic landscape to orchestrate lipid metabolism and determine intestinal stem cell fate.
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4. ⭐ GSE280531 通过派氏淋巴集结中的肠上皮免疫动力学塑造肠道免疫。

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、immunity、gut、regex:gut(-?microbiome)?、regex:intestin(e|al)
• 📝 描述：Contributors : M Zeeshan Chaudhry ; Wang Cao ; Gabrielle BelzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicrofold (M) cells are specialized antigen-sampling cells that transcytose luminal antigens to underlying immune cells to initiate mucosal immunity. How they are programmed in different intestinal tissues and their role during enteric infections has not been resolved. Here, we demonstrate that M cells are critical for B cell activation and IgA production that shapes the intestinal microbiome and maintains steady-state intestinal epithelial integrity. Tuft cells and M cells share expression of SPI-B. Molecular mapping revealed that M cells exhibit significant heterogeneity including tissue-specific and pathogen-specific tailored programs. These include key pathways regulating fatty acid uptake and metabolism in the intestinal epithelium. Confocal imaging demonstrated that Peyer’s patch SPI-B+ M cells act to retain group 3 innate lymphoid cells and IL-22 production within the Peyer’s patch epithelium. By identifying interconnected cellular and molecular programs, we uncover novel spatially organized immune-epithelial regulatory networks essential for immune protection.
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5. ⭐ GSE336978 单细胞RNA和空间转录组学分析毛里求斯猕猴和印度猕猴外周血单核细胞和组织中等位基因特异性MHC表达

• ✍️ 作者：未知作者
• 🏷️ 关键词：MHC、scRNA、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Macaca fascicularis ; Macaca mulattaThis SuperSeries is composed of the SubSeries listed below.
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6. ⭐ GSE336518 人类胰腺癌中的多核巨细胞是经历 DNA 损伤反应的独特巨噬细胞群，与侵袭性肿瘤微环境相关 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、tumor microenvironment、macrophage、RNA-seq
• 📝 描述：Contributors : AR Putignano ; M Viatore ; R Polidori ; F Marchesi ; A MantovaniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMacrophages constitute a dominant and functionally diverse immune population within the microenvironment of pancreatic ductal adenocarcinoma (PDAC), yet how this heterogeneity contributes to the tumor remains poorly defined. In an institutional cohort of 145 PDAC specimens, we identified a population of multinucleated giant cells (MGCs) of macrophage origin, an entity previously described in chronic inflammation but rarely in cancer. CD68⁺ MGCs were present in 28% of tumors, enriched in squamous, non-glandular regions, and more frequent after neoadjuvant chemotherapy. By integrating spatial transcriptomics and quantitative imaging, we defined the features of these cells, which, compared with MGCs in non-neoplastic inflammatory lesions, lacked canonical polarization markers (HLA-DR, CD163) and displayed a distinctive transcriptional program characterized by upregulation of POLR2K, TUBA8, COX5B, and VDAC1 genes, involved in DNA repair, oxidative stress, and MYC signaling. Spatial analyses revealed activation of hypoxia and extracellular matrix–remodeling pathways in MGC-associated niches, and experimental hypoxia promoted MGC formation in vitro. Consistently, a macrophage MGC gene signature was enriched in the squamous PDAC subtype and correlated with poorer overall survival in TCGA (p = 0.018). Morphometric and immunofluorescence analyses further showed increased 53BP1⁺/Ki67⁺ nuclei and nuclear atypia in MGCs, indicating ongoing proliferation despite DNA damage. Together, these data identify multinucleated macrophages as a previously unrecognized immune cell state shaped by hypoxia and stress signaling, associated with aggressive tumor phenotypes, and potentially exploitable as an immune classifier in pancreatic cancer.
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7. ⭐ GSE300017 CARM1 表观遗传酶抑制癌症免疫中的交叉呈递树突状细胞功能 [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immunity、dendritic cell、scRNA、epigenetic
• 📝 描述：Contributors : Xixi Zhang ; Yuyang HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cancer-immunity cycle requires cross-presenting dendritic cells (cDC1) that induce T cell-mediated immunity, but therapeutic strategies for enhancing intratumoral cDC1 function are inadequate. We discovered the epigenetic enzyme Carm1 as a selective negative regulator of cancer antigen presentation by cDC1s, but not cDC2s. Carm1 inactivation promoted cDC1 antigen cross-presentation, activation, and accumulation in tumors; and a Carm1 inhibitor enhanced cDC1-mediated priming of T cells by a cancer vaccine. Carm1 inhibition increased chromatin accessibility at BATF3-JUN and RELA sites critical for cDC1 function and activation. Carm1 expression was regulated by TGF-beta, explaining why Carm1 inactivation enhanced intratumoral cDC1 function without altering cDC1 homeostasis. These studies identify Carm1 as a therapeutic target for enhancing the anti-tumor function of murine and human cDC1.
• 🔗 查看原文

8. ⭐ GSE300014 CARM1 表观遗传酶抑制癌症免疫中的交叉呈递树突状细胞功能 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immunity、dendritic cell、RNA-seq、epigenetic
• 📝 描述：Contributor : Xixi ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cancer-immunity cycle requires cross-presenting dendritic cells (cDC1) that induce T cell-mediated immunity, but therapeutic strategies for enhancing intratumoral cDC1 function are inadequate. We discovered the epigenetic enzyme Carm1 as a selective negative regulator of cancer antigen presentation by cDC1s, but not cDC2s. Carm1 inactivation promoted cDC1 antigen cross-presentation, activation, and accumulation in tumors; and a Carm1 inhibitor enhanced cDC1-mediated priming of T cells by a cancer vaccine. Carm1 inhibition increased chromatin accessibility at BATF3-JUN and RELA sites critical for cDC1 function and activation. Carm1 expression was regulated by TGF-beta, explaining why Carm1 inactivation enhanced intratumoral cDC1 function without altering cDC1 homeostasis. These studies identify Carm1 as a therapeutic target for enhancing the anti-tumor function of murine and human cDC1.
• 🔗 查看原文

9. ⭐ GSE300010 CARM1 表观遗传酶抑制癌症免疫中的交叉呈递树突状细胞功能 [ATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immunity、dendritic cell、ATAC-seq、epigenetic
• 📝 描述：Contributors : Xixi Zhang ; Wen WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe cancer-immunity cycle requires cross-presenting dendritic cells (cDC1) that induce T cell-mediated immunity, but therapeutic strategies for enhancing intratumoral cDC1 function are inadequate. We discovered the epigenetic enzyme Carm1 as a selective negative regulator of cancer antigen presentation by cDC1s, but not cDC2s. Carm1 inactivation promoted cDC1 antigen cross-presentation, activation, and accumulation in tumors; and a Carm1 inhibitor enhanced cDC1-mediated priming of T cells by a cancer vaccine. Carm1 inhibition increased chromatin accessibility at BATF3-JUN and RELA sites critical for cDC1 function and activation. Carm1 expression was regulated by TGF-beta, explaining why Carm1 inactivation enhanced intratumoral cDC1 function without altering cDC1 homeostasis. These studies identify Carm1 as a therapeutic target for enhancing the anti-tumor function of murine and human cDC1.
• 🔗 查看原文

10. ⭐ GSE283733 组蛋白3赖氨酸36甲基化塑造肠道干细胞的表观遗传图谱，从而调控脂质代谢并防止细胞衰老

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolism、epigenetic、methylation、histone、regex:intestin(e|al)
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

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详细内容（全部3条）

1. 即将举办的RNA测序网络研讨会——量化月经液中的炎症消退

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq
• 📝 描述：RNA sequencing of menstrual fluid enables time-resolved analysis of inflammation, tissue repair, and the microbiome, supporting new approaches for women’s health diagnostics… The post Upcoming RNA-Seq Webinar – Quantifying Inflammatory Resolution in Menstrual Fluid appeared first on RNA-Seq Blog.
• 🔗 查看原文

2. 科学家发现一种意想不到的方法，使胰腺癌细胞自毁

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, suggesting it could help prevent the spread of tumors. Rather than suppressing cancer signaling, the treatment hyperactivated key pathways until the cells essentially self-destructed.
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3. Scientists may have finally found how Alzheimer’s spreads through the brain

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：A common brain protein may be giving Alzheimer’s disease an unexpected way to spread, carrying toxic Tau proteins from damaged neurons into healthy ones. By blocking these harmful protein packages before they reach new cells, researchers believe it may one day be possible to slow the disease’s relentless progression.
• 🔗 查看原文

• GSE283727 组蛋白 3 赖氨酸 36 甲基化塑造肠道干细胞的表观遗传图谱，从而调控脂质代谢并防止细胞衰老 [CUT&Tag]
• GSE329813 空间转录组学揭示新辅助化疗免疫疗法治疗的非小细胞肺癌中免疫微环境异质性和反应相关亚型
• GSE325816 中风通过重塑肿瘤微环境驱动胶质瘤进展 [scRNA-Seq]
• GSE336517 人类胰腺癌中的多核巨细胞是经历 DNA 损伤反应的独特巨噬细胞群，与侵袭性肿瘤微环境相关 [GeoMx DSP]
• GSE336328 CD99 是弥漫性中线胶质瘤的新型免疫治疗靶点：抗同源杀伤 CAR T 细胞可实现持久的肿瘤控制 [RNA-seq]
• GSE329635 小肠类器官自组织的单细胞RNA测序[scRNA-Seq]
• GSE300019 CARM1 表观遗传酶抑制癌症免疫中的交叉呈递树突状细胞功能 [多组学]
• GSE300012 CARM1 表观遗传酶抑制癌症免疫中的交叉呈递树突状细胞功能 [CUT&RUN]
• GSE243533 揭示肠道免疫-上皮相互作用的空间动态
• GSE307519 用细胞因子混合物和/或表观遗传调节剂处理的 Ccd18-Co 细胞系的批量 RNA 测序
• GSE336326 CD99 是弥漫性中线胶质瘤的新型免疫治疗靶点：抗同源杀伤 CAR-T 细胞可实现持久的肿瘤控制
• GSE336252 姜黄醇处理的透明细胞肾细胞癌细胞的高通量转录组测序（姜黄醇组 vs 对照组）
• GSE334564 ArchetypeShift：一个整合 KEGG 信息通路分析和 IPA 衍生功能预测以验证单细胞原型的 R 包
• GSE325846 大鼠肠道组织空间转录组分析揭示了与高脂饮食和替泽帕肽治疗相关的转录变化
• GSE311121 细胞因子诱导的具有显著代谢、表观遗传重塑和持久性的可扩增记忆NK细胞
• GSE297650 PRL2 通过抑制白血病起始细胞中的 p53 肿瘤抑制信号通路促进白血病发生
• GSE285996 通过 Aurora 激酶 B 抑制克服 MET 扩增肺癌中针对 MET 的靶向药物耐药性
• GSE274155 风险 SNP rs11067228 通过 3D 染色质相互作用促进前列腺癌耐药性和神经内分泌分化（RNA-seq 数据集）
• GSE274154 风险 SNP rs11067228 通过 3D 染色质相互作用促进前列腺癌耐药性和神经内分泌分化（ChIP-seq 数据集）
• GSE207029 Blockade of avb8 integrin synergizes with checkpoint inhibition to enhance anti-tumor immunity through Cxcl9-dependent augmentation of CD8+ T cell cytotoxicity
• GSE328184 CHCHD10 通过调节直接重编程神经元中的表观遗传图谱来缓解阿尔茨海默病的发病机制
• GSE300660 靶向棕榈酰化可增强中性粒细胞介导的肝转移癌细胞杀伤作用 [scRNA-seq]
• GSE300657 靶向棕榈酰化可增强中性粒细胞介导的肝转移癌细胞杀伤作用 [RNA-seq]
• GSE325404 FAP衍生的CCL2是单核细胞/巨噬细胞充分浸润以支持急性骨骼肌损伤修复所必需的。
• GSE314972：额部纤维化性脱发的单细胞转录组分析揭示了细胞结构得以保留，并伴有应激驱动的上皮重编程和非细胞毒性炎症。
• GSE336948 通过 RNA 测序对印度患者口腔鳞状细胞癌进行全面的转录组分析
• GSE336619 新兴真菌病原体耳念珠菌的泛基因组和基因组规模必需性 [ATAC-seq]
• GSE336575 用于模拟神经元亚型多样性和网络活动成熟的大鼠胚胎肠神经系统培养平台
• GSE336151 Weissella confusa Wc1982 通过肠道菌群重塑和肝脏 PPARα/NF-κB 信号通路改善仓鼠高脂血症
• GSE334976 HEXB 通过 HIF1α-CA9 通路促进胶质母细胞瘤的肿瘤进展，作为一种治疗方法
• GSE334845 利用克隆解析的 CRISPR 筛选发现 Tcf7 调节因子，并将 Trim28 鉴定为肿瘤中 CD8 T 细胞分化的介质 [RNA-Seq]
• GSE332629 循环肿瘤细胞的连续监测反映了不可切除肝细胞癌全身治疗的治疗反应
• GSE329314 辐射诱导 CD8+ T 细胞免疫的持续失调和功能障碍
• GSE329000 鞘氨醇激酶 2 调节脂肪细胞褐变和全身代谢 [CUT&Tag]
• GSE328946 鞘氨醇激酶2调节脂肪细胞褐变和全身代谢
• GSE326398 miR-210 在缺氧肾小球内皮细胞中的转录组调控 [RNA-seq]
• GSE313701 CXCR6+CD8+ T 细胞的双重调控驱动前列腺癌进展中的免疫耗竭 [PB-Cre；Pten 敲除和 WT]
• GSE303170 3D类器官培养中乳腺癌细胞转录组的重编程通过SNHG7/miR-486-3P/HIF1A轴促进癌症进展
• GSE301245 宫颈癌患者中差异表达的lncRNA和mRNA的生物信息学分析[安捷伦芯片]
• GSE301232 CircROBO2 通过 miR-625-5p/PDGFB 介导的 MAPK 激活调控非小细胞肺癌中的奥希替尼耐药性
• GSE300827 肺腺癌前病变的空间转录组
• GSE300802 DEHP 通过自噬过度激活和线粒体功能障碍破坏脂质代谢 [RNA-Seq]
• GSE300624 FTO 在小细胞肺癌中的功能 [RNA-seq]
• GSE299847 WT 和 Cdh5-cre Myct1^fl/fl 小鼠免疫细胞群的单细胞 RNA 测序
• GSE299570 m6A甲基化分析及与人类海马阿尔茨海默病组织中微管相关蛋白tau相互作用的mRNA的统计。
• GSE299214 孤儿药尼替西酮与索拉非尼联合使用可协同增强 MSS 结直肠癌中抗 PD-1 的疗效 [RNA-Seq]
• GSE297153 靶向巨噬细胞 SPP1 促进 CD8 T 细胞浸润
• GSE296902 靶向巨噬细胞 SPP1 促进 CD8 T 细胞浸润
• GSE296419 脑室内CAR-T细胞治疗复发性胶质母细胞瘤后宿主内源性免疫区室的关键作用
• GSE293376 抗体捕获是细胞核显微镜和基因组学研究中普遍存在的陷阱
• GSE291932 [18S rRNA 直接测序] NAT10 的 RNA 解旋酶结构域促进低修饰核糖体的生物合成，从而增强癌细胞增殖
• GSE288945 转录组分析揭示复发性和非复发性乳头状甲状腺癌 (PTC) 的性别差异
• GSE287900 子宫内膜间充质干细胞来源的外泌体 miR-4669 通过 DUSP6/ERK 通路诱导 M2 巨噬细胞极化，从而促进子宫腺肌症的 EMT。
• GSE283661 组织和染色质背景的多尺度整合将细胞异质性转化为稳定的肠道模式 [scATAC-Seq]
• GSE283660 组织和染色质背景的多尺度整合将细胞异质性转化为稳定的肠道模式 [ChIP-Seq]
• GSE280053 来自对照组和精神分裂症患者 BA8 皮层样本的基因组规模甲基化数据。
• GSE274153 风险 SNP rs11067228 通过 3D 染色质相互作用促进前列腺癌耐药性和神经内分泌分化（4C-seq 数据集）
• GSE270183 Single-cell RNA sequencing of miALI epithelial cells derived from UHOMi002-A cell line
• GSE268829 Genome-wide distribution of REC8 cohesin is correlated with active transcription and regulated by transcription suppressor BEND2 during early meiosis [ATAC-seq]
• GSE253831 Genome-wide maps in breast cancer MDA-MB-231 cells with or without siRNA interference of YB1.
• GSE253253 Genome-wide maps in breast cancer MCF-7 cells with or without the overexpression of RNPC1.
• GSE237728 miRNA-seq and RNA-seq profiles of breast cancer cell lines
• GSE236783 RNA-seq gene expression profile of SUM159PT breast cancer cell line upon manipulation of two TDMD triggers, NREP and SERPINE1
• GSE236781 small RNA-seq gene expression profile of the SUM159PT breast cancer cell line, upon overexpression of the microRNA responsive elements of candidate TDMD triggers (ABCA1, HADHB, TRAF6)
• GSE236778 small RNA-seq gene expression profile of breast cancer cell lines upon ZSWIM8 perturbation
• GSE336730 RNA-seq 分析了用阿贝西利和/或氟维司群处理的 MDA-MB-231 和 MDA-MB-453 细胞。
• GSE336729 RNA-seq 分析：用阿贝西利和/或氟维司群处理的 CAMA-1 细胞
• GSE336718 蜕膜化人子宫内膜间质细胞中TSPYL2敲低的转录组分析
• GSE332563 人类骨髓纤维化脾脏的综合空间分析 [ST_Visium]
• GSE332562 人类骨髓纤维化脾脏的全面空间分析 [snRNAseq]
• GSE328948 隐球菌肺肉芽肿的转录组学和脂质组学分析揭示了巨噬细胞边界程序和鞘脂重塑
• GSE328931 隐球菌肺肉芽肿的转录组学和脂质组学分析揭示了巨噬细胞边界程序和鞘脂重塑 [Xenium]
• GSE327914 介导激酶抑制暴露转录脆弱性并使 AML 对维奈托克敏感 [CRISPR 筛选]
• GSE327563 介导激酶抑制暴露转录脆弱性并使 AML 对维奈托克敏感
• GSE326044 自组织类器官系统中放射状胶质祖细胞谱系进展的时间解耦——mTmG scRNA-Seq
• GSE325974 I 型 IFN 动力学协调保护性 ICAM1⁺ 中性粒细胞异质性作为致命病毒感染中生存的早期检查点 [day0 RNA-Seq]
• GSE317255 TERT驱动肝脏肿瘤发生和免疫重编程，且与端粒延长无关
• CDK2抑制剂治疗后卵巢癌细胞系中Rb CUT&RUN谱分析的GSE314300
• GSE313732 I 型 IFN 动力学协调保护性 ICAM1⁺ 中性粒细胞异质性作为致命病毒感染中生存的早期检查点 [RNA-Seq]
• GSE313167 I 型 IFN 动力学协调保护性 ICAM1⁺ 中性粒细胞异质性作为致命病毒感染中生存的早期检查点 [ICAM1 RNAseq]
• GSE313165 I 型 IFN 动力学协调保护性 ICAM1⁺ 中性粒细胞异质性作为致命病毒感染中生存的早期检查点 [ICAM1 RNAseq]
• GSE313164 I 型 IFN 动力学协调保护性 ICAM1⁺ 中性粒细胞异质性作为致命病毒感染中生存的早期检查点 [BM RNAseq]
• GSE313019 I 型干扰素动力学协调保护性 ICAM1⁺ 中性粒细胞异质性作为致命病毒感染中生存的早期检查点 [scRNA-Seq]
• GSE311215 CDK4/6抑制剂治疗后雌激素受体阳性乳腺癌细胞系CAMA-1和ZR-75-1的转录组分析
• GSE311213：雌激素受体阳性乳腺癌细胞系CAMA-1在接受阿贝西利和氟维司群治疗后的转录组分析
• GSE311212 CDK2抑制剂治疗后人卵巢癌细胞系OVCAR-3的转录组分析
• GSE311210：帕博西尼和氟维司群治疗后人乳腺癌患者来源异种移植瘤的转录组分析
• GSE309511 9p21 位点细胞周期调节因子 p14ARF、p16INK4A、p15INK4A 和 ANRIL 的独立细胞类型特异性表达和远端调控 [CRISPR 和 scRNA-seq]
• GSE309498 9p21 基因座细胞周期调节因子 p14ARF、p16INK4A、p15INK4A 和 ANRIL 的独立细胞类型特异性表达和远端调控 [scRNA-seq]
• GSE309495 9p21 位点细胞周期调节因子 p14ARF、p16INK4A、p15INK4A 和 ANRIL 的独立细胞类型特异性表达和远端调控 [RNA-seq]
• GSE309493 9p21 位点细胞周期调节因子 p14ARF、p16INK4A、p15INK4A 和 ANRIL 的独立细胞类型特异性表达和远端调控 [Hi-C]
• GSE309491 9p21 位点细胞周期调节因子 p14ARF、p16INK4A、p15INK4A 和 ANRIL 的独立细胞类型特异性表达和远端调控 [ChIP-seq]
• GSE307905 串联双特异性 IL-7 受体激动剂抗体（稍后更新）
• GSE307518 批量 ATACseq 测序数据来自经细胞因子混合物和/或贝利司他处理的 Ccd18-Co 细胞系。
• GSE300661 靶向棕榈酰化可增强中性粒细胞介导的肝转移癌细胞杀伤作用
• GSE294389 BMAL1 和 YAP 协同作用劫持增强子并促进衰老表皮的炎症
• GSE290282 大规模 RNA 结合蛋白系链筛选揭示 poly(A) 位点选择的新调控因子 [RNA-Seq]
• GSE335147 巨噬细胞不同状态下的线粒体谱分析揭示了整合应激反应对IL-4/IL-13重编程的抑制作用
• GSE315409 新型低甲基化药物 NTX-301 可重编程表观遗传和 Hippo 信号通路，并在维奈托克耐药和 TP53 突变型急性髓系白血病 (AML) 中显示出临床前活性
• GSE307670 基质细胞状态的表观遗传重编程是克罗恩病病理组织微环境的基础
• GSE307526 细胞因子处理的 Ccd18-Co 细胞系的批量 RNA 测序
• GSE336789 患者来源的异种移植模型鉴定出 AK1 是原发性三阴性乳腺癌转移潜能的关键调节因子 [WES]
• GSE336648 整合转录组学鉴定曲唑酮为城市颗粒物诱导神经炎症的调节剂
• GSE336628 船舶排放的超细颗粒物会引发炎症并增加对病毒感染的易感性
• GSE336613 新兴真菌病原体耳念珠菌的泛基因组和基因组规模必需性 [插入诱变]
• GSE336313 二硫化砷激活SRC/MEK/ERK通路可恢复骨髓增生异常综合征中的巨核细胞生成和血小板生成
• GSE336183 小鼠脾脏 CD45+ 红细胞显示抗原呈递细胞的转录组特征 [NanoString]
• GSE336164 PTEN-NEDD8融合基因表达对肠道组织的影响
• GSE335970 KMT2C 催化活性调节皮层兴奋性神经元中的增强子 H3K4me1 和突触基因表达 [RNA-Seq]
• GSE335601 AC16细胞系再探：整合细胞遗传学、基因组学和转录组学分析揭示高度重排的近四倍体基因组
• GSE335366 hLMR1，一种肝细胞特异性长链非编码RNA，通过与人肝脏中的前体mRNA相互作用抑制氨基酸分解代谢[RNA-seq]
• GSE335323 琥珀酸饮食处理下坦绵羊下丘脑、垂体、肝脏和脂肪组织的转录组学研究
• GSE334846 利用克隆解析的 CRISPR 筛选发现 Tcf7 调节因子，并将 Trim28 鉴定为肿瘤中 CD8 T 细胞分化的介质 [CRISPR 筛选]
• GSE334372 人类精子和精浆在冷冻保存-解冻后 miRNA 表达谱的改变：一项小 RNA 测序研究
• GSE334033 患者来源的异种移植模型鉴定出 AK1 是原发性三阴性乳腺癌转移潜能的关键调节因子
• GSE332710 组蛋白变体 macroH2A1 的剪接异构体差异性地调控海马基因表达和记忆形成
• GSE331298 电磁调制ALS转录组：迈向非药物分子疗法
• GSE331234 胸腺醌和 5-氟尿嘧啶处理后结直肠癌细胞的表达数据。
• GSE330351 铁蛋白介导的铁稳态调节成纤维细胞活化并影响梗死后心脏重塑
• GSE326775 CRISPRi lncRNA 耗竭筛选在急性髓系白血病细胞系中
• GSE326774 CRISPRi 和 shRNA 在 M07e 急性髓系白血病细胞中敲低 SNHG29
• GSE326657 人类海马阿尔茨海默病组织中与Tau5阳性微管相关蛋白tau相互作用的mRNA的分析和统计
• GSE326399 miR-210 在缺氧肾小球内皮细胞中的转录组调控 [miRNA-Seq]
• GSE325346 [ac4C-seq] - NAT10 的 RNA 解旋酶结构域促进低修饰核糖体的生物合成，从而增强癌细胞增殖
• GSE319976 母体肥胖通过簇状细胞介导的 ECM-整合素信号通路重编程子代肠道上皮
• GSE319302 PFOS暴露对老年小鼠脑转录组的影响
• GSE316222 Hsa_circ_0000818 通过抑制 Wnt/β-catenin 通路，靶向 miR-484/HIPK1 轴以改善肝纤维化。
• GSE315382 GOT1抑制增强铁死亡并加剧急性髓系白血病细胞死亡
• GSE315381 DNA结合域中的杂合BRCA1 SNP增强乳腺癌细胞对PARP抑制剂的敏感性
• GSE315288 LncRNA H19 通过吸附 miR-22 来解除 SIRT1 的抑制，从而加剧酒精相关性肝病中的肝脏炎症和氧化应激。
• GSE315027 酰基辅酶A合成酶短链家族成员2 (ACSS2) 是结直肠癌进展所必需的，并且是结直肠癌治疗的潜在药物靶点
• GSE314515 静态磁场暴露通过促进 Ca 2+ 内流和细胞呼吸减轻肝损伤 [scRNA-Seq]
• GSE313877 人类发育中小脑的 ChIP-seq
• GSE313443 GATA2 协调雌性胎儿生殖细胞的多能性退出和减数分裂起始 [scRNA-seq]
• GSE312886 GATA2 协调雌性胎儿生殖细胞的多能性退出和减数分裂起始 [ATAC-Seq]
• GSE310653 aPKC-ζ III 通过改变 Par-3 与 Hippo 信号激酶 LATS1 的相互作用来促进滋养层细胞融合。
• GSE309488 葫芦素B通过ROS-STAT3-(EIF2α-ATF4/IRE1-XBP1)通路介导的内质网应激诱导皮肤黑色素瘤细胞发生免疫原性死亡
• GSE307777 水凝胶包裹的预处理间充质干细胞可增强全层烧伤创面的再生和免疫调节
• GSE306664：通过新的IFN转录组图谱揭示不同人类疾病中不同免疫细胞中I型和II型IFN反应的差异
• GSE303655 LCN2-FN1信号传导缺陷会损害基质细胞与免疫细胞之间的通讯，并导致反复着床失败。
• GSE303528 RNA测序揭示了人脑微血管内皮细胞（HBMECs）在氧糖剥夺/再灌注（OGD/R）条件下的差异基因表达
• GSE302608 一组与肝细胞癌相关的差异甲基化假定印记控制区
• GSE301236 平息风暴：新一代分泌组（PRS CK STORM）重塑病毒性急性呼吸窘迫综合征的免疫反应
• GSE301235 DNA甲基化预测海马依赖性长期记忆，但不能预测记忆更新
• GSE301186 中性粒细胞整体的转录和功能结构 [RNA-seq sorted_cells]
• GSE301080 基于RNA测序的青少年-青年成人和成人滑膜肉瘤患者比较
• GSE300803 DEHP 通过自噬过度激活和线粒体功能障碍破坏脂质代谢 [BS-Seq]
• GSE300732 乳酸化驱动的NSUN2介导的RNA m5C修饰促进胰腺癌的神经周围侵袭
• GSE300471 GNE肌病中的自噬缺陷可通过抑制补充性mTOR激活而逆转[类器官RNA测序]
• GSE300378 靶向硫氧还蛋白还原酶 1 (TrxR1) 揭示肺癌中与铁死亡相关的转录脆弱性
• GSE300228 Drosha 通过调节 OP9 细胞中的 miR-204/miR-15b 来调控脂肪生成 [RNA-Seq]
• GSE299571 人类海马阿尔茨海默病组织中与 7F2 阳性微管相关蛋白 tau 相互作用的 mRNA 的分析和统计。
• GSE299568 人类海马阿尔茨海默病组织中与 Tau5 阳性微管相关蛋白 tau 相互作用的 mRNA 的分析和统计。
• GSE298834 Notch-Rbpj信号通路抑制肿瘤中调节性T细胞的耗竭
• GSE297092 α-突触核蛋白过表达小鼠肠神经元的单核转录组
• GSE296739 XBP1 和 CREB3L 协调细胞器结构和细胞器间代谢流，以促进高内皮细胞和杯状细胞中粘蛋白的产生
• GSE292601 上皮干扰素刺激基因程序通过 EPSTI1 调节结直肠癌的化疗敏感性
• GSE292393 纤维化巨噬细胞通过 MMP12 介导的组织重塑驱动心脏纤维化
• GSE291934 [eCLIP-seq] NAT10 的 RNA 解旋酶结构域促进低修饰核糖体的生物合成，从而增强癌细胞增殖
• GSE291931 [DMS-Seq] - NAT10 的 RNA 解旋酶结构域促进低修饰核糖体的生物合成，从而增强癌细胞增殖
• GSE291928 [MerR-seq] NAT10 的 RNA 解旋酶结构域促进低修饰核糖体的生物合成，从而增强癌细胞增殖
• GSE289490 RA-FLS 的 RNA-seq（siNC 与 siFUNDC1）
• GSE286644：限制热量摄入和正常饮食条件下APOE-TR小鼠皮质RNA测序
• GSE283662 组织和染色质背景的多尺度整合将细胞异质性转化为稳定的肠道模式
• GSE277584 增殖性肿瘤相关巨噬细胞在胶质母细胞瘤中表现出肿瘤记忆和促突变基因特征
• GSE276712 单细胞分析揭示人类胶质母细胞瘤中表达整合素结合唾液蛋白的肿瘤相关小胶质细胞和巨噬细胞
• GSE271927 简并长程相互作用驱动异染色质相变 [Hi-C]
• GSE271919 退化的长程相互作用驱动异染色质的相变 [ChIP-Seq]
• GSE271747 退化的长程相互作用驱动异染色质的相变 [RNA-Seq]
• GSE269263 Profile of mineralocorticoid receptor-dependent transcriptome from the mouse aldosterone-sensitive distal nephron
• GSE268830 Genome-wide distribution of REC8 cohesin is correlated with active transcription and regulated by transcription suppressor BEND2 during early meiosis [CUT&Tag]
• GSE266605 Dissecting the radio-protection of hemp seed oil on splenic lymphocytes at single-cell level
• GSE264419 Canonical and non-Canonical Target-directed microRNA degradation controls cell fitness and transcriptional plasticity in breast cancer
• GSE263552 Canonical and non-Canonical Target-directed microRNA degradation controls cell fitness and transcriptional plasticity in breast cancer
• GSE263471 Methyglyoxal reshapes the transcriptional network of human retinal endothelial cells [RNA-seq]
• GSE262994 Synthetic lethal therapy reveals precision therapeutic strategy for MSH2-mutated bladder cancer
• GSE254098 Evolution of transcriptomic profiles in relapsed inv(16) acute myeloid leukemia
• GSE254097 Characterization of leukemic stem cells in FLT3-ITD-positive acute myeloid leukemia
• GSE242672 HSD17B13 Deficiency Modulates Interferon Signaling to Ameliorate Metabolic Dysfunction-Associated Steatohepatitis Fibrosis
• GSE238238 N6-methyladenosine methylation landscape of human normal skin and middle ear cholesteatoma
• GSE226668 RNA-Seq analysis TMAO effect on vascular smooth muscle cells
• GSE168406 Pattern of variation in DNA methylation