详细内容（前10条）

1. ⭐ GSE334479 全基因组亚硫酸氢盐测序揭示了绿豆在直接和预处理盐胁迫下动态的DNA甲基化变化。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、genome、methylation
• 📝 描述：Series Type : Methylation profiling by high throughput sequencingOrganism : Vigna radiataDNA methylation is an important epigenetic mechanism regulating gene expression and stress memory in plants. To investigate the role of DNA methylation in salt stress adaptation, we performed whole-genome bisulfite sequencing (WGBS) of mung bean (Vigna radiata cv. Weilv 9) leaves under two treatment regimes: T1 (pre-conditioned with 100 mM NaCl for 24 h, recovered for 48 h, then re-exposed to 100 mM NaCl) and T2 (direct exposure to 100 mM NaCl without preconditioning). Seedlings were grown hydroponically in half-strength Murashige and Skoog medium under controlled environmental conditions. Genomic DNA was extracted from the first fully expanded true leaves at 0, 6, and 48 h after the onset of the final salt treatment, with three biological replicates per condition. Bisulfite-converted DNA was sequenced to generate genome-wide methylation profiles. Comparative analysis revealed dynamic changes in CG, CHG, and CHH contexts, providing insights into the epigenetic basis of salt tolerance and stress priming in legumes.
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2. ⭐ GSE334035 利用二氧化铈纳米颗粒靶向线粒体 ROS-CK2-SET-PP2A 通路逆转 APOEε4 相关阿尔茨海默病中的 Tau 病理 [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer、scRNA、pathway
• 📝 描述：Contributors : Jong Won Han ; Yubeen Kim ; June-Hyun Jeong ; Yunjung Lee ; Dakyung Lee ; Suk-Kyung Shin ; Seok Beom Hong ; Keuntae Kim ; Sieun Choi ; Rian Kang ; Jong-Chan Park ; Kangmin Suh ; Jinyoung Chu ; Nohyun Lee ; Sang Ihn Han ; Dong-Sup Lee ; Il-Joo Cho ; Seok Chung ; Jong-Il Kim ; Taeghwan Hyeon ; Inhee Mook-JungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we used triphenylphosphonium-conjugated ceria nanoparticles (Ceria-TPP) to target mitochondrial ROS in APOEε4 human iPSC-derived brain organoid, and profiled transcriptional changes via single-cell RNA-seq.
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3. ⭐ GSE334034 利用二氧化铈纳米颗粒靶向线粒体 ROS-CK2-SET-PP2A 通路逆转 APOEε4 相关阿尔茨海默病中的 Tau 病理 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer、RNA-seq、pathway
• 📝 描述：Contributors : Jong Won Han ; Yubeen Kim ; June-Hyun Jeong ; Yunjung Lee ; Dakyung Lee ; Suk-Kyung Shin ; Seok Beom Hong ; Keuntae Kim ; Sieun Choi ; Rian Kang ; Jong-Chan Park ; Kangmin Suh ; Jinyoung Chu ; Nohyun Lee ; Sang Ihn Han ; Dong-Sup Lee ; Il-Joo Cho ; Seok Chung ; Jong-Il Kim ; Taeghwan Hyeon ; Inhee Mook-JungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we used triphenylphosphonium-conjugated ceria nanoparticles (Ceria-TPP) to target mitochondrial ROS in APOEε4 iPSC-derived neurons, and analyzed transcriptional changes using bulk RNA sequencing.
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4. GSE334477 绿豆叶片对直接和预处理盐胁迫的转录组分析 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、transcriptome
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Vigna radiataWe investigated the adaptive responses of mung bean cultivar ‘Weilv 9’ to salt stress using RNA-seq. Two treatments were applied: T1 (pre-conditioned with 100 mM NaCl for 24 h, recovered for 48 h, then re-exposed to 100 mM NaCl) and T2 (direct exposure to 100 mM NaCl without preconditioning). Samples were collected at 0, 1, 3, 6, 12, 24, and 48 h after the onset of the final salt treatment from the first fully expanded true leaves (n=3 per time point per treatment). Plants were grown under controlled conditions (25°C, 12,000 lux, 16h/8h light/dark, 70% RH) in 1/2 MS nutrient solution. The 0 h time point in T2 represents naive control, while in T1 it reflects residual effects after recovery. Data aim to reveal transcriptional reprogramming under salt stress and preconditioning.
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5. GSE255645 RNA测序结果显示，人甲状腺乳头状癌细胞TPC-1过表达PTCSC3-AS1基因

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、sequencing
• 📝 描述：Contributors : Yanqiang Wang ; Yutong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we report gene expression profiles of TPC-1 cells treated with PTCSC3-AS1 overexpressed vector (OE) or empty vector (EV). PTCSC3-AS1 gene was cloned from expressed sequence tag (AA632637). And the sequence of PTCSC3-AS1 is included in EST AA632637. A number of dysregulated genes of PTCSC3-AS1 were discovered. This study reveals the role of PTCSC3-AS1 in downstream gene regulation and its function in the tumorigenesis of thyroid cancer.
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6. GSE325469 共同菌丝网络通过利用不同的植物间代谢和生物胁迫反应来调节邻近植物对叶部病原体的防御。

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolic
• 📝 描述：Contributors : Zigmunds Orlovskis ; Ilva Nakurte ; Ēriks Voroņins ; Annija Kotova ; Daniels Pugačevskis ; Dawood Shah ; Annija Andersone ; Kārlis Blūms ; Ivars Silamiķelis ; Soon-Jae LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Medicago truncatulaInter-plant communication is key for the successful thriving of plant communities in nature with yet untapped potential for agroecosystem engineering towards more resilient crops and plant defences against pathogens. Arbuscular mycorrhizal fungi (AMF) are ubiquitous root symbionts, well-known to constitute underground common mycelial networks (CMNs) linking multiple plant hosts underground. The wired connection among plants via CMNs are hypothesized to play a key role for information exchange between plants for the neighbour-primed inter-plant defences. However, the key transcriptomic and metabolome responses in receiver plant associated with inter-plant CMN connections remain yet to be elucidated. Moreover, no studies to date have clearly resolved the confounding effects of hyphal damage from the inter-plant network disconnection. To uncover the contribution of CMN integrity to neighbour-primed plant defences, we used model AMF Rhizophagus irregularis to inter-connect two Medicago truncatula plants and explored the effect of sender wounding and flg22 elicitation on receiver plants’ leaf responses and pathogen tolerance. For the first time, we demonstrate that changes in receiver plants’ biotic stress and defence signalling pathways rely on inter-plant signals via the CMN, not on mycelial network damage itself. This response was associated with distinct leaf isoprenoid production, including volatile monoterpenes and triterpene saponins. Furthermore, CMN-mediated signals from stressed senders enhanced receiver resistance to Fusarium sporotrichoides whilst simultaneously increasing susceptibility to Botrytis cinerea. Our findings highlight the critical role of CMNs in inter-plant signalling for pathogen-specific susceptibility and resistance which can be a key for understanding plant community-level defence in nature and agroecosystems.
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7. GSE334540 雄性和雌性小鼠垂体的单核多组（RNA测序和ATAC测序）

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNAseq
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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8. GSE334478 直接和预处理盐胁迫下绿豆叶片染色质可及性的ATAC-seq分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：ATAC-seq
• 📝 描述：Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Vigna radiataSalinity is a major environmental constraint limiting crop productivity. Chromatin accessibility plays a crucial role in transcriptional regulation under stress conditions. In this study, we investigated genome-wide chromatin accessibility dynamics in mung bean (Vigna radiata cv. Weilv 9) leaves under salt stress using ATAC-seq. Two treatment groups were established: T1 (pre-conditioned with 100 mM NaCl for 24 h, recovered for 48 h, then re-exposed to 100 mM NaCl) and T2 (direct exposure to 100 mM NaCl without preconditioning). Seedlings were grown hydroponically in half-strength Murashige and Skoog medium under controlled environmental conditions. Nuclei were isolated from the first fully expanded true leaves at 0, 6, and 48 h after the onset of the final salt treatment, with three biological replicates per condition. Comparative ATAC-seq analysis revealed dynamic changes in chromatin accessibility associated with transcriptional reprogramming and stress memory. This dataset provides valuable insights into the epigenetic basis of salt tolerance and acclimation in legumes.
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9. GSE299273 环境污染物TBOEP与肾脏代谢的关系

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolism
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTris(2-butoxyethyl) phosphate (TBOEP) is a common organophosphorus compound widely used in industrial production as a plasticizer and flame retardant. In recent years, studies have shown that TBOEP may pose potential threats to human health, particularly its association with kidney metabolic function has attracted widespread attention. The kidneys, as the most important metabolic organ in the human body, play a crucial role in detoxification, synthesis, and decomposition of various biomolecules. After entering the human body, TBOEP is mainly metabolized and detoxified by the kidneys. However, TBOEP and its metabolites may interfere with the normal function of the kidneys, leading to metabolic disorders. Studies have shown that TBOEP exposure may affect the activity of enzymes in the kidneys, such as cytochrome P450 enzyme systems, which are involved in the metabolism of various endogenous and exogenous substances. In addition, TBOEP may also affect kidney metabolism by influencing gene expression. For example, TBOEP exposure may activate or inhibit genes related to lipid metabolism, glucose metabolism, and oxidative stress, thereby altering the metabolic state of the kidneys. These changes not only affect the function of the kidneys themselves but may also have a chain reaction on the health of other organs and systems through the interaction of the systemic metabolic network. Furthermore, TBOEP exposure may lead to kidney damage and dysfunction, which can further exacerbate metabolic disorders. For example, kidney damage can impair the excretion of metabolic waste products, leading to their accumulation in the body and further disrupting metabolic balance. In summary, as an environmental pollutant, the potential impact of TBOEP on kidney metabolic function cannot be ignored. Future research needs to further explore the toxicological mechanisms of TBOEP and its long-term effects on human health in order to develop effective prevention and intervention measures to protect public health.
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10. GSE330574 果蝇 tbph 突变体的转录变化以及羽化后 60 小时成虫头部可诱导的神经元 TBPH 拯救

• ✍️ 作者：未知作者
• 🏷️ 关键词：Neuronal
• 📝 描述：Contributors : Feiguin Fabian ; Romano GiuliaSeries Type : Expression profiling by arrayOrganism : Drosophila melanogasterTBPH, the Drosophila ortholog of human TDP-43, is required for normal neuronal function. To identify transcriptional programs altered by loss of TBPH and those restored by neuronal re-expression of TBPH, we performed Affymetrix microarray profiling on adult heads from wild-type (w1118) animals, two independent tbph loss-of-function mutants (tbph^Δ23 and tbph^Δ142), and a tbph mutant line carrying an elav-GeneSwitch-driven UAS-TBPH transgene activated by feeding 5 mM RU-486 for 60 hours post-eclosion (Rescue).Comparison of mutants vs control identified a shared dysregulated transcriptional signature; comparison of rescue vs mutants identified the subset of these genes whose expression was restored by inducible neuronal TBPH re-expression.
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1. Ozempic 和类似的减肥药物与乳腺癌风险降低 30% 有关。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：A large study found that women taking GLP-1 drugs, the medication class behind Ozempic, Wegovy, Mounjaro, and Zepbound, were about 30% less likely to develop breast cancer. Researchers say the findings are promising but not yet proof, and clinical trials are now being planned to test whether these drugs could help prevent breast cancer.
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• GSE259269：在nsp12编码区鉴定SARS-CoV-2基因组包装信号