详细内容（前10条）

1. ⭐ GSE285325 单细胞 RNA 测序分析揭示了淋巴液图谱并发现了一种与脓毒症相关的 T 细胞亚群

• ✍️ 作者：未知作者
• 🏷️ 关键词：lymph、T cell、regex:lymph(o|atic)?、RNA-seq、single-cell
• 📝 描述：Contributors : Hui Wang ; Jianguang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe lymphoid cycle as the sentinel of immune response, its cell subtypes and immune properties and functions during sepsis are still unclear. This study described a comprehensive picture of immune cells in rat lymph fluid by single-cell RNA sequencing and identified a unique subset of CD4+ T cells (CD4_Icos) in the early state of sepsis, confirming its crucial role in Treg cell production. Transferring with CD4+Icos+ T cells significantly alleviated CLP-induced organ injury, while Icosfl/flCd4-CreERT2 mice showed reduced number of Treg and increased inflammation and mortality risk. Further screening and validation experiments identified Npas2 as an Icos-specific transcription factor that regulates Icos expression and promotes the differentiation of CD4+Icos+ T cells. Clinical results disclosed the negative correlation between the expression of ICOS in CD4+ T cells and SOFA score in septic patients, which affected the prognosis of septic patients. These findings indicated the protective role of CD4+ T cells in sepsis.
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2. ⭐ GSE325982 全身性和乳腺慢性炎症及激素分布促进老年女性乳腺癌的肿瘤易感环境（类器官单细胞RNA测序）

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、inflammation、scRNA
• 📝 描述：Contributors : Neil Carleton ; Alexander Chang ; Steffi Oesterreich ; Adrian LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor positive (ER+) breast cancer, the most common subtype of breast cancer, is an age-related disease, with the peak incidence of diagnosis occurring around age 70 despite low circulating levels of estradiol. Despite the hormone sensitivity of these age-related tumors, our understanding of the interplay between the systemic and local hormonal disposition and chronic inflammaging is limited. We show that aged F344 rats treated with the DMBA/MPA carcinogen develop more tumors at faster rates than their younger counterparts, suggesting that the aged environment accelerates tumor growth. snRNA-seq of the tumors showed broad local immune dysfunction that was associated with circulating chronic inflammation. Across a broad cohort of specimens from patients with ER+ breast cancer and age-matched donors of normal breast tissue, we observe that even with E1-predominant estrogen disposition in the systemic circulation, tumors in older patients upregulate HSD17B7 expression to convert E1 to E2 in the TME. Age-related accumulation of tumor-associated macrophages serve as signaling hubs that integrate the E2 and chemokine-driven chronic inflammatory signaling in the TME, which polarize TAMs towards a CD206+/PD-L1+, immunosuppressive phenotype. Overall, these findings suggest that the host’s chronic inflammation and hormonal disposition shape the local tumor microenvironment and are critical contributors to the age-related nature of ER+ breast cancer development and growth.
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3. ⭐ GSE276757 全身性和乳腺慢性炎症和激素分布促进老年女性乳腺癌的肿瘤易感环境（大鼠批量 RNA 测序）

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、inflammation、RNA-seq
• 📝 描述：Contributors : Neil Carleton ; Sanghoon Lee ; Steffi Oestereich ; Adrian LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusEstrogen receptor positive (ER+) breast cancer, the most common subtype of breast cancer, is an age-related disease, with the peak incidence of diagnosis occurring around age 70 despite low circulating levels of estradiol. Despite the hormone sensitivity of these age-related tumors, our understanding of the interplay between the systemic and local hormonal disposition and chronic inflammaging is limited. We show that aged F344 rats treated with the DMBA/MPA carcinogen develop more tumors at faster rates than their younger counterparts, suggesting that the aged environment accelerates tumor growth. snRNA-seq of the tumors showed broad local immune dysfunction that was associated with circulating chronic inflammation. Across a broad cohort of specimens from patients with ER+ breast cancer and age-matched donors of normal breast tissue, we observe that even with E1-predominant estrogen disposition in the systemic circulation, tumors in older patients upregulate HSD17B7 expression to convert E1 to E2 in the TME. Age-related accumulation of tumor-associated macrophages serve as signaling hubs that integrate the E2 and chemokine-driven chronic inflammatory signaling in the TME, which polarize TAMs towards a CD206+/PD-L1+, immunosuppressive phenotype. Overall, these findings suggest that the host’s chronic inflammation and hormonal disposition shape the local tumor microenvironment and are critical contributors to the age-related nature of ER+ breast cancer development and growth.
• 🔗 查看原文

4. ⭐ GSE276755 全身性和乳腺慢性炎症和激素分布促进老年女性乳腺癌的肿瘤易感环境（人类批量 RNA 测序）

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、inflammation、RNA-seq
• 📝 描述：Contributors : Neil Carleton ; Sanghoon Lee ; Steffi Oestereich ; Adrian LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor positive (ER+) breast cancer, the most common subtype of breast cancer, is an age-related disease, with the peak incidence of diagnosis occurring around age 70 despite low circulating levels of estradiol. Despite the hormone sensitivity of these age-related tumors, our understanding of the interplay between the systemic and local hormonal disposition and chronic inflammaging is limited. We show that aged F344 rats treated with the DMBA/MPA carcinogen develop more tumors at faster rates than their younger counterparts, suggesting that the aged environment accelerates tumor growth. snRNA-seq of the tumors showed broad local immune dysfunction that was associated with circulating chronic inflammation. Across a broad cohort of specimens from patients with ER+ breast cancer and age-matched donors of normal breast tissue, we observe that even with E1-predominant estrogen disposition in the systemic circulation, tumors in older patients upregulate HSD17B7 expression to convert E1 to E2 in the TME. Age-related accumulation of tumor-associated macrophages serve as signaling hubs that integrate the E2 and chemokine-driven chronic inflammatory signaling in the TME, which polarize TAMs towards a CD206+/PD-L1+, immunosuppressive phenotype. Overall, these findings suggest that the host’s chronic inflammation and hormonal disposition shape the local tumor microenvironment and are critical contributors to the age-related nature of ER+ breast cancer development and growth.
• 🔗 查看原文

5. ⭐ GSE326121 横向主动脉缩窄诱导心脏应激下小鼠间充质基质细胞 (MSC) 的单细胞 RNA 测序 (scRNA-seq)。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cardiac、sequencing、single-cell、scRNA
• 📝 描述：Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNA-seq using the 10x Genomics platform to investigate how cardiac stress influences the transcriptional profiles of female murine MSCs. MSCs were isolated from bone marrow of control (sham-operated) and mice subjected to transverse aortic constriction (TAC) for four weeks. Comparative analysis of single-cell transcriptomes was conducted to identify stress-induced alterations in MSC states.
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6. ⭐ GSE326120 横向主动脉缩窄引起的心脏应激下小鼠造血干细胞和祖细胞 (HSPC) 和间充质基质细胞 (MSC) 的单细胞 RNA 测序 (scRNA-seq)。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cardiac、sequencing、single-cell、scRNA
• 📝 描述：Contributors : Manabe Ichiro ; Nakayama Yukiteru ; Goto KohsakuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed scRNA-seq using the 10x Genomics platform to investigate how cardiac stress influences the transcriptional profiles of murine HSPCs and MSCs. HSPCs and MSCs were isolated from bone marrow of control (sham-operated) and mice subjected to transverse aortic constriction (TAC) for four weeks. Comparative analysis of single-cell transcriptomes was conducted to identify stress-induced alterations in hematopoietic differentiation and MSC states. Integrated analysis of HSPCs and MSCs enabled the characterization of cell–cell communication networks and niche remodeling associated with cardiac stress.
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7. ⭐ GSE276760 全身性和乳腺慢性炎症和激素分布促进老年女性乳腺癌的肿瘤易感环境（所有样本；人和大鼠）

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、inflammation
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below.
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8. ⭐ GSE276759 全身性和乳腺慢性炎症和激素分布促进老年女性乳腺癌的肿瘤易感环境（大鼠 WES）

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、inflammation
• 📝 描述：Contributors : Neil Carleton ; Sanghoon Lee ; Steffi Oestereich ; Adrian LeeSeries Type : OtherOrganism : Rattus norvegicusEstrogen receptor positive (ER+) breast cancer, the most common subtype of breast cancer, is an age-related disease, with the peak incidence of diagnosis occurring around age 70 despite low circulating levels of estradiol. Despite the hormone sensitivity of these age-related tumors, our understanding of the interplay between the systemic and local hormonal disposition and chronic inflammaging is limited. We show that aged F344 rats treated with the DMBA/MPA carcinogen develop more tumors at faster rates than their younger counterparts, suggesting that the aged environment accelerates tumor growth. snRNA-seq of the tumors showed broad local immune dysfunction that was associated with circulating chronic inflammation. Across a broad cohort of specimens from patients with ER+ breast cancer and age-matched donors of normal breast tissue, we observe that even with E1-predominant estrogen disposition in the systemic circulation, tumors in older patients upregulate HSD17B7 expression to convert E1 to E2 in the TME. Age-related accumulation of tumor-associated macrophages serve as signaling hubs that integrate the E2 and chemokine-driven chronic inflammatory signaling in the TME, which polarize TAMs towards a CD206+/PD-L1+, immunosuppressive phenotype. Overall, these findings suggest that the host’s chronic inflammation and hormonal disposition shape the local tumor microenvironment and are critical contributors to the age-related nature of ER+ breast cancer development and growth.
• 🔗 查看原文

9. ⭐ GSE276758 全身性和乳腺慢性炎症和激素分布促进老年女性乳腺癌的肿瘤易感环境（大鼠 snRNA-Seq）

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、inflammation
• 📝 描述：Contributors : Neil Carleton ; Sanghoon Lee ; Steffi Oestereich ; Adrian LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusEstrogen receptor positive (ER+) breast cancer, the most common subtype of breast cancer, is an age-related disease, with the peak incidence of diagnosis occurring around age 70 despite low circulating levels of estradiol. Despite the hormone sensitivity of these age-related tumors, our understanding of the interplay between the systemic and local hormonal disposition and chronic inflammaging is limited. We show that aged F344 rats treated with the DMBA/MPA carcinogen develop more tumors at faster rates than their younger counterparts, suggesting that the aged environment accelerates tumor growth. snRNA-seq of the tumors showed broad local immune dysfunction that was associated with circulating chronic inflammation. Across a broad cohort of specimens from patients with ER+ breast cancer and age-matched donors of normal breast tissue, we observe that even with E1-predominant estrogen disposition in the systemic circulation, tumors in older patients upregulate HSD17B7 expression to convert E1 to E2 in the TME. Age-related accumulation of tumor-associated macrophages serve as signaling hubs that integrate the E2 and chemokine-driven chronic inflammatory signaling in the TME, which polarize TAMs towards a CD206+/PD-L1+, immunosuppressive phenotype. Overall, these findings suggest that the host’s chronic inflammation and hormonal disposition shape the local tumor microenvironment and are critical contributors to the age-related nature of ER+ breast cancer development and growth.
• 🔗 查看原文

10. ⭐ GSE333980 果蝇硫代谢基因敲除诱导慢性炎症和免疫失调

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、inflammation、metabolism
• 📝 描述：Contributors : O.G Zatsepina ; V.A Shilova ; M.B. Evgen’ev ; A.P Rezvykh ; D.G GarbuzSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterIn this study, we examined a unique collection of Drosophila melanogaster strains with knockouts of three key genes involved in H₂S synthesis and metabolism, with the aim of elucidating the role of this adaptive system in immunity. Genetic disruptions in sulfur metabolism—specifically, combined deletions of the cbs, cse, and tst1 genes—lead to reduced H₂S levels and hyperhomocysteinemia in flies. These metabolic changes induce oxidative stress and trigger chronic inflammatory responses. Transcriptomic analysis and q-PCR revealed significant activation of major immune pathways, including IMD, Toll, and Jac-Stat. A septic injection of Bacillus subtilis induces increased expression of antimicrobial peptides (AMPs) and pattern recognition receptors in knockout flies. Notably, double- and triple-knockout strains exhibit prolonged immune activation. The triple knockout exhibits the worst survival rate following septic injury induced by Bacillus subtilis. These results highlight the critical role of H₂S in modulating innate immunity and suggest that sulfur metabolism is an important regulator of inflammatory homeostasis in Drosophila.
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1. 人工智能设计的通用新冠病毒疫苗通过首次人体试验

• ✍️ 作者：未知作者
• 🏷️ 关键词：vaccine
• 📝 描述：Scientists have successfully tested an AI-designed universal coronavirus vaccine in humans for the first time, finding it to be safe and well tolerated. The vaccine generated immune responses against multiple coronaviruses, including SARS-CoV-2, SARS, and related bat viruses with pandemic potential. By targeting features shared across an entire virus family, it aims to provide protection even as viruses evolve.
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• GSE313448 Nynrin 通过 TXNIP 不稳定化维持白血病干细胞活力，从而维持氧化还原稳态并赋予维奈托克耐药性 [KG-1a RNA-Seq]
• GSE334490 绘制升主动脉单细胞转录组图谱，以研究衰老过程中机械感知和机械适应的变化
• GSE334220 将升主动脉的单细胞转录组映射到衰老过程中机械感知和机械适应的变化 [old_arch CITE-seq]
• GSE334216 将升主动脉的单细胞转录组映射到衰老过程中机械感知和机械适应的变化 [young_arch CITE-seq]
• GSE334154 诱导肿瘤相关巨噬细胞向 CXCL9Hi/SPP1Low 表型转化可消除胰腺癌
• GSE327535 早期巨噬细胞免疫反应和新出现的沃林斯基分枝杆菌的致病特征
• GSE312198 利用 Wt1-Cre 小鼠模型 (RNA-Seq) 分析 Vhl 缺陷型和野生型 (WT) 心室心脏组织的转录组差异
• GSE308536：鉴定能够阻断VprBP激酶活性并抑制前列腺肿瘤生长的高效抑制剂
• GSE299240 外温脊椎动物进化出了与肠道相关的生发中心样结构
• GSE236613 基于转录组分析的卵巢切除大鼠抗骨质疏松阻力运动机制：一项初步研究
• GSE235016 RNA-seq 揭示了苏拉明通过抑制 LPS 诱导的 MH-S 肺泡巨噬细胞中的 NLRP3/caspase-1/GSDMD 通路发挥抗细胞焦亡作用
• GSE326308 横向主动脉缩窄诱导心脏应激下小鼠间充质基质细胞 (MSC) 的批量 RNA 测序。
• GSE311388 Nynrin 通过 TXNIP 不稳定化维持白血病干细胞的活力，从而维持氧化还原稳态并赋予其维奈托克耐药性
• GSE334468 丁酸激酶 (Buk) 将支链脂肪酸生物合成、冷适应和单核细胞增生李斯特菌的致病性联系起来
• GSE297564 幼年干骺端固有组织稳态为骨肉瘤发展奠定基础 [RNA-seq]
• GSE297558 幼年干骺端固有的组织稳态为骨肉瘤的发展奠定了基础 [scRNA-seq]
• GSE334050 自噬相关蛋白降解剂对小鼠 4T1 乳腺癌模型的影响
• GSE333984 OsELP3/ELP4，水稻伸长因子复合物亚基，表观遗传调控水稻稻瘟病抗性。
• GSE311133 人类冠状动脉平滑肌细胞在促分化和促去分化处理下的转录组分析
• GSE311116 DDIT4 过表达重塑人冠状动脉平滑肌细胞的组蛋白修饰图谱：一项 H3K9ac 和 H3K27ac CUT&Tag 研究
• GSE310361 功能获得和功能丧失 RNA-seq 分析揭示了 DDIT4 驱动的人冠状动脉平滑肌细胞转录程序
• GSE302415 适应性下调的肝脏Recucalcin通过介导器官间免疫代谢通讯增强对肠道感染的耐受防御。
• GSE300539 小鼠四倍体器官的生成 [心脏单细胞RNA测序]
• GSE300538 小鼠四倍体器官的生成 [肝脏单细胞RNA测序]
• GSE299267 三阴性乳腺癌类器官的单细胞基因表达谱分析
• GSE299019 先天免疫活性 iNS 球状体：一种源自 hiPSC 的 3D 模型，用于研究中枢神经系统，并捕捉到对 rAAV 的早期中枢神经系统反应。
• GSE269503 转录组剂量反应模型在北美五大湖支流污染物风险优先排序中的应用 [P. promelas]