详细内容（前10条）

1. ⭐ GSE329048 巨噬细胞介导的 IL1beta/IL23 信号传导调节针对非结核分枝杆菌的 γ δ (γδ) T 细胞免疫 [脾脏 RNA-seq]。

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、T cell、macrophage、RNA-seq
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMechanistic Insights. Our study reveals the crucial role of gammadelta T cells in non-tuberculous mycobacteria (NTM) infection. We observed a significant increase and activation of gammadelta T cells in mice infected with MAB or with MAB infection combined with pulmonary fibrosis. Depletion of gammadelta T cells worsened the infection, while transfer of gammadelta T cells reversed this effect. Mechanistically, we found that MAB infection stimulates macrophages to produce IL-1beta and IL-23, which promotes the expansion of gammadelta T17 cells. MAB can also directly activate gammadelta T cells, leading to the clearance of MAB through an IL-17A-dependent pathway. Our findings suggest that gammadelta T cells represent a potential therapeutic target for NTM infections.
• 🔗 查看原文

2. ⭐ GSE324687 Eomes 维持 CD4⁺ T 辅助祖细胞，以促进免疫治疗期间的抗肿瘤免疫 [scRNA]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity、regex:immuno(logy|therapy|suppression)、scRNA
• 📝 描述：Contributors : Anne Dejean ; Liliana Lucca ; Arantxa Agesta ; Chloé Ferrand ; Anne-Louise Le Dorze ; Nadège Carrié ; Arthur Palak ; Ludovic MartinetSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusCD4⁺ T helper (Th) cells contribute to tumor immunity, yet the subsets and differentiation programs involved remain unclear. Here, we show that the transcription factor Eomesodermin (Eomes) is essential for Th–mediated anti-tumor immunity by orchestrating the differentiation and maintenance of an exhausted-like Th cell lineage, which is transcriptionally and functionally distinct from conventional effector or memory Th subsets. This Eomes-dependent program is further enhanced by 4-1BB stimulation, promoting effective Th cell–mediated tumor control. The precursor subset of this lineage (pTh) expresses stemness-associated transcription factors, displays self-renewal capacity, and can differentiate into effector cells capable of controlling tumor growth. At the transcriptional level, Eomes supports the survival, metabolic fitness, and apoptotic resistance of this lineage. Notably, Eomes⁺ pTh cells are directly relevant to human cancer, being detected across multiple tumor types, exhibiting conserved transcriptional features, and representing the most expanded Th cell population upon immune checkpoint blockade therapy.
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3. ⭐ GSE314004 通过整合单细胞 RNA 测序、光谱免疫表型分析和机器学习来解码新诊断癌症中的免疫失调

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、RNA-seq、single-cell
• 📝 描述：Contributors : Peggy Berlin ; Amin Mirzaei ; Felix Steinbeck ; Martin Becker ; Brigitte Müller-Hilke ; Wendy Bergmann-Ewert ; Daniel Dubinski ; Thomas M Freiman ; Daniel Strüder ; Theresa Momper ; Annabell Wolff ; Philipp Kaps ; Julia Henne ; Clemens Schafmayer ; Michael Linnebacher ; Charlotte Wagner ; Karen Rischmüller ; Martin Philipp ; Georg Lamprecht ; Paul Meissner ; Marcus Frank ; Christian Junghanss ; Sonja Oehmcke-Hecht ; Claudia MaletzkiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEarly cancer detection remains a major clinical challenge. Circulating immune biomarkers provide a promising, non-invasive diagnostic opportunity, yet their potential remains insufficiently defined. Here, we present an integrated multi-omics analysis of peripheral blood mononuclear cells (PBMCs) from treatment-naïve cancer patients, combining immune phenotyping (flow cytometry, FC), multiplex cytokine profiling, and single-cell RNA sequencing (sc-RNA-seq). Compared with healthy controls, patients exhibited widespread immune dysregulation, including expansion of FOXP3+ regulatory T cells, depletion of CD16+CD11b+ monocytes and CD56dim NK cells, and elevated plasma IL-6/IL-4 levels. Sc-RNA-seq identified novel cancer-specific immune signatures, notably consistent upregulation of THBS1 and CH25H, indicative of systemic imprinting by tumor-derived cues. Deep learning models integrating single cell multi-omics data (sc-FC + sc-RNA-Seq) achieved performance comparable to clinical models, enabling cancer-type stratification and mechanistic insight. These findings establish a framework for immune-based, multi-omics diagnostics in early cancer detection and disease monitoring.
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4. ⭐ GSE302810 巨噬细胞介导的 IL1beta/IL23 信号传导调节针对非结核分枝杆菌的 γ δ (γδ) T 细胞免疫 [scRNA-seq 3]。

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、T cell、macrophage、scRNA
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMechanistic Insights. Our study reveals the crucial role of gammadelta T cells in non-tuberculous mycobacteria (NTM) infection. We observed a significant increase and activation of gammadelta T cells in mice infected with MAB or with MAB infection combined with pulmonary fibrosis. Depletion of gammadelta T cells worsened the infection, while transfer of gammadelta T cells reversed this effect. Mechanistically, we found that MAB infection stimulates macrophages to produce IL-1beta and IL-23, which promotes the expansion of gammadelta T17 cells. MAB can also directly activate gammadelta T cells, leading to the clearance of MAB through an IL-17A-dependent pathway. Our findings suggest that gammadelta T cells represent a potential therapeutic target for NTM infections.
• 🔗 查看原文

5. ⭐ GSE277610 内皮细胞PD-L1抑制CD8+ T细胞耗竭，增强非小细胞肺癌的抗肿瘤免疫力

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immunity、T cell
• 📝 描述：Contributors : Peter Carmeliet ; Lisa M Becker ; Anh-Co K Truong ; Julia DmitrievaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer immunotherapies targeting PD-(L)1 offer therapeutic potential but suffer resistance. The role of PD-L1 in tumor and myeloid cells has been extensively studied, while its function in tumor endothelial cells (ECs) is overlooked. Surprisingly, we identified an unknown role of EC-specific PD-L1 in delaying the exhaustion of tumor-infiltrating CD8+ T cells in a non-small cell lung cancer mouse model. Loss of endothelial PD-L1 reduces T cell activation and exac-erbates tumor growth. Initial inhibition of CD8+ T cells by endothelial PD-L1, prior to encoun-tering cancer cells, prevents T cells from prematurely reaching a terminal exhaustion state. Initial results suggest that high EC PD-L1 expression in NSCLC patient tumors might become a potential positive predictor of anti-PD-1 outcome. These unexpected findings highlight the significance of vessel-associated PD-L1 and suggest that EC PD-L1 blockade upon systemic treatment potentially negates the overall therapeutic effect, raising the question if this might contribute to therapy resistance.
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6. ⭐ GSE331107 转录因子 AFF3 对于维持初始 CD8 T 细胞的代谢静止状态和防止过早的免疫衰老是必需的

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、aging、metabolic
• 📝 描述：Contributors : Molly E Lumnitzer ; Stefanie F Valbon ; Stephanie A Condotta ; Allison E Norlander ; Sheng Liu ; Jun Wan ; Martin J RicherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNaïve CD8 T cells must be maintained in a quiescent metabolic state in order to respond robustly to infection while avoiding inappropriate activation and causing immunopathology. With age this quiescent state is lost and the CD8 T cell response to infection decreases. The factors regulating metabolic quiescence of CD8 T cells and how this regulation is lost during aging are not completely understood. Herein, we identify the transcription factor AFF3 as a novel regulator of metabolic quiescence in naïve CD8 T cells. While naïve AFF3 deficient CD8 T cells are more metabolically active prior to infection, they have reduced accumulation in response to viral infection and this is correlated with a poor capacity to engage glycolysis. During aging in both murine and human CD8 T cells, AFF3 expression is reducing, correlating with to a loss of quiescent metabolism without the cells entering an activated state. Our data highlights the role of the metabolism in CD8 T cell quiescence and identifies a novel transcription factor that may be a target to reinvigorate CD8 T cell responses during aging.
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7. ⭐ GSE329046 巨噬细胞介导的IL1β/IL23信号调节γδT细胞对非结核分枝杆菌的免疫[TCR-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、T cell、macrophage
• 📝 描述：Series Type : OtherOrganism : Mus musculusMechanistic Insights. Our study reveals the crucial role of gammadelta T cells in non-tuberculous mycobacteria (NTM) infection. We observed a significant increase and activation of gammadelta T cells in mice infected with MAB or with MAB infection combined with pulmonary fibrosis. Depletion of gammadelta T cells worsened the infection, while transfer of gammadelta T cells reversed this effect. Mechanistically, we found that MAB infection stimulates macrophages to produce IL-1beta and IL-23, which promotes the expansion of gammadelta T17 cells. MAB can also directly activate gammadelta T cells, leading to the clearance of MAB through an IL-17A-dependent pathway. Our findings suggest that gammadelta T cells represent a potential therapeutic target for NTM infections.
• 🔗 查看原文

8. ⭐ GSE327983 空间蛋白质组学揭示 S100-RAGE 轴是转移性乳腺癌中曲妥珠单抗德鲁替康耐药性的可药物靶向介质。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、resistance、spatial
• 📝 描述：Contributors : Wenjuan Dong ; Shiruo Wang ; Bill Chen ; Matthew Vasquez ; Wei Yang ; Xiaoxian Li ; Hong Zhao ; Stephen WongSeries Type : OtherOrganism : Homo sapiensTrastuzumab deruxtecan (T-DXd) has substantially improved outcomes for HER2-positive metastatic breast cancer, yet up to 30 percent of patients with high HER2 expression exhibit de novo resistance. Mechanisms underlying this intrinsic resistance, particularly across different metastatic sites, remain poorly understood.
• 🔗 查看原文

9. ⭐ GSE306559 胶质瘤细胞系中m6A mRNA甲基化对替莫唑胺耐药性的调控

• ✍️ 作者：未知作者
• 🏷️ 关键词：glioma、resistance、methylation
• 📝 描述：Contributors : Sigrid Nachtergaele ; Emily Dangelmaier ; Dorthy Fang ; Kyal Sin Htet ; Nicole S Harry ; Renee Pascoe ; Je Won Yang ; Clara WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensN6-methyladenosine (m6A) is a critical regulator of mRNA processing and function, playing roles in mRNA processing, translation, and decay. Changes in m6A status have been implicated in various cancers, including glioblastoma (GBM), where acquired chemoresistance to temozolomide (TMZ) remains a major clinical challenge. We developed cell culture models of acquired TMZ resistance in GBM and analyzed the regulation of resistance-associated genes and pathways by m6A. We find that key resistance-associated genes and pathways are regulated by m6A methylation, including MGMT, the enzyme that repairs primary TMZ-induced DNA damage. Inhibition of METTL3 with STM2457 treatment destabilizes MGMT mRNA. Intriguingly, other TMZ resistance-associated genes are similarly regulated by m6A, suggesting that METTL3 inhibition may represent a promising therapeutic approach for overcoming TMZ resistance.
• 🔗 查看原文

10. ⭐ GSE288623 霍奇金淋巴瘤肿瘤相关巨噬细胞体外模型的转录谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、lymphoma、macrophage
• 📝 描述：Contributors : Maciej Szydlowski ; Michal PawlakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor-associated macrophages (TAMs) of classic Hodgkin Lymphoma (cHL) contribute to the development of immunosuppressive tumor microenvironment (TME) and are associated with worse treatment outcome. However, detailed features and functions of cHL TAMs and their therapeutic vulnerabilities remain largely unknown. To gain deeper insight into the biology of TAMs in cHL, we analyzed diagnostic biopsies by Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) and assessed transcriptional, proteomic and metabolic profiles of the in vitro TAM models. We show that Reed-Sternberg (RS) cells of cHL induce disease-specific TAM phenotype, characterized by elevated expression of factors involved in chemotaxis, angiogenesis, extracellular matrix remodeling and tumor immune escape. Importantly, RS cell-conditioned TAMs expressed TGFβ, CCL17 and tryptophan catabolizing enzymes, IDO1 and IL4I1, facilitating induction or and/or recruitment of Tregs. In addition, we identified PIM1/2/3 kinases in cHL TAMs. We characterized PIMs as important hubs orchestrating RS-macrophage interactions. Pharmacological PIM blockade attenuated development of TAM transcriptional profile and phenotype induced by RS cells. In established TAMs, PIM inhibition or PROTAC-mediated degradation decreased expression of multiple factors associated with pro-tumoral TAM functions, including IL8, MMP9, CHI3L1/2, CD206, CD209, PD-L1, CCL17, TGFβ, IL4I1 and IDO1. PIM blockade attenuated TAM-dependent eosinophil chemoattraction, extracellular matrix remodelling, angiogenesis and regulatory T cell development. Taken together, our study highlights the role of PIMs in regulation of TAM activities involved in cHL pathogenesis and potentially relevant for response of cHL patients to immunotherapies.
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1. 科学家发现了引发阿尔茨海默病脑部炎症的隐藏开关

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation、Alzheimer
• 📝 描述：Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the brain’s immune system stuck in overdrive, harming the connections between nerve cells.
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2. 为什么癌症在中年比老年更容易扩散？

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Melanoma may not become steadily more dangerous with age as scientists once assumed. In a surprising discovery, researchers found that cancer spread was lowest in young mice, surged in middle-aged mice, and then dropped again in very old mice. The key appears to be a special type of immune cell that helps keep cancer dormant and prevents it from spreading.
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3. 海洋的健康可能取决于鱼类体内的一种微小微生物。

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:micro(b|be|bial|organism)
• 📝 描述：A surprising new discovery suggests that tiny microbes living inside fish may be helping shape the chemistry of the world’s oceans. Scientists found evidence that bacteria in the guts of marine fish work alongside their hosts to produce calcium carbonate, a mineral that plays an important role in ocean health and carbon storage. For years, researchers believed fish handled this process on their own, but the new findings point to a hidden partnership between fish and microbes.
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• GSE282757 肠-脂肪-肝轴的证据：代谢功能障碍相关脂肪肝疾病中的微生物群侵占
• GSE269109 淋巴结中的脂质运载蛋白-2+肥大细胞通过线粒体衍生肽促进癌症干细胞特性[EO771]
• GSE269107 淋巴结中脂质运载蛋白-2+肥大细胞通过线粒体衍生肽促进癌症干性
• GSE234652 DDX6 reshapes the cancer RNA editome to suppress RNA-induced innate immunity [Bulk RNA-seq]
• GSE218337 Genotype-phenotype relationships (VPA/CHIR99021 vs. control; p53 Null vs. WT) in bulk RNA-sequencing of small intestinal murine organoids [bulk RNA-seq]
• GSE332959 单细胞 RNA 测序揭示了 LPS 诱导的急性肺损伤过程中肺泡巨噬细胞转录组的 Reg3g 依赖性改变
• GSE289950 IL-6诱导的C/EBPα驱动滤泡调节性T细胞分化，从而调节小鼠体液免疫
• GSE332992 ATR激酶抑制剂诱导CD8+ T细胞线粒体分裂并损害体内免疫记忆
• GSE331441 乳腺癌扩增序列 2 通过调节 BDNF/TrkB 信号通路挽救成年海马神经发生和阿尔茨海默病认知缺陷 [Bcas2_KD_hippo_snRNA_seq]
• GSE331130 乳腺癌扩增序列2通过调节BDNF/TrkB信号通路挽救成年海马神经发生和阿尔茨海默病认知缺陷
• GSE330884 内在心脏神经系统对各种情况下的心脏功能和生存至关重要
• GSE329520 129/Sv-Cyp2e1tm1Gonz/J (CYP2E1-KO) 和 129S1/SvImJ (WT) 小鼠肝脏 RNA 转录组学分析 [RNA-Seq]
• GSE324920 整合的单细胞和基因组分析揭示了以 CDC73 为中心的甲状旁腺癌恶性重编程
• GSE318238 IDH突变型胶质瘤恶性转化过程中空间分辨的基因表达和肿瘤微环境相互作用
• GSE316313 对接受 FOLFOX 单独治疗或与复合益生菌联合治疗的 C57BL/6J 小鼠皮下 MC38 同种异体移植肿瘤进行单细胞 RNA 测序
• GSE315303 Pygo2 缺失诱导前列腺癌三级淋巴结构形成并增强免疫治疗和去势反应
• GSE314731 血小板-免疫-神经元串扰调节皮肤炎症和瘙痒
• GSE311912益生菌复合物与FOLFOX方案协同作用，通过上调NAD+代谢增强抗肿瘤反应并改善化疗引起的肠道毒性
• GSE310771 将 AI 整合到斑马鱼中 β-葡聚糖参与的训练免疫的受体表征和信号网络构建中 [ChIP-seq]
• GSE310545 DNA 低甲基化剂增强 CD3 双特异性 T 细胞衔接器的疗效 [scATAC-seq]
• GSE300773 甲基化组分析增强了风险分层，并揭示了急性髓系白血病中与环境相关的化疗耐药机制
• GSE299188 靶向 PRMT5-FOXM1 轴抑制嘧啶代谢，从而阻碍口腔白斑和鳞状细胞癌的进展
• GSE298827 UBA6-UBE2Z-UBR2 泛素化级联通过细胞内 E-钙黏蛋白泛素化和降解维持肿瘤特异性 β-连环蛋白激活 [RNA-Seq]
• GSE297695 沿隐窝-绒毛轴的端粒细胞空间分布图揭示了它们在肠道稳态中的作用
• 利用RNA测序对SKHEP1细胞和通过敲低SETDB1诱导分化的SKHEP1细胞进行转录组分析（GSE295159）
• 利用 RNA 测序技术对 SKHEP1 细胞和通过强制表达 PPARG 诱导分化的 SKHEP1 细胞进行转录组分析 GSE295158。
• 利用 RNA 测序对 SKHEP1 细胞和通过强制表达 MYOD1 诱导分化的 SKHEP1 细胞进行转录组分析 GSE295157。
• 利用 RNA 测序技术对源自 B6 小鼠的胚胎干细胞 (mESC)、源自 mESC 的原始神经干细胞 (NSC)、肌肉纤维、脂肪细胞、脾细胞和胸腺进行转录组分析 GSE295156。
• GSE295155 利用 RNA 测序对 HCT116 细胞和通过强制表达 MYOD1 或 PPARG 诱导分化的 HCT116 细胞进行转录组分析。
• GSE295154 利用 RNA 测序对 CT26 细胞和通过敲低 Setdb1 诱导分化的 CT26 细胞进行转录组分析。
• GSE295153 利用 RNA 测序对 CT26 细胞和通过强制表达 Myod1 或 Pparg 诱导分化的 CT26 细胞进行转录组分析。
• GSE295152 利用 RNA 测序对 B16F10 细胞和通过强制表达 Myod1、Pparg 或敲低 Setdb1 诱导分化的 B16F10 细胞进行转录组分析。
• GSE286475 同源异型盒转录因子微调茉莉酸生物合成以平衡拟南芥中的植物免疫和生长 [RNA-seq]
• GSE286474 同源异型盒转录因子微调茉莉酸生物合成以平衡拟南芥中的植物免疫和生长 [ChIP-seq]
• GSE283066 特征选择模型识别预测疫苗诱导的流感保护作用的早期血液转录本（HA PR8 抗原）
• GSE283065 特征选择模型识别预测疫苗诱导的流感保护作用的早期血液转录本（HA0 A/California/04/2009 抗原）
• GSE278879 单核 RNA 测序分析揭示子宫内膜样癌的转录异质性
• GSE272977 DDX6 重塑癌症 RNA 编辑组以抑制 RNA 诱导的先天免疫 [RIP-Seq]
• GSE270054 红细胞命运重编程由 H3K4me3 减少引起，导致“逆行性”白血病发生 [scRNA-seq_mouse]
• GSE270053 红细胞命运重编程由 H3K4me3 减少引起，导致“逆行性”白血病发生 [scRNA-seq_human]
• GSE270051 红细胞命运重编程由 H3K4me3 减少引起，导致“逆行性”白血病发生 [RNA-seq]
• GSE268805 高通量单细胞染色质调节因子和可及性分析阐明了人类 B 细胞发育和肿瘤发生中的染色质动态，并揭示了 B 淋巴母细胞白血病中不良预后基因表达特征 (ATAC-Seq)
• GSE262172 GSK-J4 treatment in ovarian cancer cell lines (ATAC-Seq)
• GSE235686 Acute Myeloid Leukemia patient/ CD34+ healthy donor RNA-seq
• GSE234654 DDX6 reshapes the cancer RNA editome to suppress RNA-induced innate immunity
• GSE234653 DDX6 reshapes the cancer RNA editome to suppress RNA-induced innate immunity [eCLIP]
• GSE218340 Bulk and single-cell RNA-seq
• GSE218339 Gene expression profile at single cell level of murine colon organoids harbouring colorectal cancer-associated driver mutations [scRNA-seq]
• GSE200738 GSK-J4 treatment in ovarian cancer cell lines (RNA-Seq)
• GSE99779 The 8p11-p12 amplicon oncogene ASH2L regulates expression of genes involved in tumorigenic processes via promoter H3K4me3 in luminal breast cancer.
• GSE328688 IL-6诱导的C/EBPα驱动滤泡调节性T细胞分化，从而调节小鼠体液免疫
• GSE318978：SARS-CoV-2 N 蛋白诱导肺损伤的 GRP75 敲低小鼠肺泡巨噬细胞单细胞 RNA 测序
• GSE329257 卵黄囊来源的肝脏γδ T细胞亚群以一种不依赖于造血干细胞和胸腺的方式发育。
• GSE333859 哺乳动物衰老过程中细胞类型特异性时间动态的全局视角
• GSE333646 恶臭假单胞菌KT2440中(S)-1,3-丁二醇降解途径的转录组分析
• GSE333494 海马 CA3 Nex+ 神经元 TNFR2 通过性别依赖性地激活阿片类和内源性大麻素通路来缓解慢性神经性疼痛
• GSE333480 METTL3介导的m6A修饰控制Tcra重组中心形成和胸腺T细胞发育
• GSE331410 神经元对生殖系小RNA的调控可防止实验室驯养秀丽隐杆线虫因热诱导而导致不育
• GSE331086 CD49b (ITGA2) 胶原受体排除胰腺导管腺癌 (PDAC) 中的 CD8+ T 细胞浸润
• GSE329995 早期发育神经元活动通过AMPA受体影响少突胶质细胞分化
• GSE329473 对 129/Sv-Cyp2e1tm1Gonz/J (CYP2E1-KO) 和 129S1/SvImJ (WT) 小鼠肝脏 RNA 进行转录组学分析
• GSE329157 暴露于环境相关浓度 AO168=O 的 L4 期秀丽隐杆线虫的 RNA-seq 分析
• GSE327210 自闭症风险基因 Smarcc2 缺陷引起的认知和突触功能障碍及其通过组蛋白去乙酰化酶抑制的挽救作用
• GSE326697 天然黄酮类化合物染料木素和黄芩素作为耐受性良好的放射增敏剂可增强 177Lu-PSMA617 在前列腺癌中的疗效：体外和体内研究
• GSE326215 蝙蝠眼部转录组的季节性变化揭示了其为利用夏季黄昏而进行的适应性改变
• GSE326153 小鼠 Alcam 阳性 Sca-1 阴性骨衬细胞的单细胞转录组分析
• GSE325466 小鼠S3片段转录组学：对1型糖尿病、SGLT1/2抑制或GLP1受体激动剂的反应
• GSE325224 恢复与年龄相关的乳酸受体 GPR81 丢失可改善线粒体功能并延缓骨骼肌衰老
• GSE324715 肺纤维化消退期和持续期成纤维细胞中与年龄相关的转录组和DNA甲基化改变
• GSE324443 饮食和训练免疫对小鼠肠道蠕虫感染反应的影响
• GSE324204 线粒体铁使衰老癌细胞对铁死亡更加敏感
• GSE322699 来自从腹部和臀股部人脂肪组织分离的基质血管细胞的单细胞RNA测序
• GSE319401 运动通过 miR-21/Sox7 介导的抑制心脏成纤维细胞活化来减轻卵巢切除小鼠心肌梗死后的心脏功能障碍
• GSE319116 USP22 通过 Hippo/YAP 轴促进胃癌进展
• GSE319043 一种用于microRNA活性依赖性基因组编辑的带袖套的CRISPR向导RNA
• GSE318959 利用三维轮廓分析和轨迹分析对肺结核中三级淋巴结构的发育进行建模
• GSE318852 自身抗原TRIM21在细胞溶解性死亡后组装促炎免疫复合物
• GSE316395 人类脊髓类器官重现发育和疾病相关的少突胶质细胞谱系特征 [RNA-Seq]
• GSE316370 化疗诱导的衰老成纤维细胞促进 NF-κB 介导的肿瘤侵袭性，而罗非昔布可抑制胃癌中的这种侵袭性
• GSE316338 人类脊髓类器官重现发育和疾病相关的少突胶质细胞谱系特征 [scRNA-Seq]
• GSE316160 人工控制系统（hQSCS）对红霉素发酵过程中红霉素链霉菌天然转录组的影响
• GSE315906 HER2抑制剂对胆道癌基因表达的影响
• GSE313857 阿仑膦酸钠对诺氏鲵（Nothobranchius furzeri）存活率和骨骼特性的影响：来自加速衰老模型的启示
• GSE313537 CD4 T 细胞衍生的 IL-2 可拮抗雷帕霉素介导的急性移植物抗宿主病中 CD8 T 细胞效应分化的抑制作用
• GSE311979 中脑多巴胺神经元染色体区域的转录下调与精神分裂症相关。[Hi-C]
• GSE311978 中脑多巴胺神经元染色体区域的转录下调与精神分裂症相关。[RNA-Seq]
• GSE311566 PFAS 诱导 B 淋巴细胞活化和抗体分泌的机制研究 [PBMCs]
• GSE311507 亚型特异性依赖性和药物脆弱性助力头颈癌精准治疗
• GSE311245 绵羊胚胎干细胞启动和幼稚样状态的转录组
• GSE311234 PFAS诱导B淋巴细胞活化和抗体分泌的机制研究
• GSE310772 将人工智能整合到斑马鱼β-葡聚糖参与的训练免疫的受体表征和信号网络构建中
• GSE310428 DNA 低甲基化剂增强 CD3 双特异性 T 细胞衔接器的疗效 [BiSulfite-seq]
• GSE306560：亲代U87 MG细胞与替莫唑胺耐药U87 MG细胞间m6A甲基化的差异
• GSE303324 SARS-CoV-2 变异株增强子和突破性感染驱动记忆 B 细胞库的功能差异
• GSE303033 导电且具有生物活性的超分子支架促进神经元成熟
• GSE303032 导电且具有生物活性的超分子支架促进神经元成熟 [Stupp08_RNA-seq]
• GSE303031 导电且具有生物活性的超分子支架促进神经元成熟 [Stupp06_RNA-seq]
• GSE303030 导电且具有生物活性的超分子支架促进神经元成熟 [Stupp05_RNA-seq]
• GSE302205 研究发现，1 型糖尿病中与年龄无关的免疫亚型表现出不同的发病后进展速度和免疫治疗反应。
• GSE302086 来自 Pten、Apc 和 Smad4 基因敲除前列腺癌小鼠模型的表达数据
• GSE301264 肝脏 Yap1 在器官修复过程中激活全身分解代谢和肌肉丢失：与癌症恶病质具有共同机制的证据 [eWAT_RNAseq]
• GSE300864 小鼠2细胞和4细胞胚胎的单胚胎和单卵裂球RNA测序分析
• GSE300734 Brg1 缺陷导致核小体结构异常，并影响胚胎发生过程中全能性和多能性转录因子的结合 [RNA-seq]
• GSE300558 拟南芥Mac3a3b转录组分析及其在高温胁迫响应调控中的作用
• GSE299755 NSUN2 重塑代谢以支持蛋白质分泌并提高生物生产产量
• GSE299372 通过表观基因组编辑高效激活 LAMA1 基因作为 LAMA2-CMD 的一种治疗方法
• GSE299227 丙酮酸、乳酸和缺氧重编程小鼠 CD8 T 细胞染色质结构
• GSE299196 人参皂苷RK1通过激活HK2/ACSL4/LPCAT3/ALOX5信号通路促进肝星状细胞糖酵解介导的铁死亡
• GSE298806 先天免疫活性 iNS 球状体：一种源自 hiPSC 的 3D 模型，用于研究中枢神经系统，并捕捉到对 rAAV 的早期中枢神经系统反应。
• GSE298489 代谢手术通过循环胆汁酸分流降低CRC疾病进展
• GSE296481 研究发现，早期念珠菌与口腔肿瘤的相互作用提示 miRNA 介导的炎症和肿瘤相关过程的调控
• GSE295886 PNU282987 处理的人类诱导多能干细胞衍生的原始巨噬细胞的基因表达
• GSE295678 感觉神经元通过谷氨酸能癌神经元假突触驱动胰腺癌进展。
• GSE290910 自闭症儿童早期脑过度生长的细胞机制：GPX4 水平升高和对铁死亡的抵抗
• GSE290531 间充质干细胞通过 CCL2 依赖性巨噬细胞极化缓解系统性红斑狼疮
• GSE289230 GATA3 通过其锌指 2 调控的相分离差异性地调控转录组
• GSE288013 组蛋白伴侣 HIRA 通过促进 Pol II 暂停释放来调节脂联素表达和肥胖相关的脂肪组织扩张
• GSE287588 Yap/Taz 在神经嵴来源的颅缝间充质细胞中作为 FGF 信号传导的新介质发挥作用 [RNA-seq]
• GSE287133 心脏成纤维细胞中 PTBP1 的缺失通过选择性剪接调节促纤维化反应。
• GSE285911 MRC2 遗传变异导致心肌成纤维细胞功能障碍并增加房颤易感性
• GSE279995 Rheb 调节 mTORC1 非依赖性代谢对于小胶质细胞溶酶体功能至关重要
• GSE278167 斑马鱼ATG5诱导肝细胞癌的转录组分析
• GSE270985 肌核重编程是膝关节损伤后肌肉去神经支配和无力的基础[ChIP-Seq]
• GSE270052 红细胞命运重编程由 H3K4me3 减少引起，导致“逆行性”白血病发生 [CUT&Tag]
• GSE269118 高通量单细胞染色质调节因子和可及性分析阐明了人类 B 细胞发育和肿瘤发生中的染色质动态，并揭示了 B 淋巴母细胞白血病中不良预后基因表达特征 [患者]
• GSE268580 高通量单细胞染色质调节因子和可及性分析阐明了人类 B 细胞发育和肿瘤发生过程中的染色质动态，并揭示了 B 淋巴母细胞白血病中不良预后基因表达特征
• GSE268381 高通量单细胞染色质调节因子和可及性分析阐明了人类 B 细胞发育和肿瘤发生过程中的染色质动态，并揭示了 B 淋巴母细胞白血病中不良预后基因表达特征
• GSE262785 HNF4α is a target of the Wnt/β-catenin pathway and regulates colorectal carcinogenesis
• GSE262173 GSK-J4 treatment in ovarian cancer cell lines
• GSE254514 The role of lipocalin-2 in lung homeostasis, inflammation response, and recovery following organic dust exposure
• GSE252352 Gene expression profile at the single-cell level of Shiga toxin 2+ white cells in the blood
• GSE251819 Combined single-cell profiling and functional analysis reveals the importance of pseudogenes in human early embryonic development
• GSE249546 Single cell transcriptome of Clec3b-lineage cells in fracture callus and uninjured muscle
• GSE242792 Development and Validation of Targetable Prognostic Risk Score in Locally Advanced Nasopharyngeal Carcinoma
• GSE242787 Development and Validation of Targetable Prognostic Risk Score in Locally Advanced Nasopharyngeal Carcinoma [Nanostring]
• GSE242365 Development and Validation of Targetable Prognostic Risk Score in Locally Advanced Nasopharyngeal Carcinoma [Affymetrix]
• GSE235512 Gene expression profile at the single-cell level of skin and PBMC samples collected from patients with severe cutaneous adverse drug reactions (SCADR).
• GSE235096 Novel PAX3-FOXO1 functions in rhabdomyosarcoma [RNA-seq]
• GSE235095 Novel PAX3-FOXO1 functions in rhabdomyosarcoma [ATAC-seq]
• GSE233624 Single cell transcriptome atlas revealed the feature of contemporary ZIKA virus induced microcephaly in mice
• GSE198504 Phf6 truncating mutation drives leukemogenesis via disrupted epigenetic regulation in mice
• GSE198501 Phf6 mutation induces leukemogenesis through altered chromatin state in mice (scRNA-Seq)
• GSE198500 Phf6 mutation induces leukemogenesis through altered chromatin state in mice (ChIP-Seq)
• GSE198499 Phf6 mutation induces leukemogenesis through altered chromatin state in mice (RNA-Seq)
• GSE167106 circRNA sequencing in ethonal treated CGNs in mice
• GSE116042 ChIP-seq experiment of H3K4me3 and H3K27me3 in HH30 chicken neural tubes
• GSE324891 MBD8 作为组蛋白去甲基酶 LDL2 的保守辅助因子，调控植物开花时间 [LDL2_RNAseq]
• GSE324890 MBD8 作为组蛋白去甲基化酶 LDL2 的保守辅助因子，调控植物开花时间 [LDL2_ChIPseq]
• GSE308222 早产儿严重生长受限和肥胖症中的远端 4q 重复和延伸 10q 缺失：基因表达谱分析揭示上皮-间质相互作用和代谢调控的破坏