详细内容（前10条）

1. ⭐ GSE306514 趋化因子受体表达模式界定了肺间质巨噬细胞的不同亚群，并定义了从单核细胞到成熟巨噬细胞的演变轨迹，批量RNA测序数据

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、chemokine、sequencing、trajectory
• 📝 描述：Contributors : Heather Mathie ; Laura Medina-Ruiz ; Fabian Schuette ; Heba Halawa ; Zuzanna Pocalun ; Elise Pitmon ; John Cole ; Marieke Pingen ; Gerard J GrahamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory chemokine receptors CCR1, CCR2 and CCR5 are critical for directing recruitment of monocytes and macrophages in the context of inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Here, we have used transcriptomic approaches to examine inflammatory chemokine receptor expression on lung interstitial macrophage populations. We have demonstrated that interstitial macrophages can be divided into three distinct subsets, each of which express specific patterns of chemokine receptors, and that there are dynamic changes in chemokine receptor expression as macrophages differentiate from monocytes in the lung. Furthermore, macrophages expressing different combinations of chemokine receptors are transcriptionally distinct from one another, suggesting non-redundant functions for CCR 1, 2 and 5. Finally, we examined changes in macrophage chemokine receptor expression in vitro after treatment with varied TLR ligands, and show that CCR1 is specifically increased in response to bacterial but not viral ligands. Our data provide compelling evidence that macrophage chemokine receptor expression is not redundant, but specific and maleable in response to discrete inflammatory stimuli.
• 🔗 查看原文

2. ⭐ GSE326201：对人肝细胞癌及其邻近非肿瘤肝组织进行单细胞RNA测序，揭示了与病因相关和与病因无关的肿瘤微环境特征。

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、sequencing、single-cell
• 📝 描述：Contributors : Timothy Shuen ; Chit Lai Chee ; Rebecca Ba ; Charmaine Tan ; Joelle Chua ; Hui Shi Cheong ; Hui Min Chai ; Lip Seng Koh ; Janice Lim ; Chung Yip Chan ; Alexander Yaw Fui Chung ; Peng Chung Cheow ; Prema Raj Jeyaraj ; Jin Yao Teo ; Ye Xin Koh ; Aik Yong Chok ; Pierce Kah Hoe Chow ; Brian Goh ; Wei Keat Wan ; Wei Qiang Leow ; Tracy Jie Zhen Loh ; Po Yin Tang ; Jayanthi Karunanithi ; Nye Thane Ngo ; Tony Kiat Hon Lim ; Han Chong TohSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) arises in the context of diverse aetiological backgrounds, yet the extent to which the tumour microenvironment is shaped by aetiology-associated versus aetiology-independent programmes remains incompletely understood. This dataset was generated to support interrogation of the cellular architecture of human HCC and the surrounding liver microenvironment at single-cell resolution. By profiling tumour and adjacent non-tumour liver tissues, the study provides a resource for examining malignant, immune, stromal, and hepatic parenchymal cell populations, and for investigating shared and aetiology-linked features of the HCC tumour microenvironment.
• 🔗 查看原文

3. ⭐ GSE318171 营养响应型和 DAF-16/FoxO 靶向 H1 组蛋白 HIL-1 促进秀丽隐杆线虫对饥饿和细菌病原体的抵抗力

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:bacter(ia|ial|ium)、resistance、histone
• 📝 描述：Contributors : Kinsey C Fisher ; Rojin Chitrakar ; Ryan BaughSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansInsulin/IGF-1 signaling (IIS) mediates metabolic and developmental acclimation to stressful conditions including starvation. The transcription factor DAF-16/FoxO actuates many of the physiological effects of reduced IIS, yet the specific contributions of DAF-16 target genes to stress resistance remain poorly understood. We explore the function of C. elegans H1 linker histone variant hil-1/H1.0, a DAF-16 target that is upregulated during starvation. The HIL-1 sequence is divergent from the other eight annotated C. elegans H1 variants, and the others are not so highly responsive to nutrient availability and DAF-16 activity, suggesting distinct function. Using knock-in reporters, we find that HIL-1 is expressed ubiquitously in nuclei of L1 and dauer larvae during starvation, but that expression is largely undetectable in fed larvae. Disrupting hil-1 activity through mutation or auxin-inducible degradation led to reduced growth after extended L1 starvation, revealing reduced starvation resistance. RNA-seq of hil-1 mutants showed that hil-1 affects expression of relatively few genes. However, hil-1 activates genes involved in the innate immune response, Pseudomonas aeruginosa infection, and components of the nipi-3/TRIB1 immunity pathway. hil-1 mutants display compromised survival upon exposure to P. aeruginosa under reduced IIS, and genes activated by hil-1 promote resistance to P. aeruginosa. Together these results suggest that DAF-16/FoxO activates transcription of hil-1 during starvation to promote resistance to starvation and pathogens. We demonstrate conditional regulation of an H1 histone, and we reveal a novel mechanism for how IIS promotes stress resistance by identifying a histone variant that connects nutrient sensing to immunity.
• 🔗 查看原文

4. ⭐ GSE314985 热灭活的短乳杆菌诱导斑马鱼抗焦虑肠-脑通路的多组学分析[肠道16S rRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?、regex:intestin(e|al)
• 📝 描述：Contributors : Azusa Kubota ; Liqing Zang ; Takuro Shinkai ; Misa Nakai ; Atsushi Tajima ; Yasuhito ShimadaSeries Type : OtherOrganism : Danio rerioThis study aimed to elucidate the molecular gut-brain pathways underlying the anxiolytic effects of heat-inactivated L. brevis SBC8803 using zebrafish as a translational model. Adult fish received oral SBC8803 and were assessed in the novel tank test. To interrogate mechanisms, we combined brain RNA sequencing with 16S rRNA gene profiling of the gut microbiota and performed integrative multi‑omics analyses to identify host gene expression changes and microbial functional alterations associated with anxiolysis.
• 🔗 查看原文

5. ⭐ GSE314984 热灭活的短乳杆菌在斑马鱼中诱导抗焦虑肠-脑通路的多组学分析[脑RNA测序]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、gut、regex:gut(-?microbiome)?
• 📝 描述：Contributors : Azusa Kubota ; Liqing Zang ; Takuro Shinkai ; Misa Nakai ; Atsushi Tajima ; Yasuhito ShimadaSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThis study aimed to elucidate the molecular gut-brain pathways underlying the anxiolytic effects of heat-inactivated L. brevis SBC8803 using zebrafish as a translational model. Adult fish received oral SBC8803 and were assessed in the novel tank test. To interrogate mechanisms, we combined brain RNA sequencing with 16S rRNA gene profiling of the gut microbiota and performed integrative multi‑omics analyses to identify host gene expression changes and microbial functional alterations associated with anxiolysis.
• 🔗 查看原文

6. ⭐ GSE305101 趋化因子受体表达模式勾勒出肺中不同的间质巨噬细胞亚群，并定义了从单核细胞到成熟巨噬细胞的轨迹

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、chemokine、trajectory
• 📝 描述：Contributors : Heather Mathie ; Laura Medina-Ruiz ; Fabian Schuette ; Heba Halawa ; Zuzanna Pocalun ; Elise Pitmon ; John Cole ; Marieke Pingen ; Gerard GrahamSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusInflammatory chemokine receptors CCR1, CCR2 and CCR5 are critical for directing recruitment of monocytes and macrophages in the context of inflammation. However, the discreet role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Here, we have used transcriptomic approaches to examine inflammatory chemokine receptor expression on lung interstitial macrophage populations. We have demonstrated that interstitial macrophages can be divided into three distinct subsets, each of which express specific patterns of chemokine receptors, and that there are dynamic changes in chemokine receptor expression as macrophages differentiate from monocytes in the lung. Furthermore, macrophages expressing different combinations of chemokine receptors are transcriptionally distinct from one another, suggesting non-redundant functions for CCR 1, 2 and 5. Finally, we examined changes in macrophage chemokine receptor expression in vitro after treatment with varied TLR ligands, and show that CCR1 is specifically increased in response to bacterial but not viral ligands. Our data provide compelling evidence that macrophage chemokine receptor expression is not redundant, but specific and inducible in response to discrete inflammatory stimuli.
• 🔗 查看原文

7. ⭐ GSE301343 NQO1介导的胶质母细胞瘤氧化应激抵抗和肿瘤微环境重塑

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、tumor microenvironment、resistance
• 📝 描述：Contributors : Yangqing Li ; Tao Kang ; Zhen Jia ; Chenfei Lu ; Gaoyuan Cui ; Hang Yu ; Deobrat Dixit ; Fangshu Jin ; Danyang Shan ; Qiankun Lin ; Daqi Li ; Hao You ; Danling Gu ; Jiancheng Gao ; Zhumei Shi ; Wei Gao ; Fan Lin ; Zhe Zhu ; Qianghu Wang ; Weiwei Tao ; Junxia Zhang ; Jingshan Liang ; Yongping You ; Xu Qian ; Kailin Yang ; Xiuxing Wang ; Kun Yang ; Luan Sun ; Chaojun Li ; Qian ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Glioblastoma (GBM) is a highly aggressive brain tumor, with glioblastoma stem cells (GSCs) occupying the pinnacle of a complex tumor microenvironment (TME), conferring therapeutic resistance. The TME plays a role in tumor development by creating a niche rich in reactive oxygen species (ROS) through oxidative stress (OS). Here, we identified NAD(P)H quinone oxidoreductase-1 (NQO1) as an essential regulatory factor in antioxidant stress response, which is key to maintaining GSCs and the immunosuppressive TME. Methods: Proteomics analysis, epigenetic profile by using H3K27ac ChIP-sequencing and single-cell RNA sequencing were performed to define the high enrichment of NQO1 in GBM. In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of NQO1 in GSC proliferation and self-renewal. Patient-derived GSCs and a xenograft murine model were using to investigate the tumor-intrinsic and extrinsic mechanisms to confers resistance to oxidative stress and reprogram the immunosuppressive TME. Results: NQO1 was preferentially expressed in GSCs and regulated ROS levels, preserving the stability of nuclear Lamin B1 and inhibiting cGAS-type I interferon signaling, which helps to remodel the immunosuppressive TME. Furthermore, nuclear factor erythroid 2-related factor 2 (NRF2) transcriptionally regulates NQO1, suppressing type I interferon signaling. Conclusions: NQO1 plays critical roles at both the cell-autonomous and cell-extrinsic levels for clinical treatment. Targeting NQO1 and its downstream signaling pathways, including β-Lapachone and immune checkpoint inhibitors such as anti-PD-1 therapy, enhances our understanding of the interactions between GSCs, oxidative stress, and the TME. This offers promising new avenues for clinical intervention in GBM.
• 🔗 查看原文

8. ⭐ GSE333350 治疗性细菌训练的NK细胞可提供针对癌症转移的长期保护

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、bacteria、regex:bacter(ia|ial|ium)
• 📝 描述：Contributors : Li Rong ; Jingchu Hu ; Wei Jin ; Jiandong HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report that a single dose of therapeutic Salmonella, a prominent anti-tumor bacterial therapy, provides long-lasting protection against metastasis in mice by inducing trained NK cells. Integrated functional and multi-omics analyses revealed that Salmonella-trained NK (stNK) cells establish an enduring reprogrammed epigenome characterized by enhanced pro-survival signaling and immune effector functions, resulting in more potent IFN-gamma release and cytotoxicity upon secondary stimulation. We further showed that this training requires a transient pulse of IL-12 combined with sustained IL-18 signaling. Crucially, stNK cells significantly outperform conventional immune checkpoint therapies, including PD-1 and TIGIT blockade, in preventing metastasis, underscoring the unique immunological mechanisms in combating metastasis.
• 🔗 查看原文

9. ⭐ GSE268993 肠道上皮细胞Ceacam1缺陷可预防类固醇难治性急性肠道移植物抗宿主病

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?、regex:intestin(e|al)
• 📝 描述：Contributors : Qingxiao Song ; De F ZengSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusSteroid refractory gut acute graft-versus-host disease (SR-Gut-aGVHD) is the major cause of non-relapse death after allogeneic hematopoietic cell transplantation, due to poor understanding its pathogenesis. We recently reported that increase of donor-type IL-22+ T cells, IL-22-dependent dysbiosis, and loss of anti-inflammatory CX3CR1hi mononuclear phagocytes (MNP) play critical roles in SR-Gut-aGVHD pathogenesis, but the mechanisms remain unclear. Ceacam1 on intestinal epithelial cells (IECs) is proposed to regulate bacterial translocation and subsequent immune response in the gut tissues. Here, with imaging mass cytomtory (IMC), combined scRNA-Seq and ATAC-Seq, as well as high dimensional flow cytometry analysis, we show that Ceacam1 expression is enhanced on IECs in murine and human SR-Gut-aGVHD. Ceacam1 deficiency on host IECs effectively prevents SR-Gut-aGVHD in murine models. Ceacam1 deficiency on IECs results in 1) increase in frequencies of IL-22+IL-10+Foxp3+CD4+ peripheral Tregs (pTregs) while reducing conventional IL-22+CD4+ T (Tcon), Th/Tc1, and Th17 cells; 2) increase of beneficial commensal bacterial that augment colonic pTregs expansion, while reducing pathogenic bacteria and blocking E. Coli’s interaction with IECs; and 3) increase of anti-inflammatory CD103-CX3CR1hi MNP that produce IDO and IL-10, while reducing pro-inflammatory CD103+CX3CR1lo MNP that produce IL-6. Thus, specific targeting IEC Ceacam1 represents a novel approach for prevention of SR-Gut-aGVHD.
• 🔗 查看原文

10. ⭐ GSE318022 E18.5 小鼠后胃上皮的单细胞 RNA 测序及其衍生的 3D 类器官在不同 YAP 活性状态下的批量 RNA 测序 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell、scRNA
• 📝 描述：Contributors : Yongchun Zhang ; Rongzi MuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHippo signaling plays a crucial role in the development of multiple organs. This study consists of two transcriptomic datasets.Single-cell RNA sequencing was conducted on E18.5 mouse hindstomach epithelial cells of littermate control, YAP5SA-overexpressing and Yap knockout mice, where YAP5SA represents a constitutively active form of Yap. Bulk RNA sequencing was performed to analyze transcriptional changes in 3D organoids derived from the glandular embryonic hindstomach epithelium of control and YAP5SA-overexpressing mice. Among these, organoids were cultured under two conditions: growth medium for 5 days, or growth medium for 5 days followed by differentiation medium for an additional 7 days. Comparative gene expression profiling provides valuable insights into the role of the Hippo signaling pathway in regulating diverse biological processes during glandular stomach epithelial development.
• 🔗 查看原文

💡 该来源还有 68 条内容，详见 文末

详细内容（全部6条）

1. TAP-seq——靶向单细胞RNA和扰动测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell
• 📝 描述：TAP-seq combines genome editing with targeted RNA sequencing to enable sensitive and cost-effective single-cell functional genomics screens…
• 🔗 查看原文

2. 科学家发现隐藏的肠脑回路，可触发对蛋白质的渴望

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?
• 📝 描述：When the body runs low on protein, the gut sends powerful signals to the brain that reshape cravings and push animals to seek essential amino acids instead of sugar. Researchers say this newly discovered gut-brain network could transform our understanding of appetite, nutrition, and obesity.
• 🔗 查看原文

3. RNA测序揭示了胰腺早期病变如何癌变的过程

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：Single-cell RNA sequencing and spatial transcriptomics reveal how precancerous pancreatic lesions evolve differently from pancreatic cancer microenvironments…
• 🔗 查看原文

4. 一种流行的抗衰老药物组合导致小鼠严重脑损伤

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging
• 📝 描述：A drug combo widely explored for anti-aging may actually damage the brain, according to new mouse research showing severe loss of myelin and changes linked to “chemo brain.” Surprisingly, the damaged cells resembled those seen in multiple sclerosis, giving scientists a new lead in understanding—and potentially repairing—the disease.
• 🔗 查看原文

5. 科学家原以为脑部炎症是导致新冠后遗症的原因，但扫描结果却显示了不同的情况。

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation
• 📝 描述：A new brain imaging study has found no evidence of widespread brain inflammation in patients suffering from prolonged symptoms after COVID-19 infection. Instead, the most severe long COVID symptoms were associated with increased brain activity in regions involved in mood and emotion.
• 🔗 查看原文

6. 新的抑郁症疗法针对的是免疫系统而非大脑。

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune
• 📝 描述：A surprising new approach to depression treatment is showing early promise — not by targeting brain chemicals, but by calming the immune system. In a small clinical trial, researchers found that an anti-inflammatory drug normally used for rheumatoid arthritis appeared to ease symptoms in people with hard-to-treat depression, while also reducing fatigue and anxiety and improving quality of life.
• 🔗 查看原文

• GSE318012 E18.5 小鼠后胃上皮的单细胞 RNA 测序及其衍生的 3D 类器官在不同 YAP 活性状态下的批量 RNA 测序 [用于分化的 RNA-seq]
• GSE318007 E18.5 小鼠后胃上皮的单细胞 RNA 测序及其衍生的 3D 类器官在不同 YAP 活性状态下的批量 RNA 测序 [bulk RNA-seq]
• GSE333415 LOX 敲低对植入老年小鼠乳腺 dECM 支架上的肿瘤细胞异种移植的单细胞转录组学影响
• GSE333379 AXL磷酸化位点定位将FAK1和YAP1信号通路与EGFR突变型肺癌的厄洛替尼耐药性联系起来
• GSE310580 DNA甲基化谱分析能够对粘液性卵巢癌进行亚型分类，并将其与卵巢外粘液性转移区分开来。
• GSE326648 性二态性影响 Pax6 缺陷小鼠模型中 AAK 的轨迹，该模型表现为早期免疫激活、神经支配受损和泪液改变
• GSE312099 同种异体造血干细胞移植后免疫细胞测序 [snATAC-seq]
• GSE310071 基于原位类器官的模型追踪结直肠癌中 CD8⁺ T 细胞耗竭的动态变化。
• GSE305525 Ly6C 单核细胞亚群转录组分析（来自对照组和糖尿病小鼠）
• GSE303930 NSG 和 NBSGW 模型中长期移植的 HSPC 的单细胞 RNA-Seq 分析。
• GSE302490 转录组和蛋白质组的整合分析表明，PDCoV 感染诱导自噬依赖性铁死亡以促进病毒复制。
• GSE275432 m6A甲基化在衰老和帕金森病中的作用
• GSE333386 PARK7介导的SF3B去乙酰化重编程RNA剪接以减弱纤维化并促进抗肿瘤免疫
• GSE332772 脂肪酸结合蛋白5缺乏症会损害肺泡巨噬细胞功能和代谢
• GSE328202 BMH21 处理破坏粗线期精母细胞 XY 体中的前 rRNA 并改变基因组可及性 (ATAC-seq)
• GSE318612：E18.5小鼠后胃上皮的单细胞RNA测序及其衍生3D类器官在不同YAP活性状态下的批量RNA测序
• GSE330349 利用输卵管模型阐明孕酮信号在高级别浆液性卵巢癌中的作用
• GSE325486 ESR1 突变影响 CDK4/6 抑制剂获得性耐药的克隆动态、遗传多样性和细胞状态
• GSE316308 棕色脂肪细胞中 Cox10 介导的线粒体呼吸调节适应性产热和全身代谢
• GSE312490 尿石素 A 在体外坏死性小肠结肠炎 (NEC) 实验模型中减轻炎症并增强屏障完整性
• GSE311975 动态染色质SUMO化调控谱系重编程（RNA-seq）
• GSE311971 动态染色质SUMO化调控谱系重编程（ChIP-seq）
• GSE311969 动态染色质SUMO化调控谱系重编程（ATAC-seq）
• GSE283516 OMA1通过控制肝脏免疫原性，在衰老过程中保护肝脏免受损伤和肿瘤发生。
• GSE333539 雄激素受体二聚化界面的功能表征 [RNA-seq]
• GSE333538 雄激素受体二聚化界面的功能表征 [ChIP-seq]
• GSE319208 GDPD5-CD55-EGFR 竞争性结合轴调控直肠癌的放射抗性和脂质积累
• GSE318061 通过纳米胶囊共递送顺铂和Bmi1 siRNA克服卵巢癌的化疗耐药性
• GSE314034 预测红细胞前体细胞信号传导的顺式元件反应 [ER RNA-seq]
• GSE314033 预测红细胞前体细胞信号传导的顺式元件反应 [ATAc-seq]
• GSE314032 预测红细胞前体细胞信号传导的顺式元件反应 [RNA-seq]
• GSE313916 低级别浆液性卵巢癌药物敏感性机制
• GSE312954 二氧化硅纳米颗粒增强葡萄对霜霉病的抗性
• GSE309917 人类肠道类器官中可诱导的 POU2F3 表达作为人类簇状细胞的模型
• GSE309260 水痘-带状疱疹病毒感染的小胶质细胞的批量 RNA 测序分析
• GSE308716 敲低 TRIM35 可抑制乳头状甲状腺癌细胞的增殖、转移和糖酵解
• GSE308274 野生型 H-18 ESC 和 EpiLC 的 RNA-seq 分析
• GSE303307 超级增强子驱动的 TCF4 通过介导 GM3 合成促进神经母细胞瘤转移 [RNA-Seq]
• GSE303303 超级增强子驱动的 TCF4 通过介导 GM3 合成促进神经母细胞瘤转移 [ChIP-seq]
• GSE301678 MLL3 和 MLL4 冗余地授权 HSC 自我更新和髓系特性，同时抑制 B 细胞启动，独立于 COMPASS 酶功能 [scRNA]
• GSE301675 MLL3 和 MLL4 冗余地授权 HSC 自我更新和髓系特性，同时抑制 B 细胞启动，独立于 COMPASS 酶功能 [scATAC]
• GSE301672 MLL3 和 MLL4 冗余地授权 HSC 自我更新和髓系特性，同时抑制 B 细胞启动，独立于 COMPASS 酶功能 [ChIP-seq I]
• GSE300796 NAT10 介导的 N4-乙酰胞苷修饰通过调节染色质重塑抑制转座元件表达来促进肝内胆管癌进展 [ATAC-seq]
• GSE300795 NAT10 介导的 N4-乙酰胞苷修饰通过调节染色质重塑抑制转座元件表达来促进肝内胆管癌进展 [RNA-seq]
• GSE300554 C57BL/6Aire-/- 小鼠前列腺中的免疫失调与良性前列腺增生症 (BPH) 中的免疫失调相似。
• GSE298851 经典microRNA缺失驱动肿瘤发展，提示依诺沙星对血管肉瘤的治疗效果
• GSE298666 经典 microRNA 丢失驱动肿瘤发展，暗示依诺沙星对血管肉瘤的治疗效果。
• GSE297614 SMYD2 甲基化 KDM5A，限制其对基因组的去甲基化酶活性（并促进增殖）。
• GSE297612 SMYD2 甲基化 KDM5A，限制其对基因组的去甲基化酶活性（并驱动增殖）
• GSE292762 单细胞分辨率转录组分析揭示了原代和继发性衰老细胞的多样性和调控网络
• GSE292752 靶向 PACT 以拓宽抗病毒谱：管状苷 II 在调节 RIG-I/MAVS/IRF-3 信号通路对抗呼吸道病毒中的作用
• GSE286560 PRMT5 抑制剂可增强胶质母细胞瘤肿瘤模型对替莫唑胺的敏感性
• GSE283692 生酮饮食和自主运动可改变饮食诱导肥胖小鼠的坐骨神经和腓肠肌转录组
• GSE280371 IL-17A 在母体免疫激活的 3D 离体模型中改变人类皮层发育
• GSE271991 红肉代谢物和营养缺乏对HCT116结直肠癌细胞基因表达的影响
• GSE298628 PPARG 和 RXRA 在 PPARG 反向激动剂治疗后的全基因组占位情况
• GSE298624 胚胎氧气水平的变化提示肢体起始异时性 [scRNA-seq]
• GSE298623 胚胎氧气水平的变化引发肢体起始异时性 [批量 RNA 测序]
• GSE298581 三种尿路上皮癌细胞系对 PPARG 抑制的全局基因表达反应
• GSE173247 AVIL 是横纹肌肉瘤中真正的癌基因
• GSE333531 TPX2介导的自噬维持肺腺癌干细胞特性
• GSE333397 内皮细胞 KLF4 耗竭导致与年龄相关的神经血管功能障碍和神经精神损伤 [ChIP-Seq]
• GSE333395 内皮 KLF4 耗竭导致与年龄相关的神经血管功能障碍和神经精神损害 [ATAC-seq]
• GSE333394 内皮细胞 KLF4 的缺失导致与年龄相关的神经血管功能障碍和神经精神障碍 [scRNA-seq]
• GSE333200 SOX2促进自分泌精液凝集素1信号传导，从而调控A673人尤文氏肉瘤细胞的增殖和阿霉素耐药性
• GSE328326 小鼠雄性减数分裂过程中粗线期精母细胞的基因表达[RNA-Seq]
• GSE299314 伤害性感觉神经诱导IL4Rαhi抗炎巨噬细胞亚群，可保护肾脏免受缺血再灌注损伤[BMDM_RNAseq]
• GSE299312 伤害性感觉神经诱导IL4Rαhi抗炎巨噬细胞亚群，可保护肾脏免受缺血再灌注损伤[DRG_RNAseq]