详细内容（前10条）

1. ⭐ GSE331226 CCR5 hi 单核细胞的代谢-表观遗传重编程维持对致命性脓毒症的长期训练免疫力 [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、metabolic、scRNA、epigenetic
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTrained immunity enhances innate host defense by endowing monocytes with memory-like properties, yet the underlying integrated metabolic and epigenetic mechanisms remain elusive. Here, we demonstrate that co-immunization with Bacillus Calmette–Guérin (BCG) and bacterial lipoprotein (BLP) induces a durable form of trained immunity that provides robust, long-term protection against polymicrobial sepsis from early life into adulthood. Single-cell RNA sequencing revealed that this effect is mediated by an expansion of CCR5hi memory-like monocytes with enhanced antimicrobial capacity. Mechanistically, BCG+BLP vaccination activated the AKT–mTOR–HIF-1α axis, driving glycolytic reprogramming and subsequent lactate accumulation. We found that elevated lactate then promoted KAT2B-dependent histone H3K18 lactylation, an epigenetic mark directly facilitating the transcription of phagocytic and inflammatory genes. Critically, CCR5hi monocytes isolated from vaccinated human cord blood recapitulated these lactate-driven lactylation and trained immunity features. Together, our findings define a novel lactate–KAT2B–H3K18la epigenetic axis that orchestrates the long-term reprogramming of CCR5hi monocytes, highlighting CCR5hi monocytes as a promising therapeutic target for modulating innate immunity against lethal sepsis
• 🔗 查看原文

2. ⭐ GSE303246 MLLT3 YEATS 结构域是组蛋白标记 (H3K9/18/27ac/cr) 和非编码 RNA (7SK) 的双重读取器，连接表观遗传和 RNA 信号传导以调节造血作用 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、epigenetic、histone
• 📝 描述：Contributors : Adam Boulton ; Ashish Kabra ; Nicholas Achille ; Emmalee R Adelman ; Dimitrios Anastasakis ; Felipe Beckedorff ; Pradeepkumar Cingaram ; Ying Huang ; Benjamin Leach ; Ramin Shiekhattar ; Akihiko Yokoyama ; Markus Hafner ; Maria Figueroa ; Nancy Zeleznik-Le ; John BushwellerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHerein we describe our findings that the YEATS domain of MLLT3 is not only a reader of histone acetylation and crotonylation but also binds to ncRNA.
• 🔗 查看原文

3. ⭐ GSE284279 中性粒细胞对不同上皮/间质表型的癌细胞的不同影响导致不同的肿瘤微环境和转移行为[3]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、tumor microenvironment
• 📝 描述：Contributors : Ling Wu ; Xiang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeutrophils play complicated roles in tumor progression. Examination of several murine triple negative breast cancer (TNBC) models revealed nearly opposite impact of neutrophils on epithelial-like vs. mesenchymal-like cancer cells (ECCs vs. MCCs). Interaction with ECCs upregulates ICAM1 in neutrophils, a feature that also distinguishes tumor-infiltrating neutrophils from other neutrophils in human. Direct adhesion between ECCs and neutrophils, especially the ICAMhigh subpopulation, promote the survival of each other – forming a symbiotic relationship. In contrast, MCCs are thwarted by neutrophils due to decreased cell adhesion and elastase resistance. The ICAM1high neutrophils are known for reverse migration to circulation. The adhesive and reverse migratory properties of ICAM1high neutrophils mediate intravasation of metastatic seeds. These observations were verified in a subset of human TNBCs that unexpectedly enrich non-Hispanic European patients. Thus, we demonstrated a co-evolution through which neutrophils sculpt phenotypes and metastatic behaviors of TNBC, which may preferentially occur in patients of certain race/ethnicity.
• 🔗 查看原文

4. ⭐ GSE284277 中性粒细胞与上皮样癌细胞的共生粘附塑造肿瘤微环境并促进转移[1] [共培养]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、tumor microenvironment
• 📝 描述：Contributors : Ling Wu ; Xiang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeutrophils play complicated roles in tumor progression. Examination of several murine triple negative breast cancer (TNBC) models revealed nearly opposite impact of neutrophils on epithelial-like vs. mesenchymal-like cancer cells (ECCs vs. MCCs). Interaction with ECCs upregulates ICAM1 in neutrophils, a feature that also distinguishes tumor-infiltrating neutrophils from other neutrophils in human. Direct adhesion between ECCs and neutrophils, especially the ICAMhigh subpopulation, promote the survival of each other – forming a symbiotic relationship. In contrast, MCCs are thwarted by neutrophils due to decreased cell adhesion and elastase resistance. The ICAM1high neutrophils are known for reverse migration to circulation. The adhesive and reverse migratory properties of ICAM1high neutrophils mediate intravasation of metastatic seeds. These observations were verified in a subset of human TNBCs that unexpectedly enrich non-Hispanic European patients. Thus, we demonstrated a co-evolution through which neutrophils sculpt phenotypes and metastatic behaviors of TNBC, which may preferentially occur in patients of certain race/ethnicity.
• 🔗 查看原文

5. GSE321694 SETD2 促进 PAF1C 与延伸中的 RNA Pol II 的相互作用，并且是神经元分化所必需的 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：Neuronal、scRNA
• 📝 描述：Contributor : Tuncay BaubecSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChromatin modifications are relevant for mammalian development, and their aberrant deposition is associated with human disease. While the mechanisms that deposit and remove these modifications have been largely elucidated, their role in regulating gene activity during cellular differentiation has yet to be completely understood. By differentiating a panel of mouse embryonic stem cells lacking major chromatin regulators towards neuronal cells, we identified their requirement at different stages of cellular differentiation. We show that the H3K36me3 methyltransferase SETD2 is important for the establishment of neuronal gene expression during late stages of differentiation but is dispensable once the cells have fully differentiated. While we don’t find evidence for a requirement of the histone methyltransferase activity in this process, we identify an indirect role of SETD2 in mediating interactions between the PAF1 complex and the elongating RNA Pol II, which could be required for optimal transcriptional processivity of neuronal genes.
• 🔗 查看原文

6. GSE317913 DADA通过增强CD8+ T细胞干性抑制肿瘤生长

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、T cell
• 📝 描述：Contributors : Mingyue Bi ; Fei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo elucidate the mechanism by which DADA enhances the CD8+ T cell anti-tumor immune responses, we performed signal-cell RNA-sequencing (scRNA-seq) on tumor-infiltrating CD45+ T cells isolated from ctrl- or DADA-treated MC38-bearing mice.In this study, we found that diisopropylamine dichloroacetate (DADA) enhances CD8⁺ T cell-mediated anti-tumor immunity and promotes the accumulation of Tpex cells in the tumor microenvironment. Mechanistically, DADA promotes the conversion of pyruvate to acetyl-CoA by inhibiting pyruvate dehydrogenase kinase, thereby increasing oxidative phosphorylation (OXPHOS) levels and mitochondrial fitness, and ultimately enhancing the stemness of CD8⁺ T cells. In mouse models, DADA treatment significantly improves the efficacy of PD-1 blockade. Furthermore, the addition of DADA to the in vitro expansion system of chimeric antigen receptor (CAR)-T cells confers stemness characteristics to the cells, thereby enhancing their anti-tumor efficacy.
• 🔗 查看原文

7. GSE317219 人类成人口腔内成纤维细胞驱动的免疫调节的整合单细胞和空间蛋白质转录组学图谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、spatial
• 📝 描述：Contributors : Bruno F Matuck ; Khoa L Huynh ; Diana Pereira ; Quinn T Easter ; XiuYu Zhang ; Meik Kunz ; Nikhil Kumar ; Aditya Pratapa ; Brittany T Rupp ; Ameer Ghodke ; Alexander V Predeus ; Alexandre Fernandes ; Lili Szabó ; Stefan Hartmann ; Nadja Harnischfeger ; Zohreh Khavandgar ; Margaret Beach ; Paola Perez ; Benedikt Nilges ; Maria M Moreno ; Kang I Ko ; Rohit Singh ; Purushothama Rao Tata ; Sarah A Teichmann ; Adam Kimple ; Sarah Pringle ; Kai Kretzschmar ; Blake M Warner ; Inês Sequeira ; Jinze Liu ; Kevin M ByrdSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe immunoregulatory architecture of human oral tissues remains poorly defined despite their central role as barrier interfaces. We present the first integrated single-cell and dual-platform, spatial-proteotranscriptomic atlas of oral tissues, profiling >250,000 single-cell transcriptomes and >4 million spatially-resolved cells across 13 niches. Using our AI-enabled AstroSuite (TACIT, Constellation, STARComm, hist2omics), we defined tissue cellular neighborhoods (TCNs) and multicellular interaction modules (MCIMs) in health, revealing peri-epithelial fibroblast-centered hubs enriched for effector cytokines. We harmonized eight fibroblast subtypes (universal, immune, peri-epithelial, peri-vascular, peri-neural, APC-like, stress-responsive, and myofibroblasts) with stress-responsive subtypes partitioning between mucosae (Type I) and glands (Type II). Spatial multiomics mapped spatially recurrent receptor–ligand programs and identified mucosal stress-responsive fibroblasts as putative immunoregulatory hubs. In chronic periodontitis, niche-aware integration of healthy and diseased datasets revealed rewiring of fibroblast phenotypes and ligand::receptor networks into interdigitated inflammatory and reparative niches. Disease neighborhoods exhibited fragmentation, expansion of MHC-I⁺, MHC-II⁺, and PD-L1⁺ fibroblasts, and predicted spatial engagement with T cells at ectopic lymphoid structures. Drug2Cell analysis highlighted druggable stromal::immune networks. Together, this proteotranscriptomic atlas positions fibroblasts as central architects of structural immunity in human oral tissues and establishes a scalable framework for precision targeting of stromal::immune ecosystems across other barrier organs in health and chronic disease.
• 🔗 查看原文

8. GSE316492 伴侣犬恶性乳腺肿瘤血液样本中的DNA甲基化：表观遗传学视角

• ✍️ 作者：未知作者
• 🏷️ 关键词：epigenetic、methylation
• 📝 描述：Contributors : Keunhwan Jang ; Geunwoo Jeon ; Jungwoo Han ; Seung-Bum Cho ; Suyeon Kim ; Songju Oh ; Ha-Jung KimSeries Type : Methylation profiling by genome tiling arrayOrganism : Canis lupus familiaris ; Homo sapiensCanine mammary gland tumors (cMGTs) are neoplasms arising from mammary epithelial or supporting tissues and account for approximately 50–70% of all tumors in intact female dogs. Epigenetic regulation, such as DNA methylation, has been investigated to elucidate the molecular mechanisms of cMGTs. This study explored whether DNA methylation alterations in peripheral blood reflect tumor-related epigenetic patterns. Twenty client-owned dogs were enrolled, including ten with cMGTs and eight healthy controls. Although no individual genes reached statistical significance after multiple testing correction, exploratory gene ontology (GO) analysis identified 22 biological processes showing potential enrichment, including two hypermethylated and twenty hypomethylated regions. Comparative analysis between canine and human datasets revealed 91 overlapping hypomethylated genes displaying consistent patterns across both species. The top enriched GO terms were morphogenesis of an epithelium and cell growth. These findings provide exploratory evidence that blood-based DNA methylation profiling may capture tumor-associated epigenetic alterations in cMGTs.
• 🔗 查看原文

9. GSE316194 原位 PDAC 肿瘤中 WNT 反应性和 WNT 分泌性癌细胞群的批量 RNA 测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、RNA-seq
• 📝 描述：Contributors : Stefan R Torborg ; Jung Yun Kim ; Tuomas TammelaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) exhibits pronounced intratumoral heterogeneity driven in part by WNT signaling dynamics. To characterize transcriptional differences among distinct WNT signaling states in vivo, we performed bulk RNA sequencing of fluorescence-activated cell sorting (FACS)-isolated cancer cell populations from orthotopic PDAC tumors. WNT-responsive (WNT-R), WNT-secreting (WNT-S), double-positive (WNT-R/S), and double-negative (DN) cancer cells were isolated from KPC 7TCF-eGFP/Porcn-DMA reporter tumors. RNA libraries were prepared using the SMARTerSeq2 protocol and sequenced from four biological replicates per group. Differential gene expression analysis revealed enrichment of canonical WNT/β-catenin target genes in WNT-R cells, elevated Porcn expression in WNT-S cells, and intermediate transcriptional profiles in WNT-R/S cells, validating the fidelity of the reporter system in vivo. This dataset provides a resource for dissecting WNT-dependent cancer cell states and signaling interactions in PDAC.
• 🔗 查看原文

10. GSE312230 Stag2-粘连蛋白在调节抗体类别转换重组中起主导作用[RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：antibody、RNA-seq
• 📝 描述：Contributors : Xuefei Zhang ; Zhichen Wan ; Leyi Yu ; Zifan YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusClass switch recombination (CSR) in B lymphocytes generates different functional antibody isotypes and cohesin-mediated chromatin loop extrusion is proposed to promote CSR. However, the detailed regulatory mechanism of cohesin in CSR is largely lacking. Here, we revealed that Stag2 is a specific cohesin regulator playing critical roles in promoting CSR. Stag2-deficiency, not Stag1-deficiency, significantly decreases the interaction of acceptor CH with CSR center, leading to decreased transcription of acceptor CH and impaired CSR. Notably, Stag2 could compensate for Stag1 binding within Igh upon Stag1-deficiency, while Stag2-deficiency significantly decreases Stag1 binding within Igh. Interestingly, Stag2 expression is higher than Stag1 during germinal center (GC) B cell development and Stag2 expression has a high correlation with CSR level in GC B cells upon vaccination and SARS-Cov-2 infection. Furthermore, Stag2 is also highly expressed in GC B cells within different tumors, corresponding to the high level of CSR in tumors. Altogether, our findings uncover the unrecognized specific roles of Stag2 in regulating CSR during physiological and pathological immune responses.
• 🔗 查看原文

💡 该来源还有 72 条内容，详见 文末

详细内容（全部4条）

1. 太空转录组学：一种用于太空生物学研究的RNA测序流程

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、transcriptomics
• 📝 描述：RNA sequencing supports space biology research by enabling transcriptome-wide analysis of gene expression changes associated with spaceflight and adaptation to space environments…
• 🔗 查看原文

2. 麻省理工学院科学家发现一种有助于肠道自我修复的氨基酸。

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?
• 📝 描述：MIT scientists have identified cysteine — an amino acid found in foods like meat, dairy, beans, and nuts — as a potent trigger for intestinal repair. In mice, a cysteine-rich diet activated immune cells that released healing signals, helping stem cells rebuild damaged intestinal tissue after radiation exposure. Researchers say the discovery could eventually lead to new dietary therapies for cancer patients suffering from treatment-related gut damage.
• 🔗 查看原文

3. 科学家发现了一种隐藏的阿尔茨海默病诱因并将其关闭。

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：A newly identified enzyme called IDOL could become a major new target in the fight against Alzheimer’s disease. Researchers found that removing it from neurons sharply reduced amyloid plaques and improved key brain processes linked to resilience and communication between cells. The discovery may lead to future treatments that go beyond slowing Alzheimer’s — potentially helping protect the brain from further decline.
• 🔗 查看原文

4. 科学家发现，为何阿尔茨海默病对女性的影响远大于男性。

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：Women may be especially sensitive to the effects of common dementia risk factors, according to a new UC San Diego study of over 17,000 adults. Researchers say tailoring prevention strategies specifically for women could be key to reducing Alzheimer’s risk.
• 🔗 查看原文

• GSE312228 Stag2-粘连蛋白在调节抗体类别转换重组中起主导作用[ChIP-Seq]
• GSE308771 水稻组蛋白变体 H2A.X 在抑制活性 H3K4me3 标记沉积和限制 H2A.W 掺入方面的独特发育相关作用 [RNA-Seq]
• GSE308770 水稻组蛋白变体 H2A.X 在抑制活性 H3K4me3 标记沉积和限制 H2A.W 掺入方面的独特发育相关作用 [ChIP-Seq]
• GSE303446 超越 CD30 靶向：Brentuximab Vedotin 通过抑制 BCL2 克服耐药性，在蕈样肉芽肿中触发免疫原性细胞死亡和抗肿瘤免疫
• GSE303306 MLLT3 YEATS结构域是组蛋白修饰（H3K9/18/27ac/cr）和非编码RNA（7SK）的双重识别器，连接表观遗传和RNA信号通路以调控造血过程。
• GSE296463 BCL7A 中的 N 端精氨酸锚定微调染色质重塑并驱动 DLBCL 中的肿瘤抑制 [ATAC-seq]
• GSE296461 BCL7A 中的 N 端精氨酸锚定微调染色质重塑并驱动 DLBCL 中的肿瘤抑制 [RNA-seq]
• GSE287544 组蛋白修饰参与GPX4介导的三酰甘油代谢相关基因的调控
• GSE278957 SETD2 促进 PAF1C 与延伸的 RNA Pol II 相互作用，并且是神经元分化所必需的 [ATAC-Seq]
• GSE278956 SETD2 促进 PAF1C 与延伸的 RNA Pol II 相互作用，并且是神经元分化所必需的 [ChIP-Seq]
• GSE278955 SETD2 促进 PAF1C 与延伸的 RNA Pol II 相互作用，并且是神经元分化所必需的 [RNA-Seq]
• GSE270653 未折叠蛋白传感器 IRE1 对树突状细胞的稳态成熟至关重要 [小 RNA 测序]
• GSE270648 未折叠蛋白传感器 IRE1 对树突状细胞的稳态成熟至关重要 [RNA-seq]
• GSE332555 组蛋白伴侣 Spt6 对组蛋白 H3K36 甲基转移酶 Set2 的调控 [ChIP-Seq]
• GSE331502 组蛋白伴侣 Spt6 对组蛋白 H3K36 甲基转移酶 Set2 的调控 [RNA-seq]
• GSE331487 免疫抑制性髓系细胞通过膜结合的 TGF-β1 依赖性机制诱导间充质样乳腺癌干细胞 [scRNA-seq]
• GSE331483 免疫抑制性髓系细胞通过膜结合的 TGF-β1 依赖性机制诱导间质样乳腺癌干细胞 [RNA-seq]
• GSE303460 颅缝早闭中缝合线干细胞动态的时空单细胞图谱 [scRNA-Seq]
• GSE303247 MLLT3 YEATS 结构域是组蛋白标记 (H3K9/18/27ac/cr) 和非编码 RNA (7SK) 的双重读取器，连接表观遗传和 RNA 信号传导以调节造血作用 [PRO-Seq]
• GSE331127 端粒酶-SUCLG2 信号轴通过保护持久性细胞驱动耐药性 [ATAC-Seq]
• GSE297793 探索种系变异与体细胞突变在前列腺癌进展中的致癌协同作用
• GSE320177 全反式维甲酸抑制 CD8+ T 细胞终末耗竭，从而增强抗 PD-1 治疗胶质母细胞瘤的疗效 [RNA-Seq]
• GSE331520 乳腺癌细胞中lncRNA HOTAIR的保守结构特征
• GSE329372：Rtl1母系敲除小鼠的转录组分析
• GSE327747 石榴酸处理的卵巢癌和正常上皮细胞系的转录组分析
• GSE327663 非洲裔和欧洲裔女性宫颈上皮内瘤变中的表观遗传学改变
• GSE324472 脑室扩大型 Hoatz 基因敲除小鼠海马体的 RNA 测序
• GSE319717 产后乳腺细胞中SEMA7A和SOX9重编程及乳腺癌的意义
• GSE318640 对用 EZA 处理的 RKO 细胞进行转录组分析
• 在培养的第 6 天，收集用 DADA (40 μM) 或等体积的 DMSO 溶剂处理的 GSE317958 CD8+ T 细胞，并进行转录组分析。
• GSE317107 FGF4/HIF-1α轴介导的神经元糖酵解对神经性疼痛的影响
• GSE315912 RNA-seq 分析 Y79 视网膜母细胞瘤细胞中 MYCN 敲低的情况
• GSE314693 PABPC1诱导的PGK1 mRNA稳定化通过抑制内质网应激降低肾细胞癌的细胞凋亡和舒尼替尼敏感性。
• GSE312233 Stag2-黏连蛋白在调节抗体类别转换重组中起主导作用
• GSE312229 Stag2-粘连蛋白在调节抗体类别转换重组中起主导作用[PRO-Seq]
• GSE312227 Stag2-粘连蛋白在调节抗体类别转换重组中起主导作用[CSR-HTGTS-Seq]
• GSE312226 Stag2-粘连蛋白在调节抗体类别转换重组中起主导作用[3C-HTGTS]
• GSE311381 组织驻留单核细胞谱系细胞的细胞组成揭示了炎症性关节炎期间的异质性，图 5 和图 6
• GSE311380 组织驻留单核细胞谱系细胞的细胞组成揭示了炎症性关节炎期间的异质性，图 2 和图 3
• GSE308772 水稻组蛋白变体 H2A.X 在抑制活性 H3K4me3 标记沉积和限制 H2A.W 掺入方面的独特发育相关作用 [smallRNA-Seq]
• GSE303752 猪源细胞外囊泡的 miRNA 测序
• GSE301742 肿瘤坏死因子受体相关因子7通过TWIST1-P2RX1-Ca2+轴促进白血病发生
• GSE301636 敲低环状RNA CircMT-RNR2后人真皮成纤维细胞的全局转录组分析
• GSE299462 REP-1 缺失导致中枢性心脏病患者线粒体能量代谢改变，由糖酵解转向脂质氧化
• GSE299265 先天性心脏病患儿中持续的αβ T细胞效应活性和记忆扩增
• GSE298318 胰腺导管腺癌获得性KRASG12D抑制剂耐药机制的特征分析
• GSE296462 BCL7A 中的 N 端精氨酸锚定微调染色质重塑并驱动 DLBCL 中的肿瘤抑制 [CUT&Tag]
• GSE293886 父系热适应通过 mir-210a 的表观遗传调控增强后代的热适应能力。
• GSE293017 塞托利细胞中的糖原代谢通过乳酸穿梭维持生殖细胞存活 [RNA_maleGPI]
• GSE288480 Arp2/3复合物维持表皮朗格汉斯细胞的基因组完整性和存活
• GSE282218 WBT-DC流程：基于全血转录组学数据的疾病分类
• GSE270655 未折叠蛋白传感器IRE1对树突状细胞的稳态成熟至关重要
• GSE270649 未折叠蛋白传感器 IRE1 对树突状细胞的稳态成熟至关重要 [CITE-seq]
• GSE266221 急性紫外线对雄性和雌性野生型 (SKH-1/SV129/BL6/J) 小鼠和 PPARβ 缺陷型 (SKH-1/SV129/BL6/J PPARD-/-) 同窝小鼠表皮转录组谱的影响。
• GSE263608 通过 PSTK 调节硒蛋白生物合成选择性靶向白血病干细胞 [RNA-Seq]
• GSE332630 多模态单细胞分析揭示尤文氏肉瘤中不同的融合调控转录程序
• GSE325304 抗原特异性 mRNA-LNP 疫苗联合 mTOR 抑制剂可促进 Treg 细胞生成并限制过敏反应
• GSE303344 颅缝早闭症缝合线干细胞动态的时空单细胞图谱
• 利用抗聚糖抗体库实现单细胞糖组和转录组分析 GSE298512
• GSE331479 一夫多妻制蝙蝠的雄性偏向免疫衰老
• GSE331198 视网膜单细胞RNA测序揭示了细胞类型对细菌感染的特异性反应
• GSE329254 端粒酶-SUCLG2信号轴通过保护持续性细胞驱动耐药性
• GSE325003 人类转录组或基因表达
• GSE308782 端粒酶功能障碍策略通过下调SUCLG2克服泛癌中靶向治疗诱导的耐药性持续细胞
• GSE286544 一氧化氮通过选择性剪接驱动蛋白质组多样性 [HEK RNA-Seq]
• GSE286542 一氧化氮通过选择性剪接驱动蛋白质组多样性 [成纤维细胞 RNA-Seq]
• GSE268011 高多重易位测序 (HMTS) 检测 MCF7 和 HEK293T 细胞经不同处理后的易位，以及用 ETO 处理的 NCAPH2 缺陷细胞中的易位。
• GSE203620 小分子 miR-17-92 抑制剂的开发 [RNA-Seq]
• GSE332586 研究发现，尤文氏肉瘤中甲羟戊酸途径的激活揭示了他汀类药物与 BCL-xL 抑制剂之间存在 3D 特异性协同作用。
• GSE328627 临床批准的 HIF-PHI 调节氧化还原代谢、细胞生长和血管生成，且不依赖于 HIF-1α/HIF-2α
• GSE308516 Resf1 是正常胎盘发育和滋养层细胞特异性异染色质构型所必需的 [ChIP-seq]
• GSE308515 Resf1 是正常胎盘发育和滋养层细胞特异性异染色质构型所必需的 [RNA-seq]