详细内容（前10条）

1. ⭐ GSE311461 单细胞转录组学揭示替米沙坦在结直肠癌中的免疫调节作用

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、single-cell、transcriptomics
• 📝 描述：Contributors : Decao Yang ; Ting Zhang ; Xianlong Li ; Yan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTelmisartan, an angiotensin II type 1 receptor blocker with established anti-inflammatory and antihypertensive properties, has been reported to inhibit tumor cell proliferation, yet its impact on the tumor immune microenvironment remains poorly understood. In this study, we evaluated the immunomodulatory effects of telmisartan using a syngeneic MC38 colorectal cancer model in C57BL/6 mice. Daily intragastric administration of telmisartan significantly suppressed tumor growth and reduced endpoint tumor weight compared with controls. To elucidate the underlying mechanisms, we performed single-cell RNA sequencing on tumor-infiltrating CD45⁺ immune cells and revealed a macrophage-dominated immune landscape comprising multiple transcriptionally distinct subclusters. Telmisartan broadly downregulated pro-tumoral and M2-associated macrophage programs, including decreased expression of genes such as Mrc1 and Spp1, while also suppressing cell proliferation-related pathways. In contrast to its overall suppressive impact on macrophages, telmisartan increased the proportion of cytotoxic CD8⁺ T cells, reduced regulatory T cells, and enhanced major histocompatibility complex class I antigen presentation, consistent with an immune-activating effect. These results indicate that telmisartan reshapes the colorectal tumor immune microenvironment by simultaneously attenuating tumor-promoting macrophage activity and augmenting cytotoxic T cell responses. Although exploratory, this study provides a single-cell framework to investigate how angiotensin receptor blockade shapes immune programs, generating testable hypotheses for both cancer immunotherapy combinations and follow-up studies in cardiovascular contexts.
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2. GSE322590 人类 B 细胞发育的表观遗传和转录组特征研究 [多组]

• ✍️ 作者：未知作者
• 🏷️ 关键词：B cell、epigenetic
• 📝 描述：Contributors : Chiara Dionisi ; Audrey Kelly ; Michael J Pitcher ; Sherine H Kottoor ; Alana Dalton ; Lucia Montorsi ; Pawan Dhami ; Michelle Kleeman ; Athul Menon ; Richard Ellis ; Cynthia Bishop ; Jahangir Sufi ; Deena L Gibbons ; Paul Lavender ; Jo SpencerSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis dataset was generated as part of a multi-omics study aimed at investigating human B cells development. The study included bulk and single cell epigenetic methodologies coupled with single cell transcriptomics and proteomics.Data included in this submission were generated using the 10x Chromium Single Cell Multiome ATAC + Gene Expression method to allow simultaneous investigation of epigenetic and transcriptomic features in sorted B cells from human blood. The study demonstrated the emergence of epigenetic differences in B cell subsets at early stages of development that drive divergent developmental paths. Epigenetic features established at early stages are retained in distinct mature cell subpopulations, where they are coupled with transcription of accessible genomic regions. Identified features are retained after cell migration in secondary lymphoid organs.
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3. GSE321688 人类B细胞发育的表观遗传和转录组特征研究

• ✍️ 作者：未知作者
• 🏷️ 关键词：B cell、epigenetic
• 📝 描述：Contributors : Chiara Dionisi ; Audrey Kelly ; Michael J Pitcher ; Sherine H Kottoor ; Alana Dalton ; Lucia Montorsi ; Pawan Dhami ; Michelle Kleeman ; Menon Athul ; Richard Ellis ; Cynthia Bishop ; Jahangir Sufi ; Deena L Gibbons ; Paul Lavender ; Jo SpencerSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis dataset was generated as part of a multi-omics study aimed at investigating human B cells development. The study included bulk and single cell epigenetic methodologies coupled with single cell transcriptomics and proteomics. Data included in this submission were generated using the 10x Genomics single-cell RNA, V(D)J Sequencing and Protein feature barcoding method on sorted B cells from adult human blood.The study demonstrated the emergence of epigenetic differences in B cell subsets at early stages of development that drive divergent developmental paths. Epigenetic features established at early stages are retained in distinct mature cell subpopulations, where they are coupled with transcription of accessible genomic regions. Identified features are retained after cell migration in secondary lymphoid organs.
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4. GSE310998 外周血转录组学揭示抽动症和图雷特综合征中黏连蛋白-染色质和免疫失调

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、transcriptomics
• 📝 描述：Contributors : Shrujna Patel ; Velda Han ; Brooke Keating ; Hiroya Nishida ; Jessica Hayes ; Erica Tsang ; Nader Aryamanesh ; Lee Marshall ; Shekeeb Mohammad ; Russell DaleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTic disorders and Tourette syndrome are neurodevelopmental disorders arising from interplay between genetic and environmental factors. Gene regulation, via chromatin and other epigenetic mechanisms, may provide a key link between gene-environment interactions, yet remains under-investigated in tic disorders. We performed bulk RNA sequencing of peripheral blood from 28 children with tic disorders (19 with Tourette syndrome, aged 6-16, median age 10 years, 18 (64%) males) compared to 20 matched healthy controls (aged 1-25, median age 11 years, 13 (65%) males). Differentially expressed genes (DEGs) were identified following false discovery rate (FDR) correction, and pathway enrichment was analysed using Gene Set Enrichment Analysis (GSEA) based on Gene Ontology (GO) and Reactome databases. To assess convergence between peripheral and brain molecular changes, DEGs were compared with published post-mortem brain transcriptomic data from individuals with Tourette syndrome. A total of 4,169 DEGs (FDR < 0.05) were identified in blood transcriptomic analysis, with 2,192 upregulated and 1,977 downregulated genes. The blood transcriptomic findings included upregulation of chromatin- and cohesin-related pathways, immune activation, and cell signalling, and downregulation of translational machinery, mitochondrial function, and DNA methylation. Comparison with post-mortem brain transcriptomic data revealed 30 overlapping genes, including 20 that were concordantly upregulated in both blood and brain, predominantly associated with immune, signalling, and cellular stress responses. Our data points to gene regulation and chromatin biology as a nexus where genetic risk and environmental exposures converge in tic disorders and related neurodevelopmental disorders, and highlight epigenetic and immune-targeting therapies as promising avenues for disease modification.
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5. 在卵巢癌小鼠模型中，与4-1BB相比，GSE303863 CD28共刺激结构域可增强CER T细胞疗法的疗效

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、T cell
• 📝 描述：Contributors : Nolan Beatty ; Min Ma ; Payal Goala ; Shannon McSain ; Sae Bom Lee ; Justin C Boucher ; Meredith L Stone ; Eduardo Cortes ; Jianmin Wang ; Jun Qu ; Marco L DavilaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOvarian cancer remains a significant cause of cancer-related mortality, with epithelial ovarian cancer (EOC) being the most common subtype. Despite advances in treatment, the 5-year survival rate for late-stage EOC remains low due to factors such as tumor heterogeneity and an immunosuppressive tumor microenvironment (TME). This study investigates the therapeutic potential of chimeric endocrine receptor (CER) T cells engineered to express follicle stimulating hormone (FSH) in a syngeneic mouse model of EOC expressing follicle stimulating hormone receptor (ID8-FSHR). We compared two different co-stimulatory domains—CD28ζ and 4-1BBζ—in FSH-CER T cells and found that FSH-CD28ζ CER T cells exhibited enhanced cytotoxicity, proliferation, and cytokine secretion in vitro and in vivo. In the ID8-FSHR mouse model, FSH-28ζ CER T cells significantly reduced tumor burden and extended survival compared to FSH-hBBζ and control CER T cells. However, the therapeutic efficacy was compromised by T cell exhaustion, with all FSH-CER T cells expressing high levels of exhaustion markers after 7 days. In summary, incorporating a CD28ζ costimulatory domain enhances the efficacy of FSH-CER T cells, highlighting their therapeutic potential in ovarian cancer and supporting the development of strategies to mitigate immune exhaustion.
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6. GSE284254 基于DNA的小鼠血液免疫谱分析及甲基化细胞计数反卷积

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、methylation
• 📝 描述：Contributors : Samuel R Reynolds ; Hannah G Stolrow ; Min Kyung Lee ; Steven C Pike ; Fred Kolling ; Jacqueline Y Channon ; Daniel W Mielcarz ; Gary A Ward ; Jennifer Fields ; Lucas A Salas ; Brock C ChristensenSeries Type : Methylation profiling by genome tiling arrayOrganism : Mus musculusCell-type-specific patterns of DNA methylation have been leveraged to develop methods for accurate and reproducible DNA-based cell typing in human blood and other biospecimens. Recently developed and standardized genome -scale DNA methylation arrays for mus musculus offer an instrument for quantifying cellular composition with epigenetic signatures specific to each cell type. We present a novel murine immune cell deconvolution tool that leverages DNA methylation profiles FlowSorted.Blood.IlluminaMouseMethylation. Separately from BALB/c and C57BL/6 mice, we used flow cytometry to purify polymorphonuclear neutrophil (PMN), monocyte, B-lymphocyte, natural killer, and CD4+ and CD8+ T-cells. Genome-scale DNA methylation was measured with the Illumina MouseMethylation BeadChip array at >285,000 CpG loci in purified cells for reference profile development. For testing and validation, DNA methylation was measured in both eye bleed and terminal blood whole blood samples from four mouse strains. To benchmark and determine accuracy of reference libraries for DNA methylation cell type deconvolution, flow cytometry of independent whole blood samples from four mouse strains was used. The Identifying Optimal Libraries (IDOL) algorithm identified an optimal reference library of 300 CpGs for deconvolution with RMSE values across testing and validation samples of <1.7 for all cell types except B lymphocytes (RMSE<2.75). This methylation cytometry tool for mice offers the ability to conduct DNA-based immune profiling in archival samples and reduce confounding from cell type heterogeneity in molecular studies of whole blood samples.
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7. GSE331029 IRF3-POLR2G 轴抑制肝脏 FGF21 和代谢转录程序 [RNA-seq 肝脏 IRF3-2D]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolic、RNA-seq
• 📝 描述：Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understood. Here we show that IRF3, a master regulator of innate immunity that is activated during alcohol-associated liver disease, suppresses the hepatokine FGF21 and broader metabolic gene programs through a non-canonical transcriptional mechanism. IRF3 does not directly occupy metabolic gene loci but instead transcriptionally induces POLR2G, a core RNA polymerase II subunit, through promoter-proximal interferon-stimulated response elements. Elevated POLR2G selectively accumulates at metabolic gene promoters, reduces RNA polymerase II recruitment, and represses transcription of fatty acid oxidation and lipid metabolism genes. This regulatory axis operates in vivo, is conserved from yeast to mammals, and is evident in human alcohol-associated liver disease. These findings identify an IRF3-POLR2G axis that repurposes core transcriptional machinery to coordinate a metabolic-to-inflammatory transcriptional switch in the liver.
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8. GSE331028 IRF3-POLR2G 轴抑制肝脏 FGF21 和代谢转录程序 [RNA-seq 肝脏 POLR2G]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolic、RNA-seq
• 📝 描述：Contributors : Neethu S Alex ; Ashutosh Shukla ; Suraj J PatelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory signaling in the liver reshapes numerous transcriptional programs, but the mechanisms by which innate immune pathways actively repress metabolic gene expression remain poorly understood. Here we show that IRF3, a master regulator of innate immunity that is activated during alcohol-associated liver disease, suppresses the hepatokine FGF21 and broader metabolic gene programs through a non-canonical transcriptional mechanism. IRF3 does not directly occupy metabolic gene loci but instead transcriptionally induces POLR2G, a core RNA polymerase II subunit, through promoter-proximal interferon-stimulated response elements. Elevated POLR2G selectively accumulates at metabolic gene promoters, reduces RNA polymerase II recruitment, and represses transcription of fatty acid oxidation and lipid metabolism genes. This regulatory axis operates in vivo, is conserved from yeast to mammals, and is evident in human alcohol-associated liver disease. These findings identify an IRF3-POLR2G axis that repurposes core transcriptional machinery to coordinate a metabolic-to-inflammatory transcriptional switch in the liver.
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9. GSE296894 用人血浆或富血小板血浆 (PRP) 处理的口腔鳞状细胞癌细胞 PE/CA-PJ41 的 RNA 测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、sequencing
• 📝 描述：Contributors : Antoine Galmiche ; Lucie Veloso de Carvalho ; Zuzana Saidak ; Claire DabonnevilleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPlatelets are involved in tumor progression by influencing cancer cell behavior through molecular and cellular interactions. In this study, we investigated the transcriptional response of PE/CA-PJ41 OSCC cells upon exposure to human plasma or PRP. Three experimental conditions were analysed: control, treated with 10% human plasma and 10% Platelet-Rich Plasma (PRP). After 48h, total RNA was extracted, and libraries were generated using polyA selection prior to paired-end sequencing on the Illumina NovaSeq X Plus platform. Twelve samples in total (four biological replicates per condition) were analyzed. The aim of this study is to compare the impact of plasma and PRP on gene expression in OSCC PJ41 cells, and to identify transcriptional changes specifically associated with platelets. This dataset is intended to serve as a ressource for understanding how platelets shape the tumor microenvironment and influence OSCC cell behavior at the molecular level.
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10. GSE291997 转录组和蛋白质组分析揭示丝状真菌中硒转化的分子机制

• ✍️ 作者：未知作者
• 🏷️ 关键词：transcriptome、proteome
• 📝 描述：Contributors : Pallabi Saha ; Mary Sabuda ; Marissa Macchietto ; Arthur Eschenlauer ; Jacqueline Mejia ; LeeAnn Higgins ; Todd Markowski ; Cara SantelliSeries Type : Expression profiling by high throughput sequencingOrganism : Paraphaeosphaeria sporulosaSelenium (Se) is an essential element for most organisms, yet outside of a narrow concentration range of sufficiency, both Se deficiency and Se toxicity are critical global problems. Diverse organisms are capable of promoting Se reduction-oxidation (redox) and methylation reactions that transform Se and alter its chemical speciation, bioavailability, and toxicity. Se transformation mechanisms in environmentally-relevant filamentous fungi, however, are poorly resolved. In this study using the non-model Ascomycota Paraphaeosphaeria sporulosa AP3s5-JAC2a, comparative transcriptomics, proteomics, and geochemical analyses were employed to identify the primary genes and proteins playing a role in Se transformation. Upon exposure to aqueous selenite (Se(IV)), altered expression profiles were assessed over time in relation to changes in Se bioproducts, such as intracellular and extracellular Se(0) nanoparticles, intracellular organoselenium compounds, and volatile, methylated Se compounds. Results showed that selenite uptake can occur via upregulated ABC and MFS transporters, and multiple mechanisms for Se(IV) reduction and Se(0) nanoparticle stabilization, such as glutathione reductase and oxidoreductases enzymes, were identified. Multiple methyltransferases that promote Se volatilization and pathways for vesicle formation and exocytosis, likely for Se(0) export, were also identified. Notably, proteins involved in oxidative stress defense (e.g., catalase, peroxidase, superoxide dismutase) were induced by Se exposure. These data contribute to a more complete understanding of previously hypothesized or unresolved mechanisms behind Se transformations in filamentous fungi. On a global scale, this work sheds new light on ecological strategies for detoxification and reveals the genetic mechanisms required for biotechnological applications of fungal-produced Se products.
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1. 科学家表示，每日服用多种维生素可能有助于延缓衰老。

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging
• 📝 描述：A daily multivitamin may help slow biological aging, according to researchers studying older adults in a large clinical trial. After two years, participants taking multivitamins showed slower aging in several DNA-based “epigenetic clocks,” with the effect equal to about four months less biological aging. People who started out biologically older than their actual age appeared to benefit the most. The findings hint that a simple supplement could play a role in healthier aging.
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2. 结肠癌在年轻人中的发病率正在上升，但医生们尚未完全了解其原因。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Colorectal cancer is increasingly showing up in younger adults, with cases now appearing in people as young as their thirties — often with no family history or warning signs. A major Swiss study analyzing nearly 100,000 cases over four decades found that diagnoses in people under 50 have been steadily climbing, even as rates fall among older adults thanks to screening programs. Researchers say younger patients are also more likely to be diagnosed late, after the cancer has already spread.
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3. 一位研究生的奇思妙想引发了衰老研究领域的一项重大突破。

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging
• 📝 描述：A casual conversation between graduate students helped spark a breakthrough in aging research at Mayo Clinic. Researchers discovered that tiny synthetic DNA molecules called aptamers can selectively attach to senescent “zombie cells,” which are linked to aging, cancer, and neurodegenerative disease. The method could eventually help scientists identify and target these cells in living tissue with far greater precision.
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• GSE326191 人类B细胞表观遗传特征的研究
• GSE326004 血管紧张素II 1型受体阻滞剂通过修复紧密连接抑制胃癌转移
• GSE315572 配体刺激下人 PMA 分化的 THP-1 细胞中 RXR 结合模式 [RNA-seq]
• GSE315571 配体刺激下人 PMA 分化的 THP-1 细胞中 RXR 结合模式 [ChIP-seq]
• GSE296767 RNA-seq 分析 T17、JHU-083 和对照组的 BMDM 细胞
• GSE285553 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_SW1783_batchE
• GSE285552 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_SW1783_batchD
• GSE285551 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_SW1783_batchC
• GSE285550 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_SW1783_batchB
• GSE285549 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_SW1783_batchA
• GSE285423 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批_HT29_批次E
• GSE285422 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_HT29_batchD
• GSE285421 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批_HT29_批次C
• GSE285420 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批_HT29_B
• GSE285418 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批_HT29_批次A
• GSE284439 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_A549_batchE
• GSE284438 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_A549_batchD
• GSE284437 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_A549_batchC
• GSE284436 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_A549_batchB
• GSE284435 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_third_A549_batchA
• GSE281076 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批HepG2细胞
• GSE281075 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批HepG2细胞D
• GSE281074 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批HepG2细胞C
• GSE281073 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批HepG2细胞B组
• GSE281072 中药数字化转型：基于气相关汤剂及组成中药诱导转录组测序的生物实体数据转换_第三批HepG2细胞A组
• GSE256011 斑马鱼颅神经嵴单细胞多组学研究
• GSE324012 代谢脆弱性是母乳喂养抗肿瘤作用的目标
• GSE318521 一种口服活性双重 CBP/p300 降解剂靶向多发性骨髓瘤的核心依赖性 [ATAC-seq]
• GSE316690 3-羟基丙酸通过GAPDH羧乙基化作用将炎症巨噬细胞的糖酵解转化为线粒体氧化。
• GSE316416 解析多梳蛋白复合物以提高表型选择性 [RNA-Seq]
• GSE310921 利用器官移植溶液保存骨骼肌用于细胞和空间转录组分析
• GSE302306 健康对照组和接受心脏手术并出现血管麻痹和感染性休克综合征的患者CD66b+中性粒细胞在多个时间点的转录组分析
• GSE265952 CDK2抑制剂在CDK4/6抑制剂耐药的HR阳性乳腺癌中的临床疗效依赖于p53，但与RB无关
• GSE331036 IRF3-POLR2G轴抑制肝脏FGF21和代谢转录程序
• GSE331026 IRF3-POLR2G 轴抑制肝脏 FGF21 和代谢转录程序 [PRO-seq]
• GSE331025 IRF3-POLR2G 轴抑制肝脏 FGF21 和代谢转录程序 [CUT&Tag 肝脏 POLR2G]
• GSE331024 IRF3-POLR2G 轴抑制肝脏 FGF21 和代谢转录程序 [CUT&Tag 肝脏 IRF3-2D]
• GSE331023 IRF3-POLR2G 轴抑制肝脏 FGF21 和代谢转录程序 [CUT&Tag 肝细胞 IRF3-2D]
• GSE330622 CSF2 敲低改变 BCPAP 乳头状甲状腺癌细胞的基因表达谱
• GSE330610 外源性 24nt siRNA 通过启动子 DNA 甲基化和 H3K9me2 沉积诱导 AGO4A 依赖性沉默
• GSE330530 先天免疫受体 Toll-1 将慢性光应激转化为神经胶质细胞吞噬作用
• GSE330238 背根神经节 (DRG) 神经元的批量 RNA 测序，包含 3 种条件
• GSE329311 B细胞受体介导的CLL细胞干扰素反应扩增
• GSE329086 秀丽隐杆线虫中MYRF-1转录因子的ChIP-seq分析
• GSE297274 小分子 MYC 抑制剂通过抑制 c-Myc 介导的糖酵解来限制卵巢肿瘤的生长
• GSE296799 来自黑色素瘤癌相关成纤维细胞模型的细胞外囊泡诱导脑微血管细胞发生与转移前微环境启动一致的变化。
• GSE267697 新鲜分离的人脐带血造血干细胞和多能祖细胞的RNA测序分析
• GSE328229 高生长和低生长太平洋鲍鱼（Haliotis discus hannai）的转录组分析
• GSE325335 RNA-seq 分析外周血 Treg 细胞与各种组织中的 Treg 细胞。
• 根据 CD38 强度将人外周血 Treg 细胞分为四个相等组分，进行 GSE325333 RNA-seq 分析
• GSE325329 不同极化条件下吞噬凋亡 Treg 或常规 CD4⁺ T (Tconv) 细胞的巨噬细胞的转录组分析 [RNA-Seq]
• GSE268853 保守的转录回路调控心脏成纤维细胞介导的纤维化