详细内容（前10条）

1. ⭐ GSE301180 高级别浆液性卵巢癌 (HGSOC) 患者的输卵管、肿瘤和 PBMC 样本的全基因组测序和 DigiPico [WGS/DigiPico]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、sequencing、genome
• 📝 描述：Contributors : Luyao Wang ; Breeshey Roskams-Hieter ; Nancy Zaarour ; Ahmed AhmedSeries Type : OtherOrganism : Homo sapiensThe fallopian tube (FT) has been proposed as a potential site of origin for high-grade serous ovarian cancer (HGSOC), supporting investigation of genomic alterations across matched tissues.This dataset includes whole-genome sequencing (WGS) and DigiPico data from matched samples, including peripheral blood mononuclear cells (PBMCs), fallopian tube tissue, and tumor tissue from HGSOC patients.The data support analysis of germline and somatic variants, copy number alterations (CNAs), and neoantigen prediction across matched sample types. This submission contains the WGS data DigiPico data associated with this study.
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2. ⭐ GSE301179 高级别浆液性卵巢癌患者卵巢肿瘤样本的批量 RNA 测序 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、sequencing、RNA-seq
• 📝 描述：Contributors : Luyao Wang ; Breeshey Roskams-Hieter ; Nancy Zaarour ; Ahmed AhmedSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) is thought to originate from the fallopian tube (FT), highlighting the importance of studying molecular features across tumor samples.This dataset contains bulk RNA sequencing data from tumor samples of HGSOC patients. The data can be used for driver mutations and copy number alterations (CNAs) profiling and analysis of gene expression patterns, including regions relevant to HLA typing.This submission contains bulk RNA sequencing data associated with this study.
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3. ⭐ GSE326968 慢性肺移植功能障碍中IRF7依赖性通路的空间转录组学

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、pathway
• 📝 描述：Contributors : Banday Mudassir ; Rahman Mizanur ; Goda Yasufumi ; Naito Tatsuhiko ; Potter Andrew ; Mallidi Haripriya ; Surolia Ranu ; Lee Stefi ; Rehman Rakshinda ; Loor Gabriel ; Hayes Don ; Sharma NirmalSeries Type : OtherOrganism : Homo sapiensChronic lung allograft dysfunction (CLAD) remains a major barrier to long-term survival after lung transplantation. This study investigates the role of the type I interferon master regulator IRF7 in virus-induced airway fibrogenesis. Using NanoString GeoMx digital spatial profiling, we performed whole transcriptome spatial analysis of human lung tissue from CLAD, non-CLAD transplant, and non-transplanted normal donor lungs to characterize the spatial gene expression landscape associated with IRF7-dependent fibrotic pathways.
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4. ⭐ GSE294759 空间转录组学在类器官中的应用：高分辨率空间全转录组基准数据集

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptome、transcriptomics
• 📝 描述：Contributors : Maria Rosaria Nucera ; Natalie Charitakis ; Ryan F Leung ; Anna Leichter ; Natasha Tuano ; Marzena Walkiewicz ; Vallari Sawant ; Lynn Rowley ; Michelle Scurr ; Pei X Er ; Ker S Tan ; Rebecca Sutton ; Feroz Ahmad ; Ritika Saxena ; Alexander Maytum ; Declan L Turner ; Holly K Voges ; Hieu T Nim ; Kira X Sun ; Bicheng Yang ; Nick L Li ; Gareth Ball ; Andrew G Elefanty ; Shireen R Lamande’ ; Kynan T Lawlor ; Jessica M Vanslambrouck ; Richard J Mills ; Elizabeth S Ng ; Edouard G Stanley ; Rhiannon B Werder ; Melissa H Little ; David A Elliot ; Enzo R Porrello ; Maree C Faux ; David D Eisenstat ; Silvia Velasco ; Fernando J Rossello ; Mirana RamialisonSeries Type : OtherOrganism : Homo sapiens ; Mus musculusStem cell-derived organoids hold promise to model tissue-specific disease. To enable this, it is crucial to assess how transcriptional signatures, cellular organisation and composition of organoids compare to in vivo counterparts. However, spatial transcriptomics has been challenging to apply to organoids to elucidate regional molecular identity. This study presents the first systematic profiling of multiple stem cell derived organoid models (brain, heart muscle, heart valve, kidney, lung, cartilage, and haematopoietic) with Stereo-seq, a full transcriptome, spatial assay using on-chip in situ RNA capture. It describes assay optimisation for characterisation, use of multiple organoid samples on a single chip, assesses limitations in RNA capture efficiency compared to reference tissues. Furthermore, it introduces a bespoke analysis method that partitions samples into regions for characterisation. These findings inform future works to characterise organoids using spatial transcriptomics, providing insights in optimising RNA capture of multiple organoids across a chip and regional analysis.
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5. ⭐ GSE327098 EZH2阻断通过破坏乳腺癌的代谢和DNA修复网络逆转阿霉素耐药性

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、metabolic、resistance
• 📝 描述：Contributors : Xiaomin Wang ; Yunxiao Mai ; Yuhang Ding ; Wenlong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Doxorubicin (DOX) resistance remains a major obstacle to effective chemotherapy in breast cancer. However, the pharmacologically actionable regulators sustaining this resistant phenotype and its therapeutic vulnerabilities remain incompletely defined. Methods: DOX-resistant breast cancer cell models were established and treated with the EZH2 inhibitors tazemetostat or GSK126, alone or in combination with DOX. Cell viability, oxidative stress, DNA damage, and mitochondrial function were assessed in vitro. Transcriptomic profiling was performed to identify pathway alterations. A pH-responsive liposomal system for delivery of DOX and tazemetostat was developed and evaluated in vivo. Results: EZH2 was highly expressed in breast cancer and correlated with poor clinical outcomes. DOX treatment induced adaptive upregulation of EZH2 in both sensitive and resistant cells. Pharmacological inhibition of EZH2 markedly restored DOX sensitivity and exhibited strong synergistic cytotoxicity in resistant models. EZH2 blockade enhanced DOX-induced oxidative stress and DNA damage, with concomitant suppression of multiple DNA repair pathways and increased γH2AX accumulation. Transcriptomic and functional analyses revealed disrupted mitochondrial function and energy metabolism, characterized by loss of mitochondrial membrane potential and ATP depletion. In vivo, combined EZH2 inhibition and DOX significantly suppressed tumor growth, while pH-responsive liposomal delivery further enhanced antitumor efficacy and reduced systemic toxicity. Conclusion: EZH2 is a critical determinant of DOX resistance in breast cancer by sustaining DNA damage tolerance and metabolic homeostasis. Pharmacological targeting of EZH2 in combination with DOX represents a rational strategy to overcome chemoresistance in breast cancer.
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6. ⭐ GSE326942 空间转录组学将海马突触重塑与突触核蛋白病中的小胶质细胞吞噬作用联系起来

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Min-Tae Jeon ; Jisu Jeong ; Moonseok Choi ; Suhyeon Son ; Wonjin Yang ; Mookyung Cheon ; Do-Geun KimSeries Type : OtherOrganism : Mus musculusSynucleinopathies, including Parkinson’s disease and Lewy body dementia, show region-specific vulnerability across the brain, but the molecular basis of selective regional involvement remains incompletely understood. We performed spatial transcriptomic profiling of brain sections from 6-month-old G2-3 alpha-synuclein transgenic mice and wild-type littermates using the 10x Genomics Visium Spatial Gene Expression platform to characterize region-specific transcriptional alterations associated with alpha-synuclein pathology. This dataset provides a resource for investigating spatially resolved molecular changes in the synucleinopathy mouse brain.
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7. GSE327167 胸膜间皮瘤和对照胸膜标本的单细胞RNA测序分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、single-cell
• 📝 描述：Contributors : David Severson ; Sam Freyaldenhoven ; Ben Wadowski ; William G Richards ; Raphael BuenoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis GEO submission contains processed single-cell RNA sequencing data generated using the Seq-Well platform from pleural mesothelioma tumors and comparator pleural specimens. Raw sequencing data are available through controlled access in dbGaP under accession phs004285. Processed expression matrices and cell-level metadata for the single-cell libraries are provided in this submission.
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8. GSE318565 神经板边界和神经源性基板的单细胞、克隆和空间图谱阐明了它们的特化和演化。

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、spatial
• 📝 描述：Contributors : Aliia Murtazina ; Julia Fatieieva ; Felix Waern ; Helen R. Maunsell ; Ankita Thawani ; Bettina Semsch ; Johan Bostroem ; Caleb Reagor ; Polina Kameneva ; Karina Araslanova ; Sergei Isaev ; Franziska Schelb ; Kaj Fried ; Alek Erickson ; Alexander Klimovich ; Andrea Streit ; Lena Kutscher ; Iryna Kozmikova ; Zbynek Kozmik ; Emma R. Andersson ; Gerhard Schlosser ; Andrew K. Groves ; Igor AdameykoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurogenic placodes are specialized ectodermal thickenings that generate key sensory structures of the vertebrate head. This dataset provides a clonal atlas of mouse neural plate border and neurogenic placodes, integrating single-cell RNA-sequencing, spatial transcriptomics, and high-resolution clonal tracing. These data define the lineage architecture of placodal and cranial ectodermal progenitors and provide a resource for understanding the emergence and diversification of vertebrate sensory structures.
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9. GSE293974 空间分辨谱分析和类固醇核受体足迹分析揭示了无序 N 端结构域在基因组靶向和 AP-1 相互作用中的作用

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatially、genome
• 📝 描述：Contributors : Zigdon Inbal ; Shoham Achinoam ; Mindel Vladimir ; Manadre Wajd ; Yahav Har-Shai Dekel ; Antebi Yaron ; Barkai NaamaSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculus ; Saccharomyces cerevisiaeTranscription factors (TFs) regulate gene expression by binding to cis-regulatory regions within vast genomes. In budding yeast, intrinsically disordered regions (IDRs) emerged as key effectors of genome preferences, but whether this holds in the complex mammalian genomes remains unclear. Mammalian TFs are enriched with long IDRs, exemplified by the disordered N-terminal domains (NTDs) of the nuclear steroid receptors (SRs). Here, by comparing genomic locations of three SRs and their truncation mutants, we show that the NTDs direct the selection of SR target sites. Footprint analysis revealed that SR mutants lacking the NTD become dependent on the AP-1 motif and further suggest that the NTD can direct genome recognition independent of co-binding TFs, which we confirmed by testing SR binding across the budding yeast genome. Our results suggest that IDRs assist in defining the TF binding targets, opening new avenues for modulating activities of therapeutically relevant TFs.
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10. GSE289742 EPIMETRIC（基于表观遗传甲基化的呼吸系统疾病分类算法 - COPD）

• ✍️ 作者：未知作者
• 🏷️ 关键词：epigenetic、methylation
• 📝 描述：Contributors : Cristóbal Fresno ; Abel Garcia-Diaz ; María J Serrano ; Valeria C Denninghoff ; Marta AlarconSeries Type : Methylation profiling by arrayOrganism : Homo sapiensEPIMETRIC is an innovative algorithm based on the analysis of epigenetic methylation profiles for diagnosing and accurately stratifying Chronic Obstructive Pulmonary Disease (COPD). This approach combines advanced molecular biology techniques with computational tools, enabling the identification of specific DNA methylation patterns associated with the progression and severity of COPD.
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1. 体内RNA测序揭示了对感染的实时免疫反应

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、sequencing
• 📝 描述：RNA sequencing of newly synthesized transcripts reveals dynamic immune cell activation and gene regulation during infection, providing real-time insight into how immune responses are coordinated…
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2. 下一代测序技术对分子病理实验室产生了巨大影响。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：RNA sequencing and next generation sequencing expand cancer diagnostics by enabling multi gene analysis, improving mutation detection, and supporting targeted therapy decisions in clinical settings…
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3. 科学家解开了困扰科学家30年的谜团：一种隐藏的营养物质能够保护大脑并对抗癌症。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Scientists have finally uncovered the missing link in how our bodies absorb queuosine, a rare micronutrient crucial for brain health, memory, stress response, and cancer defense. For decades, researchers suspected a transporter had to exist, but it remained elusive—until now. By identifying the gene SLC35F2 as the gateway into cells, this breakthrough opens new possibilities for therapies and highlights how diet and gut microbes profoundly shape human health.
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4. 科学家们刚刚实时目睹了阿尔茨海默病造成的损害。

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：Scientists at Oregon State University have captured something researchers have long struggled to see: the real-time chemical interactions that help drive Alzheimer’s disease. By watching how metal ions—especially copper—trigger harmful protein clumping in the brain, the team uncovered a clearer picture of how the disease develops at a molecular level.
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5. 这种“主控基因”可能正在驱动胰腺癌的扩散。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：A gene called KLF5 may be a key force behind the spread of pancreatic cancer—but not in the way scientists expected. Rather than mutating DNA, it rewires how genes are turned on and off, helping tumors grow and invade new areas. Researchers found it plays a major role in metastatic cells and even controls other genes linked to cancer progression. The discovery opens the door to new treatments that target cancer’s epigenetic “control system.”
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• GSE277691 阐明早期肠道干细胞对细菌感染的反应
• GSE243355 一种新型三效铂(IV)前药具有多种抗癌作用并能克服顺铂耐药性
• GSE301739 人类脑胰岛素抵抗的循环表观遗传特征分类
• GSE301736 循环表观遗传特征对人类脑胰岛素抵抗进行分类 [2]
• GSE301735 循环表观遗传特征对人类脑胰岛素抵抗进行分类 [1]
• GSE327208 控制细胞分化轨迹以逆转癌症
• GSE327166 胸膜间皮瘤和对照胸膜标本的批量 RNA-seq 分析
• 小鼠耳蜗类器官细胞的GSE326100单细胞RNA测序
• GSE320583 坏死性凋亡触发患者来源的转移性乳腺癌类器官中的炎症干扰素特征
• GSE308982 玻璃体内注射AAV可诱导整合素依赖性眼部炎症，并激活补体、抗病毒和DNA损伤反应
• GSE305242 平滑肌细胞中 Sphk1 缺失对小鼠高血压动脉转录组的影响
• GSE262651 Sirtuin 7 调节剂量补偿并保护女性 X 染色体 [Hi-C]
• GSE256285 Sirtuin 7 调节剂量补偿并保护女性 X 染色体 [RNA-seq TTF]
• GSE256284 Sirtuin 7 调节剂量补偿并保护女性 X 染色体 [RNA-seq ES]
• GSE325635 抗逆转录病毒疗法在发育过程中会损害啮齿动物模型的心脏逆向重塑
• GSE325173 围产期抗逆转录病毒疗法会损害啮齿动物模型中妊娠后心脏逆向重塑
• GSE297816 结肠基质细胞和iNKT细胞的早期RNA测序
• GSE289396 抗HIV免疫毒素和抗体药物偶联物靶向同一抗gp41抗体，表现出不同的细胞杀伤模式
• GSE283574 用于单细胞扰动筛选和 CRISPRi 的可调谐 Cas12a 平台
• GSE327064 耳念珠菌与铜绿假单胞菌相互作用过程中的代谢和转录变化
• GSE326921 染色质组装因子 CHAF1b 作为 RORγt 的表观遗传放大器，促进 Th17 致病性和自身免疫
• GSE326782 线粒体 L-2-羟基戊二酸是一种生理信号代谢物 [scRNA-seq]
• GSE326781 BAG2 凝聚体将蛋白质稳态与 CD8 + T 细胞监视联系起来
• GSE326768 CTCF 和组蛋白 H3.3 在 K27M 弥漫性中线胶质瘤中协同发挥表观基因组作用的证据
• GSE326738 AKT抑制剂capivasertib逆转急性髓系白血病中EVI1驱动的对维奈托克的耐药性
• GSE326413 组蛋白伴侣 ASF1s 通过抑制 PRX69 来控制种子萌发
• GSE326407 EPHB2 通过 ERK–ETV4 转录程序驱动 EMT 相关血管生成拟态和宫颈癌进展
• GSE314400 CIPHER-seq 可实现低应激细胞内多模态免疫激活分析
• GSE294075 Delta-catenin 是病毒阳性默克尔细胞癌细胞系细胞增殖所必需的，但在人类成纤维细胞中则不是。
• GSE327055 LncRNA Gas5 指导 SUV39H2 建立异染色质并维持基因组稳定性