详细内容（前10条）

1. ⭐ GSE326102 全基因组组蛋白乙酰化凸显了光热疗法在卵巢癌中诱导的肿瘤内在免疫信号传导

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immune、genome、histone
• 📝 描述：Contributors : Reddick Walker III ; Melissa Hadley ; Jose Colina ; Kevin Nestler ; Abby Lee ; Elizabeth Sweeney ; Rohan Fernandes ; Katherine B ChiappinelliSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensOvarian cancer remains the most lethal gynecological malignancy with few durable responses to standard of care platinum-based chemotherapies and emerging immunotherapies. This poor response is attributed to the immunosuppressive tumor microenvironment which lacks effector lymphocytes necessary for tumor clearance. Therefore, increasing tumor intrinsic immune signaling remains a therapeutic goal for OC. One strategy for improved tumor intrinsic immune signaling relies on induction of tumor cell immunogenic cell death (ICD) features including tumor cell surface expression of Calreticulin and Hsp70 with concurrent release of immunostimulatory signals that activate innate and adaptive immune cells. The induction of ICD through a nanoparticle-based heat shock treatment, termed Prussian blue nanoparticle photothermal therapy (PBNP-PTT), has shown strong recruitment of antigen-specific lymphocytes to the tumor microenvironment in glioblastoma and neuroblastoma preclinical models. While the molecular signatures of ICD are well described, the epigenetic reprogramming during treatment-induced tumor intrinsic immune signaling remains unknown. Therefore, this study sought to determine the efficacy of PBNP-PTT heat shock in ovarian cancer and characterize epigenetic responses that accompany its induced tumor intrinsic immune signaling. We first demonstrate that PBNP-PTT activates tumor intrinsic immune signaling in ovarian cancer and leads to improved monocyte activation through tumor cell proinflammatory cytokine release and presentation of Calreticulin and Hsp70. Accompanying this intrinsic immunostimulatory effect, PBNP-PTT induces genome-wide chromatin accessibility via H3K9ac, which associates with chromatin remodeling and heat shock response genes. Lastly, we show targeting histone acetylation via histone deacetylase inhibition (Panobinostat) improves the tumor intrinsic immune signaling potential of PBNP-PTT. These findings indicate that PBNP-PTT activates the release of immunostimulatory factors in ovarian cancer cells through H3K9ac rewiring and suggests the potential of combination with HDACi to improve tumor intrinsic immune signaling in ovarian cancer.
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2. ⭐ GSE317287 果蔬补充饮食通过调节宿主转录组和肠道宏基因组反应改善葡聚糖硫酸钠（DSS）诱导的结肠炎

• ✍️ 作者：未知作者
• 🏷️ 关键词：transcriptome、gut、regex:gut(-?microbiome)?
• 📝 描述：Contributors : Gloria Solano-Aguilar ; Sukla Lakshman ; Celine Chen ; Ethiopia Beshah ; Aleksey Molokin ; Bryan Vinyard ; Harry Dawson ; Monica Santin-Duran ; Gonzalo Bruna ; Allen Smith ; Joseph UrbanSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaDietary intake of fruits and vegetables (FV) has been inversely associated with lower risk of ulcerative colitis. A pig model was used to evaluate the impact of feeding FV on the host response to dextran sulfate sodium (DSS)-induced colitis. Methods: Six-week-old pigs were fed a grower diet alone or supplemented with lyophilized FV equivalent to the half (half-FV) or full (full-FV) daily levels recommended for humans by the Dietary Guidelines for Americans (DGA). Pigs were fed a 1) grower diet alone (negative control), 2) grower diet and orally treated with 4% DSS for 10 days to induce colitis (positive control), 3) half-FV diet treated with 4% DSS or 4) full-FV diet treated with 4% DSS. Pigs were monitored for the development of clinical signs of colitis. Proximal colon (PC) contents and mucosa (PCM) were collected for gut metagenome, tissue transcriptome and histopathological analysis. Results: Pigs fed the full-FV diet did not exhibit diarrhea, showed less fecal occult blood (FOB), PCM crypt hyperplasia but with no differential expressed genes (DEG) or changes in PC microbiome diversity (p < 0.05). Pigs within the half-FV group exhibited increased group FOB and DEG associated with tissue remodeling, crypt and goblet cell hyperplasia in the PCM and no changes in PC microbiome diversity and two pigs exhibiting diarrhea (p < 0.05). Pigs within the DSS positive control group exhibited a reduced DEG involved with intestinal immune response and PC microbiome diversity with altered metagenome, increased group PCM erosion and FOB with persistent diarrhea in one pig (p < 0.05) Conclusions: Overall, our results showed that pigs fed a three-week full-FV supplemented diet, were resistant to DSS-induced colitis with a differential dose-dependent protective effect on host intestinal tissue and gut metagenome when exposed to an inflammatory challenge.
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3. ⭐ GSE304150 人类黑色素瘤细胞中芳烃受体的激活增强癌细胞固有的 MHC-II 表达 [全基因组 CRISPR 筛选]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、MHC、genome
• 📝 描述：Contributors : Yiteng Jin ; Zexian ZengSeries Type : OtherOrganism : Homo sapiensCancer immunotherapy has revolutionized patient outcomes by enhancing immune responses, with major histocompatibility complex class II (MHC-II) playing a pivotal role. While MHC-II is classically expressed by professional antigen-presenting cells (pAPCs), emerging evidence highlights its expression by cancer cells, where it correlates with enhanced immune infiltration and favorable clinical outcomes. However, the regulatory mechanisms of cancer cell-intrinsic MHC-II remain unclear. Here, using genome-wide CRISPR-Cas9 screens, we identify the aryl hydrocarbon receptor (AhR) and its nuclear translocator (ARNT) as key regulators of MHC-II expression in human melanoma cells. The expression level and ligand-dependent activity of AhR and ARNT significantly correlate with cancer cell-intrinsic MHC-II expression. Multi-omics analyses reveal that this regulation is mediated through transcriptional activation of the MHC-II transactivator, CIITA, via binding of AhR-ARNT to its second promoter, pII. Our findings uncover a previously unrecognized regulatory axis for MHC-II expression in tumors, presenting new targets for enhancing immunotherapy.
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4. ⭐ GSE304149 人类黑色素瘤细胞中芳烃受体的激活增强癌细胞固有 MHC-II 表达 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、MHC、RNA-seq
• 📝 描述：Contributors : Yiteng Jin ; Zexian ZengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer immunotherapy has revolutionized patient outcomes by enhancing immune responses, with major histocompatibility complex class II (MHC-II) playing a pivotal role. While MHC-II is classically expressed by professional antigen-presenting cells (pAPCs), emerging evidence highlights its expression by cancer cells, where it correlates with enhanced immune infiltration and favorable clinical outcomes. However, the regulatory mechanisms of cancer cell-intrinsic MHC-II remain unclear. Here, using genome-wide CRISPR-Cas9 screens, we identify the aryl hydrocarbon receptor (AhR) and its nuclear translocator (ARNT) as key regulators of MHC-II expression in human melanoma cells. The expression level and ligand-dependent activity of AhR and ARNT significantly correlate with cancer cell-intrinsic MHC-II expression. Multi-omics analyses reveal that this regulation is mediated through transcriptional activation of the MHC-II transactivator, CIITA, via binding of AhR-ARNT to its second promoter, pII. Our findings uncover a previously unrecognized regulatory axis for MHC-II expression in tumors, presenting new targets for enhancing immunotherapy.
• 🔗 查看原文

5. ⭐ GSE304148 人类黑色素瘤细胞中芳烃受体的激活增强癌细胞固有的 MHC-II 表达 [ChIP-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、MHC、ChIP-seq
• 📝 描述：Contributors : Yiteng Jin ; Wenjin Zheng ; Zexian ZengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCancer immunotherapy has revolutionized patient outcomes by enhancing immune responses, with major histocompatibility complex class II (MHC-II) playing a pivotal role. While MHC-II is classically expressed by professional antigen-presenting cells (pAPCs), emerging evidence highlights its expression by cancer cells, where it correlates with enhanced immune infiltration and favorable clinical outcomes. However, the regulatory mechanisms of cancer cell-intrinsic MHC-II remain unclear. Here, using genome-wide CRISPR-Cas9 screens, we identify the aryl hydrocarbon receptor (AhR) and its nuclear translocator (ARNT) as key regulators of MHC-II expression in human melanoma cells. The expression level and ligand-dependent activity of AhR and ARNT significantly correlate with cancer cell-intrinsic MHC-II expression. Multi-omics analyses reveal that this regulation is mediated through transcriptional activation of the MHC-II transactivator, CIITA, via binding of AhR-ARNT to its second promoter, pII. Our findings uncover a previously unrecognized regulatory axis for MHC-II expression in tumors, presenting new targets for enhancing immunotherapy.
• 🔗 查看原文

6. ⭐ GSE304147 人类黑色素瘤细胞中芳烃受体的激活增强癌细胞固有的 MHC-II 表达 [ATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、MHC、ATAC-seq
• 📝 描述：Contributors : Yiteng Jin ; Zexian ZengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCancer immunotherapy has revolutionized patient outcomes by enhancing immune responses, with major histocompatibility complex class II (MHC-II) playing a pivotal role. While MHC-II is classically expressed by professional antigen-presenting cells (pAPCs), emerging evidence highlights its expression by cancer cells, where it correlates with enhanced immune infiltration and favorable clinical outcomes. However, the regulatory mechanisms of cancer cell-intrinsic MHC-II remain unclear. Here, using genome-wide CRISPR-Cas9 screens, we identify the aryl hydrocarbon receptor (AhR) and its nuclear translocator (ARNT) as key regulators of MHC-II expression in human melanoma cells. The expression level and ligand-dependent activity of AhR and ARNT significantly correlate with cancer cell-intrinsic MHC-II expression. Multi-omics analyses reveal that this regulation is mediated through transcriptional activation of the MHC-II transactivator, CIITA, via binding of AhR-ARNT to its second promoter, pII. Our findings uncover a previously unrecognized regulatory axis for MHC-II expression in tumors, presenting new targets for enhancing immunotherapy.
• 🔗 查看原文

7. ⭐ GSE291525 KMT2A重排儿童急性髓系白血病中RET受体酪氨酸激酶的表观遗传调控和治疗靶向机制研究

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、kinase、epigenetic
• 📝 描述：Contributor : Samrat Roy ChoudhurySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPediatric acute myeloid leukemia (pAML) driven by KMT2A gene rearrangements (KMT2A-r; 11q23 translocations) is a high-risk leukemia with limited treatment options and a poor prognosis. Previously, we reported (PMID: 38226414) that the RET receptor tyrosine kinase is epigenetically upregulated in major KMT2A-r subgroups. In this study, we utilized a synthetic drug, 8p, which serves as a dual inhibitor of RET and cyclin-dependent kinase 8 (CDK8). We conducted RNA sequencing analysis on 8p-treated KMT2A-MLLT3 fusion-positive MOLM-13 cells to profile genome-wide gene expression changes. This study enhances our understanding of the major pathways affected by the dual inhibition of RET and CDK8 in KMT2A-r AML.
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8. ⭐ GSE263196 人类小细胞肺癌的空间转录组测序数据

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、sequencing、spatial
• 📝 描述：Contributors : Xiaodong Ma ; Ming Liu ; Hua Wu ; Jun Wu ; Yang LiuSeries Type : OtherOrganism : Homo sapiensSmall cell lung cancer is a lung tumor with extremely poor prognosis, and its tumor heterogeneity and unique microenvironment remain unclear. This study aimed to reveal the early tumorigenesis and microenvironment of small cell lung cancer by performing idle transcriptomic sequencing of patients’ small cell lung cancer tissues.
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9. GSE319576 催乳素受体信号传导介导β细胞表观遗传适应以促进OVOL2结合[scATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：scATAC、epigenetic
• 📝 描述：Contributors : Nelmari Ruiz-Otero ; Jin-Yong Chung ; Ronadip R BanerjeeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculus"Maternal pancreatic β-cells undergo functional and structural changes to adapt to increased metabolic demands during pregnancy. Lactogen signaling via the prolactin receptor (PRLR) contributes to these adaptations by increasing β-cell mass, insulin transcription and glucose-stimulated insulin secretion. Lactogen-responsive tissues such as the mammary glands and some hypothalamic nuclei display gestationally induced epigenetic changes, some of which persist long after birth. We have previously found that prolactin treatment in islets regulates the expression of epigenetic modifiers. However, whether lactogen signaling in β-cells mediates epigenetic changes to regulate chromatin accessibility has not been examined. Therefore, our objective was to determine whether PRLR signaling alters chromatin accessibility of β-cells to facilitate transcriptional regulation. We identified differentially accessible regions in wild type β-cells which had 718 overrepresented motifs following prolactin treatment of murine islets. Validating this approach, these included motifs bound by established PRLR signaling effectors such as the STAT family of transcription factors (TFs). Using RNA-sequencing we identified transcriptional changes in 41 TFs whose motifs were overrepresented in DARs. These TFs included several previously linked to PRLR signaling within β-cells, including Myc, Mafb and Esr1. Importantly, we also identified several TFs not previously associated with PRLR signaling, which included OVOL2 which is often associated with epigenetic regulation. OVOL2 is a transcription factor involved in EMT inhibition and energy homeostasis with unknown roles in β-cell functions. Here, we establish that OVOL2 acts as a negative regulator of PRL-dependent effects on glucose stimulated insulin secretion and β-cell proliferation, establishing a novel regulatory pathway for PRLR signaling.
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10. GSE288641 PTPMT1依赖性调节性T细胞介导对肠道致病菌的免疫耐受

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?
• 📝 描述：Contributors : Mauro Corrado ; David E SaninSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMitochondrial dysfunctions are emerging as key drivers of gut inflammation, colitis, and IBD, yet their role in regulating immune tolerance remains unclear. Meanwhile, pathobiont infections, such as those caused by Helicobacter species, affect nearly half the global population, with symptoms manifesting in only 20%, adding a new layer of complexity. The genetic and environmental factors that disrupt gut tolerogenic mechanisms, tipping the balance toward disease in symptomatic infections, are not fully understood. Here, we show that PTPMT1 impairs tolerance to Helicobacter via Treg cells, independently from T cell-generated Type I or Type II interferons. Without cardiolipin, Treg cells lose metabolic fitness and immunosuppressive potential, unleashing pro-inflammatory myeloid cells in the gut. As a result, PTPMT1 ΔT mice are highly vulnerable to pathobiont infections even without microbiome imbalance. Inflammation and helper T cell imbalance are conserved in Barth syndrome, linked to cardiolipin deficiency from TAFAZZIN mutations. Overall, we propose that T cell-specific PTPMT1 governs the balance between tolerance and inflammation in the gut, dictating outcomes in pathobiont infections.
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1. 单细胞RNA测序为皮肌炎治疗提供新的见解

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell
• 📝 描述：RNA sequencing reveals inflammatory monocytes driving vascular damage in dermatomyositis, identifying JAK1 inhibition as a potential therapeutic strategy and clarifying differences from lupus…
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2. RNA测序提高了胆管癌的早期检出率

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、sequencing
• 📝 描述：RNA sequencing enhances detection of cancer in bile duct strictures, improving diagnostic sensitivity and enabling identification of actionable mutations for better clinical decision-making…
• 🔗 查看原文

3. longcallR – 利用长 RNA-seq 读段进行 SNP 检测、单倍型定相和等位基因特异性分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq
• 📝 描述：RNA sequencing with long-read technology links genetic variants to transcript structure, uncovering allele-specific splicing and previously unannotated RNA events across human samples…
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4. 科学家在细胞内发现隐藏的“风”，这或许可以解释癌症的扩散。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Cells aren’t as passive as scientists once thought—they actively create internal currents to move proteins quickly and efficiently. These “cellular winds” push materials to the front of the cell, enabling faster movement and repair. Discovered by chance and confirmed with advanced imaging, this system challenges decades of textbook biology. It may also reveal why some cancer cells spread so rapidly.
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5. 结肠癌内部隐藏的秘密可能会改变治疗方案。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Colorectal cancer may carry a unique microbial “fingerprint,” setting it apart from other cancers and opening a new frontier in diagnosis and treatment. By analyzing DNA from over 9,000 patients, researchers discovered that only colorectal tumors consistently host distinct microbial communities—challenging the long-held belief that all cancers have their own microbial signatures.
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• GSE282074 利用经济高效的全长总RNA测序技术扩展基于液滴的微流控单细胞工具箱
• GSE322777 细胞因子刺激后小鼠肝脏中 RNA 聚合酶 II 和 HNF4α 的 ChIP-seq（WT 与 TG）
• GSE313401转录组分析揭示了皮肤癣菌病原体趾间毛癣菌中PacC介导的代谢适应
• GSE306764 实验性自身免疫性重症肌无力 (EAMG) 的跨组织单细胞图谱，包括中枢和外周免疫组织
• GSE305296 人类黑色素瘤细胞中芳烃受体的激活增强癌细胞内在的MHC-II表达
• GSE304366 ZIC2 通过 LYPLA2 调节甘油磷酸胆碱代谢，从而影响口腔鳞状细胞癌的干性
• GSE300966 Dicer解旋酶结构域精氨酸甲基化在26G内切siRNA通路活性和卵母细胞减数分裂程序中​​的功能需求
• GSE246341 研究发现，急性髓系白血病 (AML) 细胞系对双功能亲电试剂白消安的获得性耐药与线粒体拷贝数以及脂质和胆固醇代谢的变化相关。
• GSE326081 细胞大小依赖性 mRNA 转录驱动蛋白质组重塑 [RNA-seq]
• GSE325872 动态悬浮培养系统揭示 HIF-1α 通过双重抑制 p53 通路维持癌症干细胞的干性
• GSE325822 双模态成像引导的联合化疗和DC疫苗免疫疗法的时间优化
• GSE325321 表型和转录组特征的综合分析揭示了慢性应激和免疫反应在寻常痤疮发病机制中的重要作用
• GSE294730 肿瘤抑制基因型影响肺癌免疫监视的程度和方式
• GSE326719 黄芪甲苷IV调节卵巢切除大鼠的氧化应激和骨免疫-Wnt信号通路：RNA测序、分子对接和实验验证的综合研究
• GSE326699 DYRK1B 过表达促进 A549 肺癌细胞中衰老样转录和分泌程序
• GSE325911 I型干扰素驱动中枢神经系统中T细胞对β-淀粉样蛋白的反应
• GSE325402 EGF诱导MDA-MB-468乳腺癌细胞系EMT
• GSE319525 催乳素受体信号传导介导β细胞表观遗传适应以促进OVOL2结合
• GSE316924 8周龄小鼠下颌骨单细胞RNA测序揭示骨髓微环境
• GSE313826 癌症相关成纤维细胞促进胰腺癌细胞的上皮间质转化和经典基底细胞转化，并伴有IL-8表达缺失
• GSE307211 KDM5C 和 KDM5D 影响成年小鼠肝脏的 DNA 甲基化
• GSE305159 Affymetrix SNP 芯片数据揭示了家族性白血病中一种新的 RUNX1 变异。
• GSE298553 SD大鼠循环外泌体的小RNA测序
• GSE298544 妊娠和产后神经转录组的持续性多巴胺依赖性重塑
• GSE293315 MRPGRX2拮抗剂治疗可预防特应性皮炎小鼠模型中的炎症和疾病（数据集2）
• GSE293241 MRPGRX2拮抗剂治疗可预防特应性皮炎小鼠模型中的炎症和疾病 数据集1
• GSE285449 普拉梭菌在人类单核细胞中诱导抗炎反应和代谢重编程 [回肠]
• GSE285037 粪杆菌（Faecalibacterium prausnitzii）诱导人类单核细胞产生抗炎反应和代谢重编程
• GSE282622 BMAL1 重编程谷氨酰胺代谢以控制造血干细胞和祖细胞的扩增
• GSE281370 DYRK1A 通过 mTORC1 激活增强 1 型常规树突状细胞的抗肿瘤免疫力
• GSE326651 体内人类胚胎脊髓图谱验证了干细胞衍生的人类背侧中间神经元，并揭示了 ASD 脊髓特征 [day0NMP_bulk RNAseq]
• GSE325970 细胞不渗透性激酶抑制剂诱导的 Glypican-1 上调及其过表达增强 HIV 感染
• GSE324693 慢性乙醇摄入的系统性后果：从微生物群变化到代谢障碍
• GSE320114 口服伊斯拉曲韦可降低猕猴的淋巴细胞和单核细胞数量，并与免疫失调有关
• GSE319719 口腔黏膜下纤维化及其恶性转化的转录组分析
• GSE318882：由阿糖胞苷耐药性产生的复杂突变特征
• GSE318387 钙黏蛋白-7启动子低甲基化：一种与脑小血管病相关的新型表观遗传标记
• GSE317008 银杏酸通过分子伴侣介导的自噬依赖性GPX4降解靶向HSPA8，从而触发肝细胞癌中的铁死亡
• GSE317007 FLARE：一种整合拷贝数、甲基化和末端基序分析的长读长纳米孔片段组学流程，用于液体活检
• GSE317005 HSV-2感染的HFF-1细胞中m6A基因的甲基化及其基因表达谱
• GSE316979 非洲猪瘟病毒 R238L 和 R298L 通过靶向含有 zf-C2H2 结构域的转录因子破坏肺细胞的胶原蛋白形成和细胞黏附通路
• GSE315683 暴露于电子烟气溶胶冷凝物的人支气管上皮细胞 BEAS-2B 的转录组和蛋白质组分析
• GSE313595 单核 RNA 测序和功能研究急性甲基苯丙胺诱导的认知障碍
• GSE309322 ChemR23 可阻止动脉粥样硬化中血管平滑肌细胞向巨噬细胞样泡沫细胞的表型转换。
• GSE302297 ANGPTL3 在足细胞中通过激活巨噬细胞中的 MSR1 参与狼疮性肾炎的发病机制
• GSE301802 基于肽的Wnt信号激活可实现临床级患者来源肠道类器官的规模化生产，用于再生细胞治疗。
• GSE300247 TACI KO 和 WT 小鼠边缘区和滤泡 B 细胞的转录组
• GSE296390 p75 神经营养因子受体塑造阿尔茨海默病成年海马神经发生的动态过程
• GSE230860 Overlapping and Distinct Transcriptional Functions of an Extended Repertoire of KRAS Mutations
• GSE223721 SWI/SNF复合物亚基Smarce1通过Jak/Stat3信号通路控制心肌细胞增殖[RNA-seq]
• GSE223720 SWI/SNF复合物亚基Smarce1通过Jak/Stat3信号通路控制心肌细胞增殖[ATAC-seq]
• GSE326773 韩国小型猪（Sus scrofa）从头转录组组装[II]
• GSE326397 胶质母细胞瘤肿瘤内异质性研究 [scRNA-seq]
• GSE326293 线粒体 L-2-羟基戊二酸是一种生理信号代谢物 [ATAC-seq]
• GSE326291 线粒体 L-2-羟基戊二酸是一种生理信号代谢物 [RNA-seq]
• GSE326270 DEK 中丝氨酸 287/288 的磷酸化调节细胞类型特异性染色质占据和压缩 [ATAC-seq]
• GSE292992 MDM2降解克服了默克尔细胞癌中p53信号的反馈调节
• GSE273473 线粒体 L-2-羟基戊二酸是一种生理信号代谢物 [ChIP-seq]
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