详细内容（前10条）

1. ⭐ GSE304621 非人灵长类动物基因治疗相关视网膜炎症的单细胞和空间转录组分析 [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation、single-cell、scRNA、spatial
• 📝 描述：Contributors : Célia Sourd ; Joel Quinn ; Molly C John ; Cristina Martinez-Fernandez de la Camara ; Lakshanie Wickramasinghe ; Moustafa Attar ; Hoda Shamsnajafabadi ; Ahmed Salman ; Sally A Cowley ; Calliope Dendrou ; Robert E MacLaren ; Jasmina Cehajic-Kapetanovic ; Kanmin XueSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaAdeno-associated viral (AAV) vectors are rapidly advancing as gene therapies for inherited and common retinal disorders, but gene therapy-associated uveitis (GTAU) limits their broader application. To investigate the primate ocular immune response, we administered subretinal AAV gene therapy to two non-human primates (NHPs): NHP1 received AAV2-CAG-hRPE65 (voretigene neparvovec) bilaterally at clinical dose; NHP2 received AAV8-GRK1-hRPGRco alongside an analogous mScarlet reporter vector in separate blebs. Longitudinal assessments over three months included multimodal imaging, electroretinography and cytokine profiling, followed by immunohistological, single-cell and spatial transcriptomic analyses of retinal punches. Both therapies were well-tolerated, with preserved retinal structure and function. Single-cell RNA-sequencing revealed that the AAV8 vector transduced 80% of cones/rods in treated areas, while AAV2 targeted 30% of retinal pigment epithelium (RPE)/rods. Transgene expression did not correlate with apoptotic markers. Persistent immune infiltration (dominated by myeloid and T cells) suggested a type 1 cell-mediated response. Adjunctive intravitreal anti-TNFα (adalimumab) did not appear to mitigate this anti-viral response. Spatial analysis highlighted microglia migration to the subretinal space, consistent with upregulated cytokines (MCP-1/CCL2, IP-10/CXCL10, IL-8/CXCL8, IL-6), which implicate monocytic phagocytes in driving local inflammation. These findings elucidate the mechanism of GTAU and identify potential therapeutic targets to prevent immune-mediated complications in retinal gene therapy.
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2. ⭐ GSE325746 肿瘤内在的PHGDH抑制重塑巨噬细胞表观遗传程序，使结直肠癌对PD-1阻断剂敏感

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、macrophage、epigenetic
• 📝 描述：Contributors : Jieping Qiu ; Jing Bai ; Xuelei MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolic reprogramming in tumor cells profoundly shapes the tumor microenvironment (TME) and limits the efficacy of immunotherapy in colorectal cancer (CRC). However, how tumor-intrinsic metabolic alterations orchestrate immune remodeling remains poorly understood. Here, we identify phosphoglycerate dehydrogenase (PHGDH), a key enzyme in the serine biosynthesis pathway, as a critical metabolic regulator of antitumor immunity. Pharmacological inhibition and genetic suppression of PHGDH significantly enhanced the therapeutic response to PD-1 blockade in CRC models. Integrated single-cell transcriptomic analyses revealed that PHGDH inhibition reprograms tumor metabolism, leading to reduced α-ketoglutarate (α-KG) levels in the TME and subsequent epigenetic remodeling of tumor-associated macrophages. Mechanistically, α-KG depletion suppresses KDM5B activity, maintains H3K4me3 enrichment at STAT1 target promoters, and activates JAK–STAT1 signaling, thereby promoting macrophage inflammatory polarization with augmented antigen-presenting capacity. These reprogrammed macrophages promote CD8+ T cell infiltration and cytotoxic function, ultimately amplifying antitumor immunity and sensitizing tumors to ICB. Consistently, clinical analyses demonstrate that low PHGDH expression correlates with an immune-active phenotype and improved immunotherapy outcomes. Collectively, our findings uncover a tumor–macrophage metabolic–epigenetic crosstalk that governs immune responsiveness and highlight PHGDH as a promising therapeutic target and candidate biomarker for immunotherapy in CRC.
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3. ⭐ GSE299598 空间分析揭示了一种新的炎症性肿瘤过渡状态，该状态促进巨噬细胞驱动的肉瘤样肾细胞癌的诱导 [GeoMx]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、carcinoma、macrophage、spatial
• 📝 描述：Contributors : Allison May ; Evan KellerSeries Type : OtherOrganism : Homo sapiensSarcomatoid renal cell carcinoma (sRCC) is an aggressive trans-differentiation of epithelioid clear cell RCC (ccRCC) tumors that shows heightened response to immunotherapy. The underlying biology leading to sarcomatoid transformation and mechanisms contributing to immunotherapy response are not well understood. Novel single cell spatial techniques were used in ccRCC and sRCC tumors from 40 patients to understand the spatial sRCC transformation and corresponding immune changes. A transcriptional transition state in epithelioid ccRCC cells along a continuum to mesenchymal sRCC was identified which expresses high levels of pro-inflammatory cytokines and an immune infiltrate. In vitro studies demonstrated that M2-like macrophages, recruited to the tumor by the transition state, induce full transition to the sarcomatoid state. A combination of increased PD-L1 expression and T cells recruited by the transition state was observed consistent with the increased immunotherapy response. This study enriches our understanding of the mechanisms leading to development and immune responsiveness of sRCC paving the way for novel approaches to diminish RCC progression.
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4. ⭐ GSE299368 空间分析揭示了一种新的炎症性肿瘤转化状态，该状态促进巨噬细胞驱动的肉瘤样肾细胞癌的诱导。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、carcinoma、macrophage、spatial
• 📝 描述：Contributors : Allison May ; Evan KellerSeries Type : OtherOrganism : Homo sapiensSarcomatoid renal cell carcinoma (sRCC) is an aggressive trans-differentiation of epithelioid clear cell RCC (ccRCC) tumors that shows heightened response to immunotherapy. The underlying biology leading to sarcomatoid transformation and mechanisms contributing to immunotherapy response are not well understood. Novel single cell spatial techniques were used in ccRCC and sRCC tumors from 40 patients to understand the spatial sRCC transformation and corresponding immune changes. A transcriptional transition state in epithelioid ccRCC cells along a continuum to mesenchymal sRCC was identified which expresses high levels of pro-inflammatory cytokines and an immune infiltrate. In vitro studies demonstrated that M2-like macrophages, recruited to the tumor by the transition state, induce full transition to the sarcomatoid state. A combination of increased PD-L1 expression and T cells recruited by the transition state was observed consistent with the increased immunotherapy response. This study enriches our understanding of the mechanisms leading to development and immune responsiveness of sRCC paving the way for novel approaches to diminish RCC progression.
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5. ⭐ GSE290670 空间转录组分析揭示乳腺癌浸润性小叶癌的分子特征。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、carcinoma、spatial、transcriptome
• 📝 描述：Contributors : Momoko Tokura ; Jun Nakayama ; Yusuke YamamotoSeries Type : OtherOrganism : Homo sapiensThese samples were collected for spatial transcriptome analysis of invasive lobular carcinoma of the breast (ILC). We analyzed differences in the molecular profiles of classical ILCs (C-ILCs) and polymorphic ILCs (P-ILCs). We obtained transcriptome data from ● different spots. The cell type of each spot was inferred from copy number changes and gene expression data of human tumors by SpaCET. There were 11 cell types, with cancer-dominant and CAF-dominant spots accounting for the majority. Analysis of canonical pathways and upstream regulators by IPA indicated that the cell cycle is upregulated in P-ILC cancer-dominant spots than in C-ILC cancer-dominant spots. Furthermore, EMT and angiogenesis were upregulated in P-ILC stroma-dominant spots than in C-ILC stroma-dominant spots.
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6. ⭐ GSE262679 High-protein diet alleviate cardiac damage, adipose tissue inflammation, and alterations in the gut microbiota induced by chronic sleep fragmentation

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation、cardiac、gut、regex:gut(-?microbiome)?
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Sleep is fundamental to growth, immune function, and overall health. We initiate our study to elucidate the impact of sleep fragmentation (SF) on the cardiac function, gut microbiome diversity, and the transcriptomic profile of inguinal white adipose tissue (iWAT) in mice, as well as the regulatory role of a high protein diet. Methods: We constructed chronic SF and high protein diet intervention mouse models for this research. Cardiac structure and function were evaluated by echocardiographic analyses. Gut microbiota composition was determined by 16s rDNA amplicon sequencing. Transcriptome alterations of iWAT were assessed by RNA-sequencing. Results: Our result revealed that SF interventions induced inflammatory changes in adipose tissue and perturbed the diversity and composition of the gut microbiota. Concurrently, 6-week SF intervention led to a significant decline in left ventricular systolic function in mice, manifested by a notable decrease in EF and FS. Masson staining revealed distinctions compared to the control group, suggesting an increase in myocardial collagen fiber content following SF intervention. High-protein diet intervention partially mitigated the damage to cardiac structure and function caused by SF. Meanwhile, high-protein diet coupled with improvements in the adipose tissue transcriptome changes induced by SF. Conclusions: In conclusion, chronic SF intervention induced cardiac damage, alters gut microbiota composition and induce adipose tissue inflammation. High-protein diet could partially mitigate the changes above.
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7. ⭐ GSE322495 不同的巨噬细胞调节T细胞状态决定高危膀胱癌对卡介苗（BCG）的反应

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、T cell、macrophage
• 📝 描述：Contributors : Andrew Houston ; Mairah Khan ; Ryan Brown ; Joshua MeeksSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe primary therapy for high-risk bladder cancer (BCa) is repeated instillations of the tuberculosis vaccine, Bacillus Calmette-Guerin (BCG). While BCG decreases the risk of recurrence by more than half, the concerted mechanisms of immune activation from BCG are unknown. Our objective was to investigate how the immune response differs between responders and non-responders to BCG therapy. We performed single-cell RNA-sequencing of isolated immune cells adjacent to high-risk bladders before and after BCG in BCG responders and non-responders. We identify an increase in Th17-like Th1 cells in BCG responders, characterized by greater expression of pro-inflammatory cytokines. Alternatively, non-responders had increased CD8+ T-cell exhaustion and T-regulatory cells. We identify that the primary mechanism of divergent T cell activity is driven by altered polarization and immunosuppressive signaling with myeloid cells. Through a machine-learning-based approach, we identified a Th17-like Th1 cytokines, such as IL17, IL21, and IL26, were predictive of a response, which were then validated in a separate BCG-treated BCa cohort. Together, this suggests that dynamic regulation of myeloid-T cell interactions can be targeted to improve BCG activity.
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8. ⭐ GSE304504 非人灵长类动物基因治疗相关视网膜炎症的单细胞和空间转录组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation、single-cell、spatial
• 📝 描述：Contributors : Célia Sourd ; Joel Quinn ; Molly C John ; Cristina Martinez-Fernandez de la Camara ; Lakshanie Wickramasinghe ; Moustafa Attar ; Hoda Shamsnajafabadi ; Ahmed Salman ; Sally A Cowley ; Calliope Dendrou ; Robert E MacLaren ; Jasmina Cehajic-Kapetanovic ; Kanmin XueSeries Type : OtherOrganism : Macaca mulattaAdeno-associated viral (AAV) vectors are rapidly advancing as gene therapies for inherited and common retinal disorders, but gene therapy-associated uveitis (GTAU) limits their broader application. To investigate the primate ocular immune response, we administered subretinal AAV gene therapy to two non-human primates (NHPs): NHP1 received AAV2-CAG-hRPE65 (voretigene neparvovec) bilaterally at clinical dose; NHP2 received AAV8-GRK1-hRPGRco alongside an analogous mScarlet reporter vector in separate blebs. Longitudinal assessments over three months included multimodal imaging, electroretinography and cytokine profiling, followed by immunohistological, single-cell and spatial transcriptomic analyses of retinal punches. Both therapies were well-tolerated, with preserved retinal structure and function. Single-cell RNA-sequencing revealed that the AAV8 vector transduced 80% of cones/rods in treated areas, while AAV2 targeted 30% of retinal pigment epithelium (RPE)/rods. Transgene expression did not correlate with apoptotic markers. Persistent immune infiltration (dominated by myeloid and T cells) suggested a type 1 cell-mediated response. Adjunctive intravitreal anti-TNFα (adalimumab) did not appear to mitigate this anti-viral response. Spatial analysis highlighted microglia migration to the subretinal space, consistent with upregulated cytokines (MCP-1/CCL2, IP-10/CXCL10, IL-8/CXCL8, IL-6), which implicate monocytic phagocytes in driving local inflammation. These findings elucidate the mechanism of GTAU and identify potential therapeutic targets to prevent immune-mediated complications in retinal gene therapy.
• 🔗 查看原文

9. ⭐ GSE324758 急性高强度运动改变不同品系小鼠的肠道菌群组成和能量代谢

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolism、gut、regex:gut(-?microbiome)?
• 📝 描述：Series Type : OtherOrganism : mouse metagenomeThe gut microbiota plays a critical role in host energy metabolism and immune regulation, yet the temporal dynamics of microbial community responses to acute physiological stressors remain poorly characterized. While exercise is recognized as a modulator of gut microbial composition, the immediate post-exercise shifts in microbial community structure across different genetic backgrounds have not been systematically examined. Here, we present a longitudinal 16S rRNA gene sequencing dataset profiling the temporal dynamics of gut microbiota following acute high-intensity exercise in two widely used laboratory mouse strains. Age-matched male BALB/c and C57BL/6J mice were subjected to a single bout of acute exercise. The colonic content samples were collected to capture early temporal responsesat. Total genomic DNA was extracted from colonic contents and the 16S rRNA V4 region was amplified and sequenced on the NovaSeq6000 platform. This dataset enables identification of strain-specific and conserved exercise-responsive microbial taxa, and supports functional predictions related to energy metabolism and intestinal homeostasis.
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10. ⭐ GSE302244 高脂饮食衍生的微生物代谢组诱导肠上皮细胞（类器官）产生炎症表型

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:micro(b|be|bial|organism)、metabolome、regex:intestin(e|al)
• 📝 描述：Contributors : Rebecca Springer ; Christoph Otto ; Nicolas SchlegelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe investigated transcriptomic changes in mouse organoids treated with colonic contents from diet-induced obese and normal-weight rats. 2D Mouse organoids were harvested after 40 h of treatment with 10% solutions of rat colonic content. Our findings revealed induction of local inflammatory processes under treatment with content derived from rats fed a high-fat diet.
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1. 利用长读长测序了解可变剪接

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：Long-read RNA sequencing reveals full-length isoforms, improving understanding of alternative splicing and enabling deeper insight into gene regulation and disease mechanisms…
• 🔗 查看原文

• GSE302243 高脂饮食衍生的微生物代谢组诱导肠上皮细胞出现炎症表型[结肠]
• GSE296275 不同的组织微环境促进前列腺 TRM 细胞分化和异质性 [空间转录组学]
• GSE295181 HIF2α 需要与 YAP/TAZ 和 AP-1 转录因子相互作用才能维持透明细胞肾细胞癌中的致癌转录 [RNA-Seq]
• GSE326335 嵌合体来源的单核细胞衍生巨噬细胞在实验性自身免疫性脑脊髓炎高峰期线粒体活性氧靶向的批量RNA测序
• GSE294616 生理和病理性 Nodal 缺陷妊娠中母胎界面白细胞的单细胞 RNA 测序
• GSE280411 非洲慈鲷鱼类肠道细胞的适应性进化 [scRNA-Seq]
• GSE280410 非洲慈鲷鱼类肠道细胞的适应性进化 [RNA-Seq]
• GSE325547 染色质重塑因子 Mit1 促进组蛋白修饰 H3K9me 的传播 [RNA-seq]
• GSE323347 解决癌症预测建模中转录组学检测异质性问题（RNA-seq）
• GSE319248 组蛋白去甲基化酶 KDM4A 激活 ERRγ 依赖性细胞周期进程以促进子宫内膜癌进展
• GSE317091 利用可逆固定剂进行突触体分选——一种用于突触转录组测序的多功能方法 (SynSURF-Seq)
• GSE316535 POFUT1 通过激活 PI3K/AKT 通路在胶质瘤中发挥独立预后因子和治疗靶点的作用
• GSE315388 A20 稳定 IRF8：新生的吞噬细胞 cDC2 在 cDC1 缺陷型 A20cKO 小鼠中协调强大的抗肿瘤免疫
• GSE315189 油酸饮食对小鼠异种移植模型卵巢癌肿瘤生长的影响
• GSE310508 合作照料影响栗冠噪鹛雏鸟基因组范围内的DNA甲基化水平
• GSE305855 酪蛋白激酶 1δ/ε 抑制通过细胞内在和微环境机制抑制 CLL [RNA-Seq]
• GSE295183 HIF2α 需要与 YAP/TAZ 和 AP-1 转录因子相互作用才能维持透明细胞肾细胞癌中的致癌转录 [CUT&Tag]
• GSE293489 小鼠心肌梗死后非心肌细胞的单细胞RNA测序
• GSE293488 心肌梗死后小鼠心脏注射抗IgG和抗PD-1抗体后T细胞的单细胞RNA测序
• GSE293279 对弓形虫速殖子全基因组进行 TgSNF2L ChIP-seq 数据分析 [SNF2L ChIP-seq]
• GSE284171 单细胞 RNA 测序揭示激素诱导的人阴道上皮类器官转录组重编程
• GSE277418 Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation [ATAC-seq]
• GSE275654 抑制盐诱导激酶可重编程卵巢癌中的T细胞和抗肿瘤免疫
• GSE275341 血浆蛋白质组学和单细胞RNA测序揭示造血干细胞移植后移植物排斥的细胞和可溶性机制
• GSE273961 抑制盐诱导激酶可重编程卵巢癌中的T细胞和抗肿瘤免疫
• GSE270151 开发一种理想的 COVID-19 灭活疫苗（小鼠肺 RNA 测序数据）
• GSE249979 非经典 PRC1.1 激活转录反应，从而促进 Treg 在免疫适应中的可塑性 [RNA-Seq]
• GSE227933 树突状细胞的成熟/迁移是由染色质可及性和持续的机体IFNγR1反应梯度所调控的，该梯度控制着免疫启动和耐受。
• GSE171151 NINJ2 抑制通过降低化疗耐药胃癌中的 CIC 来提高化疗敏感性（抗体芯片）
• GSE326391 患者来源气道基底细胞和分化的3D支气管类器官的全基因组DNA甲基化谱分析
• GSE307977 组织内在机制使 HIV-1 颗粒对 TLR 触发的先天免疫反应更加敏感
• GSE325045 推断昼夜节律相位并量化单细胞转录组中的生物失同步性
• GSE309604 利用嵌合抗原受体星形胶质细胞（CARA）疗法靶向治疗β-淀粉样蛋白病理
• GSE301563 粗糙脉孢菌中端粒重复序列处的保护蛋白亚基 TRF-1 介导 PRC2 功能 [ChIP-seq]
• GSE300388 HNF1A-MODY 对胰岛干细胞的影响 [scRNA-Seq]
• GSE299112 R环塑造H2A.Z景观并促进分化过程中平衡的谱系分配[scRNA-Seq]
• GSE299110 R环塑造H2A.Z景观并促进分化过程中平衡的谱系分配[RNA-Seq]
• GSE299105 R环塑造H2A.Z景观并促进分化过程中平衡的谱系分配[ATAC-Seq]
• GSE298507 抑制 BCL2 家族蛋白可克服部分 BRAFV600E 突变型黑色素瘤对标准疗法 BRAF 和 MEK 抑制剂的获得性耐药性
• GSE288431 HNF1A-MODY 对胰岛干细胞的影响 [scRNA-seq]
• GSE314899 FACT 维持启动子周围的核小体，并阻止染色质因子的扩散，从而在染色质结构中发挥重要作用 [ChIP-seq]
• GSE314894 FACT 维持启动子周围的核小体，并阻止染色质因子的扩散，从而在染色质结构中发挥重要作用 [RNA-Seq]
• GSE314892 FACT 维持启动子周围的核小体，并阻止染色质因子的扩散，从而在染色质结构中发挥重要作用 [ATAC-seq]
• GSE312449 持久控制自身免疫需要持续刺激调节性 T 细胞 [TCR scRNA-Seq]
• GSE302016 交感神经-嗜酸性粒细胞神经免疫轴协调心理压力以加剧皮肤炎症
• GSE326326 人类胚胎原肠胚形成后的时空转录组图谱
• GSE326106 人类 (Homo sapiens)、大猩猩 (Gorilla gorilla)、猩猩 (Pongo abelii) 和食蟹猴 (Macaca fasciculis) 诱导的多能干细胞和神经前体细胞系的长读长 RNA-seq
• GSE325921 利多卡因通过下调 SLC6A3 抑制肝细胞癌细胞的增殖、迁移和侵袭
• GSE325798 支配颅骨结构的交感神经回路的回路组织和转录组异质性 [scRNA-seq]
• GSE325653转录组测序揭示了光生物调节介导的小鼠低压缺氧诱导突触可塑性缺陷改善的基因表达谱
• GSE324977 弥漫性大B细胞淋巴瘤蛋白基因型的发病机制
• GSE324685 CD7 驱动慢性病毒感染期间的 T 细胞耗竭
• GSE322784 解决癌症预测建模中转录组学检测异质性问题（NanoString）
• GSE322563 Cas9介导的甲基化敏感编辑的分子基础
• GSE320000 氯化胆碱培养引起的牛胚泡基因表达和DNA甲基化改变
• GSE319128 拟南芥中响应非生物胁迫的磷脂酸基逆行信号通路。
• GSE318870 核ADAMTS1酶原作为转录共激活因子，通过非经典cGAS-STING信号通路驱动乳腺癌化疗诱导的转移
• GSE317566 黏附相关巨噬细胞通过 CAV-1 依赖性调节代谢稳态
• GSE316882 KDM5B 组蛋白赖氨酸去甲基化酶缺乏小鼠出现自闭症样表型和 NMDAR2D 表达增加 [CUT&Tag]
• GSE316526 组蛋白密码中的 H3 瓜氨酸化串扰
• GSE316420 HTLV-1 Tax 重塑转录因子 IRF4 的 DNA 结合模式并破坏宿主基因调控 [ChIP-seq]
• GSE316418 HTLV-1 Tax 重塑转录因子 IRF4 的 DNA 结合模式并破坏宿主基因调控 [ATAC-seq]
• GSE316417 HTLV-1 Tax 重塑转录因子 IRF4 的 DNA 结合模式并破坏宿主基因调控 [RNA-seq]
• GSE315252 CDK4/6抑制剂治疗ER阳性转移性乳腺癌的外泌体miRNA谱分析
• GSE315013 SORL1 是多发性骨髓瘤中 KRAS 驱动的肿瘤发生的介质
• GSE313878 KrasG12D/+ 和野生型小鼠骨髓的空间转录组分析
• GSE313553：KrasG12D/+ JMML小鼠模型中c-Kit⁺ HSPC的单细胞转录组分析
• GSE311793 ZipV 是烟曲霉氧化应激抵抗力和致病性所必需的
• GSE310706 鉴定参与神经元亚型分化时间调控的一组转录调控因子 [RNA-Seq]
• GSE310582 MEX3A 对线粒体功能的调控对于卵巢透明细胞癌的肿瘤发生和肝转移至关重要
• GSE310189 热中性饲养增强 T 细胞受体 (TCR) 介导的 CD4+ T 细胞反应性
• GSE308612 转化生长因子α在单壁碳纳米管诱导的人肺上皮细胞恶性转化中的作用及其在非小细胞肺癌进展中的作用
• GSE308320 VSV感染的骨髓来源巨噬细胞（BMDM）中IRF1结合的ChIP-seq分析
• GSE308059 结核分枝杆菌 VapBC52 (Rv2514c-Rv2515c) 毒素-抗毒素系统的结构和功能表征揭示了其在细菌生理和噬菌体防御中的作用。
• GSE304722 酪蛋白激酶 1δ/ε 抑制通过细胞内在和微环境机制抑制慢性淋巴细胞白血病
• GSE303893 模拟微重力下培养的干细胞衍生人类滋养层类器官的单核RNA测序
• GSE302254 肥胖大鼠模型中微生物群落组成的研究 [16S rRNA-seq]
• GSE299387 比较转录组学揭示了后兽类-真兽类分化时皮层结构的涌现和可塑性[snRNA-Seq]
• GSE299386 比较转录组学揭示了后兽类-真兽类分化时皮层结构的涌现和可塑性 [立体序列]
• GSE298900 转录因子编码大脑神经元基本模式
• GSE298850 抗原非依赖性、成纤维细胞介导的Ttek激活在淋巴细胞浸润之前驱动干燥综合征中的腺泡功能障碍
• GSE296277 Distinct tissue niches contribute to prostate TRM cell differentiation and heterogeneity [scRNA-seq]
• GSE296276 不同的组织微环境促进前列腺 TRM 细胞分化和异质性 [RNA-seq]
• GSE294522 通过抑制锌转运使干细胞衍生的胰岛类器官预适应缺氧环境，从而驱动快速新生血管形成 [scRNA-seq, MGISEQ-2000RS]
• GSE293800 靶向尿激酶型纤溶酶原激活物受体的CAR-T细胞的癌症非特异性治疗潜力
• GSE293500 Runx1 是驱动类风湿性关节炎滑膜成纤维细胞致病性的关键转录因子 [ChIP-seq]
• GSE293473 喹诺辛修饰依赖的组氨酰 tRNA 片段促进细胞类型依赖性增殖 [RNA-Seq]
• GSE293320：葡萄糖或果糖处理Huh7细胞的转录组数据
• GSE293091 胃癌细胞系中NINJ1过表达后差异表达基因
• GSE292960 单核 RNA 测序分析用于灵长类屏状核的分子分类
• GSE292934 机制解卷积揭示 DHODH 是 KDM4 抑制剂 QC6352 的关键靶点 [RNA-Seq]
• GSE292863 小鼠心肌梗死后7天心脏中PD1+/- T细胞的批量RNA测序
• GSE292489 同种异体诱导多能干细胞衍生不变自然杀伤T细胞与α-半乳糖神经酰胺脉冲抗原呈递细胞联合疗法的临床前疗效
• GSE291996 源自造血类器官的 CD3+KLRB1+ 和 CD3+KLRB1- T 细胞的 RNA 序列
• GSE291546 NOP16 调控 B 细胞类别转换重组为 IgA
• GSE291395 非经典 PRC1.1 激活转录反应，从而促进 Treg 在免疫适应中的可塑性 [SMART-seq]
• GSE291011 Flavokawain A 通过 CDT1 依赖性 p27 调控诱导细胞周期阻滞，并与维奈托克在急性髓系白血病中产生协同作用
• GSE285194 E18.5 Taf4b缺陷型雌性小鼠卵母细胞转录组变化
• GSE277417 非经典 PRC1.1 激活转录反应，从而促进 Treg 在免疫适应中的可塑性 [CUT&TAG]
• GSE267882 Foxp3 和 BATF 协同指导效应 Treg 细胞分化的顺式调控程序和基因表达 [ChIP-Seq]
• GSE267881 Foxp3 和 BATF 协同指导效应 Treg 细胞分化的顺式调控程序和基因表达 [ATAC-Seq]
• GSE262509 CTCF R567 突变通过 3D 基因组重排和转录失调影响小鼠心脏发育 [4C-seq]
• GSE249981 非经典 PRC1.1 激活转录反应，使 Treg 在免疫适应中具有可塑性。
• GSE249980 非经典 PRC1.1 激活转录反应，从而在免疫适应中实现 Treg 可塑性 [PRO-Seq]
• GSE228973 人类 Huh7 细胞的 m5C MeRIP-seq 转录组
• GSE186567 小鼠脾脏全基因组重测序模型
• GSE303448 呼吸道合胞病毒感染诱导的I型干扰素改变肺微环境并抑制肺转移性乳腺癌细胞的播散