详细内容（前10条）

1. ⭐ GSE317103 HER2 特异性合成抗原受体 (SAR) T 细胞疗法与放射疗法协同作用，提高非小细胞肺癌 (NSCLC) 的抗肿瘤疗效

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、T cell、antigen
• 📝 描述：Contributors : Olga-Demetra Biziotis ; Christopher M Silvestri ; Allyson E Moore ; Russta Fayyazi ; Simon Wang ; Elham Ahmadi ; Daniel Del Rosso ; Amr Ali ; Evangelia E Tsakiridis ; Christopher L Baker ; Craig W Aarts ; Bojana Bojovic ; Joanne A Hammill ; Gregory R Steinberg ; Jonathan L Bramson ; Theodoros TsakiridisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn non-small cell lung cancer (NSCLC), radiotherapy not only mediates cytotoxicity but also activates radioresistance drivers like HER2. We investigated radiotherapy combined with HER2-targeted T cell therapy in an NSCLC model. The antitumor efficacy of radiotherapy and engineered T cells expressing a DAP12-associated synthetic antigen receptor (SAR) targeting HER2 was evaluated in HER2-expressing A549 xenografts. HER2 modulation, transcriptional regulation, and tumor T cell infiltration were assessed using immunoblotting, realtime quantitative polymerase chain reaction, flow cytometry, RNA-seq, and immunohistochemistry. High-dose HER2-SAR T cell infusion abolished A549 tumor growth but induced graft-vs-host disease. Low-dose T cell infusion was well-tolerated and provided partial tumor inhibition. Induction radiotherapy (7 d before T cell infusion) synergistically improved tumor control and survival. Radiotherapy transiently upregulated HER2 expression (4 to 24 h), though administering HER2-SAR T cells within this window did not enhance antitumor efficacy. Radiation did not enhance T cell-mediated cytotoxicity in vitro. However, in tumors, radiotherapy increased intratumoral proliferation and accumulation of HER2-SAR T cells and enhanced the extrinsic apoptotic pathway, including induction of Fas transcript and protein levels and cleaved caspase-3 (CC3). RNA-seq of irradiated tumors revealed lasting transcriptional reprogramming with increased immune activation and decreased proliferation and oncogenic signaling. Induction radiotherapy enhances HER2-SAR T cell infiltration and provides synergistic tumor suppression, likely through additional activation of immune-mediated apoptosis. These findings support further assessment of HER2-SAR T cell therapy in HER2-expressing NSCLC.
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2. ⭐ GSE325195 树突状细胞冗余可启动胰腺癌中的抗肿瘤 CD4 T 细胞

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、dendritic cell
• 📝 描述：Contributors : Chong Zuo ; Stephanie DouganSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is resistant to current immunotherapies and lacks effective CD8 T cell responses, which is potentially due to a paucity of cross-presenting dendritic cells (cDC1s). Here, we combine an innate immune adjuvant with anti-CTLA-4 and anti-PD-1 to achieve durable remissions and immunologic memory in multiple mouse models of poorly immunogenic PDAC. Tumor regression does not depend on CD8 T cells or tumor cell MHC class I expression but instead requires IFNγ-producing CD4 T cells (Th1s) that were primed by dendritic cells in lymph nodes. Combination immunotherapy induces an influx of activated cDC2s carrying tumor antigen into tumor-draining lymph nodes; cDC2s are required for orthotopic tumor clearance. Intratumoral CD4 T cells and cDC2s remain present in treatment-naïve and chemotherapy-exposed human PDAC. Even in chemotherapy-exposed patients’ blood, cDC2s outnumber cDC1s by ten-fold. Therefore, therapeutic targeting of the cDC2-CD4 T cell axis could be efficacious in pancreatic cancer.
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3. ⭐ GSE298777 人类幼稚B细胞和记忆B细胞亚群的转录组-蛋白质组分析揭示了同型和亚类特异性表型

• ✍️ 作者：未知作者
• 🏷️ 关键词：B cell、transcriptome、proteome
• 📝 描述：Contributors : Jana Koers ; Arie Hoogendijk ; Simon Tol ; Floris van Alphen ; Ninotska Derksen ; Maartje van den Biggelaar ; Theo RispensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAntibodies produced by B cells aid in recognition and clearance of pathogens and is the cornerstone of vaccination strategies. Humans produce nine different antibody isotypes and their effector functions differ according to the type of antigen and route of exposure. Phenotypic variation between isotype-swithched B cell subsets is expected but not studied in detail. To obtain a molecular definition of isotype-defined B cell identity, we performed proteomics and transcriptomics on isotype-defined populations of human naive and memory B cells (MBCs): CD27-IgM+IgD+, CD27+CD38lo/-IgM+IgD+, CD27+CD38lo/-IgM+IgD-, and IgA1, IgA2, IgG1, IgG2, IgG3, and IgG4 MBCs (CD27+CD38lo/-Ig+). Combined proteome and transcriptome analysis revealed that mRNA and protein expression profiles segregate separate isotype-defined B cell subsets according to their differentiation status. mRNA and protein expression levels correlated reasonably well for many genes. IgG4+ MBCs were most distinct from naive B cells. Besides a distinct expression profile of cytokine and Fc receptors, we identified a high expression of IgE-coding mRNA in IgG4-switched B cells. SDR16C5 was identified as uniquely upregulated in IgG4-switched B cells.
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4. ⭐ GSE287519 将功能性精准肿瘤学与免疫结构相结合，预测粘膜黑色素瘤的免疫治疗策略。

• ✍️ 作者：未知作者
• 🏷️ 关键词：oncology、immune、regex:onco(logy|logist|gene|genic)
• 📝 描述：Contributors : Matilde Monti ; Sara Picinoli ; Anna Bozzola ; Marco Ferrari ; Mattia Bugatti ; Irene Pezzali ; Marco Carlomagno ; Giada Carta ; Matteo Orlandi ; Giacomo Lora ; Luisa Benerini Gatta ; Francesco Missale ; Giorgia Ferrari ; Marcello Manfredi ; Veronica De Giorgis ; Emilio Marengo ; Mario Turri-Zanoni ; Piero Nicolai ; Francesca Consoli ; Davide Lombardi ; Paolo Martini ; Marzia Rossato ; William VermiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMucosal melanomas (MM) arise from mucosal melanocytes at various anatomical sites. These tumors are rare, highly aggressive, and often associated with poor outcomes. Current treatments, including immune checkpoint inhibitors, show limited efficacy in advanced disease. Compared to cutaneous melanomas, there is a lack of data on the immunogenicity and IFN-γ sensitivity of MM. In this study, we examine these features in sino-nasal melanoma (SN-MM) cell lines and clinical samples using microscopy and functional genomics. Microscopic analysis reveals that most SN-MM tumors are immune “desert” with few tumor-infiltrating lymphocytes (TILs), a characteristic linked to poor prognosis. Additionally, SN-MM tumors are CD274/PD-L1 negative. SN-MM cell lines express transcripts for melanocytic and cancer testis antigens. They also show normal surface expression of IFN-γ receptors (IFNGR) and maintain the integrity of the IFNGR/JAK/STAT signaling pathway. Transcriptomic and proteomic analyses demonstrate that SN-MM cell lines, as a group, respond to IFN-γ by upregulating genes involved in immune recognition and antigen presentation. In 60% of SN-MM lines, IFN-γ also induces cytotoxic and anti-proliferative effects, the release of CXCL10 and upregulation of CD274/PD-L1. The remaining SN-MM cell lines, characterized by poor differentiation, show refractoriness to these effects, likely due to post-transcriptional regulation. These findings suggest that combining functional precision oncology with immune context analysis could refine our understanding of immune escape mechanisms in MM and improve patient stratification for immune therapies.
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5. ⭐ GSE280859 AMP-dT 对小鼠淋巴结免疫反应的影响

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?
• 📝 描述：Contributors : Martin P Steinbuck ; Peter C DeMuth ; Lochana M Seenappa ; Erica PalmerSeries Type : Expression profiling by arrayOrganism : Mus musculusAdjuvants are immuno-activators capable of shaping the magnitude and quality of antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable and balanced humoral and cellular responses. Here, we engineered a class of Amphiphile (AMP)-modified, immunostimulatory DNA-adjuvants designed for targeted delivery to lymph nodes and enhanced stimulation of TANK-binding kinase 1 (TBK1)-mediated danger-sensing pathways to generate strong adaptive immunity and long-term memory with potent recall potential. AMP-DNA adjuvants induced robust interferon type-I (IFN-I)-driven inflammatory environments in mouse and non-human primate (NHP) lymph nodes, leading to significantly enhanced cytokine secretion by polyfunctional CD8+ and CD4+ T cells in multiple tissues, as well as strongly elevated TH1-associated and neutralizing antibody responses, in the absence of systemic toxicity. These results demonstrate that AMP-modification enables lymph node-targeted DNA-adjuvants to potently activate IFN-I-signaling to generate substantial cellular and humoral responses crucial for vaccine efficacy.
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6. ⭐ GSE280856 AMP-dT 对恒河猴淋巴结免疫反应的影响

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?
• 📝 描述：Contributors : Lisa K McNeil ; Peter C DeMuth ; Martin P Steinbuck ; Lochana M SeenappaSeries Type : Expression profiling by arrayOrganism : Macaca fascicularis ; Macaca mulattaAdjuvants are immuno-activators capable of shaping the magnitude and quality of antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable and balanced humoral and cellular responses. Here, we engineered a class of Amphiphile (AMP)-modified, immunostimulatory DNA-adjuvants designed for targeted delivery to lymph nodes and enhanced stimulation of TANK-binding kinase 1 (TBK1)-mediated danger-sensing pathways to generate strong adaptive immunity and long-term memory with potent recall potential. AMP-DNA adjuvants induced robust interferon type-I (IFN-I)-driven inflammatory environments in mouse and non-human primate (NHP) lymph nodes, leading to significantly enhanced cytokine secretion by polyfunctional CD8+ and CD4+ T cells in multiple tissues, as well as strongly elevated TH1-associated and neutralizing antibody responses, in the absence of systemic toxicity. These results demonstrate that AMP-modification enables lymph node-targeted DNA-adjuvants to potently activate IFN-I-signaling to generate substantial cellular and humoral responses crucial for vaccine efficacy.
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7. ⭐ GSE313305 致癌和抑癌力量汇聚于祖细胞调控的微环境，从而塑造早期肿瘤发生 [KPLOH scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、regex:onco(logy|logist|gene|genic)、scRNA
• 📝 描述：Contributors : José Reyes ; Yu-Jui Ho ; Scott W Lowe ; Dana Pe’erSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. Here, we integrate lineage tracing, single-cell and spatial transcriptomics to visualize the molecular, cellular and tissue-level events that promote or restrain malignancy during the tumor initiation in mouse models of pancreatic ductal adenocarcinoma (PDAC). We identify a discrete progenitor-like population of KRAS-mutant cells that co-activates oncogenic and tumor-suppressive programs—including p53, CDKN2A, and SMAD4—engaging senescence-like responses and remodeling their microenvironment, ultimately assembling a niche that mirrors invasive PDAC. Even brief KRAS inhibition in the epithelial compartment depletes progenitor-like cells and dismantles their niche, substantially delaying cancer initiation. Conversely, p53 suppression enables progenitor cell expansion, epithelial–mesenchymal reprogramming, and immune-privileged niche formation. These findings position the progenitor-like state as the convergence point of cancer-driving mutations, plasticity, and tissue remodeling—revealing a critical window for intercepting malignancy at its origin.
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8. GSE324779：吉西他滨驱动的肿瘤-基质上清液转移模型中胰腺星状细胞和胰腺癌细胞的转录组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer
• 📝 描述：Contributors : Ciarán McDonnell ; Valeriya Zinina ; Amina Othman ; Larissa Launhardt ; Anna Brichkina ; Fatma Aktuna ; Magdalena Brkic ; Matthias Lauth ; Eliana Stanganello ; Mark SchmittSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is characterized by extensive tumor-stroma interactions that influence disease progression and therapy response. To investigate transcriptional changes associated with chemotherapy-induced tumor-stroma signaling, RNA sequencing was performed in a supernatant transfer system. Murine pancreatic cancer cells (KPC4) were treated with gemcitabine, and supernatants from gemcitabine-treated or vehicle-treated tumor cells were transferred to murine pancreatic stellate cells (PSC4). In a second experiment, supernatants from PSC4 cells previously exposed to tumor cell supernatants were transferred back to pancreatic cancer cells. RNA sequencing was performed to characterize gene expression changes associated with chemotherapy-induced tumor-stroma communication.
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9. GSE315734 高海拔去适应性导致 Treg 细胞中 Nrf2 表达上调，从而引起长期免疫抑制 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、RNA-seq
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: High-altitude exposure imposes hypoxic, low-pressure, and cold conditions that challenge immune homeostasis. The long-term effects of high-altitude de-acclimatization (HADA) remain poorly understood. Objectives: The purpose of this study is to investigate how HADA affects the immune populations, both quantitatively and functionally, and to dissect the underlying molecular mechanisms involved. Methods: Peripheral blood was collected from both human cohorts and mice models while other immune organs including spleen, thymus and bone marrow were obtained from mice models. Proportions of immune cell populations in peripheral blood and other immune organs were analyzed using flow cytometry. The immune-suppressive functions of Tregs were determined by in vitro co-culture with CD8+ T cells. Transcriptomic and chromatin-accessibility feature induced by HADA were obtained through RNA-seq and ATAC-seq. The functional validation of HADA target gene was performed using specific agonist during in vitro co-culture. Results: HADA perturbed the proportions of immune populations in multiple immune site. Both data from human and mice showed increased regulatory T cells (Tregs) and enhanced immune-suppressive function in the peripheral blood. As a consequence, these Tregs mediated long-term immune suppression, impairing the immunity against tumor cells. Multi-omic analyses predicted Nrf2 as the key mediator of molecular alterations in Tregs caused by HADA, which was further confirmed by the functional assay. Conclusion: High-altitude de-acclimatization mediates the expansion of peripheral Tregs and enhances long-lasting immunosuppressive function of Tregs, increasing the probability of serious health consequences. Nrf2 plays as a key regulator mediating the effects of HADA on Tregs. These findings provide novel insights into altitude-related immune regulation and implications for health management in populations transitioning between high and low altitudes.
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10. GSE312789 抑制BIRC5和MCL-1作为克服套细胞淋巴瘤耐药性的潜在治疗策略

• ✍️ 作者：未知作者
• 🏷️ 关键词：lymphoma、resistance
• 📝 描述：Contributor : Amit K MitraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMantle cell lymphoma (MCL) is a difficult-to-cure, highly heterogeneous, and aggressive form of non-Hodgkin lymphoma with a high recurrence rate and poor long-term prognosis. Using a novel optimization-regularization-based computational prediction algorithm called “secDrug,” we have identified therapeutic targets for treating resistant cancers. When applied to B-cell malignancies, the secDrug algorithm predicted the pro-survival proteins BIRC5 and MCL1 as top targets. Here, using a panel of MCL cell lines representing PI/BTKi sensitive, innate resistance, and clonally derived acquired resistance, we demonstrated that small molecule-based inhibition of BIRC5 and MCL1 is effective in killing MCL cells as single agents and in combination with Bortezomib or Ibrutinib. Further, using RNAseq (transcriptomics) and funcional genomics, we identified genes and molecular networks associated with their mechanism of action and synergy. Our results underlined the clinical potential of these candidates in curbing MCL progression and drug resistance.
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1. 直接RNA测序提高了RNA修饰的检测率，可用于临床应用。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：RNA sequencing using direct Nanopore methods improves detection of RNA modifications, enabling more accurate transcriptome analysis and supporting clinical…
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2. 利用RNA测序和人工智能技术从零开始设计新药

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：RNA sequencing combined with deep learning enables prediction of gene expression changes from chemical structures, supporting the design of new therapeutics that reverse disease associated transcriptional signatures…
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3. Building in silico patients using RNA sequencing and AI

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：RNA sequencing combined with AI enables in silico patient models that integrate tumor data to predict individualized drug responses and improve precision oncology strategies…
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4. 猫与人类之间令人惊讶的癌症联系

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Scientists have mapped the genetics of cancer in cats for the first time at scale, uncovering major overlaps with human cancers. Key mutations—like those linked to breast cancer—appear in both species, and some human cancer drugs may also work in cats. Because pets share our environments, these similarities could reveal shared causes of cancer. The research could lead to new treatments that benefit both animals and humans.
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5. 新药可在肠道手术后保护肝脏并促进营养吸收

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:intestin(e|al)
• 📝 描述：A risky but often lifesaving surgery that removes damaged parts of the small intestine can leave patients facing a new threat: serious liver damage with no available treatment. Now, scientists have developed a promising compound that works directly in the gut to shield the liver and improve how the body absorbs nutrients. In mouse studies, the drug boosted weight gain, reduced harmful liver scarring, and avoided side effects by staying confined to the intestines.
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• GSE310318 人类iPSC衍生肺类器官的单细胞RNA测序分析
• GSE310216 DPP4 抑制影响 hiPSC 衍生的脂肪变性 HLC 中的代谢和炎症相关通路 [Vilda]
• GSE310214 DPP4 抑制影响 hiPSC 衍生的脂肪变性 HLC 中的代谢和炎症相关通路
• GSE308263 综合质谱筛选衍生的 HDAC 抑制剂图谱揭示组蛋白特异性乙酰化变化 [ChIP-seq]
• GSE308262 综合质谱筛选衍生的 HDAC 抑制剂图谱揭示组蛋白特异性乙酰化变化 [RNA-seq]
• GSE306780 HMGCS1 在驱动致病性 Th17 细胞免疫和自身免疫性疾病中的非常规作用 [scRNA-seq]
• GSE304840 肺部单细胞RNA测序揭示成骨不全小鼠的慢性炎症和肺气肿表型
• GSE304661 通过单细胞RNA测序鉴定接受高剂量美法仑治疗的多发性骨髓瘤患者自体造血干细胞移植后骨髓中的免疫重建和造血功能恢复情况
• GSE301611 药用大麻植物提取物 (NTI164) 可改变儿童急性起病神经精神综合征的表观遗传、核糖体和免疫通路
• GSE301196 对显微切割的化疗耐药和化疗敏感的高级别浆液性卵巢癌样本进行 Ion Torrent RNA 测序
• GSE299764 药用大麻植物提取物 (NTI164) 可改变儿童急性起病神经精神综合征的表观遗传、核糖体和免疫通路
• GSE296038 体外丁酸盐可改变与染色质失调相关的神经发育障碍儿童外周血单核细胞的表观遗传和免疫通路
• GSE276088 小鼠颞下颌关节骨关节炎关节盘滑膜的单细胞转录组和空间亚细胞图谱
• GSE317073 致癌和抑癌力量汇聚于祖细胞调控的微环境，从而塑造早期肿瘤发生 [kras_inhibitor_scRNA-seq]
• GSE315670 致癌和抑癌力量汇聚于祖细胞调控的微环境，从而塑造早期肿瘤发生 [多组测序]
• GSE315644 致癌和抑癌力量汇聚于祖细胞调控的微环境，从而塑造早期肿瘤发生 [Xenium]
• GSE315243 致癌和抑癌力量汇聚于祖细胞调控的微环境，从而塑造早期肿瘤发生
• GSE315242 致癌和抑癌力量汇聚于祖细胞调控的微环境，从而塑造早期肿瘤发生 [injury_shp53_scRNA-seq]
• GSE315241 致癌和抑癌力量汇聚于祖细胞调控的微环境，从而塑造早期肿瘤发生 [FLEX]
• GSE295395 鱼素食品成分协同促进结肠细胞铁死亡，从而降低结肠癌风险 [scRNA-seq]
• GSE267911 KAT2B介导的RAD51C表观遗传抑制增强结直肠癌对奥拉帕尼的敏感性
• GSE249309 端粒 RNA 的表观遗传控制维持端粒酶驱动癌症中的异染色质 [ChIP-Seq]
• GSE211312 端粒RNA的表观遗传控制维持端粒酶驱动癌症中的异染色质[测序]
• GSE324889 肺移植后临床稳定的结缔组织病相关间质性肺病（CTD-ILD）患者外周血单核细胞的单细胞RNA测序
• GSE324885 水稻TAC4/TAC4L双敲除突变体茎秆脆性表型的转录组测序分析
• GSE292423 抑制人泡沫细胞中的LXR信号传导会损害巨噬细胞与内皮细胞之间的相互作用并促进内皮细胞炎症
• GSE297390 ICMT 缺乏可减轻肝癌小鼠模型的体重减轻和死亡率，但不能抑制肿瘤形成。
• GSE325200 线粒体丰富热溶性（MAHS）蛋白表达调节人脂肪干细胞的代谢动力学
• GSE319493 人类母胎界面中表型相似但功能不同的NK细胞群
• GSE315544 高海拔去适应性损伤通过上调 Treg 细胞中 Nrf2 的表达导致长期免疫抑制
• GSE313674 雄性小鼠暴露于尼古丁会导致其雄性和雌性后代出现代谢功能障碍
• GSE311626 纳米颗粒免疫佐剂复合物增强抗原特异性生发中心反应
• GSE307331 HMGCS1在驱动致病性Th17细胞免疫和自身免疫性疾病中的非常规作用 II
• GSE306371 HMGCS1在驱动致病性Th17细胞免疫和自身免疫性疾病中的非常规作用
• GSE305271 PTPN2 缺陷增强干扰素信号传导并损害人类干细胞衍生胰岛的功能成熟 [scRNA-seq]
• GSE303371 PTPN2 缺陷增强干扰素信号传导并损害人类干细胞衍生胰岛的功能成熟 [RNA-Seq]
• GSE303368 PTPN2 缺陷增强干扰素信号传导并损害人类干细胞衍生胰岛的功能成熟 [ATAC-Seq]
• GSE301530 鉴定模拟转染和 miR-625-3p 转染的卵巢癌细胞中的基因特征
• GSE299130 环境污染物TBOEP与肝脏代谢的关联
• GSE298240 抑制p38 MAPK可改善重复性轻度脑外伤后的免疫信号传导和行为缺陷
• GSE297965 HK1过表达对肝细胞癌细胞的影响
• GSE296997 DNMT3B 调控急性髓系白血病中的顺式调控染色质和细胞周期程序
• GSE295564 brincidofovir 在外周 T 细胞和 NK/T 细胞淋巴瘤中的临床前活性 [RNAseq_NKTCLcelllines]
• GSE295563 brincidofovir 在外周 T 细胞和 NK/T 细胞淋巴瘤中的临床前活性 [RNAseq_tumor]
• GSE295562 brincidofovir 在外周 T 细胞和 NK/T 细胞淋巴瘤中的临床前活性 [RNAseq_PTCLcelllines]
• GSE295561 brincidofovir 在外周 T 细胞和 NK/T 细胞淋巴瘤中的临床前活性 [RNAseq_KAI3_NKS1_posttreatment]
• GSE295560 brincidofovir 在外周 T 细胞和 NK/T 细胞淋巴瘤中的临床前活性 [RNAseq_PTS1_posttreatment]
• GSE295559 brincidofovir 在外周 T 细胞和 NK/T 细胞淋巴瘤中的临床前活性 [RNAseq_DLBCLcelllines]
• GSE295380 Pla2g12b 对肠道脂质吸收至关重要，而 C129Y 是一种显性负突变。
• GSE295001 DNMT3B 在急性髓系白血病分子亚型增强子转录活动中的作用。
• GSE293367 brincidofovir 在外周 T 细胞和 NK/T 细胞淋巴瘤中的临床前活性
• GSE287501 衰老与肺部鸟分枝杆菌复合群（MAC）疾病的病理生理学
• GSE285665 祖先双酚A暴露通过精子基因体CpG岛甲基化的跨代遗传诱导性别二态性非酒精性脂肪肝疾病
• GSE278362 DHX9 sustains hematopoietic stem cell function in cooperation with H3 acetylation [RNA-Seq]
• GSE235489 miR-34a 缺乏与阿尔茨海默病动物模型相关
• GSE325257 NK细胞促进心肌梗死中的心肌细胞死亡并调节髓系造血
• GSE325193 GeCas12a2 CRISPR-Cas核酸酶PFS筛选的深度测序数据
• GSE316553 非人灵长类动物早期实验性青光眼视神经乳头空间转录组变化。
• GSE309819 核小体间距通过DNMT3A2/3B3调控连接区甲基化
• GSE309619 阻力训练可恢复透析患者的肌肉健康
• GSE296689 系统转录组分析揭示了替代启动子在造血谱系中的关键作用
• GSE295394 鱼素食品成分协同促进结肠细胞铁死亡，从而降低结肠癌风险 [bulkRNA-seq]
• GSE294601 CD371靶向CAR T细胞分泌白细胞介素-18，表现出强大的扩增能力并能清除难治性急性髓系白血病
• GSE285849 播散性儿童低级别胶质瘤的临床和分子综合图谱
• GSE279000 端粒 RNA 的表观遗传控制维持端粒酶驱动癌症中的异染色质 [纳米孔]
• GSE266948 BAP1 缺失与 TP53 缺陷协同作用，转化共同的髓系-红系祖细胞（单细胞 RNA 测序 - 小鼠）
• GSE223716 端粒 RNA 的表观遗传控制维持端粒酶驱动癌症中的异染色质 [体内]
• GSE211313 端粒RNA的表观遗传调控维持端粒酶驱动癌症中的异染色质
• GSE211297 端粒 RNA 的表观遗传控制维持端粒酶驱动癌症中的异染色质 [芯片]
• GSE324950 RAD51C作为膀胱癌关键基因和治疗靶点的潜力
• GSE314559 代谢编程促进细胞对细胞外囊泡的摄取并提高体内治疗效果
• GSE313521 多次心肌内注射脐带血单核细胞（UCB-MNCs）后心脏修复的独特转录组
• GSE289326 CITEgeist：转录组和表位的细胞索引用于引导探索内在空间趋势
• GSE261882 MAGED2介导AKT通路调控胶质母细胞瘤的生物学功能
• GSE316472 多梳抑制性去泛素化酶复合物通过抑制多梳蛋白活性来保护卵母细胞表观基因组和女性生育能力