详细内容（前10条）

1. ⭐ GSE318315 MERTK抑制剂与免疫调节剂环磷酰胺协同作用，诱导三阴性乳腺癌中CXCL9阳性单核细胞-巨噬细胞的程序化和持久的抗肿瘤免疫。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immunity、macrophage、monocyte
• 📝 描述：Contributors : Alex Smith ; Jeffrey RosenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTriple negative breast cancer (TNBC) has high rates of recurrence despite chemotherapy and immune checkpoint blockade (ICB). Tumor associated macrophages (TAMs) can either suppress or support anti-tumor immunity, but the mechanisms governing these states and their therapeutic targeting remain unclear. Here, by integrating public single-cell datasets with TNBC patient cohorts, we identify a prognostic myeloid signature defined by CXCL9-high and C1Q-low TAM programs that is associated with improved survival and increased lymphocyte activation pathways. Using immunocompetent p53-null syngeneic TNBC models spanning basal-like (2153L) and claudin-low (T12) subtypes, we show that immunomodulatory cyclophosphamide (CTX) reprograms hematopoiesis toward the monocytic lineage and induces an interferon conditioned tumor microenvironment that supports CXCL9-positive monocyte-derived macrophages in basal-like disease. Combining CTX with the next generation MERTK-selective inhibitor ULC2371 (MRX-2843) drives complete tumor remissions in both models; however, durable long-term responses occur selectively in the basal-like subtype. Responding tumors exhibit expansion of antigen-presenting CXCL9-positive monocyte-derived macrophages and a reduction of C1q-positive phagocytic TAMs. Mechanistically, MERTK inhibition relieves MAPK and SOCS1 mediated restraint of interferon signaling, driving a positive feedback loop involving IRF7, STAT1, and IRF1 that promotes sustained CXCL9 induction. Functionally, tumor control requires CXCL9-CXCR3 dependent CD4 T cell recruitment, accumulation of stem-like memory CD4 T cells, and germinal center-like immune organization in tumor draining lymph nodes. PD-1 blockade further enhances response durability, preventing recurrence in most treated basal-like tumors.Together, these findings define an interferon-licensed, MERTK-regulated myeloid checkpoint that can be therapeutically targeted to convert immunosuppressive TNBC microenvironments into durable adaptive immunity, supporting clinical translation of CTX and MRX-2843 based combination therapies in basal-like TNBC.
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2. ⭐ GSE275178 单细胞 RNA 测序揭示了慢性应激诱导的结直肠癌免疫抑制

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、regex:immuno(logy|therapy|suppression)、sequencing、single-cell
• 📝 描述：Contributors : Yan Wang ; Yingru ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe high prevalence of depressive disorders in individuals with cancer and their contribution to tumour progression is a topic that is gradually gaining attention. Recent evidence has shown that there are prominent connections between immune gene variants and mood disorders. The ho_x0002_meostasis of the tumour immune microenvironment (TIME) and the infiltration and activation of immune cells play a very important role in the antitumour effect. In this study, we established a compound mouse model with chronic unpredictable mild stress (CUMS) and orthotopic colorectal cancer to simulate colorectal cancer (CRC) patients with depression. Using 10✕Genomics single_x0002_cell transcriptome sequencing technology, we profiled nearly 30,000 cells from tumour samples of 8 mice from the control and CUMS groups, revealed that immune cells in tumours under a chronic stress state trend toward a more immunosuppressive and exhaustive status, and described the crosstalk between the overall inflammatory environment and immunosuppressive landscape to provide mechanistic information or efficacious strategies for immune-oncology treatments in CRC with depressive disorders.
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3. ⭐ GSE324505 跨物种转录组整合揭示了一条保守的、MIRO1介导的巨噬细胞-T细胞信号通路驱动胶质瘤免疫抑制

• ✍️ 作者：未知作者
• 🏷️ 关键词：T cell、macrophage、glioma、regex:immuno(logy|therapy|suppression)
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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4. ⭐ GSE324504 跨物种转录组整合揭示了保守的、MIRO1 介导的巨噬细胞到 T 细胞信号轴驱动胶质瘤中的免疫抑制 [snRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：T cell、macrophage、glioma、regex:immuno(logy|therapy|suppression)
• 📝 描述：Contributors : Xinnan Wang ; Menghan Li ; Brandon Bergsneider ; Zehui DuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe generated single-nucleus RNA sequencing (snRNA-seq) data from murine gliomas treated in vivo with a MIRO1-binding compound or vehicle control. Tumors were dissociated and processed for nucleus isolation followed by high-throughput transcriptomic profiling to characterize cell-type-specific gene expression programs within the tumor microenvironment (TME). The dataset captures malignant cells and diverse stromal and immune populations, including macrophages, microglia, and T cells, enabling analysis of treatment-associated transcriptional changes at single-cell resolution. These data provide a resource for investigating mitochondrial-associated transcriptional regulation and immune microenvironment remodeling in murine glioma.
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5. ⭐ GSE306253 小鼠肌肉损伤及对合成生物材料植入物异物反应的免疫细胞和基质细胞的单细胞RNA测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、RNA-seq、single-cell
• 📝 描述：Contributors : Anna Ruta ; Joscelyn Mejias ; Kavita Krishnan ; Alexandra Rindone ; Frank H Yu ; Christopher Cherry ; Michael Patatanian ; Jennifer ElisseeffSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe main objective of this study is to characterize the immune and stromal cell response to tissue injury and the foreign body response (synthetic polycaprolactone PCL implant). We enrich CD45+ immune cells from injured murine muscles with fibrotic PCL implants (6 week time point) and perform transcriptomic profile using single-cell RNA-sequencing.
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6. ⭐ GSE298364 批量 RNA 测序 - SV40 大 T 抗原永生化小鼠原代肠上皮干细胞和祖细胞

• ✍️ 作者：未知作者
• 🏷️ 关键词：antigen、RNAseq、regex:intestin(e|al)
• 📝 描述：Contributors : Julie Y Zhou ; Ryan J Musich ; Amalu Job ; Thaddeus S StappenbeckSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDeveloping new tools for studying the intestinal epithelium is essential for addressing unan-swered questions in development, physiology, and disease pathology. Primary intestinal epitheli-al stem cell (ISC) cultures are an invaluable in vitro model system. However, their cultivation re-mains technically demanding and costly, limiting their accessibility and use. Though commonly utilized, most extant intestinal epithelial cell lines were derived from colon adenomas from vari-ous animals, are largely uncharacterized, and possess a plethora of genetic abnormalities, thus restricting rigor, reproducibility, and physiological relevance. Here we derived immortalized intestinal epithelial cell lines (iIECs) from six jejunal and six colonic stem cell-enriched spheroid cultures from wild type C57BL/6 mice. We transduced ISCs with a lentiviral vector encoding the SV40 large T antigen, and subsequently selected lines through adaptation to growth on plastic. Additionally, we weaned these lines off conditioned medium including the growth factors Wnt3a, Rspo3, and Noggin. We found that iIECs have growth characteristics similar to conventional plastic adapted cell lines. While we observed transcriptional signatures of epithelial-mesenchymal transition (EMT), these cells still exhibited epithelial characteristics including ex-pression of junctional proteins, mounted an innate immune response to viral infection, and se-creted cytokines in response to LPS stimulation. We further demonstrated the utility of iIECs through transient and stable genetic manipulation. iIECs occupy an important experimental niche through offering a scalable, practical, and physiologically relevant model system that can func-tion as a discovery platform before transitioning to primary spheroid cultures and/or animal models. We propose that they will be a valuable tool for advancing understanding of intestinal epithe-lial biology.
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7. ⭐ GSE261438 TERT 表达通过促进脂肪细胞形成和重塑巨噬细胞景观来减轻肥胖小鼠的代谢紊乱 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、metabolic、RNA-seq
• 📝 描述：Contributors : Laura Braud ; Manuel Bernabe ; Julien Vernerey ; Dmitri Churikov ; Manon Richaud ; Antonio M Miranda ; Liam Mc Allan ; Christophe Lachaud ; Jesus Gil ; William Scott ; Vincent GeliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is linked to limited adipose tissue (AT) remodeling capacity, leading to hypertrophic adipocytes, senescence, and inflammation. We used a mouse model expressing mTert, or its catalytically inactive form mTertCi, from the Cdkn1a locus to investigate the role of mTERT in obesity-induced metabolic disorders in mice on a high-fat-diet (HFD). We found that mTERT expression attenuates p21 expression, telomere attrition, senescence, and inflammation in the AT of HFD-induced obese mice, thereby reducing associated metabolic disorders. In vivo and in vitro data reveal that mTERT promotes differentiation of adipose stem and progenitor cells into adipocytes in obese mice. Strikingly, single nucleus RNA-seq data show that both mTERT and mTERTCi remodels the landscape of macrophages in AT of obese mice thereby reducing the immune response. These results emphasize involvement of the canonical and non-canonical mTERT functions in ameliorating metabolic disorders and suggest conditional TERT expression as a potential therapeutic option for obesity.
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8. ⭐ GSE310166 组蛋白串扰介导的互斥 H3K79 甲基化区域的建立 [ChIP-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：ChIP-seq、methylation、histone
• 📝 描述：Contributors : Na Hyun Park ; Hwa-Ryeon Kim ; Jae-Seok Roe ; TaeSoo KimSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeHistone H3 lysine 79 (H3K79) methylation plays critical roles in various cellular processes, including development and DNA repair, potentially through modulation of chromatin structure and gene expression. Despite its importance, the genome-wide distribution patterns, mechanisms of establishment, and functional distinctions among its mono-, di-, and tri-methylated forms (H3K79me1, me2, and me3) remain largely unclear. Here, we generated genome-wide maps of H3K79me1, H3K79me2, and H3K79me3 using ChIP-seq and found that each methylation state is predominantly associated with a unique subset of genes, which we term state-specific H3K79 methylation zones. These zones are mutually exclusive and are stably maintained even during global transcriptional reprogramming. We further demonstrate that H2B ubiquitination mediated by the Rad6-Bre1 complex is essential for the integrity of these methylation zones. Specifically, deletion of RAD6 leads to the complete loss of the H3K79me3 zone and its conversion into an H3K79me1-enriched region. Interestingly, the H3K79me1 zone is also significantly diminished upon RAD6 deletion, indicating that H2B ubiquitination supports both the maintenance and establishment of specific methylation zones. Similar disruption of the H3K79me1 landscape is observed upon loss of H4K16 acetylation. Functionally, H3K79me1 and H3K79me3 appear to have opposing roles in transcriptional regulation as loss of H3K79 methyltransferase Dot1 results in transcriptional activation of genes within the H3K79me1 zone and repression of genes within the H3K79me3 zone. Together, our findings reveal that distinct H3K79 methylation states define specific and functionally divergent chromatin domains, whose establishment and maintenance depend on trans-histone crosstalk and contribute to opposing transcriptional outputs.
• 🔗 查看原文

9. ⭐ GSE310163 组蛋白串扰介导的互斥 H3K79 甲基化区域的建立 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、methylation、histone
• 📝 描述：Contributors : Na Hyun Park ; Hwa-Ryeon Kim ; Jae-Seok Roe ; TaeSoo KimSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeHistone H3 lysine 79 (H3K79) methylation plays critical roles in various cellular processes, including development and DNA repair, potentially through modulation of chromatin structure and gene expression. Despite its importance, the genome-wide distribution patterns, mechanisms of establishment, and functional distinctions among its mono-, di-, and tri-methylated forms (H3K79me1, me2, and me3) remain largely unclear. Here, we generated genome-wide maps of H3K79me1, H3K79me2, and H3K79me3 using ChIP-seq and found that each methylation state is predominantly associated with a unique subset of genes, which we term state-specific H3K79 methylation zones. These zones are mutually exclusive and are stably maintained even during global transcriptional reprogramming. We further demonstrate that H2B ubiquitination mediated by the Rad6-Bre1 complex is essential for the integrity of these methylation zones. Specifically, deletion of RAD6 leads to the complete loss of the H3K79me3 zone and its conversion into an H3K79me1-enriched region. Interestingly, the H3K79me1 zone is also significantly diminished upon RAD6 deletion, indicating that H2B ubiquitination supports both the maintenance and establishment of specific methylation zones. Similar disruption of the H3K79me1 landscape is observed upon loss of H4K16 acetylation. Functionally, H3K79me1 and H3K79me3 appear to have opposing roles in transcriptional regulation as loss of H3K79 methyltransferase Dot1 results in transcriptional activation of genes within the H3K79me1 zone and repression of genes within the H3K79me3 zone. Together, our findings reveal that distinct H3K79 methylation states define specific and functionally divergent chromatin domains, whose establishment and maintenance depend on trans-histone crosstalk and contribute to opposing transcriptional outputs.
• 🔗 查看原文

10. GSE319956 FOXM1在肺癌中普遍存在，可通过T细胞受体工程进行靶向治疗。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、T cell
• 📝 描述：Contributors : Minying Zhang ; Emily Bontekoe ; Peixin Jiang ; Alexandre ReubenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified epitopes derived from FOXM1 which were immunogenic on HLA-A02:01, HLA-A24:02, and HLA-A*23:01, endogenously-processed and presented, and resulted in T cell activation and cytotoxic T cell responses. Following the generation of TCR-T cells, sensitivity and specificity were confirmed by peptide dose-response and X-scan, respectively. Most importantly, adoptive transfer of TCR engineered T cells led to a significant reduction in tumor growth, as well as significantly prolonged survival in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) tumor-bearing murine model. Our studies confirm the immunogenicity of FOXM1 and feasibility of targeting this antigen using TCR-engineering.
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1. 高保真长读长RNA测序技术可增强罕见疾病的临床诊断。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：Long read RNA sequencing improves detection of disease related splicing abnormalities, revealing complex transcript structures that help explain genetic causes of rare disorders…
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2. 海洋变暖可能会极大地促进一种控制海洋营养物质的微小微生物的繁殖。

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:micro(b|be|bial|organism)
• 📝 描述：As deep-sea waters warm, scientists expected trouble for the microbes that help keep ocean chemistry in balance. Instead, researchers found that Nitrosopumilus maritimus can adapt to warmer, iron-limited conditions by using iron more efficiently. Because these microbes control key nitrogen reactions that support marine life, their adaptability could help sustain ocean productivity. In a warming world, they may play an even bigger role in shaping marine nutrient cycles.
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• GSE313569 p300 介导的组蛋白 H3K18 乳化通过抑制线粒体自噬促进线粒体 ROS 积累，从而增强多巴胺激动剂在催乳素瘤中的疗效 [RNA-seq]
• GSE309388 人类膀胱癌细胞系 T24 的化疗耐药变体和化疗敏感变体之间的基因差异 [RNA-Seq UC3]
• GSE309348 清除 CX3CR1+ 巨噬细胞后，UPEC 感染的睾丸和附睾 (5d) 的全转录组测序
• GSE297692 从头 H3.2K9me2 沉积途径建立异染色质以抑制体细胞发育过程中的转座子动员 [RNA-Seq]
• GSE297691 从头 H3.2K9me2 沉积途径建立异染色质以抑制体细胞发育过程中的转座子动员 [ChIP-Seq]
• GSE295723 UVI-5008：一种首创的可逆性非共价双重表观遗传和激酶抑制剂，靶向耐药性B细胞恶性肿瘤中的布鲁顿酪氨酸激酶。
• GSE293378 基于单细胞转录组学的辐射诱导肝病机制
• GSE290126 DLD1结肠癌细胞过表达TRMT6和TRMT61A基因的综合转录组分析[RNA甲基化]
• GSE290123 过表达 TRMT6 和 TRMT61A 基因的 DLD1 结肠癌细胞的综合转录组分析 [RNA-seq]
• GSE277995 单纯疱疹病毒 1 (HSV-1) R 环是 APOBEC 介导的先天免疫的靶标 [ChIP-Seq]
• GSE269061 肝脏运动因子通过靶向脑血管逆转衰老和阿尔茨海默病相关的记忆丧失
• GSE248423 阿尔茨海默病（AD）患者的全转录组基因表达
• GSE248422 阿尔茨海默病 (AD) 患者的全转录组基因表达 [sRNA]
• GSE248417 阿尔茨海默病 (AD) 患者的全转录组基因表达 [lncRNA]
• GSE324489：单细胞分辨率下抗原特异性 CD4+ T 细胞的全蛋白筛选和多模态分析
• GSE314603 套细胞淋巴瘤细胞系和患者外周血单核细胞中MCL-1抑制剂反应和耐药性的转录组分析
• GSE310856 顺铂化疗联合放疗可诱导局部晚期头颈癌患者体内肿瘤特异性T细胞延迟扩增
• GSE309768 CyCLoPs：一种利用细胞因子活性体内标记检测免疫反应的方法
• GSE306146 生物材料植入物纤维化中野生型和GD T细胞缺陷小鼠基质亚群的批量RNA测序
• GSE303921 肌酸治疗荷瘤小鼠的单细胞RNA测序
• GSE303899 揭示肌少症性肥胖的表观遗传图谱：一项针对老年女性的初步研究揭示DNA甲基化机制
• GSE300131 系统性给予体外诱导的CD28缺失的调节性T细胞可减轻压力超负荷诱导的心脏纤维化引起的病理性重塑
• GSE297901：新生儿手指截肢后4天，经FGF2处理24小时的伤口原代培养细胞的单细胞RNA测序
• GSE293078 针对细菌聚糖的抗体反应在生发中心亲和力成熟和多样化。
• GSE291961 c-Rel 通过纤连蛋白-整合素信号通路诱导的隔离应激抵抗和 EMT 激活驱动胰腺癌转移
• GSE291889 c-Rel 通过纤连蛋白-整合素信号诱导的隔离应激抵抗和 EMT 激活驱动胰腺癌转移 [Cut&Run]
• GSE243972：从感染了表达MOG或OVA的沙门氏菌的TCRMOG动物肠系膜淋巴结中提取的淋巴细胞的单细胞水平基因表达谱
• GSE324226 肠-脑轴紊乱导致断奶仔猪低采食综合征
• GSE291804 多组学分析揭示脑转移瘤中肥胖诱导的前列腺素串扰抑制肿瘤微环境中 CD8T 细胞扩增
• GSE261439 TERT 表达通过促进脂肪细胞形成和重塑巨噬细胞景观来减轻肥胖小鼠的代谢紊乱 [snRNA-Seq]
• GSE318166 新型 CRISPR-Cas9 BAP1 敲除临床前肿瘤模型重现了人类黑色素瘤的肿瘤发生和免疫进化
• GSE271616 STAT5B驱动的肝脾γδ T细胞淋巴瘤小鼠模型揭示JAK抑制剂的治疗效果
• GSE324254 putzig 通过两阶段的方式参与 Piwi 介导的果蝇雌性生殖细胞中转座子活性的抑制，从而保障基因组完整性。
• GSE313568 p300 介导的组蛋白 H3K18 乳化通过抑制线粒体自噬促进线粒体 ROS 积累，从而增强多巴胺激动剂在催乳素瘤中的疗效 [CUT&Tag]
• GSE313483 皮质抑素拮抗 Piezo1-STING 轴，通过减弱糖尿病溃疡中 AGEs 的积累来促进角质形成细胞的线粒体稳态 [RNA-Seq IFN1]
• GSE313457 急性髓系白血病骨髓中乳酸水平升高通过 GPR81 信号通路促进巨噬细胞极化
• GSE313293 线粒体功能通过果蝇中TORC1的激活决定卵母细胞命运 [RNA-Seq]
• GSE311000 肿瘤内微生物群和宿主基因型共同影响中性粒细胞在结直肠癌中的抗肿瘤活性
• GSE309386 人类膀胱癌细胞系T24的化疗耐药变体和化疗敏感变体之间的基因差异
• GSE308936 通过多组学分析简化尿路上皮癌分子分型：对精准治疗的启示
• GSE307342 大豆 JmjC 结构域蛋白 JMJ19/20 具有内肽酶活性，并与 LUX 相互作用以调节开花时间 [RNA-seq]
• GSE307341 大豆 JmjC 结构域蛋白 JMJ19/20 具有内肽酶活性，并与 LUX 相互作用以调节开花时间 [ChIP-seq]
• GSE300348 Cdkn2a/p16INK4A 缺失影响年轻成年小鼠海马转录，且与阿尔茨海默病相关遗传通路无关
• GSE297750 从头 H3.2K9me2 沉积途径建立异染色质，以抑制体细胞发育过程中的转座子动员
• GSE297693 从头 H3.2K9me2 沉积途径建立异染色质，以抑制体细胞发育过程中的转座子动员 [纳米孔]
• GSE293645 选择性 Janus 激酶抑制剂在小鼠骨髓衰竭中表现出不同的作用
• GSE293533 对接受或未接受巴瑞替尼治疗的 BMF 小鼠在不同时间点的骨髓 CD8+ T 细胞进行批量 RNA 测序
• GSE290501 肿瘤分泌的SPP1激活肝星状细胞中的CD44-Hedgehog信号通路，促进纤维化
• GSE289834 由 KDELR1 和 KDELR3 调控的回路精细调节早期分泌途径的组成
• GSE284648 E-钙黏蛋白上调促进克唑替尼耐药的ALK重排肺癌中球状体的形成
• GSE284474 单纯疱疹病毒 1 (HSV-1) R 环是 APOBEC 介导的先天免疫的靶标 [RNaseH_DRIP-seq]
• GSE277996 单纯疱疹病毒 1 (HSV-1) R 环是 APOBEC 介导的先天免疫的靶标 [DRIP-seq]
• GSE324435 单细胞染色质谱分析揭示大脑和视网膜发育中的动态调控逻辑和增强子元件
• GSE319238 维持小胶质细胞修复功能可增强中风恢复 [scRNA-seq]
• GSE319237 维持小胶质细胞修复功能可增强中风恢复 [批量 RNA 测序]
• GSE319235 维持小胶质细胞修复功能可增强中风恢复 [ATAC-seq]
• GSE317794 稳定的生物反应器控制揭示了酸性 pH 驱动的人类淋巴母细胞代谢重编程和线粒体功能障碍
• GSE314230 体外和体内淋巴瘤模型中MCL-1抑制剂反应的转录组分析
• GSE313372 结核分枝杆菌感染期间Nr4a1-KO小鼠肺部T细胞的单细胞转录组分析
• GSE312077 研究发现，干扰 SCD 活性可通过调节细胞应激、mTOR 信号通路和 DNA 损伤来抑制前列腺癌骨转移的进展。
• GSE310351 人类大隐静脉移植的空间转录组分析揭示了早期新生内膜增殖过程中的分子重塑和平滑肌细胞表型转变
• GSE306147 小鼠肌肉损伤和对合成生物材料植入物的异物反应中T细胞的单细胞RNA/TCR测序
• GSE305184 RIPK3在炎症疾病中激酶依赖性和非依赖性功能的解析
• GSE304218 牙龈卟啉单胞菌对巨噬细胞的活化和侵袭受PPAD和辅助菌毛亚基的调节
• GSE303532 IL-4 全身应用可减轻大鼠创伤性脊髓损伤后的继发性局部炎症过程并增强功能恢复。
• GSE302730 代谢紊乱依赖性α-酮戊二酸/琥珀酸比例失衡会损害TDG功能和碱基切除修复过程，从而增加胰腺癌的易感性
• GSE302182 对 K. phaffii 培养物进行系统扰动，发现与重组蛋白 1 特定生产力相关的基因特征 [K. phaffii S-1076 RNA-seq]
• GSE302181 对 K. phaffii 培养物进行系统扰动，发现与重组蛋白 1 特定生产力相关的基因特征 [K. phaffii S-953 RNA-seq]
• GSE299406 马尿酸靶向 UGDH/FOXK1/CD36 信号轴调节代谢功能障碍相关脂肪肝疾病的作用机制研究
• GSE298147 CUX1 缺陷细胞中二甲基组蛋白 H3K9 (H3K9me2) 的减少。
• GSE293347 RNA-seq 针对 AML 细胞系在有或无 USP20 的情况下进行分析
• GSE289117 甲型流感病毒感染在非人灵长类动物中诱导胎盘和胎儿免疫失调，但无垂直传播
• GSE279498 多组学图谱辅助发现选择性T细胞状态编程的转录因子
• GSE275229 细胞葡萄糖摄取的瞬时升高加剧压力超负荷诱导的心脏肥大和功能障碍
• GSE268046 嘌呤能受体 P2rx7 介导的 ATP 感应对于通过调控 MSC 的线粒体功能来预防骨骼衰老是必需的
• GSE324285 CSDE1敲低感觉神经元中总RNA和线粒体沉淀物中分离的RNA的总RNA测序分析
• GSE323396 DNA双链断裂和端粒修复在程序性DNA消除过程中的序列基序[Hi-C]
• GSE312320 SETDB1/HUSH modulates Xist RNA levels during establishment of X chromosome inactivation [ChIP-Seq, 2]
• GSE310108 SETDB1/HUSH 在 X 染色体失活建立过程中调节 Xist RNA 水平 [RNA-Seq]
• GSE309423 SETDB1/HUSH 在 X 染色体失活建立过程中调节 Xist RNA 水平 [ChIP-Seq]
• GSE293783 人类肾上腺皮质类器官模型揭示类固醇生成和分区的驱动因素 [空间]
• GSE292946 一项针对晚期低级别浆液性癌女性患者的新辅助氟维司群联合阿贝西利治疗的II期试点研究
• GSE291875 人类卵泡液细胞外囊泡的microRNA谱揭示了应激反应通​​路及其在卵巢衰老中的作用
• GSE303357 2′-O-甲基化依赖的N2-甲基鸟苷在U6内部茎环中的安装促进了剪接体的高效组装
• GSE302527 5’tRNA衍生片段调节2型糖尿病中β细胞稳态和胰岛巨噬细胞活化[RNAseq_BMDM]
• GSE302250 5’tRNA衍生片段调节2型糖尿病中β细胞稳态和胰岛巨噬细胞活化 - 转录组学
• GSE302056 5’tRNA衍生片段调节2型糖尿病中的β细胞稳态和胰岛巨噬细胞活化[iMAC]
• GSE302055 5’tRNA衍生片段调节2型糖尿病中的β细胞稳态和胰岛巨噬细胞活化[β]
• GSE293781 人类肾上腺皮质类器官模型鉴定类固醇生成和分区的驱动因素 [scRNA-seq]
• GSE270753 2′-O-甲基化依赖的N2-甲基鸟苷在U6内部茎环中的安装促进了剪接体的高效组装
• GSE270752 2′-O-甲基化依赖的N2-甲基鸟苷在U6内部茎环中的安装促进了剪接体的高效组装