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1. ⭐ GSE315254 Smyd5 介导 IL-4 表观遗传控制巨噬细胞抗原呈递，从而驱动协同 T 细胞介导的肿瘤抑制 [CUT&Tag]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、T cell、macrophage、antigen、epigenetic
• 📝 描述：Contributors : Buyun Dang ; Yuling Hong ; Qingxiang Gao ; Shih-Chin ChengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIL-4 is classically associated with “M2” macrophages considered tumor-immunosuppressive, yet marker-based labels poorly reflect macrophage function in tumors. Reports of a non-canonical, IL-4–imprinted macrophage state (M2inf) with trained-immunity features prompted us to test whether such imprinting contributes to antitumor immunity in vivo. Here we show that, in B16F10 melanoma, IL-4 programs macrophages through the lysine methyltransferase Smyd5 to deposit promoter-proximal H3K36me3, increase MHC class II, and potentiate T cell activation. Myeloid Il4ra deletion increased tumor burden and reduced MHC class II and intratumoral T cell activation, whereas co-transfer of IL-4–primed macrophages suppressed tumors and expanded activated CD4 and CD8 T cells. Antitumor benefit required adaptive lymphocytes and macrophage-intrinsic MHC class II, as Rag1 deficiency or macrophage Rfx5 deletion abrogated tumor suppression. These findings identify a non-canonical, IL-4–imprinted macrophage program that enables antigen presentation and cooperative T cell immunity in this tumor context.
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2. ⭐ GSE317029 非细胞溶解性病毒疫苗载体通过触发 I 型干扰素诱导持久的效应记忆 CD8 T 细胞免疫 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、vaccine、T cell、scRNA
• 📝 描述：Contributors : Matias Ciancaglini ; Robin Avanthay ; Anna-Friederike Marx ; Tiago Abreu-Mota ; Davide Finozzi ; Jonas Fixemer ; Florian Geier ; Dominik Burri ; Ingrid Wagner ; Ilena Vincenti ; Mario Kreuzfeld ; Doron Merkler ; Gert Zimmer ; Daniel D PinschewerSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusReplication-deficient viral vector systems hold promise for CD8 T cell-based vaccination, but the molecular mechanisms accounting for platform-specific differences in immunogenicity remain ill-defined. Here we compared lymphocytic choriomeningitis virus- (rLCMV) and vesicular stomatitis virus-based (rVSV) single-cycle vectors to explore vector-specific features determining long-lived effector-memory CD8 T cell induction. rLCMV, a non-cytolytic vector, elicited more durable CD8 T cell responses and a higher proportion of effector-memory CD8 T cells than cytolytic rVSV. When rVSV was re-engineered to be non-cytolytic (rVSVMq), also this vector induced durable and effector-differentiated CD8 T cell memory, reminiscent of rLCMV-induced responses, and it afforded superior protection against Listeria challenge than rVSV. Improved CD8 T cell responses of non-cytolytic rVSVMq depended on an elevated type I interferon (IFN-I) response and its direct sensing by vaccination-induced CD8 T cells. Many rVSVMq-infected cells in the splenic marginal zone that were in contact with antigen-specific CD8 T cells expressed not only vectorized antigen but also IFN-I, suggesting that non-cytolytic viral vectors promote the integration of peptide-MHC and IFN-I signals during T cell activation. These mechanistic insights should help to refine vaccines aimed at eliciting durable and protective effector-memory CD8 T cell immunity.
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3. ⭐ GSE310552 DAB2IP 通过增强肠道 ILC3 功能来调节肠道炎症

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation、gut、regex:gut(-?microbiome)?、regex:intestin(e|al)
• 📝 描述：Contributors : Liang Liu ; Zhiheng HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGroup 3 innate lymphoid cells (ILC3s) protect the intestinal barrier by producing IL-22 and IL-17A, yet the molecular mechanisms that sustain their cytokine output during inflammation remain poorly defined. Here, we identify the cytosolic scaffold DAB2IP as a critical ILC3-intrinsic regulator of effector function. In human IBD, DAB2IP expression is reduced in inflamed tissues, correlating with impaired epithelial repair and decreased IL-22. In mice, DAB2IP expression in ILC3s declines during intestinal inflammation, and silencing DAB2IP markedly diminishes IL-22 and IL-17A production. Adoptive transfer of Dap2ip-deficient ILC3s exacerbates DSS-induced colitis and increases susceptibility to Citrobacter rodentium. Mechanistically, DAB2IP promotes NF-κB activation, sustaining transcription of Il22 and Il17a. These results reveal a context-dependent role for DAB2IP as a positive regulator of NF-κB in ILC3s, highlighting its previously unknown function in mucosal immunity and epithelial repair, and suggesting that restoring DAB2IP signaling could enhance barrier protection during intestinal inflammation.
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4. ⭐ GSE311208 单细胞和批量 RNA 测序相结合揭示骨髓炎中免疫微环境的变化

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、RNA-seq、single-cell
• 📝 描述：Contributors : Zhenhua Zhu ; Xiaopeng Jing ; Jun Chen ; Jie Tan ; Ji Zeng ; Zheng JinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObjective: This study profiled the osteomyelitis immune micro-environment in depth, pinpointed driver genes and cell populations that fuel disease progression, and mined the data for actionable drug targets. Methods: We analyzed time-series transcriptomic sequencing data from mouse tibial osteomyelitis samples in dataset GSE168896. Fuzzy c-means clustering was applied to reveal gene sets linked to disease progression. Immune cell infiltration analysis was conducted through online tool ImmuCellAI-mouse. Furthermore, by leveraging single-cell sequencing data, we characterized immune cell subpopulations and pinpointed the key cell subtypes that exhibited in osteomyelitis mouse. Results: We identified six gene clusters exhibiting distinct temporal expression patterns and functional roles in osteomyelitis processes, such as leukocyte and lymphocyte activation, ossification. Single-cell sequencing analysis further revealed 7 distinct cellular subpopulations. Among these, M2-like macrophages demonstrated a significant increase following osteomyelitis. Arg+Sdc4+ Mac and Cxcl1+Ccl4+ Mac were new subpopulations of macrophages that emerged after osteomyelitis, the infiltration of Mif+Cd63+ Mac significantly increased. Besides, Cxcl2-Cxcr2 ligand-receptors contributed mostly in immune cells.
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5. ⭐ GSE295580 细菌 CARD-NLR 免疫系统控制基因转移因子的释放 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、regex:bacter(ia|ial|ium)、RNA-seq
• 📝 描述：Contributors : Emma Banks ; Tung LeSeries Type : Expression profiling by high throughput sequencingOrganism : Caulobacter vibrioidesBacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are often selfish, exploiting their bacterial hosts to propagate, however they can also provide adaptive advantages through horizontal gene transfer. Gene transfer agents (GTAs), which are non-infectious domesticated prophages, represent a unique class of beneficial MGEs that facilitate bacterial gene transfer. Despite their domestication, GTAs retain phage-like features, including the requirement for host cell lysis to release particles, that may inadvertently trigger host immunity. How GTAs might avoid, subvert, or possibly adopt host immune systems to complete their life stages is poorly understood. Here, we identify a tripartite system, LypABC, that is essential for GTA-mediated cell lysis in Caulobacter crescentus. LypABC resembles caspase recruitment domain-nucleotide-binding leucine-rich repeat (CARD-NLR) anti-phage defence systems that mediate abortive infection wherein infected cells die to prevent phage proliferation, thereby protecting the overall bacterial population. LypABC-deficient cells produce host DNA-packed GTA particles and eventually die but cannot lyse to release GTA particles. Moreover, overproduction of LypABC is highly toxic to both GTA-producing and non-producing cells, highlighting the need for strict regulation. We find that such regulation is achieved transcriptionally by a repressor, CdxB, which binds the promoters of lypABC and of essential GTA activator genes, thus coupling GTA activation and host cell lysis. While traditionally considered antagonistic towards MGEs, our findings here suggest that immunity components are versatile and can be adapted to support MGEs.
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6. ⭐ GSE295577 细菌 CARD-NLR 免疫系统控制基因转移剂的释放 [ChIP-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、regex:bacter(ia|ial|ium)、ChIP-seq
• 📝 描述：Contributors : Emma Banks ; Tung LeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caulobacter vibrioidesBacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are often selfish, exploiting their bacterial hosts to propagate, however they can also provide adaptive advantages through horizontal gene transfer. Gene transfer agents (GTAs), which are non-infectious domesticated prophages, represent a unique class of beneficial MGEs that facilitate bacterial gene transfer. Despite their domestication, GTAs retain phage-like features, including the requirement for host cell lysis to release particles, that may inadvertently trigger host immunity. How GTAs might avoid, subvert, or possibly adopt host immune systems to complete their life stages is poorly understood. Here, we identify a tripartite system, LypABC, that is essential for GTA-mediated cell lysis in Caulobacter crescentus. LypABC resembles caspase recruitment domain-nucleotide-binding leucine-rich repeat (CARD-NLR) anti-phage defence systems that mediate abortive infection wherein infected cells die to prevent phage proliferation, thereby protecting the overall bacterial population. LypABC-deficient cells produce host DNA-packed GTA particles and eventually die but cannot lyse to release GTA particles. Moreover, overproduction of LypABC is highly toxic to both GTA-producing and non-producing cells, highlighting the need for strict regulation. We find that such regulation is achieved transcriptionally by a repressor, CdxB, which binds the promoters of lypABC and of essential GTA activator genes, thus coupling GTA activation and host cell lysis. While traditionally considered antagonistic towards MGEs, our findings here suggest that immunity components are versatile and can be adapted to support MGEs.
• 🔗 查看原文

7. ⭐ GSE317032 非细胞溶解性病毒疫苗载体通过触发 I 型干扰素诱导持久的效应记忆 CD8 T 细胞免疫

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、vaccine、T cell
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

8. ⭐ GSE317031 非细胞溶解性病毒疫苗载体通过触发 I 型干扰素诱导持久的效应记忆 CD8 T 细胞免疫 [TCR-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、vaccine、T cell
• 📝 描述：Contributors : Matias Ciancaglini ; Robin Avanthay ; Anna-Friederike Marx ; Tiago Abreu-Mota ; Davide Finozzi ; Jonas Fixemer ; Florian Geier ; Dominik Burri ; Ingrid Wagner ; Ilena Vincenti ; Mario Kreuzfeld ; Doron Merkler ; Gert Zimmer ; Daniel D PinschewerSeries Type : OtherOrganism : Mus musculusReplication-deficient viral vector systems hold promise for CD8 T cell-based vaccination, but the molecular mechanisms accounting for platform-specific differences in immunogenicity remain ill-defined. Here we compared lymphocytic choriomeningitis virus- (rLCMV) and vesicular stomatitis virus-based (rVSV) single-cycle vectors to explore vector-specific features determining long-lived effector-memory CD8 T cell induction. rLCMV, a non-cytolytic vector, elicited more durable CD8 T cell responses and a higher proportion of effector-memory CD8 T cells than cytolytic rVSV. When rVSV was re-engineered to be non-cytolytic (rVSVMq), also this vector induced durable and effector-differentiated CD8 T cell memory, reminiscent of rLCMV-induced responses, and it afforded superior protection against Listeria challenge than rVSV. Improved CD8 T cell responses of non-cytolytic rVSVMq depended on an elevated type I interferon (IFN-I) response and its direct sensing by vaccination-induced CD8 T cells. Many rVSVMq-infected cells in the splenic marginal zone that were in contact with antigen-specific CD8 T cells expressed not only vectorized antigen but also IFN-I, suggesting that non-cytolytic viral vectors promote the integration of peptide-MHC and IFN-I signals during T cell activation. These mechanistic insights should help to refine vaccines aimed at eliciting durable and protective effector-memory CD8 T cell immunity.
• 🔗 查看原文

9. GSE306901 京都透明细胞癌队列的 RNA-seq。

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、RNA-seq
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFresh frozen tumor tissues from 38 cases diagnosed as clear cell carcinoma (CCC) were submitted to total RNA-sequencing.
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10. GSE300837 PM2.5暴露的遗传易感性驱动儿童哮喘的转录反应：来自单细胞转录组学的启示

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、transcriptomics
• 📝 描述：Contributors : Jelte Kelchtermans ; Huiqi Qu ; Cuiping Hou ; Frank Mentch ; Sharon A McGrath-Morrow ; Hakon HakonarsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground. Exposure to fine particulate matter (PM2.5) increases asthma severity and reduces glucocorticoid responsiveness in children, yet the molecular mechanisms underlying PM2.5 sensitivity remain unclear. We previously identified a PM2.5-sensitive asthma phenotype and developed a PM2.5 sensitivity polygenic risk score (sPRS) correlated with asthma exacerbations and lung function decline. This study expands on these results using genetic mapping and single-cell transcriptomics to elucidate the biological pathways mediating PM2.5 sensitivity and generate hypotheses regarding potential therapeutic targets. Research Question. We aimed to determine whether genetic variants associated with PM2.5 sensitivity converge on specific pathways or transcriptional regulators and assess their role in glucocorticoid responsiveness. Methods. We mapped sPRS variants to genes using regulatory annotation tools and performed pathway enrichment analysis. Single-cell RNA sequencing (scRNA-seq) was conducted on peripheral blood mononuclear cells (PBMCs) from patients stratified by sPRS and matched by PM2.5 exposure to identify transcriptional perturbations in response to PM2.5 exposure. In silico analyses predicted regulatory networks and small molecules that could modulate these pathways. Results. sPRS-associated genes were enriched for SMAD2/3 and MAPK signaling, implicating TGF-β1 as a key mediator of PM2.5 sensitivity. scRNA-seq revealed immune cell-specific transcriptional changes linked to inflammation. Notably, HDM2 inhibition downregulated the PM2.5-sensitive transcriptomic signature, suggesting a role in restoring glucocorticoid responsiveness. Interpretation. Our findings suggest a TGF-β1–HDM2–p53 axis may contribute to PM2.5-induced glucocorticoid resistance and identify HDM2 as a potential therapeutic target for future investigation in PM2.5-sensitive children with asthma.
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1. ⭐ 带状疱疹疫苗可能延缓生物衰老并减轻炎症

• ✍️ 作者：未知作者
• 🏷️ 关键词：vaccine、aging、inflammation
• 📝 描述：A shingles shot might do more than prevent a painful rash — it could actually help slow down the aging process. In a large national study of more than 3,800 Americans age 70 and older, those who received the shingles vaccine showed slower biological aging compared to those who didn’t. Researchers found lower levels of chronic inflammation and slower changes in gene activity linked to aging, suggesting the vaccine may calm the body’s “inflammaging” — the low-grade inflammation tied to heart disease, frailty, and cognitive decline.
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2. RNA测序鉴定出与衰老相关的线粒体环状RNA

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging、RNA-seq
• 📝 描述：Using RNA sequencing of human PBMCs, researchers identify aging-associated mitochondrial circular RNAs and link circMT-RNR2 and GRSF1 to mitochondrial metabolism and cellular senescence…
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3. 一款用户友好的工具将RNA测序分析引入课堂。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：ERSAtool simplifies RNA sequencing analysis through an interactive R Shiny interface, guiding users from normalization to differential expression and functional analysis without requiring advanced coding skills…
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4. 研究显示，90%的前列腺癌肿瘤中都发现了微塑料。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Researchers have detected microplastics in nearly all prostate cancer tumors examined in a new study. Tumor tissue contained about 2.5 times more plastic than nearby healthy prostate tissue. Scientists say this is the first Western study to directly measure plastic particles in prostate tumors. More research is needed, but the findings suggest microplastic exposure could play a role in cancer development.
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• GSE295581 细菌 CARD-NLR 免疫系统控制基因转移因子的释放 [Tn-Seq]
• GSE292453 骨关节炎多部位细胞疗法的单细胞转录组学：组织特异性特征和治疗相关性 [完整试验]
• GSE280004 单细胞转录组学揭示Agdb-地中海贫血中异质细胞γ-珠蛋白基因表达
• GSE269083 敲低 PRCC-TFE3 融合基因后 TFE3 重排肾细胞癌 UOK120 细胞系的基因差异表达分析
• GSE244979 保守的转录反应对逆境相关炎症有影响，促进梅尼埃病进展 [RNA-Seq 2]
• GSE244978 保守的转录反应对逆境相关炎症有影响，促进梅尼埃病进展 [RNA-Seq 1]
• GSE311114 致癌长链非编码RNA SLC16A1-AS1 与 NSUN2 协同作用，通过 m5C 修饰稳定胃癌中的 GRP78 mRNA [AGS]
• GSE310529 致癌长链非编码RNA SLC16A1-AS1与NSUN2协同作用，通过m5C修饰稳定胃癌中的GRP78 mRNA
• GSE310035 SF3B1-K700E 驱动癌症细胞周期检查点基因的致癌性选择性剪接
• GSE304332 单细胞 RNA 测序揭示与自身免疫性神经炎症相关的嗜中性粒细胞簇
• GSE302064 转录组分析 RAD52 敲除对 BRCA2 缺陷型、奥拉帕尼耐药小鼠卵巢癌细胞 (ID8-OR) 中奥拉帕尼反应的影响
• GSE291400 HIF-1α+ CD4 T 细胞协调肺组织驻留免疫细胞网络 [scRNA-seq]
• GSE318000 Lnc-GATS-3:3/MCM7 通过调控 CDK/Rb/E2F 信号通路促进宫颈鳞状细胞癌细胞的增殖和侵袭
• GSE314706 对配对的鼻腔刷取物和组织样本进行单细胞分析，揭示了不同的细胞图谱和免疫表型
• GSE292109 DGAT1抑制诱导铁死亡增强癌症免疫疗法
• GSE320473 巨噬细胞通过Tcf4-Col3轴控制胶原蛋白拓扑结构，从而限制肿瘤免疫浸润3
• GSE320163 基因组编辑中最大限度减少大范围染色质扰动可保持干细胞特性 [ATAC-Seq]
• GSE320162 基因组编辑中最大限度减少大范围染色质扰动可保持干细胞特性 [RNA-Seq]
• GSE320161 基因组编辑中最大限度减少远距离染色质扰动可保持干细胞特性 [长读扩增子测序]
• GSE313953 研究发现，B细胞对拉沙病毒糖蛋白的免疫力与疫苗接种诱导的病毒载量控制相关。
• GSE311098 CUT&RUN 分析了来自未经治疗的体外 ccRCC 和 HGSOC 患者来源的异种移植的 CD70⁻ 和 CD70⁺ 肿瘤细胞中 EZH2、H3K27me3 和 H3K4me3 的富集情况。
• GSE297113 线粒体 RNA 降解在 AML 中增加，并控制分化、干细胞功能和对免疫介导杀伤的敏感性 [RNA-seq]
• GSE290603 CBFA2T3-GLIS2 驱动的儿童急性巨核细胞白血病中增强子甲基化的转录重编程 [DNA 甲基化]
• GSE289754 表征小鼠肝脏中与年龄相关的染色体外环状 DNA：肝脏衰老的潜在生物标志物 [ChIP-Seq]
• GSE314019 乳腺癌揭示了 BMPR2 相关的潜在肺动脉高压易感性
• GSE311167 LIPA靶向治疗的优化，以诱导卵巢癌内质网应激和细胞死亡
• GSE309181 血管基底膜层粘连蛋白调节脑微血管的功能分区 [RNA-seq]
• GSE308748 血管基底膜层粘连蛋白调节脑微血管的功能分区 [scRNA-seq]
• GSE307794 DhQS 激活嗜热栖热菌 HB27 中的莽草酸途径
• GSE307292 JGOG3025-TR1 卵巢透明细胞癌队列的多组学数据分析。
• GSE304015 泽芪汤抑制中性粒细胞胞外陷阱形成，从而抑制非小细胞肺癌的进展和转移
• GSE300738 基因工程改造的ErbB2过表达可增强同源胃癌模型中类器官来源肿瘤对检查点抑制剂的敏感性
• GSE300509 弓形虫速殖子在不同宿主细胞系上的体外培养可筛选出侵袭效率和寄生虫表面抗原基因表达的变化
• GSE299569 棕榈酸通过双重棕榈酰化依赖性通路激活c-Myc促进结肠癌
• GSE294030 IL-36家族细胞因子介导干燥综合征中的免疫激活，并可能成为该疾病的新型生物标志物。
• GSE282645转录组动态分析揭示了禽致病性大肠杆菌攻击期间肝脏和脾脏的恢复能力
• GSE275188 淋巴内皮细胞CCL2增强心肌梗死后淋巴管生成和巨噬细胞的淋巴清除
• GSE265755 温度升高诱导裂殖酵母转录激活基因体中组蛋白的Atf1/Pcr1依赖性快速消耗
• GSE255302 met1衍生epiRILs的基因组学分析[亚硫酸氢盐测序]
• GSE255301 met1衍生epiRILs的基因组学分析
• GSE244980 保守的转录反应对逆境相关炎症的响应促进梅尼埃病进展
• GSE316714 血管平滑肌细胞状态轨迹介导冠心病风险的分子机制 [RNA-seq]
• GSE316713 血管平滑肌细胞状态轨迹介导冠心病风险的分子机制 [ChIP-seq]
• GSE315958 癌症对交联溶瘤肽的敏感性受膜胆固醇和炎症信号传导的影响
• GSE309952 IL-7 疗法对慢性病毒感染期间病毒特异性 CD8 T 细胞反应的影响 [多组学]
• GSE309827 CADM1作为免疫治疗靶点的鉴定及新型CADM1靶向抗体药物偶联物在临床前骨肉瘤模型中的评价
• GSE307106 RNA-seq 用 HDAC 抑制剂 panobinostat、romidepsin 和 ricolinostat 处理 OPM2 多发性骨髓瘤细胞。
• GSE302469 组蛋白去乙酰化酶抑制剂 SAHA 对肺腺癌和肺鳞癌转录组的差异性调控
• GSE291425 人类心脏成纤维细胞 (HCF) 中 NAV3 敲低的转录组分析
• GSE279687 HIV-1 利用 LEDGF 在转录中的作用来定位整合 [ChIP-Seq]
• GSE278223 IL-7疗法对慢性病毒感染期间病毒特异性CD8 T细胞反应的影响
• GSE320402 小鼠听神经衰老相关分子变化的特征分析[重新分析]
• GSE314474 海七鳃鳗胚胎程序性DNA消除过程中组蛋白甲基转移酶的功能分析
• GSE303852 肥胖小鼠接受 Roux-en-Y 胃旁路手术或假手术后，分别在普通饲料或高脂饲料条件下进行肝脏 RNA 测序
• GSE300278 人类痣及其邻近正常皮肤总RNA测序
• GSE291177 RNA测序研究UVB诱导的大鼠眼部玫瑰痤疮模型中盐皮质激素受体（MR）过表达情况
• GSE320165 基因组编辑中最大限度减少大范围染色质扰动可保持干细胞特性 [Cut&Tag]
• GSE320164 基因组编辑中最大限度减少大范围染色质扰动可保持干细胞特性 [PEM-seq]
• GSE320037 H3K79me2 分析揭示 MLL 重排 AML 中 DOT1L 调控的剪接 [RNA-Seq]
• GSE320036 H3K79me2 分析揭示 MLL 重排 AML 中 DOT1L 调控的剪接 [ChIP-Seq]
• GSE320001 Parp7-/-肺的单核转录组学
• GSE311802：KDM5B组蛋白赖氨酸去甲基化酶缺陷小鼠出现自闭症样表型和NMDAR2D表达增加
• GSE311096 敏感 CAR T 细胞重新定义了实体瘤中可靶向的 CD70 表达 [ATAC-seq]
• GSE308040 AID 在弥漫性大B细胞淋巴瘤中调控MYC/E2F靶基因激活和细胞起源转录程序
• GSE306609 敏感 CAR T 细胞重新定义了实体瘤中可靶向的 CD70 表达 [RNA-seq RCC]
• GSE306267 敏感 CAR T 细胞重新定义了实体瘤中可靶向的 CD70 表达 [RNA-seq OV]
• GSE300836 TopBP1 通过 PU.1 和 IRF8 控制常规树突状细胞发育和 Flt3L 驱动的 cDC1 分化
• GSE297114 线粒体RNA降解在急性髓系白血病（AML）中增加，并控制分化、干细胞功能和对免疫介导杀伤的敏感性
• GSE297053 线粒体 RNA 降解在 AML 中增加，并控制分化、干细胞功能和对免疫介导杀伤的敏感性 [NS_Immunology_v2_C2328]
• GSE290689 利用核糖体标记增强型RNA测序表征球孢子菌形态的转录组变化
• GSE290584 核糖体生物合成及其由输出蛋白 CSE1L 调控，是儿童和青年急性髓系白血病中的选择性依赖性 4
• GSE275358 细胞存活偏倚作为肌肉干细胞衰老的机制驱动因素
• GSE270932 鼻腔 CD4⁺ 组织驻留记忆 T 细胞提供对流感的交叉保护性免疫
• GSE268013 诱导干细胞衍生胰岛的单细胞RNA测序分析
• GSE221578 基于 CRISPR 的基因筛选，用于研究 AML 患者细胞中肿瘤维持和异质性的治疗靶点