详细内容（前10条）

1. ⭐ GSE309269 神经母细胞瘤淋巴结转移中决定肿瘤细胞命运的转录程序[空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、lymph、regex:lymph(o|atic)?、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Natalie Wu ; Richard LuSeries Type : OtherOrganism : Homo sapiensNeuroblastoma, a deadly pediatric cancer from the sympathetic ganglia of the peripheral nervous system, frequently metastasizes, driving poor outcomes in high-risk cases. While primary tumors are well-characterized, the cellular and molecular dynamics of metastasis remain poorly understood. Here, we employed single-cell multi-omics and spatial transcriptomics to profile lymph node metastases in high-risk neuroblastoma compared to primary adrenal masses. We found that lymph node metastases displayed unique cellular heterogeneity and plasticity marked by a shift toward mesenchymal-like and cancer stem cell states, with enriched epithelial-to-mesenchymal transition (EMT) programs. Lymph node metastatic niche exhibited altered tumor microenvironment dynamics, characterized by increased immunosuppressive myeloid subsets, heightened immune checkpoint signaling and lymphocyte exhaustion, indicative of immune evasion and dysfunction. Our multi-omics studies reveal distinct features of high-risk neuroblastoma that contribute to metastasis and therapy resistance, pointing to potential therapeutic vulnerabilities of the aggressive metastatic disease.
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2. ⭐ GSE294509 ALOX15B 低表达通过 TAP1/MHC-I 轴调节弥漫性大 B 细胞淋巴瘤中的免疫抑制性肿瘤微环境

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、lymphoma、tumor microenvironment、B cell、MHC
• 📝 描述：Contributors : Lanxin Zhang ; Yucui ShangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe arachidonic acid (AA) metabolism is closely related to tumor immune evasion and chemo-resistance. ALOX15B (arachidonate 15-lipoxygenase type B), located on chromosome 17p, encodes a key enzyme in AA pathway. Interestingly, the expression of ALOX15B is independent of 17p status but is epigenetically regulated. Low ALOX15B expression predicts poor prognosis, with PGE2 activation and TAP1 suppression, reducing MHC-I expression and creating an immunosuppressive microenvironment. Tucidinostat, a histone deacetylase (HDAC) inhibitor, restores ALOX15B and enhances the TAP1/MHC-I axis, thus promoting lymphoma cell apoptosis, which correlates with the effect of tucidinostat plus immunochemotherapy in a phase II trial of patients with newly diagnosed DLBCL (NCT02753647). Our study provides insight into a novel therapeutic strategy to improve patient prognosis by epigenetically modulating lymphoma metabolism and optimizing the tumor microenvironment.
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3. ⭐ GSE317063 单核和空间转录组学揭示 SAP 诱导的肠道损伤中肠道细胞异质性、分化和细胞通讯机制

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below.
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4. ⭐ GSE317062 单核和空间转录组学揭示 SAP 诱导的肠道损伤中肠道细胞异质性、分化和细胞通讯机制 [空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Contributors : Lechang Zhang ; Changqin Xu ; Tong Su ; Tong Xiao ; Xu Yi ; Yuemin Feng ; Jing Wang ; Shulei ZhaoSeries Type : OtherOrganism : Rattus norvegicusBackground Acute pancreatitis (AP) is a severe inflammatory disease that frequently causes multi-organ damage, with intestinal injury being a major complication. The mechanisms underlying SAP-induced intestinal injury remain unclear, particularly regarding spatial cellular reorganization and functional interactions. Methods This study constructed a severe acute pancreatitis (SAP) rat model and employed single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptome sequencing (stRNA-seq) technologies to systematically analyze the dynamic changes in intestinal cellular composition, spatial distribution, and function during SAP-induced intestinal injury. Results snRNA-seq identified 18 major ileal cell populations spanning epithelial, immune, stem/TA, and stromal compartments. SAP was associated with compositional remodeling characterized by downward trends in Lgr5⁺/Olfm4⁺ stem cells, TA1, goblet cells, and Paneth cells, with a reciprocal increase in enterocytes, although most proportion changes did not reach statistical significance at the animal level. Spatial transcriptomics independently captured SAP-associated tissue remodeling, including a significant reduction in Paneth cells accompanied by increases in fat cells, macrophages, goblet cells, and TA2 cells. Across epithelial lineages, SAP induced a transcriptional shift toward immune interaction with up-regulation of antigen presentation–related genes (e.g., Cd74, Apoa1) and down-regulation of antimicrobial/barrier effectors (e.g., Defa24, Pla2g2a, Dmbt1), which was corroborated by spatial expression patterns and spatially variable gene programs enriched for host defense responses. Pseudotime analysis suggested a redistribution of epithelial states along the stem/TA-to-enterocyte continuum, with relative depletion of early states and expansion of enterocyte-dominant states in SAP. CellChat analysis revealed globally intensified intercellular communication and nominated FN1 as the pathway with the highest differential information flow, with Lgr5⁺ stem cells predicted as prominent FN1 senders targeting enterocytes and smooth muscle cells. SCENIC identified reduced activity and expression of Hmga2/Myb regulons in stem compartments, and immunofluorescence showed decreasing trends in Hmga2/Myb-positive Olfm4⁺ and Lgr5⁺ stem cells in SAP. Conclusion…
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5. ⭐ GSE317060 单核和空间转录组学揭示 SAP 诱导的肠道损伤中肠道细胞异质性、分化和细胞通讯机制 [snRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Contributors : Lechang Zhang ; Changqin Xu ; Tong Su ; Tong Xiao ; Xu Yi ; Yuemin Feng ; Jing Wang ; Shulei ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground Acute pancreatitis (AP) is a severe inflammatory disease that frequently causes multi-organ damage, with intestinal injury being a major complication. The mechanisms underlying SAP-induced intestinal injury remain unclear, particularly regarding spatial cellular reorganization and functional interactions. Methods This study constructed a severe acute pancreatitis (SAP) rat model and employed single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptome sequencing (stRNA-seq) technologies to systematically analyze the dynamic changes in intestinal cellular composition, spatial distribution, and function during SAP-induced intestinal injury. Results snRNA-seq identified 18 major ileal cell populations spanning epithelial, immune, stem/TA, and stromal compartments. SAP was associated with compositional remodeling characterized by downward trends in Lgr5⁺/Olfm4⁺ stem cells, TA1, goblet cells, and Paneth cells, with a reciprocal increase in enterocytes, although most proportion changes did not reach statistical significance at the animal level. Spatial transcriptomics independently captured SAP-associated tissue remodeling, including a significant reduction in Paneth cells accompanied by increases in fat cells, macrophages, goblet cells, and TA2 cells. Across epithelial lineages, SAP induced a transcriptional shift toward immune interaction with up-regulation of antigen presentation–related genes (e.g., Cd74, Apoa1) and down-regulation of antimicrobial/barrier effectors (e.g., Defa24, Pla2g2a, Dmbt1), which was corroborated by spatial expression patterns and spatially variable gene programs enriched for host defense responses. Pseudotime analysis suggested a redistribution of epithelial states along the stem/TA-to-enterocyte continuum, with relative depletion of early states and expansion of enterocyte-dominant states in SAP. CellChat analysis revealed globally intensified intercellular communication and nominated FN1 as the pathway with the highest differential information flow, with Lgr5⁺ stem cells predicted as prominent FN1 senders targeting enterocytes and smooth muscle cells. SCENIC identified reduced activity and expression of Hmga2/Myb regulons in stem compartments, and immunofluorescence showed decreasing trends in Hmga2/Myb-positive O…
• 🔗 查看原文

6. ⭐ GSE309268 神经母细胞瘤淋巴结转移中决定肿瘤细胞命运的转录程序[单细胞多组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、lymph、regex:lymph(o|atic)?、single-cell
• 📝 描述：Contributors : Natalie Wu ; Brian Weiss ; Richard LuSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma, a deadly pediatric cancer from the sympathetic ganglia of the peripheral nervous system, frequently metastasizes, driving poor outcomes in high-risk cases. While primary tumors are well-characterized, the cellular and molecular dynamics of metastasis remain poorly understood. Here, we employed single-cell multi-omics and spatial transcriptomics to profile lymph node metastases in high-risk neuroblastoma compared to primary adrenal masses. We found that lymph node metastases displayed unique cellular heterogeneity and plasticity marked by a shift toward mesenchymal-like and cancer stem cell states, with enriched epithelial-to-mesenchymal transition (EMT) programs. Lymph node metastatic niche exhibited altered tumor microenvironment dynamics, characterized by increased immunosuppressive myeloid subsets, heightened immune checkpoint signaling and lymphocyte exhaustion, indicative of immune evasion and dysfunction. Our multi-omics studies reveal distinct features of high-risk neuroblastoma that contribute to metastasis and therapy resistance, pointing to potential therapeutic vulnerabilities of the aggressive metastatic disease.
• 🔗 查看原文

7. ⭐ GSE309267 神经母细胞瘤淋巴结转移中决定肿瘤细胞命运的转录程序 [批量 RNA 测序]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、lymph、regex:lymph(o|atic)?、RNA-seq
• 📝 描述：Contributors : Natalie Wu ; Brian Weiss ; Richard LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma, a deadly pediatric cancer from the sympathetic ganglia of the peripheral nervous system, frequently metastasizes, driving poor outcomes in high-risk cases. While primary tumors are well-characterized, the cellular and molecular dynamics of metastasis remain poorly understood. Here, we employed single-cell multi-omics and spatial transcriptomics to profile lymph node metastases in high-risk neuroblastoma compared to primary adrenal masses. We found that lymph node metastases displayed unique cellular heterogeneity and plasticity marked by a shift toward mesenchymal-like and cancer stem cell states, with enriched epithelial-to-mesenchymal transition (EMT) programs. Lymph node metastatic niche exhibited altered tumor microenvironment dynamics, characterized by increased immunosuppressive myeloid subsets, heightened immune checkpoint signaling and lymphocyte exhaustion, indicative of immune evasion and dysfunction. Our multi-omics studies reveal distinct features of high-risk neuroblastoma that contribute to metastasis and therapy resistance, pointing to potential therapeutic vulnerabilities of the aggressive metastatic disease.
• 🔗 查看原文

8. ⭐ GSE298759 母体肠道微生物遗传影响后代肠道健康和结肠炎易感性

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:micro(b|be|bial|organism)、gut、regex:gut(-?microbiome)?、regex:intestin(e|al)
• 📝 描述：Contributors : Ji-Min Lee ; Hoyul Lee ; Eun Soo KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOffspring born to mothers with colitis exhibited gut microbial dysbiosis, impaired barrier function, low-grade intestinal inflammation, compromised Wnt signaling and reduced crypt cell proliferation, which collectively increased their susceptibility to colitis in adulthood.
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9. ⭐ GSE299589 克隆动力学揭示癌症耐药性源于适应性程序 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、resistance、RNA-seq
• 📝 描述：Contributors : Haiyin Li ; Yeqing Chen ; Jessica Kaster ; Maggie Dunne ; Min Xiao ; Ling Li ; Monzy Thomas ; Nazifa Promi ; Dylan Fingerman ; Gregory S Brown ; Xingyue Zhu ; Meenhard HerlynSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMost advanced cancers initially respond to targeted therapies but eventually relapse1. Rather than acquiring new mutations, resistance is driven by drug-tolerant persister cells (DTP) that enter a reversible drug-refractory state and sustain minimal residual disease2. Here, we developed MeRLin, a high-resolution barcoding platform combining single-cell RNA sequencing, RNA fluorescence in situ hybridization, and computational analyses to track clonal and transcriptional dynamics of melanoma cells during targeted therapy. Clonal tracking reveals that dominant resistant clones arise from minor pre-treatment subpopulations. The pre-treatment melanoma populations diversify into phenotypically distinct DTP subpopulations, marked by stress-like, lipid metabolism, PI3K signaling, and extracellular matrix remodeling programs associated with adaptive resistance. Spatial transcriptomics revealed the co-localization of lipid metabolism and PI3K signaling programs near the tumor boundaries, and a complex network of autocrine and paracrine interactions among DTP subpopulations. Using barcoded RNA fluorescence in situ hybridization, we identified a dominant persister subpopulation in resistant tumors marked by SLC2A1 expression. Thus, MeRLin provides a robust framework to dissect melanoma heterogeneity and uncover vulnerabilities in persister populations to improve long-term treatment efficacy.
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10. ⭐ GSE294261 阿尔茨海默病小鼠模型的多组学单核分析表明 ACSS2 赋予神经元抵抗 tau 蛋白病变的能力 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer、Neuronal、RNA-seq
• 📝 描述：Contributors : Gabor Egervari ; Desi Alexander ; Hua Huang ; Greg Donahue ; Connor Hogan ; Mariel Mendoza ; Hong Xu ; Virginia Lee ; Ben A Garcia ; Nancy M Bonini ; Shelley L BergerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of cell identity and global epigenomic dysregulation are emerging as key contributors to Alzheimer’s disease (AD). The mechanisms by which protective or risk-conferring epigenetic marks are established and maintained are under intense investigation. ACSS2 (Acetyl-CoA Synthetase 2) is a key metabolic enzyme that is nuclear-localized in neurons. In healthy brains, ACSS2 fuels histone acetylation and drives expression of neuronal genes that regulate learning and memory. Here, we examine how loss of ACSS2 contributes to AD-associated cellular, genomic and behavioral outcomes, focusing on long-term steady state changes. Using a mouse model of human pathological AD-Tau injection, we show that loss of ACSS2 exacerbates Tau-related memory impairments, while dietary supplementation of acetate rescues learning in an ACSS2-dependent manner. Combining state-of-the-art proteomic and genomic approaches, we demonstrate that this effect is accompanied by ACSS2-dependent incorporation of acetate into hippocampal histone acetylation, which facilitates gene expression programs related to learning. We identify the most severely affected hippocampal neuronal populations, including pyramidal cells of the perforant pathway and Cajal-Retzius cells. Overall, these results reveal ACSS2 as a neuroprotective metabolic enzyme in key hippocampal neuronal populations, and dysregulation of which may play an important role in the etiology of AD. These findings may guide development of future therapies for AD, other tauopathies and related dementia.
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1. 伟哥和带状疱疹疫苗在对抗阿尔茨海默病方面展现出令人惊讶的潜力。

• ✍️ 作者：未知作者
• 🏷️ 关键词：vaccine、Alzheimer
• 📝 描述：A major new study has spotlighted three familiar medicines that could take on an unexpected new role in the fight against Alzheimer’s disease — with a shingles vaccine emerging as the front-runner. After reviewing 80 existing drugs, an international panel of experts identified Zostavax, Viagra (sildenafil), and riluzole as the most promising candidates for repurposing.
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2. 这种经过重新设计的HPV疫苗可以训练T细胞来对抗癌细胞。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、vaccine
• 📝 描述：Northwestern researchers have shown that when it comes to cancer vaccines, arrangement can be just as important as ingredients. By repositioning a small fragment of an HPV protein on a DNA-based nanovaccine, the team dramatically strengthened the immune system’s attack on HPV-driven tumors. One specific design slowed tumor growth, extended survival in animal models, and unleashed far more cancer-killing T cells than other versions made with the exact same components.
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3. 液滴与皮孔——单细胞转录组分析的考量因素

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell
• 📝 描述：A head to head comparison of single cell RNA sequencing platforms reveals how droplet and picowell methods differ in preserving epithelial cells and data quality in human colon biopsies
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• GSE274051：HIV相关非霍奇金淋巴瘤的空间转录组学分析（按EBV状态和起源细胞分类）
• GSE319949 利用空间转录组学进行逻辑回归以估计功能效应
• GSE287688 性别特异性 KDM6A-HNF4A-CREBH 网络通过肝细胞的表观遗传重编程控制脂蛋白胆固醇代谢和动脉粥样硬化 [RNA-seq]
• GSE319840 患者来源细胞系揭示 COL1A2 可作为乳腺癌多西他赛耐药性的预测因子
• GSE316985 CRISPR筛选发现PRMT7是增强乳腺癌中T细胞介导杀伤作用的治疗靶点
• GSE311274 动力蛋白1通过激活PI3K/Akt信号通路促进结直肠癌进展
• GSE310656 杏仁核中的社会加工：单核RNA测序揭示了对优势线索和劣势线索的不同神经元反应
• GSE308582 单核细胞在遇到患者来源的结肠癌类器官后获得肿瘤相关的IL1B程序
• GSE306674 太平洋白虾肝胰腺感染副溶血弧菌的单细胞RNA测序
• GSE305993 肾细胞癌组织转录组分析
• GSE304262 肾细胞癌中肿瘤浸润淋巴细胞的单细胞转录组分析，用于基因表达和T细胞受体免疫谱分析
• GSE301394 研究发现，辛伐他汀通过钙-NFATC3通路抑制CD4+T细胞活化，从而缓解ConA诱导的自身免疫性肝炎。
• GSE299761 METTL5阻断通过诱导新抗原生成增强抗肿瘤免疫反应
• GSE298789 多功能外泌体抑制自噬可改善非小细胞肺癌的免疫耐受 II
• GSE298562 多功能外泌体抑制自噬可改善非小细胞肺癌的免疫耐受性
• GSE283984 通过多组学细胞转录组和表位测序（CITE-seq）分析揭示人类外周血 B 细胞区室复杂性的流程
• GSE280614 利用 CRISPR 条形码作为分子钟以单细胞分辨率捕获动态过程 [scRNA-seq]
• GSE280613 利用 CRISPR 条形码作为分子钟捕获单细胞分辨率的动态过程 [RNA-seq]
• GSE278771 CD44v6 与膀胱癌的肿瘤侵袭性和化疗耐药性相关
• GSE276685 CD44v6 与膀胱癌的肿瘤侵袭性和化疗耐药性相关
• GSE276545 CD44v6 与膀胱癌的肿瘤侵袭性和化疗耐药性相关
• GSE247166 线粒体应激对肠道肿瘤发展的影响取决于Apc状态
• GSE319930 Delta-8-四氢大麻酚通过表观遗传调控免疫动力学减轻小鼠自身免疫性肝炎
• GSE319924 Netrin-1阻断可缓解局部晚期胰腺癌对一线化疗的耐药性
• GSE304367 抗体 CR3022 的体内进化扩大了对 SARS-CoV-2 变种的交叉中和作用，并为泛沙贝病毒免疫提供了信息
• GSE294631 非洲爪蟾变态发育过程中脊髓的单细胞RNA测序
• GSE255827 基因组异质性驱动人类肿瘤细胞的机械适应 [ATAC-seq]
• GSE215962 通过单细胞表达突变谱揭示的亚克隆进化，揭示了黑色素瘤对免疫疗法的适应机制 [bWTS]
• GSE215961 通过单细胞表达突变谱揭示的亚克隆进化，揭示了黑色素瘤对免疫疗法的适应机制 [bWES]
• GSE215959 通过单细胞表达突变谱揭示的亚克隆进化，揭示了黑色素瘤对免疫疗法的适应机制 [M4_aCTLA4_scRNA]
• GSE319589 DNA甲基化模式揭示了炎症致敏缺氧缺血性脑病中神经系统风险的细胞机制
• GSE315460 巨噬细胞-神经胶质细胞相互作用调节西尼罗河病毒感染期间对肠神经元的免疫损伤[4]
• GSE315459 巨噬细胞-神经胶质细胞相互作用调节西尼罗河病毒感染期间对肠神经元的免疫损伤[3]
• GSE315457 巨噬细胞-神经胶质细胞相互作用调节西尼罗河病毒感染期间对肠神经元的免疫损伤[2]
• GSE315454 巨噬细胞-神经胶质细胞相互作用调节西尼罗河病毒感染期间对肠神经元的免疫损伤[1]
• GSE308548 单核细胞在遇到患者来源的结肠癌类器官后获得肿瘤相关的IL1B程序
• GSE296864 腹主动脉瘤平滑肌细胞内源性 CSE/H₂S 的新型表观遗传机制 [ChIP-Seq]
• GSE287736 性别特异性 KDM6A-HNF4A-CREBH 网络通过肝细胞的表观遗传重编程控制脂蛋白胆固醇代谢和动脉粥样硬化
• GSE287680 性别特异性 KDM6A-HNF4A-CREBH 网络通过肝细胞的表观遗传重编程控制脂蛋白胆固醇代谢和动脉粥样硬化 [CUT&Tag]
• GSE261694 Agonistic GITR therapy in combination with chemotherapy to promote tumor immunity in pancreatic ductal adenocarcinoma
• GSE244562 AtDEK2，一种双组蛋白标记读取蛋白，调控植物免疫
• GSE319829 CD8+ T 细胞分化状态下 STAT5 旁系同源基因的不对称性和冗余性
• GSE319604 GPR43通过调节TGF/Smad信号通路抑制髓核细胞衰老
• GSE317586 研究表明，3-羟基硬脂酸通过ALKBH5/PAX-8/ABCA1通路促进胆固醇外流并减轻动脉粥样硬化。
• GSE316523 解析ERK5信号通路在三阴性乳腺癌中的背景特异性效应
• GSE314831 COP9信号体是维持脂肪组织和代谢健康所必需的
• 对自然感染副结核分枝杆菌（Mycobacterium avium subsp. paratuberculosis）的亚临床荷斯坦牛的血液和空肠样本进行GSE313938 RNA-Seq分析，揭示了宿主对潜伏性副结核分枝杆菌感染的转录适应性。
• GSE313646 激活的干扰素信号抑制年龄依赖性肝癌 [RNAseq_肝细胞]
• GSE313551 Myt3翻译失调使胰岛β细胞在肥胖诱导的代谢应激下易发生功能障碍
• GSE313201 METTL3 过表达调控卵巢癌细胞的转录组程序
• GSE313200 METTL3 敲低调控卵巢癌细胞的转录组程序
• GSE311309 比较 45 日龄主细胞特异性 Tsc1 敲除 (Tsc1f/f/Aqp2 Cre) 与野生型 (WT) 小鼠的肾脏转录组。
• GSE311308 比较28日龄主细胞特异性Tsc1敲除（Tsc1f/f/Aqp2 Cre）小鼠与野生型（WT）小鼠的肾脏转录组
• GSE311307 比较45日龄主细胞特异性Tsc1敲除（Tsc1f/f/Aqp2 Cre）、45日龄主细胞特异性Tsc1/Foxi1双敲除（Tsc1/Foxi1 dKO）小鼠和45日龄野生型小鼠的肾脏转录组
• GSE310793 PRECISE：用于预测乳头状甲状腺癌预后的甲状腺滤泡细胞衍生基因特征
• GSE309965 老年小鼠肝脏中肝细胞 CD44 与免疫调节和纤维化启动相关
• GSE308662 日本血吸虫感染早期阶段 CD4+ T 细胞的免疫反应
• GSE307599 单核 RNA 测序解析减肥手术后棕色/米色脂肪组织微环境动态
• GSE307569 新型人源化功能缺失型NF1小鼠幼年骨髓单核细胞白血病模型
• GSE306402 GJB2 c.109G>A 突变通过线粒体凋亡途径导致遗传性非综合征性耳聋
• GSE305930 对两个月大的 Csf1r+/- 小鼠脑组织进行单细胞核 RNA 测序分析
• GSE304101 ATM 的缺失导致 R 环相关的转录失调，并减弱对 DNA 损伤的相关反应 [RNA-Seq]
• GSE303780 Atf4 外显子 3 移码敲除小鼠胚胎心脏发育的 RNA-Seq
• GSE303775 Rps19bp1 cKO Xmlc2Cre E11.5 小鼠心脏 RNA测序
• GSE303514 ARSI细胞系或IL-10对巨噬细胞极化的影响
• GSE302526 粪杆菌作为益生菌策略对抗代谢功能障碍相关性脂肪性肝炎
• GSE296327 单核转录组学研究小鼠大肠杆菌肾盂肾炎中的性别差异
• GSE290014 微图案培养板中 iPSC 衍生的肺上皮细胞 [scATAC-seq]
• GSE289953 靶向 CPT1A 可触发 cGAS/STING 激活，从而调动中性粒细胞清除肿瘤
• GSE289846 微图案培养板中 iPSC 衍生的肺上皮细胞 [scRNA-seq]
• GSE286885 MCF-7细胞中CUL4B和KDM5B的ChIP测序
• GSE286175 Larp1 的缺失会破坏 TOP mRNA 的突触定位并损害空间记忆。
• GSE283571 糖尿病肾病中蛋白质稳态和糖脂代谢的昼夜节律重编程
• GSE282463 剪接因子 3a 亚基 1 通过抑制 Syntaxin12 的程序性细胞死亡促进结直肠癌的生长。
• GSE282352 揭示脑膜瘤中缺氧驱动的基因和甲基化特征：识别新的生物标志物和治疗靶点
• GSE282351 解码脑膜瘤肿瘤发生过程中缺氧诱导的DNA甲基化模式
• GSE276929 Aurka-Bhlhe41轴可预防类似早衰的小胶质细胞功能障碍并促进髓鞘再生
• GSE260530 SETα 和 SETβ 在早期细胞命运决定中的独特作用 [RNA-Seq]
• GSE260525 SETα 和 SETβ 在早期细胞命运决定中的独特作用 [ChIP-Seq]
• GSE252019 长春花品种“Vitae Rose Red”的转录组
• GSE251771 利用小分子揭示循环肿瘤细胞的脆弱性。
• GSE319944 组织碎裂术诱导的神经母细胞瘤小鼠模型免疫反应
• GSE319935 定义所谓“实性-管囊性肝内胆管癌与 NIPBL::NACC1 融合肝癌”中实性/假乳头状和假腺状模式的分子特征
• GSE313237 对四种软组织肉瘤细胞系进行批量 RNA 测序，这些细胞系在体外用 BO-112 或载体对照处理 6 小时。
• GSE303276 核酸酶-NTP酶系统利用共同的分子特征来控制细菌的抗噬菌体防御
• GSE301075 单核RNA测序揭示胰腺神经内分泌肿瘤中免疫抑制性髓系信号传导和不同的恶性细胞状态
• GSE297249 未折叠蛋白反应信号促进髓系细胞生成并与致癌突变协同作用
• GSE294805 核受体亚家族 4 A 组成员 2 (NR4A2) 心肌细胞特异性激活对小鼠心脏中 poly(A) RNA 表达谱的影响 [RNA-seq]
• GSE294803 心肌细胞特异性激活核受体亚家族 4 A 组成员 2 (NR4A2) 对小鼠心脏基因表达调控的影响 [ChIP-Seq]
• GSE294712 内皮脯氨酰羟化酶 3 减轻适应不良性炎症以促进缺血后肾脏修复
• GSE291056 Hh 和 EGFR-Ras 信号通路促进果蝇卵泡上皮肿瘤进展的不同阶段
• GSE290241 Hh 和 EGFR-Ras 信号通路促进果蝇卵泡上皮肿瘤进展的不同阶段
• GSE256099 翻译缺陷 mRNA 的细胞质衰变与转录适应之间的联系机制 [RNA-seq]
• GSE255831 基因组异质性驱动人类肿瘤细胞的机械适应 [RRBS]
• GSE319948 生物缩醛 1,1-二乙氧基乙烷通过激活 AMP 激活蛋白激酶增强有氧呼吸
• GSE319601 内皮细胞 GARP 调控肺驻留 CD8 T 细胞记忆的寿命
• GSE313731 整合体内和多参数体外筛选揭示 NFIL3 是 T 细胞功能障碍的驱动因素
• GSE313036 用交感神经衍生的细胞外囊泡 (SNEV) 处理的乳腺癌 (BCa) 细胞的基因表达谱。
• GSE307041 Runx蛋白的磷酸化调控胸腺细胞命运。[RNA-Seq]
• GSE290627 内源性CSE/H₂S在平滑肌细胞中对腹主动脉瘤的新型表观遗传机制
• GSE290136 BRAF 改变的儿童低级别胶质瘤的甲基化谱分析
• GSE289983 肩胛硬蜱唾液腺的单细胞分辨率转录组