详细内容（前10条）

1. ⭐ GSE291280 心脏放射治疗诱导的表观遗传记忆是电生理和代谢重编程的基础 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolic、cardiac、RNA-seq、epigenetic
• 📝 描述：Contributors : Samuel D Jordan ; Shuhua Fu ; Abigail Fulkerson ; Khadija Khan ; Donghua Hu ; Sherwin Ng ; David Zhang ; Sneha Manikandan ; Jeff Szymanski ; Anish Bedi ; James Tabor ; Lauren Boggs ; Lori Strong ; Stephanie Hicks ; Lavanya Aryan ; Nishanth Gabriel ; Kuo-Chan Weng ; Nathaniel Huebsch ; Julie K Schwarz ; Bo Zhang ; Stacey L RentschlerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusStereotactic arrhythmia radiotherapy (STAR) is emerging as a highly effective treatment for ventricular tachycardia (VT). Growing evidence indicates that STAR favorably reprograms the electrical substrate via modulating ion channel expression, though the mechanisms whereby single-fraction radiation mediates durable changes in gene expression are incompletely understood. The DNA damage response (DDR) recruits epigenetic regulators during the repair process after irradiation (IR). Here, we demonstrate acute changes in the cardiomyocyte epigenome and transcriptome after IR in vivo and in vitro. A subset of changes persist as late as 6 weeks post-IR in mice, including increased Scn5a expression and chromatin accessibility (encoding the alpha subunit of the sodium channel, NaV1.5), demonstrating a role for epigenetic memory in conduction velocity increases observed after STAR. Transcriptomic and epigenetic sequencing further identify dynamic changes to gene expression and regulatory regions involved in cellular repolarization, calcium handling, and metabolism after IR. Gene expression changes are mirrored by dose-dependent and cell-autonomous changes in repolarization, calcium flux, and mitochondrial respiration after IR, highlighting important cellular processes which may mediate both therapeutic and toxic effects of STAR. Cardiomyocyte-specific knockout of p53 failed to blut conduction velocity changes post-IR, and improved ROS scavenging via SOD2 overexpression had minimal impact on the post-IR transcriptome. Overall, we find that cardiomyocytes exposed to a single fraction of high-dose IR exhibit epigenetic reprogramming that mediates broad and dynamic physiologic responses.
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2. ⭐ GSE291268 心脏放射治疗诱导的表观遗传记忆是电生理和代谢重编程的基础 [ATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolic、cardiac、ATAC-seq、epigenetic
• 📝 描述：Contributors : Samuel D Jordan ; Shuhua Fu ; Abigail Fulkerson ; Khadija Khan ; Donghua Hu ; Sherwin Ng ; David Zhang ; Sneha Manikandan ; Jeff Szymanski ; Anish Bedi ; James Tabor ; Lauren Boggs ; Lori Strong ; Stephanie Hicks ; Lavanya Aryan ; Nishanth Gabriel ; Kuo-Chan Weng ; Nathaniel Huebsch ; Julie K Schwarz ; Bo Zhang ; Stacey L RentschlerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusStereotactic arrhythmia radiotherapy (STAR) is emerging as a highly effective treatment for ventricular tachycardia (VT). Growing evidence indicates that STAR favorably reprograms the electrical substrate via modulating ion channel expression, though the mechanisms whereby single-fraction radiation mediates durable changes in gene expression are incompletely understood. The DNA damage response (DDR) recruits epigenetic regulators during the repair process after irradiation (IR). Here, we demonstrate acute changes in the cardiomyocyte epigenome and transcriptome after IR in vivo and in vitro. A subset of changes persist as late as 6 weeks post-IR in mice, including increased Scn5a expression and chromatin accessibility (encoding the alpha subunit of the sodium channel, NaV1.5), demonstrating a role for epigenetic memory in conduction velocity increases observed after STAR. Transcriptomic and epigenetic sequencing further identify dynamic changes to gene expression and regulatory regions involved in cellular repolarization, calcium handling, and metabolism after IR. Gene expression changes are mirrored by dose-dependent and cell-autonomous changes in repolarization, calcium flux, and mitochondrial respiration after IR, highlighting important cellular processes which may mediate both therapeutic and toxic effects of STAR. Overall, we find that cardiomyocytes exposed to a single fraction of high-dose IR exhibit epigenetic reprogramming that mediates broad and dynamic physiologic responses.
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3. ⭐ GSE298324 小鼠B16-F0黑色素瘤肿瘤浸润淋巴细胞（TILs）的单细胞RNA测序（scRNA-Seq）分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、sequencing、single-cell、scRNA
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo comprehensively analyze the influences on the tumor infiltrated immune cells after deficiency of APPL2 specifically in Tregs, we employed single-cell RNA sequencing (scRNAseq) to profile CD45+ TILs from both Foxp3YFP-Cre Appl2f/f and Foxp3YFP-Cre control mice. To our surprise, tumor infiltrated B cells were dramatically decreased in Foxp3YFP-Cre Appl2f/f mice. Hereby, there was a trend of increase for most of the other immune subsets. These data indicated that the infiltrated B cells, as a whole, were tumor supportive and restricting protumoral B cell infiltration was critical for Appl2-KO Tregs in suppressing tumor growth.
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4. ⭐ GSE291264 心脏放射治疗诱导的表观遗传记忆是电生理和代谢重编程的基础 [CUT&Tag]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolic、cardiac、epigenetic
• 📝 描述：Contributors : Samuel D Jordan ; Shuhua Fu ; Abigail Fulkerson ; Khadija Khan ; Donghua Hu ; Sherwin Ng ; David Zhang ; Sneha Manikandan ; Jeff Szymanski ; Anish Bedi ; James Tabor ; Lauren Boggs ; Lori Strong ; Stephanie Hicks ; Lavanya Aryan ; Nishanth Gabriel ; Kuo-Chan Weng ; Nathaniel Huebsch ; Julie K Schwarz ; Bo Zhang ; Stacey L RentschlerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensStereotactic arrhythmia radiotherapy (STAR) is emerging as a highly effective treatment for ventricular tachycardia (VT). Growing evidence indicates that STAR favorably reprograms the electrical substrate via modulating ion channel expression, though the mechanisms whereby single-fraction radiation mediates durable changes in gene expression are incompletely understood. The DNA damage response (DDR) recruits epigenetic regulators during the repair process after irradiation (IR). Here, we demonstrate acute changes in the cardiomyocyte epigenome and transcriptome after IR in vivo and in vitro. A subset of changes persist as late as 6 weeks post-IR in mice, including increased Scn5a expression and chromatin accessibility (encoding the alpha subunit of the sodium channel, NaV1.5), demonstrating a role for epigenetic memory in conduction velocity increases observed after STAR. Transcriptomic and epigenetic sequencing further identify dynamic changes to gene expression and regulatory regions involved in cellular repolarization, calcium handling, and metabolism after IR. Gene expression changes are mirrored by dose-dependent and cell-autonomous changes in repolarization, calcium flux, and mitochondrial respiration after IR, highlighting important cellular processes which may mediate both therapeutic and toxic effects of STAR. Overall, we find that cardiomyocytes exposed to a single fraction of high-dose IR exhibit epigenetic reprogramming that mediates broad and dynamic physiologic responses.
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5. ⭐ GSE294977 Foxp3-Cre-YFP 和 Foxp3-Cre-YFP Appl2f/f 黑色素瘤小鼠肿瘤浸润和淋巴结来源的 Treg 和 B 细胞的转录组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、lymph、regex:lymph(o|atic)?
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTregs are a critical target for developing anti-tumor immunotherapy, however, they are also critical for maintaining systemic immune tolerance and homeostasis. It remains a formidable challenge to specifically disable Tregs in the tumor microenvironment without compromising systemic immune tolerance. An ideal target is that barely expressed or dispensable in peripheral Tregs but significantly increased and critical for the immunosuppressive activity of tumor infiltrated Tregs (TIL-Tregs). In an attempt to search for specific targets that mediate TIL-Tregs fitness in the tumor microenvironment, we performed RNA-seq of TIL-Tregs and Tregs from the draining lymph nodes (dLN-Tregs) of mice bearing B16-F0 melanoma.
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6. ⭐ GSE311664 植物组蛋白 H3.3 特异性氨基酸保护 H3K36 甲基化的沉积，以保证植物的正常发育和应激反应 [ATXR5 H3K36me3 ChIP-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：ChIP-seq、methylation、histone
• 📝 描述：Contributors : Danhua Jiang ; Xiaoyi Li ; Jie PanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaHistone variants are critical determinants for chromatin function with diverse regulatory mechanisms. The H3 variants, H3.1 and H3.3, evolved independently in animals and plants. A significant difference between H3.1 and H3.3 is the amino acid variation at position 31, with H3.1 carrying alanine (A), while H3.3 bearing serine (S) in animals or threonine (T) in plants. Both S and T can be phosphorylated, but why plants have selectively adopted T over S remains unclear. Here, we report the specific role of plant H3.3T31 in controlling plant development and stress responses by promoting the deposition of histone H3 lysine 36 trimethylation (H3K36me3) on H3.3. T31 prevents plant-specific H3K27 methyltransferases, ATXR5 and ATXR6, from depositing H3K27 monomethylation (H3K27me1), which inhibits the activity of H3K36 methyltransferase EFS. Substituting H3.3T31 with an S or A residue results in increased ATXR5/6 activity and elevated H3K27me1 levels, leading to a reduction in H3K36me3. Moreover, we show that unlike H3.3 T31S and T31A mutations, cancer-associated G34R and G34W mutations directly disrupt H3K36me3 deposition without affecting H3K27me1. These G34 mutations may also influence H3.3 function through mechanisms beyond the disruption of H3K36me3. Our data suggest a co-evolution of the plant-specific H3.3T31 residue and H3K27 methyltransferases ATXR5/6, which ensures the selective accumulation of H3K27me1 on H3.1 and H3K36me3 on H3.3, thereby enabling proper chromatin function.
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7. GSE304165 股骨细胞单细胞RNA测序揭示了慢性间歇性缺氧诱导骨生长障碍的细胞异质性和分子机制

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、single-cell
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed single-cell RNA sequencing to analyze cells isolated from the spongiosa region of the femoral bone in young female mice exposed to chronic intermittent hypoxia (CIH) or normoxia for 4 weeks. This study provides novel insights into cellular heterogeneity and molecular mechanisms involved in CIH-induced bone growth impairment.
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8. GSE303634 STAT1-GBP3-STING 正反馈环路控制炎症、氧化应激和 DNA 损伤，从而引发急性主动脉夹层 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation、scRNA
• 📝 描述：Contributors : Siming Bu ; Wenli Wang ; Zhixue Song ; Dong MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAcute aortic dissection (AAD) is a degenerative aortic remodeling disease characterized by exceedingly high mortality without effective pharmacologic therapies. Although oxidative stress, DNA damage, and inflammation are associated with AAD, the precise interplay among these responses has remained unclear. In this study, aortas from mouse Control and AD models were subjected to integrative ATAC-seq, RNA-seq and scRNA-seq analysis.
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9. GSE303300 新辅助免疫检查点阻断疗法在放化疗前用于FIGO IB3-IVA期宫颈鳞状细胞癌患者：GINECO机会窗口COLIBRI研究

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、immune
• 📝 描述：Contributors : Isabelle Ray-Coquard ; Marie-Christine Kaminsky-Forrett ; Ryotaro Ohkuma ; Aymeric de Montfort ; Florence Joly ; Isabelle Treilleux ; Sarah Ghamry-Barrin ; Diana Bello-Roufai ; Pierre Saintigny ; Antoine Angelergues ; Lucas Michon ; Anne-Claire Hardy-Bessard ; Valéry Attignon ; Jessie Auclair ; Gabriel Chemin ; Alexandra Lainé ; Hélène Pere ; David Veyer ; Aude-Marie Savoye ; Justine Berthet ; Christophe Caux ; Fabrice Lecuru ; Bertrand Dubois ; Sarah BétrianSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCombining immune checkpoint blockade (ICB) with chemoradiation is effective in locally advanced cervical cancer. However, the impact of dual ICB before any therapy on immune modulation and treatment response is poorly understood.
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10. GSE296539 DNA损伤诱导的核STING易位协调先天免疫激活和染色质重塑[ChIP-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、ChIP-seq
• 📝 描述：Contributors : Yihao Wang ; Jianfeng Shen ; Lingjie Li ; Zan ShenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of nuclear STING and its regulatory mechanisms, we treated wild-type (WT) HeLa cells with BMN673 for 24 hours to promote nuclear STING translocation. ChIP-seq was performed using HeLa cells treated with BMN673 for 24 hours.
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详细内容（全部4条）

1. ⭐ 科学家将肿瘤免疫细胞转化为癌细胞杀手

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immune
• 📝 描述：Scientists at KAIST have found a way to turn a tumor’s own immune cells into powerful cancer fighters—right inside the body. Tumors are packed with macrophages, immune cells that should attack cancer but are usually silenced by the tumor environment. By injecting a specially designed drug directly into tumors, researchers were able to “reprogram” these dormant cells to recognize and destroy cancer.
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2. omn​​ideconv——一个用于使用和评估基于单细胞信息的批量RNA测序数据反卷积的统一框架

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、single-cell
• 📝 描述：A large scale benchmark shows how single cell informed deconvolution methods perform across diverse datasets, guiding better use of RNA sequencing to infer cell type composition…
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3. 癌症免疫疗法经常失败的隐藏原因

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、regex:immuno(logy|therapy|suppression)
• 📝 描述：Cancer immunotherapy has been a game-changer, but many tumors still find ways to slip past the immune system. New research reveals a hidden trick: cancer cells can package the immune-blocking protein PD-L1 into tiny particles that circulate through the body and weaken immunotherapy’s impact. Scientists in Japan discovered that a little-known protein, UBL3, controls this process—and surprisingly, common cholesterol-lowering drugs called statins can shut it down.
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4. 这些纳米颗粒可以破坏导致痴呆症和癌症的致病蛋白。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Researchers have developed smart nanoparticles that can seek out and destroy disease-causing proteins the body can’t normally eliminate. Unlike traditional drugs, these particles can reach hard-to-access tissues, including the brain, and precisely target problem proteins without widespread side effects. Early results show promise against major cancer drivers, and the platform is designed to be easily adapted to many diseases. The work could reshape the future of precision medicine.
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• GSE296538 DNA损伤诱导的核STING易位协调先天免疫激活和染色质重塑[RNA-Seq]
• GSE292583 突变型 p53 负调控 ERα 活性，从而导致对内分泌治疗的耐药性 [ChIP-seq]
• GSE292582 突变型 p53 负调控 ERα 活性，从而导致对内分泌治疗的耐药性 [RNA-seq]
• GSE289444 支链氨基酸 (BCAA) 调节代谢炎症
• GSE287998 I 型和 II 型干扰素通过 STAT1 驱动小鼠巨噬细胞活化综合征中的炎症。
• GSE277894 对 3 对胶质瘤组织和正常组织进行了胶质瘤甲基化 RNA 免疫沉淀测序 (MeRIP-seq)。
• GSE273700 全转录组分析揭示脓毒症伴血小板减少症患者的 T 细胞信号激活
• GSE264286 联合靶向聚（ADP-核糖）聚合酶和受体酪氨酸激酶可通过破坏核糖体生物合成抑制卵巢透明细胞癌的进展
• GSE254267 RNA测序分析，研究对象为来源于新生儿心脏组织的三个Islet-1+心脏干细胞克隆
• GSE253955 研究发现，肿瘤 B 细胞来源的 IL-10 可调节弥漫性大 B 细胞淋巴瘤的微环境并影响免疫治疗反应。
• GSE293106 ALDH1A3抑制剂CLM296对MDA-MB-231三阴性乳腺癌细胞转录组学的影响
• GSE275795 速激肽信号传导定义了肠神经系统中不同的神经胶质细胞群 [scRNA-seq]
• GSE275794 速激肽信号传导定义了肠神经系统中不同的神经胶质细胞群 [批量 RNA 测序]
• GSE307715 对曼氏血吸虫雌性进行单细胞 RNA 测序，以研究 BATT 诱导的性成熟。
• GSE303142 FVE 和 HDA9 形成复合物，通过组蛋白去乙酰化减少 H2A.Z 沉积来促进热形态发生 [ChIP-Seq]
• GSE303133 FVE 和 HDA9 形成复合物，通过组蛋白去乙酰化减少 H2A.Z 沉积来促进热形态发生 [RNA-Seq]
• GSE295871 Dnmt1介导克隆螯虾入侵性状的表观遗传限制[RNA-seq]
• GSE295870 Dnmt1介导克隆螯虾入侵性状的表观遗传限制[scRNA-seq]
• GSE290278 植物组蛋白 H3.3 特异性氨基酸保护 H3K36 甲基化的沉积，以保证植物的正常发育和应激反应 [亚硫酸氢盐测序]
• GSE290160 植物组蛋白 H3.3 特异性氨基酸保护 H3K36 甲基化的沉积，以保证植物的正常发育和应激反应 [H3K27me1_ChIPseq]
• GSE290158 植物组蛋白 H3.3 特异性氨基酸保护 H3K36 甲基化的沉积，以保证植物的正常发育和应激反应 [T31A_RNAseq]
• GSE290084 植物组蛋白 H3.3 特异性氨基酸保护 H3K36 甲基化的沉积，以保证植物的正常发育和应激反应 [H3K36me3_ChIPseq]
• GSE290083 植物组蛋白 H3.3 特异性氨基酸保护 H3K36 甲基化的沉积，以保证植物的正常发育和应激反应 [GFP_ChIPseq]
• GSE289944 植物组蛋白 H3.3 特异性氨基酸保护 H3K36 甲基化的沉积，以保证植物的正常发育和应激反应 [G34]
• GSE289942 植物组蛋白H3.3特异性氨基酸可保护H3K36甲基化的沉积，从而确保植物正常发育和应对胁迫。
• GSE280050 衰老细胞清除剂可逆转人类心脏类器官中的衰老性心肌病
• GSE224575 新一代测序技术促进了野生型和FAD4T甲状腺转录组、年轻和衰老甲状腺转录组的定量分析
• GSE316925 小鼠眶下神经慢性压迫损伤模型中三叉神经节的转录组变化 - TRPM3 的作用。
• GSE315764 利用基于血液的表观遗传标记对高危糖尿病前期人群进行分层
• GSE311844 肠球菌 LTA 刺激后 hPDLSC 的转录组分析
• GSE311076 Rab37介导的OPN分泌通过自分泌-旁分泌信号富集SPP1+巨噬细胞，从而驱动肺肿瘤进展
• GSE304512 为偏远地区的肝癌患者开发精准医疗
• GSE303662 人类IDH+胶质瘤干细胞培养物的细胞异质性和治疗反应分析
• GSE303069 人类IDH野生型胶质瘤干细胞培养物的细胞异质性和治疗反应分析
• GSE302554 人类IDH野生型胶质瘤干细胞培养物的细胞异质性和治疗反应分析
• GSE301749 TTBK2驱动的纤毛发生是脊髓损伤后神经元内在再生所必需的
• GSE301614 研究发现，靶向 ATR 可为膀胱癌治疗提供多方面的策略，包括 RAD51 介导的代偿性 DNA 修复。
• GSE299132 不同饮食对衰老心脏自噬控制和未折叠蛋白反应的影响
• GSE295911 两步纯化方法 ViREn 鉴定出一种由 NSUN6 介导的 5-甲基胞嘧啶修饰，可促进登革病毒 RNA 基因组的周转。
• GSE292625 突变型 p53 负调控 ERα 活性，从而导致内分泌治疗耐药
• GSE291841 抗生素处理小鼠粪便样本中细菌群落组成的16S rRNA测序分析
• GSE291840 脾脏和派氏淋巴集结 T 滤泡辅助细胞基因表达谱的 RNA 测序分析
• GSE283368 甲状旁腺切除术可恢复原发性甲状旁腺功能亢进患者的骨骼肌力量和转录组
• GSE233596 CD99通过调节蛋白质合成促进造血干细胞和白血病干细胞的自我更新
• GSE227688 KDM4A 通过调控 MYC 表达促进 NEPC 进展 [ChIP-seq]
• GSE225702 绘制鳉鱼不同年龄和组织中的DNA甲基化图谱
• GSE216267 对人类 3 型固有淋巴细胞 (ILC3) 进行启动子捕获 Hi-C 分析
• GSE317922 抑制 Cxcr4 趋化因子受体信号传导可改善斑马鱼神经纤维瘤病模型中的习惯化学习
• GSE316619 结肠炎的克隆记忆积累并促进肿瘤生长
• GSE307576 遗传背景和维生素 A 信号传导的短暂产前紊乱决定小鼠对气道高反应性的易感性 [RNA-Seq]
• GSE303090 源自人类胚胎干细胞的成熟极化肝细胞类器官，用于模拟代谢功能障碍相关脂肪肝疾病的发病机制和进展以及治疗药物筛选
• GSE298145 Foxp3-Cre-YFP黑色素瘤小鼠肿瘤浸润性Treg细胞的转录组分析
• GSE294060 RNA-seq 数据来自脓毒症患者和非脓毒症对照组的 RAW264.7 细胞系和外周血单核细胞。
• GSE278045 潜伏性巨细胞病毒会破坏NK细胞对恶性疟原虫的反应并削弱寄生虫控制能力
• GSE317319 Wnt 激活和双重 SMAD 抑制诱导和维持 hiPSCs 中类似后脑的神经干细胞 [RNA-Seq]
• GSE316798 睡眠期间摇晃对小鼠大脑皮层整体转录组的影响。
• GSE302157 出生时感染 MCMV 的 6 月龄 Balb/c 小鼠视网膜小胶质细胞的 scRNA-Seq 数据
• GSE295869 Dnmt1介导克隆螯虾入侵性状的表观遗传限制[BiSulfite-seq]
• GSE295867 Dnmt1介导克隆螯虾入侵性状的表观遗传限制[MNase-seq]
• GSE293866 利用无细胞DNA甲基化对细胞状态进行非侵入性体外监测
• GSE279697 交感神经-上皮细胞串扰调控皮肤中区域性 CD8+ TRM 细胞免疫监视 [scRNA-seq]
• GSE186311 胶质瘤中 CDK12/13 抑制引起的 RNAPII 占位、RNAPII 磷酸化和转录的全基因组变化
• GSE186310 胶质瘤中 CDK12/13 抑制引起的新生转录组变化
• GSE186309 胶质瘤中 CDK12/13 抑制引起的 RNAPII 占位和磷酸化全基因组变化