详细内容（前10条）

1. ⭐ GSE275604 肿瘤细胞胞质细菌促进乳腺癌转移复发期间的免疫逃逸

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immune、bacteria、regex:bacter(ia|ial|ium)
• 📝 描述：Contributors : Bingqing Yao ; Xiaoqin Liu ; Xiunan Fang ; Yajing Guo ; Shang CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntratumor microbiota represents an understudied yet influential component of the cancer ecosystem, impacting the physical, chemical and immunological tumor microenvironment. However, the interplay between intratumor microbiota and the tumor-immune network as well as its physiological significance remain poorly understood. In this study, we investigated the long-term developmental process of metastatic seeds from PyMT breast tumor, and identified the key role of intratumor bacteria for efficient metastasis outgrowth after tumor cell colonization in distant organ in an immune-mediated process. Cytosolic bacteria, the dominant form of intratumor bacteria in PyMT tumors, promote metastatic tumor cell immune evasion through activating tumor cell intrinsic cGAS-STING-Il17b response pathway, ultimately inducing neutrophil into a protumor state to suppress cytotoxic T cells. Intriguingly, the upregulation of Il17b is dependent on the intracellular invasion of bacteria and accumulation of cytosolic dsDNA. The extracellular bacteria can not activate the STING pathway but induce neutrophils into an anti-tumor state instead. Under the physiological condition, the eradication of intracellular bacteria effectively abrogates metastatic immune suppression and prevents post-surgical metastatic recurrence, akin to the effect of introducing extracellular bacteria. Our findings underscore the critical role of intratumor bacteria in modulating the immune landscape of recurrent metastatic niches, and emphasize the bacteria-host interaction mode as a novel key factor for immune regulation.
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2. ⭐ GSE250146 Octopus-inspired triple-engineered bacteria for precision cancer immunotherapy

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、bacteria、regex:bacter(ia|ial|ium)、regex:immuno(logy|therapy|suppression)
• 📝 描述：Contributors : Leyang Wu ; Lin Li ; Zichun HuaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBacterial cancer therapies face precision and safety challenges, which limit their clinical application. This study presents a triple-engineered Salmonella typhimurium strain (OITE-bacteria), designed for targeted cancer therapy, inspired by octopus biology and leveraging synthetic biology and biomimetic principles. The strain incorporates SpyTag proteins on the outer membrane, allowing covalent attachment of SpyCatcher-fused quadruple RGD peptides to enhance tumor adhesion via integrin αvβ3 interactions. This promotes bacterial enrichment in various solid tumors and lung metastases. Subsequently, Quorum sensing induces expression of strain HtrA protein within tumors, enhancing extracellular polysaccharide-mediated immunogenicity for activating immune cells. Additionally, the bacteria locally release anti-PD1 nanobodies to anti-immunosuppressive. In murine models, OITE-bacteria achieved a ninefold increase in tumor colonization within 12 hours and sustained melanoma growth suppression for over 40 days, with a 100% response rate. This modular approach, integrating safety and efficacy, provides a new strategy in microbial therapeutics for solid tumors.
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3. ⭐ GSE301873 TGF-βRII/IL-15 免疫治疗复合物靶向淋巴结和肿瘤中耗竭的 CD8+ T 细胞亚群

• ✍️ 作者：未知作者
• 🏷️ 关键词：lymph、T cell、regex:lymph(o|atic)?
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExhausted CD8+ T cells, located within the tumor-draining lymph nodes (TDLNs) are responsible for maintaining tumor-specific responses in cancer. Here, we demonstrate that a bifunctional TGF-βRII/IL-15 protein complex (HCW9218), with TGF-β neutralization and IL-15 immunostimulatory activities, is capable of localizing to the TDLNs and tumors after subcutaneous administration, neutralizes TGF-β, expands progenitor stem-like exhausted T cells (TPEX) in TDLNs, and promotes their infiltration into tumors. Immune-checkpoint-inhibitors (ICIs) significantly enhanced the effects of HCW9218 on TPEX, and synergistically improved HCW9218 anti-tumor efficacy in melanoma and reduced spontaneous lung metastasis in breast cancer models. In a dose-escalating clinical trial in patients with chemo-refractory/relapsed solid tumors, HCW9218 monotherapy was well-tolerated, reduced serum TGF-β levels, promoted CD8+ T cell expansion in peripheral blood and CD8+ T cell infiltration in tumor biopsies. These findings provide a strong basis for using HCW9218 to enhance the efficacy of ICIs against solid tumors in the clinical setting.
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4. ⭐ GSE295918 TREM2+巨噬细胞浸润是紫杉醇治疗引起的乳腺癌肺转移的基础[ATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、macrophage、ATAC-seq
• 📝 描述：Contributors : Yuqi Xing ; Hongquan Zhang ; Jun ZhanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMetastasis is a major cause of breast-cancer-related death and frequently occurs following paclitaxel neoadjuvant chemotherapy failure. Tumor microenvironment contributes to metastasis, while the role of specific host cells in lung metastases induced by paclitaxel (PTX) treatment remains poorly understood. Here, we demonstrate that PTX neoadjuvant chemotherapy promotes triggering receptor expressed on myeloid cells-2 (TREM2)-positive macrophage infiltration in the breast cancer tissues of patients. Meanwhile, we also show that more TREM2-positive macrophage infiltrates in breast cancer tissues of patients with lung -metastasized. Genetic TREM2 deficiency decreases breast cancer lung metastases induced by PTX treatment in vivo, suggesting that TREM2-positive macrophages are essential for PTX-promoting lung metastasis of breast cancer. We further reveal that PTX promotes tumor cell secretion of fibroblast growth factor 2 (FGF2), triggering TREM2 transcription via upregulating its transcriptional factor early growth response-1 (EGR1) in macrophages. Increased TREM2 activates epithelial-mesenchymal transition (EMT)-related cytokine secretion in macrophages, inducing tumor cell lung metastases. Targeting TREM2 significantly suppressed lung metastasis in breast-cancer-bearing mice. Our findings establish that tumor-cell-derived FGF2 induced by paclitaxel treatment upregulates TREM2 in myeloid macrophages, which in turn promotes the EMT of neighboring tumor cells through cytokine secretion. Our results highlight TREM2 as a potential therapeutic target to mitigate lung metastasis due to PTX treatment.
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5. ⭐ GSE292981 外周血单核细胞对不同免疫佐剂刺激的单细胞转录组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、single-cell、transcriptome
• 📝 描述：Contributors : Ken Takashima ; Hiroyuki OshiumiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmune adjuvants are agents that enhance the immunogenicity of vaccines when co-administered with antigens. While their primary mode of action involves activation of innate immune pathways in antigen-presenting cells such as myeloid cells—leading to cellular maturation and enhanced antigen presentation—how adjuvants affect other hematopoietic cell types remains largely unclear. To address this, we performed single-cell RNA sequencing of human PBMCs treated with various immune adjuvants, aiming to characterize cell type–specific transcriptional responses at single-cell resolution.
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6. ⭐ GSE315099 HIF-1α 在 K172 位点的乳酸化驱动 HIF1 复合物组装，从而促进食管鳞状细胞癌中缺氧诱导的免疫逃逸 [ATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、immune、ATAC-seq
• 📝 描述：Contributors : Ji Cong ; Sujuan ZhengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHypoxia is a hallmark of the tumor microenvironment, but its role in immune evasion in esophageal squamous cell carcinoma (ESCC) remains to be fully elucidated. Here, we demonstrate hypoxia inversely correlated with anti-tumor immune signatures and CD8+ T cell infiltration in clinical samples and murine models. Functionally, reducing hypoxia with the agents TH-302 or PX-478 in the AKR model enhanced intratumoral CD8+ T cell infiltration and increased their expression of Granzyme B, IFNγ, and TNFα. Mechanistically, hypoxia-induced immune suppression was dependent on protein lactylation. Inhibiting lactylation reversed the hypoxic suppression of CD8+ T cell function and abrogated the hypoxia-driven transcriptional program, which involved pathways like glycolysis, TGFβ, and Notch signaling. This lactylation-dependent regulation operated by facilitating the formation of the HIF1 transcription complex. Specifically, mass spectrometry identified lactylation at the K172 site of HIF1α, which was crucial for its binding to HIF1β and subsequent target gene activation. Furthermore, in a preclinical ESCC model, pharmacological inhibition of HIF1α with PX-478 synergized with anti-PD-1 therapy, leading to superior tumor control and enhanced CD8+ T cell cytotoxicity. Our study identifies HIF1α K172 lactylation as a pivotal mechanism of hypoxia-mediated immune escape in ESCC, suggesting a therapeutic strategy to improve immunotherapy.
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7. ⭐ GSE315097 HIF-1α 在 K172 位点的乳酸化驱动 HIF1 复合物组装，从而促进食管鳞状细胞癌中缺氧诱导的免疫逃逸 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、immune、RNA-seq
• 📝 描述：Contributors : Ji Cong ; Sujuan ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypoxia is a hallmark of the tumor microenvironment, but its role in immune evasion in esophageal squamous cell carcinoma (ESCC) remains to be fully elucidated. Here, we demonstrate hypoxia inversely correlated with anti-tumor immune signatures and CD8+ T cell infiltration in clinical samples and murine models. Functionally, reducing hypoxia with the agents TH-302 or PX-478 in the AKR model enhanced intratumoral CD8+ T cell infiltration and increased their expression of Granzyme B, IFNγ, and TNFα. Mechanistically, hypoxia-induced immune suppression was dependent on protein lactylation. Inhibiting lactylation reversed the hypoxic suppression of CD8+ T cell function and abrogated the hypoxia-driven transcriptional program, which involved pathways like glycolysis, TGFβ, and Notch signaling. This lactylation-dependent regulation operated by facilitating the formation of the HIF1 transcription complex. Specifically, mass spectrometry identified lactylation at the K172 site of HIF1α, which was crucial for its binding to HIF1β and subsequent target gene activation. Furthermore, in a preclinical ESCC model, pharmacological inhibition of HIF1α with PX-478 synergized with anti-PD-1 therapy, leading to superior tumor control and enhanced CD8+ T cell cytotoxicity. Our study identifies HIF1α K172 lactylation as a pivotal mechanism of hypoxia-mediated immune escape in ESCC, suggesting a therapeutic strategy to improve immunotherapy.
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8. ⭐ GSE304090 药理学抑制表观遗传酶 EZH2 可减轻心肌梗死小鼠模型中的心脏功能障碍并缓解脂质代谢紊乱

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolism、cardiac、epigenetic
• 📝 描述：Contributors : Sylvain Fraineau ; Hugues Boël ; Matthieu RuizSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRational: EZH2, an epigenetic enzyme, acts as a transcriptional repressor for genes dysregulated after myocardial infarction (MI). Objective: This study aims to assess the benefits of GSK-343 (EZH2 inhibitor) on cardiac function and lipid metabolism after MI. Methods: Mice were treated daily with vehicle or GSK-343 for 7 days after MI and we evaluated cardiac function (echocardiography), gene expression profiling (RNA-seq) and circulating lipidome (untargeted lipidomics). Results: The 28% MI decreased ejection fraction (EF) was improved by 20% with GSK-343. RNA-seq analysis revealed wide changes in MI normalized with GSK-343: 16 mitochondrial DNA-encoded genes, 57 genes related to mitochondrial function and 15 to lipid metabolism among the 561 down-regulated genes (FC 0.5 and 2; p=10-4). In plasma, while MI enhanced 18 triglycerides (1.24-2.43-fold; p<0.05) and decreased 32 choline glycerophospholipids (PC; 0.55-0.81-fold, p<0.05), GSK-343 normalized these perturbations. In MI, some of these lipids positively correlated with EF (e.g. PC40:6; R=0.84, p=0.004) or with cardiac hypertrophy (e.g. DG18:1_18:2; R=0.81, p=0.007) and GSK-343 abolished most of these correlations. Conclusion: Our study suggests that inhibiting EZH2 is of therapeutic interest to normalize lipid metabolism perturbations and improve cardiac function after MI.
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9. ⭐ GSE304005 CBTi-seq 分析小鼠脑功能区的空间分辨单细胞转录组学

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、spatially、transcriptomics
• 📝 描述：Contributors : Liyong He ; Kaitong DangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo evaluate the potential utility of the CBTi-seq for spatially resolved transcriptomics tissue analysis, we performed a proof-of-concept experiment by microneedle sampling and analyzing three typical mouse brain regions (cerebral cortex (Ccx), corpus callosum (Cc), and hippocampus (Hi)) under the specific zone. CBTi-seq enables spatially resolved transcriptomics analysis in the tissue microenvironment, and holds great potential for revealing the spatial and temporal characteristics and functional heterogeneity of cells.
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10. ⭐ GSE303385 基于纳米抗体的 MSLN.CAR-T 细胞疗法在转移性实体瘤中的抗肿瘤作用的时间映射[总 RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、T cell、RNA-seq
• 📝 描述：Contributors : Chaido Stathopoulou ; Mingming Zhao ; Qun Jiang ; Jessica Hong ; Jing Bian ; Jingli Zhang ; Mitchell Ho ; Raffit HassanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStudies on the dynamic changes occurring in the tumor microenvironment (TME) following CAR-T cell therapy have been confounded by host lymphodepletion, multiple dosing and immunodeficient models. Here, a nanobody-based, mouse mesothelin-targeting CAR-T cell (A101) was developed, achieving effective primary tumor suppression, metastasis reduction, and improved survival after a single dose in immunocompetent, syngeneic mouse models without lymphodepletion. Temporal tumor profiling using RNA sequencing revealed initial downregulation of cell proliferation genes followed by upregulation of inflammation, epithelial-to-mesenchymal-transition (EMT) and extracellular matrix (ECM) modification genes in the CAR-T-treated tumors relative to mock-T-treated controls. This phenotype was reversed at a later timepoint which coincided with downregulation of immunosuppressive Cd274+ Lcn2+ neutrophils and upregulation of anti-tumor P2rx1+ Nrf2- neutrophils. At the same time, upregulation of Ccl2+ in fibroblasts and a more immunomodulatory macrophage phenotype was observed in CAR-T-treated tumors, indicating a tumor adaptation mechanism. This study demonstrates complex dynamic changes in the TME, and highlights time-dependent responses of solid tumors to CAR-T cell therapy. It further highlights Lcn2+ neutrophils and Ccl2+ fibroblasts as potential therapeutic targets for improving CAR-T cell anti-tumor efficacy for solid tumors.
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1. 蛋白质缺失可能导致免疫系统衰老

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、aging
• 📝 描述：As we age, our immune system quietly loses its edge, and scientists have uncovered a surprising reason why. A protein called platelet factor 4 naturally declines over time, allowing blood stem cells to multiply too freely and drift toward unhealthy, mutation-prone behavior linked to cancer, inflammation, and heart disease. Researchers found that restoring this protein in older mice — and even in human stem cells in the lab — made aging blood and immune cells behave strikingly younger again.
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2. 麻省理工学院的研究表明，高脂肪饮食会使肝癌的发生发展获得危险的先机。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：A high-fat diet does more than overload the liver with fat. New research from MIT shows that prolonged exposure to fatty foods can push liver cells into a survival mode that quietly raises the risk of cancer. Faced with ongoing metabolic stress, these cells abandon their normal roles and revert to a more primitive state that helps them endure harsh conditions. Over time, that shift leaves the liver less functional and far more vulnerable to tumor formation, helping explain why fatty liver disease so often precedes liver cancer.
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• GSE303224 基于纳米抗体的 MSLN.CAR-T 细胞疗法在转移性实体瘤中的抗肿瘤作用的时间映射 [scRNA-Seq]
• GSE291360 周围神经衰老与退化研究：基于单细胞测序的细胞变化与机制探索
• GSE286386 METTL3 依赖的 m6A RNA 修饰协调 HNF1B 相关的氧化还原和癌症代谢脆弱性 [ChIP-seq]
• GSE286384 METTL3 依赖的 m6A RNA 修饰协调 HNF1B 相关的氧化还原和癌症代谢脆弱性 [RNA-seq]
• GSE285905 阿斯巴甜引起的肠道上皮细胞应激、炎症和屏障损伤
• GSE253718 Single-cell transcriptome reveals drug-resistance signature and immunosuppressive microenvironment in lung adenocarcinoma harboring EGFR mutation
• GSE305295 Tet2 和 Tp53 协同促进白血病并调节炎症反应
• GSE305288 Tet2 和 p53 协同促进白血病并调节炎症反应 [拷贝数]
• GSE300000 Tet2 和 Tp53 协同促进白血病并调节炎症反应 [亚硫酸氢盐测序]
• GSE294536 NRF1介导的先天免疫反应驱动细胞衰老和老化
• GSE291894 衰老依赖性KAT7 (HBO1)活性降低通过促进免疫特性损害基于imMKCL的血小板生成
• GSE285329 TREM2+巨噬细胞浸润是紫杉醇治疗引起的乳腺癌肺转移的基础
• GSE284785 TNF-α 驱动的 m6A 修饰通过调节 HDAC5 依赖性超级增强子破坏 MSC 的免疫调节功能 [RNA-seq]
• GSE283905 解码贝沙罗汀治疗对 AD 样模型小鼠大脑的影响：单细胞转录组和染色质可及性分析 ​​[scRNA-seq]
• GSE280586 心脏骤停小鼠模型中心肌炎症和转录组变化的动态变化
• GSE276131 小鼠颞下颌关节骨关节炎关节盘滑膜的单细胞转录组和空间亚细胞图谱
• GSE281309 新一代测序技术促进了对照组和BET溴结构域抑制剂处理的子宫肌瘤细胞转录组的定量分析
• GSE315098 HIF-1α 在 K172 位点的乳酸化驱动 HIF1 复合物组装，从而促进食管鳞状细胞癌中缺氧诱导的免疫逃逸 [CUT&Tag]
• GSE311064 人类肝脏在正常衰老和癌症状态下的细胞衰老
• GSE310392 正常衰老和癌症下人类肝脏细胞衰老 [Xenium]
• GSE308555 通过 rPAL 富集法从急性髓系白血病细胞系及其衍生的细胞外载体中鉴定糖 RNA
• GSE306378 基于对狼疮性肾炎患者的 CD4+ T 细胞和 B 细胞的单细胞测序分析，研究了这些细胞的异质性。
• GSE303934 利用单细胞RNA测序解析鼻窦腺癌的转录异质性
• GSE303374 研究发现，父亲长期饮酒会导致精子 miRNA 表达差异，并扰乱后代的生长发育和代谢。
• GSE302201 Mn-MOF驱动的增强型手枪核酶活化和递送：一种用于检查点沉默和癌症免疫治疗的策略
• GSE301650 咪喹莫特诱导的银屑病小鼠模型中分离的非实质细胞的单细胞 RNA 测序。
• GSE300344 抗雄激素治疗诱导线粒体氧化磷酸化促进前列腺癌去势抵抗 [LNCaP]
• GSE299083 超加工食品中的7-酮谷甾醇通过诱导肠道菌群失调和PDLIM3激活加重结肠炎
• GSE297978 ATP转位酶表达细菌（ATEB）和巨噬细胞的共生系统。
• GSE297541 新生转录本测序可视化小鼠植入前胚胎基因组激活
• GSE294292 OCT4 和 SOX2 活性增强通过调节细胞周期促进表观遗传重编程 [OSK CCC/FN RNA-seq]
• GSE294281 OCT4 和 SOX2 活性增强通过调节细胞周期促进表观遗传重编程 [CCB/FNB ATAC-seq]
• GSE294191 Tatton-Brown-Rahman综合征神经元发育模型中的DNA甲基化变化
• GSE292490 利用蛋白脂质纳米囊泡靶向肿瘤相关 CCR2+ 巨噬细胞以抑制不可逆电穿孔后胰腺癌的复发
• GSE289587 宏观机械应力诱导的核膜破裂重组肿瘤-基质相互作用（scRNA-seq）
• GSE287554 NSD2 通过抑制 TFEB 介导的自噬-溶酶体途径加剧代谢功能障碍相关的脂肪肝疾病进展。
• GSE286385 METTL3 依赖的 m6A RNA 修饰协调 HNF1B 相关的氧化还原和癌症代谢脆弱性 [MeRIP-seq]
• GSE285873 神经酰胺通过干细胞再生程序驱动结直肠癌转移 [scRNA-seq]
• GSE285872 神经酰胺通过干细胞复苏程序驱动结直肠癌转移 [ATAC-seq]
• GSE285854 光合细菌蛋白肽抑制线粒体能量产生，从而抑制肿瘤生长
• GSE285843 10X Genomics 和 Parse 单细胞 RNA 技术在 PBMC 和 CD8+ TEMRA 细胞中的系统比较
• GSE282893 在室温 (RT) 和热中性 (TN) 条件下，对腹股沟脂肪库的基质血管组分 (SVF) 进行单细胞 RNA 测序。
• GSE274957 染色质重塑 SWI/SNF 复合物对纤毛稳定性和肾脏发育的表观遗传调控 [ATAC-seq]
• GSE262968 Machine learning identifies spatial signatures of kidney resident immune cells
• GSE245962 RNA editing enzyme ADAR2 regulates P-glycoprotein expression in murine breast cancer cells via the circRNA-miRNA pathway
• GSE242518 Competitive colonization of Akkermansia muciniphila clades by microbial extracellular vesicles through direct inhibition and immune stimulation
• GSE237700 Mrc1 facilitates epigenetic inheritance through proper parental histone segregation
• GSE236112 Comparative analysis of the cardiac structure and transcriptome of scallop and snail, perspectives to heart evolution
• GSE222745 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [scRNA-Seq]
• GSE222738 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [RNA-Seq]
• GSE222735 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [ATAC-Seq]
• GSE315315 单细胞转录组分析揭示了小胶质细胞对模拟银河宇宙辐射的性别特异性反应，且不伴有经典的炎症激活。
• GSE314218 基因组决定因素的纳入提高了少单核细胞性慢性粒单核细胞白血病的诊断准确性
• GSE312510 从腰痛患者穴位 BL23（肾俞穴）获得的细胞的单核 RNA 测序。
• GSE311619 不良童年经历、DNA甲基化和黑人孕妇的抑郁症状
• GSE311458 一项评估西达米德联合维奈托克、阿扎胞苷、阿克拉霉素、阿糖胞苷和粒细胞集落刺激因子治疗难治性/复发性急性髓系白血病的 I 期研究：临床安全性、有效性和相关性分析
• GSE307546 对 129/Sv-Cyp2e1tm1Gonz/J (CYP2E1-KO) 和 129S1/SvImJ (WT) 小鼠解剖脑区（内侧前额叶皮层、小脑和海马）的大量 RNA 进行转录组学分析
• GSE306999 维生素 B12 改善糖尿病并发症：昼夜节律通路和 NAMPT–NAD⁺–SIRT1 通路的潜在作用
• GSE306765 bZIP转录因子AtfA协调构巢曲霉的无性孢子形成与初级代谢
• GSE301925 RNAseq 分析分化的大鼠 PAC1 肺动脉平滑肌细胞 (SMC) 与增殖细胞的比较，以及分化的 PAC1 细胞中 RBPMS 敲低和 MBNL1&2 敲低。
• GSE301708 细胞内C3通过NF-κB信号通路调节对感染的免疫反应
• GSE300857 持续性癌细胞的脂质组学变化驱动铁死亡敏感性增强
• GSE298791 源自耐药性舌鳞状细胞癌细胞的外泌体 SNHG26 抑制微环境中 NK 细胞的抗癌作用
• GSE297845 YAP的致癌潜能需要胆管细胞中的Y357磷酸化，但不需要肝细胞中的磷酸化
• GSE296834 源自耐药性舌鳞状细胞癌细胞的外泌体 SNHG26 抑制微环境中 NK 细胞的抗癌作用_scRNAseq
• GSE293936 HMGB3 通过募集 SSBP1 进行核转位以重塑线粒体代谢，从而促进肺腺癌脑转移
• GSE291607 miR192-LNP对先天免疫反应调控的影响
• GSE291296组学分析揭示了孕激素受体对乳腺癌细胞中线粒体和线粒体介导的细胞凋亡的显著影响，且该影响独立于caspase。
• GSE289721 高通量鉴定阿尔茨海默病中小胶质细胞炎症过程的遗传调控因子。
• GSE287642 心肌细胞 Klf9 的组成性表达可导致代谢功能障碍和自发性心力衰竭。
• GSE284786 TNF-α 驱动的 m6A 修饰通过调节 HDAC5 依赖性超级增强子破坏 MSC 的免疫调节功能 [CUT&Tag]
• GSE284046 小鼠肺细胞单细胞水平的整合转录组和表观基因组分析
• GSE283765 木瓜蛋白酶和 CpG 在肺基质细胞中交叉调控的表观遗传记忆
• GSE283452 人类肺泡巨噬细胞功能在结核病接触者合并糖尿病患者中受损
• GSE273382 长链非编码 RNA ELDR 通过干扰 DNA 复制和染色质可及性来抑制具有 MLL 重排的 AML 细胞系的致瘤性 [ATAC-Seq]
• GSE273380 长链非编码 RNA ELDR 通过干扰 DNA 复制和染色质可及性来抑制具有 MLL 重排的 AML 细胞系的致瘤性 [RNA-Seq]
• GSE268628 新型 ATG4B-SESN3 轴促进 T 细胞急性淋巴细胞白血病细胞的生长
• GSE261845 靶向黑色素瘤细胞内在β2整合素抑制ICAM-1介导的肿瘤进展
• GSE245672 密码子对特异性翻译缺陷诱导核糖体相关质量控制以避免蛋白毒性应激 [RNA-seq]
• GSE237863 核糖核酸酶 5 抑制肠道肿瘤发生
• GSE210586 RNAseq 分析大鼠 PAC1 肺动脉平滑肌细胞 (SMC) 中 RBPMS、RBFOX2 和 QKI 敲低
• GSE279981 全基因组 CRISPRa 筛选 CDK4/6i 反应中的 lncRNA 功能 [siRNA_RNAseq]
• GSE254283 全基因组 CRISPRa 筛选 CDK4/6i 反应中 lncRNA 的功能 [activation_RNAseq]
• GSE253290：一项全基因组CRISPRa筛选，旨在阐明lncRNA在CDK4/6i反应中的功能。
• GSE315142转录组学揭示了NHEJ在分枝杆菌抗噬菌体防御中的作用
• GSE315125 MED12 通过 YAP-TEAD1 信号通路决定上皮性卵巢癌细胞对铁死亡的敏感性
• GSE315124 MED12 通过 YAP-TEAD1 信号通路决定上皮性卵巢癌细胞的铁死亡敏感性
• GSE314636 FTO抑制剂对小细胞肺癌细胞系MeRIP-seq谱的影响
• GSE314526 肌萎缩侧索硬化症中语言和执行功能衰退的差异性细胞机制 [RNA-seq]
• GSE314144 内源性DNA损伤导致的非典型NF-κB激活驱动衰老
• GSE314072 功能异质性肿瘤内 CD4+CD8+ 双阳性 T 细胞可产生单阳性 T 细胞 [scRNA-seq + scTCR-seq]
• GSE313944 PHF8 敲除 CT26 细胞和亲代细胞的 ATAC-seq。
• GSE312707 膳食菊粉和多子小瓜虫（Ich）感染对斑马鱼鳃转录组的影响
• GSE312591 RUNX1 在真皮成纤维细胞亚群中表达，并且与系统性硬化症的疾病严重程度相关 [scRNA-seq]
• GSE312298 昼夜节律调节的皮质酮和褪黑激素反向调控内毒素诱导的急性免疫反应
• GSE311848 MFAP2 通过 β-catenin 信号通路促进小鼠异种移植头颈部鳞状细胞癌的生长和进展
• GSE310490 PTEN 变异和遗传背景共同作用，改变自闭症谱系障碍患者的小脑神经元分化
• GSE310280 小鼠星状神经节单细胞测序，取自肩胛间棕色脂肪组织和前肢的逆向标记细胞。
• GSE309091 利用RNA-Seq方法探索骨肉瘤及其邻近正常组织中差异表达的lncRNA
• GSE309012 SETD7–H3K4me1–APLNR轴通过表观遗传信号传导调控人类多能干细胞的内胚层分化
• GSE307121 维生素 B12 促进耐碳青霉烯类鲍曼不动杆菌产生头孢地洛耐药性和小菌落变异。
• GSE306603 NMN 通过 NAD+/SIRT1 途径保护顺铂诱导的 AKI
• GSE306117 生殖系TP53驱动的乳腺癌中独特的基因组和免疫肿瘤演变
• GSE305843 单细胞 RNA 分析显示，在接受包括贝利木单抗在内的临床适用免疫抑制剂治疗的胰岛异种移植中，CXCR5+ 非典型记忆 B 细胞的频率和活性降低。
• GSE304637 MAPK1 介导 C/EBPβ 磷酸化以促进 hESC 衍生肝细胞的成熟并抑制 EMT 过程 [RNA-seq]
• GSE304402 RNA-seq 分析血管紧张素 II 高血压小鼠的主动脉内皮细胞
• GSE303735 揭示海湾战争综合症退伍军人诱导多能干细胞衍生神经元中的单细胞调控网络
• GSE302914 EIF5A 通过精子发生过程中的染色中心重组将翻译控制与转录重编程联系起来 [ATAC-Seq]
• GSE302912 EIF5A 在精子发生过程中通过染色中心重组将翻译控制与转录重编程联系起来 [RNA-Seq]
• GSE301710 抗生素 JNJ8464 对鸟分枝杆菌 MAC101 株转录组的影响
• GSE301338 Hpb定植和训练小鼠对腹膜巨噬细胞基因表达的影响
• GSE301337 表观遗传规律对Hpb定植和训练小鼠腹膜巨噬细胞的影响
• GSE300997 成年 Chd8 单倍体不足小鼠持续性皮层兴奋性神经元功能失调 [RNA-Seq]
• GSE300749 CB2R下调通过重组HER2二聚体来逃避IFN-γ并增强EGFR信号传导，从而驱动曲妥珠单抗耐药性
• GSE299803 利用CRAC技术对酵母中sni445-HTP结合位点进行全基因组定位
• GSE299203 青藤碱 (SIN) 改善代谢相关性脂肪性肝炎 (MASH) 的机制
• GSE297082 circ72039 过表达对胰腺癌细胞系中吉西他滨敏感性相关基因表达的影响
• GSE296797 CD38+CD93+小胶质细胞和巨噬细胞通过糖酵解-组蛋白乳酸化轴驱动多发性硬化症模型小鼠的神经炎症
• GSE295597 PDAC细胞诱导原发性纤毛和对照的转录组分析
• GSE294288 OCT4 和 SOX2 活性增强通过调节细胞周期促进表观遗传重编程 [OSK/OvSvK CUT&TAG]
• GSE294189 Tatton-Brown-Rahman综合征神经元发育模型中的转录组变化
• GSE294186 Tatton-Brown-Rahman综合征神经元祖细胞中H3K27me3的变化
• GSE293220 先天性淋巴细胞整合感知和可塑性以控制真菌感染 [ILC 测序]
• GSE291328 多发性硬化症中克隆富集的CD8+ T细胞的抗原特异性
• GSE289972 红蚯蚓的组织特异性长读长 RNA 测序。
• GSE287892 胃癌 AVIL 过表达和 GES1 和 AGS 细胞系中的药理学抑制。
• GSE287832 衰老对骨骼肌基因表达的影响
• GSE287513 整合应激反应的谱系可塑性是肺癌演变的标志。
• GSE286449 头颈部鳞状细胞癌肿瘤演变过程中基因定义的类器官模型单细胞水平的基因表达谱
• GSE286169 神经酰胺通过干细胞再生程序驱动结直肠癌转移 [BulkRNAseq_InVitro]
• GSE286168 神经酰胺通过干细胞复苏程序驱动结直肠癌转移 [BulkRNAseq_GFP]
• GSE286167 神经酰胺通过干细胞复苏程序驱动结直肠癌转移 [BulkRNAseq_HFD]
• GSE286166 神经酰胺通过干细胞再生程序驱动结直肠癌转移 [BulkRNAseq_CRISPR]
• GSE286125 转录因子T-bet在调节双阴性T细胞的免疫调节功能中起着至关重要的作用
• GSE285860 结肠 RNA 测序
• GSE285792 利用 MitoRiboSeq 扩展线粒体基因组的编码潜力
• GSE285600 生态设计的三成员微生物群落通过调节生长-防御权衡促进十字花科植物的生长
• GSE285353 弓形虫速殖子中 AP2XI-3 依赖性基因调控 [RNA-seq]
• GSE285071 辛伐他汀和 2,3,7,8-四氯二苯并-对-二恶英 (TCDD) 共同暴露小鼠的肌肉 RNA 测序
• GSE284803 RNA结合蛋白HuR损害胰腺癌恶病质中的脂肪组织合成代谢
• GSE282512 通过无创性游离DNA甲基化谱分析推进先兆子痫的诊断和早期风险评估
• GSE280018 I型干扰素驱动中枢神经系统中T细胞对β-淀粉样蛋白的反应
• GSE279537 开发微阵列以研究 veA 和 patL 基因的作用以及 DMSO 在调节扩展青霉转录组中的作用。
• GSE279105 LKB1缺失通过上调NNMT使肺癌细胞对PRMT5抑制剂敏感
• GSE277564 染色质重塑 SWI/SNF 复合物对纤毛稳定性和肾脏发育的表观遗传调控 [72hpf]
• GSE277562 染色质重塑 SWI/SNF 复合物对纤毛稳定性和肾脏发育的表观遗传调控 [30hpf]
• GSE277230 m6A 对发育中大脑神经元 mRNA 从胞体到神经突转运的影响
• GSE276911 Tbc1d23ΔE15/ΔE15 和野生型小鼠骨髓的单细胞转录组学
• GSE276150 平滑肌细胞中的芳烃受体可防止二恶英诱导的动脉粥样硬化不良重塑 [RNA-seq]
• GSE276145 平滑肌细胞中的芳烃受体可防止二恶英诱导的动脉粥样硬化不良重塑 [ATAC-seq]
• GSE275289 染色体重排增强的mRNA稳定性驱动儿童白血病中癌基因融合的致癌性
• GSE275102 连翘苷通过激活内质网应激促进先天免疫的分子机制。
• GSE274953 染色质重塑 SWI/SNF 复合物对纤毛稳定性和肾脏发育的表观遗传调控 [FitCUT&RUN]
• GSE272235 Gene expression profile at single cell level of all CD45+ cells infiltrating B16-SIY-dsRed syngeneic tumors implanted subcutaneously after 26 days of tumor growth in Wildtype and PRKCD KO bone marrow engrafted animals
• GSE271497 Transcriptome analysis of 92.1-parental and 92.1-resistant uveal melanoma cells
• GSE270206 Therapeutic efficacy of CDK7 inhibition in pancreatic cancer through proliferation arrest and inducing replication stress [PDX]
• GSE270204 Therapeutic efficacy of CDK7 inhibition in pancreatic cancer through proliferation arrest and inducing replication stress [8898T]
• GSE266579 APC loss promotes intestinal transformation though B-CATENIN-independent dysregulation of a GSK3-AJUBA-YAP signaling axis
• GSE264669 A Novel Acute Erythroleukemia Cell Line Derived from Ascitic Fluid in a Patient with Congenital Acute Myeloid Leukemia
• GSE262581 Transcriptional condensates enrich phosphorylated PRMT2 to stimulate H3R8me2a deposition and hypoxic response in cancers-RNA-seq
• GSE253365 TLR5 expression marks brain boarder associated macrophage
• GSE252677 Analysis of EZH2 target genes in senescent nucleus pulposus mesenchymal stem cells by integrating CUT&Tag and RNA-seq data
• GSE252676 Analysis of EZH2 target genes in senescent nucleus pulposus mesenchymal stem cells by integrating CUT&Tag and RNA-seq data [CUT&Tag]
• GSE252675 Analysis of EZH2 target genes in senescent nucleus pulposus mesenchymal stem cells by integrating CUT&Tag and RNA-seq data [RNA-seq]
• GSE246746 Profiling R loop in mouse and human hematopietic cells with low cell input using S9.6 antibody coupled cut&tag [MOLM13]
• GSE246552 Profiling R loop in mouse and human hematopietic cells with low cell input using S9.6 antibody coupled cut&tag [cut&tag K562]
• GSE236218 Profiling R loop using S9.6 antibody coupled cut&tag
• GSE236217 Profiling R loop in cd34+ and ckit+ of mouse and human hematopietic cells input using S9.6 antibody coupled cut&tag [single cell]
• GSE236216 Profiling R loop in mouse and human hematopietic cells with low cell input using S9.6 antibody coupled cut&tag
• GSE226786 YTHDF1 mitigates acute kidney injury via safeguarding m6A-methylated mRNAs in stress granules of renal tubules [RNA-Seq]
• GSE222989 CUT&Tag sequencing of human pancreatic acinar and ductal cells
• GSE222746 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle
• GSE222737 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [CUT&Tag]
• GSE222615 Triclocarban affects early embryo development in mouse through disrupting maternal-to-zygotic transition and epigenetic modifications
• GSE222535 Arsenite exposure disturbs maternal-to-zygote transition by attenuating H3K27ac during mouse preimplantation development [RNA-seq]
• GSE222534 Arsenite exposure disturbs maternal-to-zygote transition by attenuating H3K27ac during mouse preimplantation development [ChIP-seq]
• GSE222497 Circular RNA as new serum metabolic biomarkers in patients with Premature Ovarian Insufficiency
• GSE222457 Activity of PDGFRA inhibitor Avapritinib in H3K27M Diffuse Midline Glioma
• GSE221897 Endogenous Real Time Imaging Reveals Dynamic Chromosomal Mobility During ER-Mediated Transcriptional Burst Events [ChIP-seq]