详细内容（前10条）

1. ⭐ GSE266136 10X Visium Spatial transcriptomics of murine small intestine 6 and 14 days post Heligmosomoides polygyrus infection with or without LXR agonist GW3965

• ✍️ 作者：未知作者
• 🏷️ 关键词：10x、spatial、Visium、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Contributors : Xinxin Luo ; Ludvig Larsson ; Eduardo J VillablancaSeries Type : OtherOrganism : Mus musculusIn this dataset, we investigate the murine proximal small intestine spatial transcriptomic profile at the day 6 and day 14 post Heligmosomoides polygyrus infection and compare the genes alteration with and without LXR activation by sythetic ligand GW3965 diet.
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2. ⭐ GSE295401 空间转录组学揭示胃不完全肠化生的谱系复杂性及其与胃癌的关系 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：scRNA、spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis research underscores the unique molecular phenotype and lineage complexity of Inc IM, emphasizing its significance as a precancerous lesion in gastric tissues. Our findings lay the groundwork for future investigations into the epigenetic and transcriptional dynamics governing metaplastic changes, highlighting the importance of Inc IM in GC progression.
• 🔗 查看原文

3. ⭐ GSE294729 空间转录组学揭示胃不完全肠化生的谱系复杂性及其与胃癌的关系 [ATAC-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：ATAC-seq、spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis research underscores the unique molecular phenotype and lineage complexity of Inc IM, emphasizing its significance as a precancerous lesion in gastric tissues. Our findings lay the groundwork for future investigations into the epigenetic and transcriptional dynamics governing metaplastic changes, highlighting the importance of Inc IM in GC progression.
• 🔗 查看原文

4. ⭐ GSE295640 空间转录组学揭示胃不完全肠化生的谱系复杂性及其与胃癌的关系 [甲基]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Series Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThis research underscores the unique molecular phenotype and lineage complexity of Inc IM, emphasizing its significance as a precancerous lesion in gastric tissues. Our findings lay the groundwork for future investigations into the epigenetic and transcriptional dynamics governing metaplastic changes, highlighting the importance of Inc IM in GC progression.
• 🔗 查看原文

5. ⭐ GSE301367 CD300e 通过巨噬细胞重编程驱动免疫抑制性肿瘤微环境和结直肠癌进展 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、tumor microenvironment、scRNA
• 📝 描述：Contributors : Gaia Codolo ; Laura Masatti ; Enrica Calura ; Annica BarizzaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusColorectal cancer progression is strongly influenced by the tumor microenvironment, particularly by tumor-associated macrophages, which often acquire immunosuppressive features that dampen antitumor immunity. CD300e is a myeloid receptor known to modulate immune responses, but its role in CRC remains unexplored. Here, we show that CD300e is selectively upregulated in tumor-infiltrating monocytes and monocyte-derived macrophages in human CRC, displaying an immunosuppressive phenotype characterized by reduced antigen presentation. Using in vitro co-cultures of patient-derived tumor organoids and human monocytes, we demonstrate that tumor-derived signals are sufficient to induce CD300e expression and skew macrophages toward a pro-tumorigenic profile. To investigate the functional relevance of CD300e, we employed CD300e knockout mice in AOM/DSS-induced and MC38 subcutaneous CRC models. In both settings, CD300e deletion led to reduced tumor burden, enhanced major histocompatibility complex expression in TAMs, and improved T cell-mediated antitumor responses. Transcriptomic and functional analyses revealed that CD300e-deficient macrophages display increased phagocytic activity, upregulated antigen presentation pathways, and a greater ability to support T cell proliferation and cytotoxicity. Adoptive transfer experiments confirmed that CD300e expression on macrophages alone is sufficient to promote tumor growth and suppress effector T cell function. These findings identify CD300e as a key regulator of macrophage-mediated immune suppression in CRC and suggest that targeting CD300e may represent a novel strategy to reprogram TAMs and enhance the efficacy of cancer immunotherapy.
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6. ⭐ GSE181359 通过单核甲基化测序研究大脑衰老的表观遗传特征 [FC-9mo-m-020]

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging、sequencing、epigenetic、methylation
• 📝 描述：Contributors : Wei Tian ; Anna Bartlett ; Jordan Altshul ; Rosa Gomez Castanon ; Joseph R Nery ; Jacinta D Lucero ; Julia K Osteen ; Huaming Chen ; M M Behrens ; Joseph R EckerSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusIllustrating aging effects on the epigenomic features of brain is critical to understand brain functional decline and neurodegeneration. Single nucleus methylation sequencing was applied to brain regions of both male and female mouse at the age of 2, 9 and 18 months. We use these data to identify the epigenomic changes with aging in mouse brains.
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7. ⭐ GSE306986 胰腺癌中协同基质重塑和双重化疗-免疫疗法：一种分两阶段进行的氯沙坦预处理后纳米载体策略用于肿瘤微环境重编程

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、tumor microenvironment、regex:immuno(logy|therapy|suppression)
• 📝 描述：Contributors : Xun Hu ; Qian WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is marked by a dense, fibrotic stroma that hinders drug delivery and promotes an immunosuppressive microenvironment. We developed a two-stage therapeutic strategy (LIGEL) that combines losartan-mediated stromal preconditioning with the targeted delivery of a hybrid nanocarrier (IGEL) co-loaded with gemcitabine and IL-12 circRNA. The efficacy of this approach was evaluated in vitro and in vivo, with RNA sequencing used to explore transcriptomic changes in the tumor microenvironment after treatment. Losartan pretreatment significantly reduced extracellular matrix deposition and cancer-associated fibroblast activation, enhancing cellular uptake and tumor penetration. This resulted in notable tumor growth inhibition, prolonged survival, and minimized gemcitabine-associated systemic toxicity. Transcriptomic analysis revealed tumor cell depletion and immune microenvironment activation. These findings highlight the potential of losartan-primed nanotherapy to reprogram the tumor microenvironment and improve the efficacy of combined chemotherapy-immunotherapy.
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8. ⭐ GSE296955 肿瘤-基质相互作用和巨噬细胞富集与膀胱癌化疗反应相关

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、macrophage、enrichment
• 📝 描述：Contributors : Janik Riese ; Sophie Leypold ; Michael Rose ; Lancelot SeillierSeries Type : OtherOrganism : Homo sapiensThis dataset provides a spatial transcriptomic atlas of bladder cancer tissue treated ex vivo with standard chemotherapy. Tumor specimens from eight bladder cancer patients were excised and treated for 48 hours with gemcitabine and cisplatin (GemCis) or medium control (MSC), followed by formalin fixation and paraffin embedding. Spatial gene expression profiling was performed using the NanoString GeoMx Digital Spatial Profiler Whole Transcriptome Atlas (WTA), capturing expression of over 18,000 transcripts. Tumor regions were identified by cytokeratin (CK) staining and analyzed alongside adjacent stroma (CK-negative). Chemotherapy treatment led to significant transcriptomic alterations, including downregulation of pathways related to substance uptake (e.g., endocytosis) and metabolism (e.g., glycolysis), and upregulation of cell death pathways. Cellular deconvolution using xCell revealed stromal M2 macrophage enrichment in chemotherapy-resistant samples, suggesting a microenvironmental contribution to resistance.
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9. ⭐ GSE293951 黑色素瘤引流淋巴结中髓系免疫细胞的单细胞RNA测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、lymph、regex:lymph(o|atic)?、RNA-seq
• 📝 描述：Contributor : Lothar C DieterichSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor-draining lymph nodes are crucial for tumor immunity and immunotherapy outcomes. In this study, myeloid immune landscapes were profiled in lymph nodes draining either immunotherapy-sensitive or immunotherapy-resistant melanoma in mice.
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10. ⭐ GSE280149 SOAT1 敲除重塑肿瘤免疫微环境，增强 CD8+ T 细胞浸润和效应功能 [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immune、T cell、scRNA
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the mechanism, we performed single-cell RNA sequencing (scRNA-seq) to profile the in vivo transcriptome and immune landscape (Figure 4F). Tumors from PBS- and anti-PD1-treated mice were purified using Ficoll and subjected to scRNA-seq, recovering 9,431 and 9,970 cells from SOAT1-KO tumors, and 10,880 and 8,580 cells from vector tumors, respectively.
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1. 单细胞RNA测序数据标准化基准测试

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、single-cell
• 📝 描述：Benchmarking shows how RNA sequencing normalization methods like Dino, scTransform, and SCnorm perform across clustering, differential expression, and computation, guiding better selection for single-cell analyses…
• 🔗 查看原文

2. CellUntangler——利用深度生成模型分离单细胞数据中不同的生物信号

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell
• 📝 描述：CellUntangler uses RNA sequencing data to separate overlapping biological signals in single cells, helping researchers isolate cell cycle effects, cell identity, and other processes with greater clarity…
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3. 利用优化的RNA测序分析揭示蝎毒转录组结构

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq
• 📝 描述：ToxIR uses RNA sequencing to accurately map complex venom gland transcripts, revealing hundreds of toxin candidates and improving discovery of bioactive peptides with medical…
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4. 即使每天只喝一杯酒也可能增加患口腔癌的风险。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：New research suggests that even light alcohol use may carry serious risks. A large study in India found that drinking just one standard drink a day is linked to a roughly 50% higher risk of mouth cancer, with the greatest danger tied to locally brewed alcohol. When alcohol use overlaps with chewing tobacco, the effect becomes especially severe, potentially explaining nearly two-thirds of all cases nationwide.
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5. 你居住的地方可能正在助长侵袭性乳腺癌的发生。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：New research shows that women living near Superfund sites are more likely to develop aggressive and metastatic breast cancers. The studies found higher risks for hard-to-treat subtypes like triple-negative breast cancer, especially in areas with greater air pollution. Scientists also discovered molecular tumor changes linked to neighborhood deprivation. The findings point to environmental exposure and social conditions as key factors shaping cancer outcomes.
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• GSE280148 SOAT1 敲除增强肝癌细胞对基于 T 细胞的免疫疗法的敏感性 [RNA-seq]
• GSE275714 scRNA-seq and TCR-seq of T cells and APCs in tumor-draining lymph nodes with versus without pharmacological LXR activation.
• GSE268069 Epigenetic Activation of BCL11B Mediates Profibrotic Cardiac Remodeling Triggered by Colitis-Associated Gut Dysbiosis
• GSE262391 B cell leukemia co-opts a hematopoietic stem cell-CD4 T cell tolerance program that facilitates relapse [scATAC-Seq]
• GSE315244 免疫检查点 B7x 促进膀胱癌的免疫逃逸和对 PD-1/PD-L1 阻断的耐药性
• GSE300901 CD300e 通过巨噬细胞重编程驱动免疫抑制性肿瘤微环境和结直肠癌进展
• GSE305008 ZSTK3744，一种新型芳烃受体激动剂，克服三阴性乳腺癌的化疗耐药性[RNA-seq]
• GSE303075 SARS-CoV-2 Omicron 感染食蟹猴肺和纵隔淋巴结的单细胞转录组分析
• GSE296665 过度活跃的RNA选择性剪接促进小细胞肺癌的免疫逃逸[RNA-Seq]
• GSE296664 过度活跃的RNA选择性剪接促进小细胞肺癌的免疫逃逸[scRNA-Seq]
• GSE294745 单细胞转录组和m6A甲基化分析揭示脓毒症中血小板介导的免疫调节机制
• GSE292098 增强免疫疗法效果：非小细胞肺癌的空间多组学预测模型 [GeoMx DSP]
• GSE288416 宿主 MTDH 协调肝脏脂质代谢和 CD8+ T 细胞以抑制抗肿瘤免疫 [肿瘤]
• GSE285340 窄谱紫外线 B 诱导外周调节性 T 细胞发挥抗原特异性免疫抑制作用 [RNA-seq]
• GSE285339 窄谱紫外线 B 诱导外周调节性 T 细胞发挥抗原特异性免疫抑制作用 [scRNA-seq]
• GSE278041 Rhythmic Transcription and Aging: _x000B_Insights from the Drosophila Photoreceptor Transcriptome and Epigenome
• GSE276106 Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity [scRNA-seq]
• GSE276105 Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity [Tumor CD8 T cells]
• GSE275967 Study title: B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters- 5’ single cell transcriptomics with VDJ T cell receptor analyses on splenic CD3+ cells from aged µMT and WT mice
• GSE272758 Driver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy [scRNA-seq]
• GSE272757 Driver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy [RNA-seq]
• GSE270767 Disseminated tumor cell of colorectal cancer adopt the wound healing program of epidermal keratinocyte [scRNA-seq]
• GSE264447 Cold-inducible brown fat thermogenesis enhances MHC class I expression and antitumor immunity in ovarian cancer.
• GSE262395 B cell leukemia co-opts a hematopoietic stem cell-CD4 T cell tolerance program that facilitates relapse
• GSE262394 B cell leukemia co-opts a hematopoietic stem cell-CD4 T cell tolerance program that facilitates relapse [CITE-Seq]
• GSE234218 Single-cell transcriptomics reveals diverse and complex gene expression alterations in human fetal spinal cord [Visium]
• GSE309697 构建透明细胞肾细胞癌的综合表观基因组图谱，揭示肾癌进展和遗传机制
• GSE305286：对年轻和年老小鼠脊髓中Nf1缺陷型Prss56衍生细胞进行单细胞RNA测序分析
• GSE305088 单细胞转录组分析揭示高龄产妇蜕膜微环境紊乱
• GSE300035 利用批量RNA转录组学分析抗生素治疗对结核分枝杆菌感染小鼠肺部炎症的影响
• GSE297794 化疗相关口咽念珠菌病转录组分析揭示了黏膜固有细菌在发病机制中的新作用
• GSE315136 全面的长读长转录组分析揭示了卵巢癌进展中的RNA选择性加工特征和异构体多样性
• GSE314954 溶瘤病毒疗法和铂类化疗协同作用，通过靶向激活化疗持续存在的旁观者 CD8+ T 细胞来增强抗肿瘤免疫力
• GSE309867 microRNA-17-5p 调控腹侧海马转录组和突触蛋白质组：对成年雄性大鼠情绪调节的影响
• GSE309456 RNA-seq 分析小鼠口腔癌 MOC2 细胞中 p62 敲除的情况
• GSE309341 KRAS-ERK信号通路通过磷酸化依赖性激活ZBTB20-TGFBR2轴驱动结直肠癌转移
• GSE308632 化敌为友：H2S消耗型多功能纳米平台用于光热-纳米催化协同疗法诱导铁死亡以增强结直肠癌免疫疗法
• GSE307897 LKB1 过表达和 NNMT 敲低 A549 细胞的全基因组亚硫酸氢盐测序 (WGBS)
• GSE306695 基于测序的无细胞DNA甲基化谱分析中酶法和亚硫酸氢盐法的比较
• GSE305680 角质形成细胞中的线性泛素化通过 TNF-α/NF-κB 信号通路增强银屑病炎症 [RNA-seq 2]
• GSE305677 角质形成细胞中的线性泛素化通过 TNF-α/NF-κB 信号通路增强银屑病炎症 [RNA-seq]
• GSE305009 ZSTK3744，一种新型芳烃受体激动剂，克服三阴性乳腺癌的化疗耐药性[微阵列]
• GSE302453 三阴性乳腺癌抗PD-1联合化疗期间肿瘤内异质性的单细胞图谱
• GSE302188 多组学分析强调了衰老相关认知衰退与全身炎症和组织维持改变之间的联系
• GSE300055 组胺 H4 受体拮抗剂可阻止受体介导和 EBV 诱导的 B 细胞增殖 [RNA-Seq]
• GSE299133 宿主 MTDH 协调肝脏脂质代谢和 CD8+ T 细胞以抑制抗肿瘤免疫 [肝细胞]
• GSE296791 粒细胞来源的抵抗素诱导CMML中经典单核细胞重新分布和免疫抑制
• GSE285978 Connectome-seq：通过条形码测序实现单突触分辨率的神经元连接高通量映射
• GSE285702 RNA转录组测序：皮肤黑色素瘤细胞系A375和SK-MEL-28经siNC或siLINC01291处理
• GSE284238 结直肠腺瘤成人背景黏膜差异性DNA甲基化的全基因组关联研究
• GSE283380 TCR 顺式邻近引导的 LAG-3 抑制 T 细胞活化和自身免疫 [scRNA-seq]
• GSE283377 TCR 顺式邻近引导的 LAG-3 抑制 T 细胞活化和自身免疫 [批量 RNA 测序]
• GSE283320 Clara细胞RhoA激活通过间质巨噬细胞相互作用破坏气道屏障完整性，从而加剧过敏性气道炎症。
• GSE276107 Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity
• GSE276104 Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity [Liver]
• GSE275630 Histone H3K4me3 modification regulates innate immunity.
• GSE275466 Study title: B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters - B and T Cell Singlet and PIC Single Cell RNA Seq
• GSE275096 DNA-damaging Chemotherapy altered the Cardiac Pathogenesis by reshaping the Composition and Functionality of Cardiac Resident Macrophages (bulk RNA-Seq).
• GSE275095 DNA-damaging Chemotherapy altered the Cardiac Pathogenesis by reshaping the Composition and Functionality of Cardiac Resident Macrophages (scRNA-Seq).
• GSE274806 RRM2 Promotes Liver Metastasis of Pancreatic Cancer by Stabilizing YBX1 and Activating the TGF-beta Pathway
• GSE274687 Atlas of the aging mouse intestine
• GSE269893 Differential DNA methylation reveals metabolic adaptation in recent modern human evolution
• GSE267399 Critical Role of MALAT1 in Gram-negative Bacteria-induced Coagulation via regulating GSDMD-dependent TF activity
• GSE261435 Combining SHP2 inhibition with CX3CR1 inhibition shrinks tumors and normalizes the tumor microenvironment
• GSE253783 Irgm1-Ifi35 Axis Promotes Renal Cancer Cell Immune Evasion Through Reprogramming the Differentiation of Myeloid-derived Suppressor Cell.
• GSE252728 Next Generation Sequencing Facilitates Quantitative Analysis of wild type and Phlpp1-deficient Bone Marrow Derived macrophage Transcriptomes
• GSE251652 ERα mediated gene state switching regulates the extent of the single-cell estrogen response [scRNA-seq]
• GSE250221 PKC inhibition overcomes chemo-resistance in TNBC by restoring Aurora kinase B expression
• GSE244424 Identification of potential targets of PPDPF in cholangiacarcinoma via transcriptome-wide RNA-seq
• GSE243881 An Optimized Hepatocyte-like Cells Differentiation Protocol Using Machine Learning Assisted Approach and Multi-omics Analysis [RNA-seq and ATAC-seq]
• GSE240194 Extracellular vesicles derived from HuMSCs alleviate daunorubicin-induced cardiac microvascular injury via miR-186-5p/PARP9/STAT1 signal pathway
• GSE237487 Polycomb and trithorax epigenetic marks regulate temperature response in the phytoplanktonic microalgae Ostreococcus tauri [RNA-seq]
• GSE237486 Polycomb and trithorax epigenetic marks regulate temperature response in the phytoplanktonic microalgae Ostreococcus tauri [ChIP-seq]
• GSE237290 Immune gene expression profiling to inform individualized treatment of early-stage basal-like breast cancer
• GSE235832 Piezoeletric cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy
• GSE234409 Whole genome sequencing i.e. DNA seq in WT S. cerevisiae WT post treatment with six different replication inhibitors
• GSE234219 Single-cell transcriptomics reveals diverse and complex gene expression alterations in human fetal spinal cord
• GSE223789 NIT2 epigenetically restrains oxidative phosphorylation to overcome fluorouracil resistance in gastric cancer
• GSE218037 Transcriptome sequencing reveals expression characteristics of osteosarcoma before and after neoadjuvant chemotherapy
• GSE215851 Single-cell transcriptomics reveals diverse and complex gene expression alterations in human fetal spinal cord [scRNAseq]
• GSE215058 Single-cell RNA-sequencing of Gmnc and Mcidas knockout primary mouse tracheal epithelial cells (mTECs)
• GSE215046 Single-cell RNA-sequencing of cultured primary mouse tracheal epithelial cells (mTECs) at air/liquid interface for three days
• GSE183102 Defective prelamin A processing promotes RIPK1-driven necroptosis and inflammation in premature aging
• GSE165710 Genome-wide mapping of the chromatin enrichment of CEBPB in NCM460 cell
• GSE298119 先兆子痫患者胎盘单细胞RNA测序
• GSE296973 高危子痫前期与正常血压妊娠外周血转录组比较分析
• GSE294318 α-生育酚通过以LKB1依赖的方式调节ILC2铁死亡来缓解过敏性气道炎症_Aa-cko VS Aa-flox
• GSE294316 α-生育酚通过以LKB1依赖的方式调节ILC2铁死亡来改善过敏性气道炎症_Aalter vs VE
• GSE278144 Nlrp5 +/+ 和 -/- 以及生殖泡小鼠卵母细胞的 DNA 甲基化和转录谱分析
• GSE278123 Nlrp5 +/+ 和 -/- 以及生殖泡小鼠卵母细胞的 DNA 甲基化谱
• GSE312526 DSS诱导的急性结肠炎结肠组织单细胞RNA测序
• GSE312411 不同时间点硝酸盐限制和恢复条件下高粱的 RNAseq 分析。
• GSE312408 玉米在硝酸盐限制和恢复条件下不同时间点的 RNAseq 分析。
• GSE310336 Nup93R388W 敲入 (KI) 小鼠（品系：129S1/SvlmJ）的 RNA 转录组分析
• GSE307664 胎盘DNA甲基化在病因不明的慢性绒毛间炎发病机制中的作用
• GSE303316 LXR激动剂在初始CD8+ T细胞中引发效应前状态[RNA-seq]
• GSE301399 德拉韦综合征小鼠模型脑干代谢变化
• GSE299675：感染牛巴贝虫强毒株的高易感成年牛外周血单核细胞转录组分析
• GSE299189 E9.5神经管缺陷小鼠脑和E9.5正常小鼠脑的ATAC-seq
• GSE295589 白细胞介素-1介导的炎症导致围产期窒息后长期认知缺陷
• GSE294967 VEGFA灌注后雄性和雌性腰骶背根神经节的批量RNA测序
• GSE294755 两组苯丙酮尿症患者的全转录组比较：rs113883650 非携带者与携带者
• GSE285907 天冬酰胺内肽酶通过调节IGF2和整合素αvβ5促进乳腺癌相关的心包钙化
• GSE281709 HepG2细胞染色质状态的全基因组图谱
• GSE281305 利用高通量分子谱分析人类DNA甲基化数据生成多组学数据集
• GSE281219 人类衰老肺细胞图谱
• GSE272765 外酶 CD38 在星形胶质细胞转录和代谢稳态维持中的新作用
• GSE270271 血管生成素-2的拯救通过拮抗VEGFR3信号通路抑制淋巴管畸形内皮细胞增殖
• GSE249710 LXR激动剂增强LXR-DKO BMDC交叉呈递后的T细胞活化。
• GSE248588 RNA转录组分析，针对LNCaP、Hela和足细胞中的shMETTL3和shNUP93基因。
• GSE303677 空肠人肠道类器官 (HIO) 中对 GII.3 型人诺如病毒感染的上皮细胞差异性反应
• GSE315078 转录因子FvADS-1对ABC转运蛋白和麦角甾醇生物合成的调控控制着串珠镰刀菌的唑类抗性和毒力
• GSE314253 烟草细胞培养物在其生命周期不同阶段的转录组比较
• GSE314128 与平滑肌细胞的接触决定内皮细胞转录组
• GSE312849 QPRT 过表达对癌周细胞基因表达的影响
• GSE311736 脓毒症诱导的小鼠肝细胞通讯变化：纯化细胞的RNA测序
• GSE311735 FTO 耗竭不改变 AML mRNA 中的 m6A 化学计量：使用直接 RNA 纳米孔测序（GLORI 数据）的重新评估
• GSE311676 FTO 耗竭不改变 AML mRNA 中的 m6A 化学计量：使用直接 RNA 纳米孔测序（CROWN-seq 数据）的重新评估
• GSE311653 FTO 耗竭不改变 AML mRNA 中的 m6A 化学计量：使用直接 RNA 纳米孔测序的重新评估（Direct-RNA Nanopore-seq 数据）
• GSE311500 RNA-seq 分析 PRAME 敲低在 A375SM 皮肤黑色素瘤细胞中的作用
• GSE311340 发现一种选择性RXRγ降解剂WCF-598用于治疗去势抵抗性前列腺癌
• GSE307158 单细胞 RNA 测序结果表明，霍乱弧菌 Mak 毒素是杀死四膜虫以及在原生动物排出的食物泡中存活所必需的。
• GSE306905 IL-36γ 装甲 CAR T 细胞重编程中性粒细胞以诱导内源性抗肿瘤免疫
• GSE306720 微生物色氨酸代谢产物吲哚作用于胃肠道，通过增强 GLP-1 分泌和 L 细胞分化来改善葡萄糖稳态。
• GSE306575 慢性乙型肝炎肝活检的空间和单核转录组分析
• GSE305874 线粒体微蛋白 MOCCI 通过改变胶质细胞活化状态来控制神经炎症 [scRNA-seq]
• GSE305613 CD31+细胞富集部分增强了基质血管成分在实验性原发性骨关节炎中的治疗效果
• GSE305528 克罗恩病中持续性炎症上皮祖细胞状态的表观遗传学基础
• GSE305363 单次关节内注射胎盘扩增的间充质样基质细胞可通过炎症和软骨稳态的联合调节阻止实验性原发性骨关节炎的进展
• GSE305263 中体残余物中细胞类型特异性RNA特征：来自癌细胞、干细胞和分化细胞的启示
• GSE302860 A52 小鼠肝细胞癌细胞系的分子特征
• GSE302075 3D打印nHA/PA66多孔支架：协同调节免疫平衡和血管生成，促进骨再生
• GSE300929 综合分析揭示食肝麻黄汤调节哮喘的免疫代谢和炎症反应 [scRNA-seq]
• GSE300921 综合分析揭示食肝麻黄汤调节哮喘的免疫代谢和炎症反应 [RNA-seq]
• GSE300858 使用 NanoString nCounter 对接受手术治疗的胰腺癌患者进行基因表达谱分析。
• GSE300610 在生理葡萄糖浓度为 4.5 mM 的条件下，用或不用 1 µM 或 10 µM 西地那非，培养 MT-ATP6 患者和正常对照者的 iPSC 衍生神经元前体细胞 (NPC) 6 或 24 小时。
• GSE299804 ECRG4 作为一种新型诊断血浆标志物，可在阿尔茨海默病早期阶段检测到
• GSE299690 研究了苔藓植物小立碗藓（Physcomitrium patens）醛脱氢酶突变体的非生物胁迫响应，重点关注与 GABA 旁路途径相关的成员。
• GSE299222 金黄色葡萄球菌中翻译起始及其调控的独特机制[RNA-Seq]
• 使用 nCounter Nanostring 平台对人类效应 1 型 T 辅助 (Th1) 细胞进行自身免疫基因特征的 GSE298668 mRNA 分析 [代谢组]
• GSE298385 对照饮食和高脂饮食喂养的 C57BL/6 小鼠结直肠肝转移瘤相关巨噬细胞的转录谱。
• GSE297970 ChIP-Seq 用于绘制野生型酿酒酵母经五种不同复制抑制剂处理后的 DNA 双链断裂图谱
• GSE297952地物养肝胶囊通过调节YAP信号传导减轻肝细胞癌进展
• GSE297575 FOXF2 调节新生儿高氧肺损伤期间周细胞-内皮信号传导所需的周细胞功能 [scRNA-seq]
• GSE297573 FOXF2 调节新生儿高氧肺损伤期间周细胞-内皮细胞信号传导所需的周细胞功能 [RNA-Seq]
• GSE297118 新一代测序技术促进了对 Lut 处理组和载体对照处理组 EDE 小鼠角膜组织的定量分析
• GSE296987 癌细胞中外源性神经节苷脂 GM2 处理引起的基因差异调控。
• GSE296099 甲状腺癌（TC）患者来源的工程化类器官模型的基因表达分析
• GSE295909 ALDH18A1在调节代谢功能障碍相关性脂肪性肝炎进展中的作用
• GSE295053 Ptbp1 通过 mTOR-PKCα 通路促进支持细胞中的细胞骨架组织，从而支持精子发生
• GSE294531 H19/miR-760/BST2轴调控乳腺癌的肿瘤发生和转移
• GSE292833 表观遗传调控巨噬细胞亚群可促进小鼠心脏移植模型中同种异体移植物的长期存活
• GSE290881 Clania variegata 转录组测序
• GSE290780 胸斑火腔菌转录组测序
• GSE290613 新一代测序技术促进了从 Prrx1-creERT;Ptch1 和 ctrl 小鼠中分选出的角质细胞的定量分析
• GSE290490 新一代测序技术促进了从 Prrx1-creERT;Ptch1 和 ctrl 小鼠中分选出的上皮细胞的定量分析
• GSE290463 增强子相关长链非编码RNA-ITGA2通过介导ITGA2启动子-增强子相互作用促进血管平滑肌重塑[RNA-seq]
• GSE289993 长期循环热量限制期间的肝脏代谢适应
• GSE288609 对未感染过疟疾的成年人进行实验性感染恶性疟原虫后，早期疟疾免疫特征显示出高反应者和低反应者。
• GSE288095 TET 依赖的 β 细胞信号传导是宫内高血糖诱导后代葡萄糖耐受不良的基础 [scRNA-seq]
• GSE287215：不同Cas9转染后原代人支气管上皮细胞的批量RNA测序
• GSE286743 H3K27 突变型弥漫性半球胶质瘤表现出弥漫性中线胶质瘤的典型分子特征：病例报告和文献综述。
• GSE286446 ANGPT1 作为大规模泛癌分析中的预后生物标志物
• GSE286376 多方面纳米药物增强金属免疫疗法治疗肝细胞癌
• GSE285626 强效抑制心肌细胞中血红素诱导的铁死亡可增强心肌梗死/再灌注损伤后的心脏功能
• GSE285625 寻找肝细胞癌（HCC）中索拉非尼反应特征
• GSE285610 组蛋白H1非自主地促进抑郁果蝇的脂肪分解
• GSE285374 缺氧诱导的 circPRELID2 通过 PCBP1 O-GlcNAc 化促进 ZEB2 翻译，从而促进胃癌转移
• GSE285297 RNA-seq数据分析TgNF7对弓形虫速殖子发育的影响
• GSE284486 GABA调节的能量代谢重构正向调控棉花（陆地棉）在涝渍后恢复期的响应
• GSE284387 DNMT1 RFTS 突变通过其 RNA 结合功能改变 RNA 剪接并驱动神经退行性变 [RNA-Seq]
• GSE283724 子宫​​液炎症蛋白质组学可能是一种预测子宫内膜容受性的非侵入性指标：一项初步研究
• GSE283339 脂肪组织中1-脱氧鞘脂水平升高促进炎症
• GSE282962 囊泡相关膜蛋白相关蛋白B通过激活SMAD信号通路促进主动脉瓣间质细胞的成骨分化
• GSE282612 脾脏转录组图谱将B淋巴细胞定义为预防单纯疱疹病毒1型眼部感染的策略
• GSE281944 出生后第5天，从Aclyfl/fl（对照组）或Pdgfra-creERT;Aclyfl/fl（Acly CKO）前脑中FACS分选的少突胶质细胞祖细胞的单细胞RNA测序
• GSE281681 C57BL6/j 和 129S1/SvImJ 小鼠白色脂肪组织中的转录因子占位受遗传变异的影响 [ATAC-seq]
• GSE279868 小鼠的雄性代谢和生殖健康均受营养不足和营养过剩的影响
• GSE279292 SAS（一种鳞状细胞癌细胞系）培养过程中培养基中缺乏 L-苯丙氨酸引起的细胞反应。
• GSE279051 雌激素信号在 PDGFRα+ 细胞中通过 IGFBP5 正向调节雌性小鼠的皮质骨代谢。
• GSE278231 Transcriptomic analysis of human breast cancer cells upon carboplatin treatment
• GSE277916 Asprosin Transcription Underlies Obesity Relapse and Inheritance [ATAC-seq]
• GSE277913 Asprosin Transcription Underlies Obesity Relapse and Inheritance [RNA-seq]
• GSE276917 RNA-seq analysis further corroborated the reversal effect of asp on AOA-enhanced ISG expression in L929 cells [2]
• GSE275247 TAF1D promotes tumorigenesis and metastasis by activating PI3K/AKT/mTOR signaling in clear cell renal cell carcinoma
• GSE274585 Single cell RNA-sequencing reveals murine periodontium under diabetic periodontitis resolution
• GSE274310 Host transcriptome in human lung A549 cells infected with SARS-CoV-2 expressing wild-type and mutant (H234A and N277A) Nsp15
• GSE273859 The effect of aspartame on the innate immune ability of Caenorhabditis elegans.
• GSE273443 ATF3’s Dual Role in Zebrafish: Early Proliferation Enhancement and Modulates Muscle Growth while Accelerated Aging in Adulthood via Overexpression and Deficiency
• GSE272896 RNA-seq analysis further corroborated the reversal effect of asp on AOA-enhanced ISG expression in L929 cells
• GSE272157 RNA sequencing of lung tissue from wildtype and hypoxia-induced pulmonary hypertension/hypoxia-induced pulmonary hypertension mice under aerobic exercise conditions
• GSE271636 WDFY3 loss-of-function leads to increased proliferation and altered differentiation of neuronal cells underlying the haploinsufficient human phenotype
• GSE271475 Single cell atlas of enthesitis reveals a mechanical strain responsing and SOX5 programmed SDC1+ sheath fibroblast in ankylosing spondylitis [scRNA-seq]
• GSE271473 Single cell atlas of enthesitis reveals a mechanical strain responsing and SOX5 programmed SDC1+ sheath fibroblast in ankylosing spondylitis [bulk RNA-seq]
• GSE271229 Single-nuclear RNA sequencing of human left atrial appendage
• GSE270605 Transcriptome Atlas of the Developing Honeybee Brain
• GSE270068 MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma.
• GSE269713 Bovine Formative Embryonic Stem Cell Plasticity in Embryonic and Extraembryonic Differentiation [scRNA-seq]
• GSE269148 Impact of lysine, methionine, and histidine deficiencies on gene expression and upstream transcriptional regulators in bovine mammary epithelial cells: an RNA-sequencing analysis
• GSE268904 Defining the vascular niche of human adipose tissue across metabolic conditions
• GSE267894 Effect of B cell deficiency in mice during Acientobacter baumannii respiratory infection
• GSE267731 Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinom
• GSE265795 Impact of Depletion or Overexpression on Gene Expression in Triple Negative Breast Cancer
• GSE262862 The role of the circadian transcriptional network in the aging Drosophila eye
• GSE262513 Inducible (B-estradiol) RNA-seq analysis of Arabidopsis root
• GSE262476 Transcriptome changes in lung after the intervention of Wendan Decoction on COPD rats
• GSE254008 Epigallocatechin gallate ameliorates retinal pigment epithelial cell damage via the CYFIP2 /AKT pathway
• GSE253941 Next Generation Sequencing Facilitates Quantitative Analysis of WT and cry1 cry2 in blue light or WT, cry2 and prr5 at ZT11 in 12/12 white light condition Transcriptomes
• GSE253177 CLK and CYC CUT&RUN in aging Drosophila photoreceptors
• GSE252886 Ezh2 in NK cell functional regulation
• GSE252727 RNA-Seq analysis of WT and Phlpp1-deficient alveolar macrophages in bleomycin-induced PF model
• GSE252726 ATAC-seq to profile the chromatin accessibility in WT and Phlpp1-deficient BMDMs
• GSE252725 PHLPP1 Cut&Tag profiling of bone marrow derived macrophage
• GSE252269 Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity [CUT&Tag/ATAC-seq]
• GSE249805 Surfactant Protein D promotes the inhibition of tumor growth and metastatic progression with a potential for therapeutic intervention
• GSE248293 Baicalein Alleviates Acute-on-Chronic Liver Failure by Promoting TREM2-dependent Macrophage Polarization
• GSE247885 HMGB1 regulates autophagy of placental trophoblast through MAPK/ERK signaling pathway
• GSE246266 Genome-wide Mapping of Gata4 and Cul4b in MOVAS Cell Chromatin State.
• GSE245594 Transcrptiome profiling of aging mouse hearts following swimming trainning
• GSE241845 The effects of cell-cell orientation in modeling the hallmarks of lung cancer in vitro
• GSE241083 Lung-innervating neurons expressing TMC3 control broncho-constriction and dilation with direct impact on lung tidal volume (scRNA-Seq)
• GSE240911 A single-cell gene expression analysis in an in vitro co-culture model containing fibroblast cells directly mixed with NMU-manipulated lung adenocarcinoma cells
• GSE240633 Lysosomal control of type I interferon induction via Ragulator-Rag complex [RNA-seq]
• GSE240632 Lysosomal control of type I interferon induction via Ragulator-Rag complex [ATAC-seq]
• GSE239576 Comparison of Renal Transcriptome Profiles in Patients with Active Lupus Nephritis Reveals Possible New Mechanisms of Disease Progression
• GSE237488 Polycomb and trithorax epigenetic marks regulate temperature response in the phytoplanktonic microalgae Ostreococcus tauri.
• GSE236412 Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity [ChIP-Seq]
• GSE236411 Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity [ATAC-Seq]
• GSE236211 The HOG and pheromone pathway MAPKinase-kinases (MAPKK) TR80186 and TR21168 in Trichoderma reesei
• GSE236210 The HOG pathway MAPKKK TR_57513 in Trichoderma reesei
• GSE234702 Single-cell genomic profile of articular chondrocytes from rheumatoid arthritis and osteoarthritis patients
• GSE234410 RNA-Seq to map gene expression pattern in WT S. cerevisiae WT post treatment with six different replication inhibitors
• GSE232496 Lung-innervating neurons expressing TMC3 control broncho-constriction and dilation with direct impact on lung tidal volume (RNA-Seq)
• GSE230500 Single-cell genomic profile of articular chondrocytes from CIA rats
• GSE230091 scATAC-seq of mouse 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) induced liver injury model
• GSE230085 scRNA-seq of mouse 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) induced liver injury model
• GSE229984 Attenuation of DNMT1-mediated DNA methylation upregulates CYP11A1 expression in progesterone synthesis during syncytialization of placental trophoblasts
• GSE228906 Transcriptome changes in lung after the intervention of Sang Ju Yin on ALI rats
• GSE226892 RNAi-mediated regulation of alg-3 and alg-4 coordinates the spermatogenesis developmental program in C. elegans [small RNA-seq]
• GSE225116 A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (CUT&RUN)
• GSE225114 ChIP-seq analysis of changes in H3K27me3 between WT and RORA-deficient primary mouse splenic regulatory T (Treg) cells activated in culture
• GSE225113 ChIP-seq analysis of changes in H3K27ac between WT and RORA-deficient primary mouse splenic regulatory T (Treg) cells activated in culture
• GSE225111 ATAC-seq analysis of WT versus RORA-deficient primary mouse splenic regulatory T (Treg) cells activated in culture
• GSE221768 Small molecule-induced adult-like human hepatocytes from pluripotent stem cells (ATAC-Seq)
• GSE221213 AhR promotes Th17 cells differentiation in chronic hepatitis B via JAK1/STAT3/SOCS3 pathway
• GSE218036 Transcriptome analysis of osteosarcoma cell lines treated with FDA-approved drugs
• GSE216775 Total RNA bulk sequencing of T helper cells [mRNA]
• GSE216774 Total RNA bulk sequencing of T helper cells [circRNA]
• GSE216773 circIkzf1 and Ikzf1 overexpression in Th cells [scRNA-seq B]
• GSE216772 circIkzf1 and Ikzf1 overexpression in Th cells [scRNA-seq A]
• GSE214770 An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection [Pseudovirus Infected Proximal Lung Organoid scRNA-seq]
• GSE214762 An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection [Prox, Distal, and Whole Lung Organoid scRNA-seq]
• GSE214752 An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection [Combined Proximal, Distal, and Whole Lung Organoid scRNA-seq]
• GSE214482 An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection [bulk RNA-seq]
• GSE212111 CRISPRa screen identifies a role for c-KIT signaling in tamoxifen resistance, potentially through upregulation of ABC transporters
• GSE209718 Erk activity at naïve:prime transition biases lineage specification during gastrulation [scRNA-seq]
• GSE209717 Nanog expression at naïve to prime transition biases lineage specification [CHIP-seq]
• GSE208779 A novel H2B variant with TERRA-promoter enrichment, H2BW2, forms decompacted nucleosomes in human spermatogenesis
• GSE207858 Heterologous synthesis of poly-γ-glutamic acid enhanced drought resistance in maize (Zea mays L.)
• GSE200019 HDAC3 is required for self-renewal and metabolism of AMs
• GSE200017 HDAC3 is required for self-renewal and metabolism of Ams [CUT&TAG]
• GSE190416 RNAseq of low-pigmented and high-pigmented cells from mouse B16 melanoma cell lines (experiment 2)
• GSE190252 RNAseq of low-pigmented and high-pigmented cells from LM-MEL-28 human melanoma cell line.
• GSE173328 Transcriptome of U251-APP cells with CTCF-binding sites knockout
• GSE171320 The crown-root inducible system (CRIS) coupled to RNAseq allows identifying the early molecular events of crown-root initiation in barley (Hordeum vulgare L.)
• GSE162738 Immune gene signatures in oropharyngeal cancers are associated with inverse prognosis by HPV-status
• GSE161562 Transcriptome alteration in Nrf2 mutant developing oligodendrocytes treated with interferon gamma and thapsigargin in comparison with wild-type developing oligodendrocytes treated with interferon gamma and thapsigargin
• GSE161561 Transcriptome alteration in wild-type developing oligodendrocytes treated with interferon gamma and thapsigargin in comparison with untreated wild-type developing oligodendrocytes
• GSE160730 RNA-seq during HCC progression
• GSE158778 Sperm circular RNAs: Types, expression patterns and epigenetic potential
• GSE157492 Tenofovir and dolutegravir reduce human T-cell leukemia virus 1 transmission and de novo viral spread in vivo
• GSE150914 RNA-seq for rapid response to glyphosate in Ambrosia trifida
• GSE144178 A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts
• GSE144177 A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (microRNA)
• GSE144176 A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (mRNA)
• GSE93697 High-throughput RNA-sequencing of preadipocyte subsets in obese mice