详细内容（前10条）

1. ⭐ GSE268161 单细胞分辨率下免疫检查点阻断抵抗中 T 细胞耗竭的转录调控 [离体-scRNA]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、T cell、resistance、single-cell、scRNA
• 📝 描述：Contributors : Tzu-Yang Tseng ; Ching-Huang Hsieh ; Chia-Lang Hsu ; Yu-Ching Wu ; Chiun Hsu ; Hsuan-Cheng Huang ; Da-Liang Ou ; Hsueh-Fen JuanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor-specific CD8+ T lymphocytes are crucial for anti-cancer immunity but can lose cytotoxic function in the immunosuppressive tumor microenvironment. Immune checkpoint blockades (ICB), like anti-PD-1 therapy, enhance and prolong anti-tumor T cell responses. Despite its widespread clinical use, resistance to ICB develops in some patients, characterized by the proliferation of exhausted T cell (Tex). Here, we establish two single-cell murine hepatocellular carcinoma (HCC) models to explore regulatory network in Tex with ICB resistance. We uncover distinct T cell compositions, including both early and terminal Tex subsets, following prolonged ICB treatment, and reveal the differentiation trajectory of Tex subsets. Finally, we not only identify transcription factor Runx2 and its downstream targets as contributors to T cell exhaustion in both models, but discover ICB response correlates to Runx2 level in human tumor-infiltrating lymphocytes. These findings elucidate Runx2 regulates T cell exhaustion in response to prolonged ICB treatment, influencing ICB effICBency, and suggest potential targets for combination therapy alongside ICB in HCC.
• 🔗 查看原文

2. ⭐ GSE268160 单细胞分辨率下免疫检查点阻断耐药中 T 细胞耗竭的转录调控 [ex vivo-scATAC]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、T cell、resistance、single-cell、scATAC
• 📝 描述：Contributors : Tzu-Yang Tseng ; Ching-Huang Hsieh ; Chia-Lang Hsu ; Yu-Ching Wu ; Chiun Hsu ; Hsuan-Cheng Huang ; Da-Liang Ou ; Hsueh-Fen JuanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTumor-specific CD8+ T lymphocytes are crucial for anti-cancer immunity but can lose cytotoxic function in the immunosuppressive tumor microenvironment. Immune checkpoint blockades (ICB), like anti-PD-1 therapy, enhance and prolong anti-tumor T cell responses. Despite its widespread clinical use, resistance to ICB develops in some patients, characterized by the proliferation of exhausted T cell (Tex). Here, we establish two single-cell murine hepatocellular carcinoma (HCC) models to explore regulatory network in Tex with ICB resistance. We uncover distinct T cell compositions, including both early and terminal Tex subsets, following prolonged ICB treatment, and reveal the differentiation trajectory of Tex subsets. Finally, we not only identify transcription factor Runx2 and its downstream targets as contributors to T cell exhaustion in both models, but discover ICB response correlates to Runx2 level in human tumor-infiltrating lymphocytes. These findings elucidate Runx2 regulates T cell exhaustion in response to prolonged ICB treatment, influencing ICB effICBency, and suggest potential targets for combination therapy alongside ICB in HCC.
• 🔗 查看原文

3. ⭐ GSE268165 单细胞分辨率下免疫检查点阻断耐药中T细胞耗竭的转录调控

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、T cell、resistance、single-cell
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

4. ⭐ GSE268163 免疫检查点阻断抵抗中 T 细胞耗竭的转录调控（单细胞分辨率）[体内]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、T cell、resistance、single-cell
• 📝 描述：Contributors : Tzu-Yang Tseng ; Ching-Huang Hsieh ; Chia-Lang Hsu ; Yu-Ching Wu ; Chiun Hsu ; Hsuan-Cheng Huang ; Da-Liang Ou ; Hsueh-Fen JuanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor-specific CD8+ T lymphocytes are crucial for anti-cancer immunity but can lose cytotoxic function in the immunosuppressive tumor microenvironment. Immune checkpoint blockade (ICB), like anti-PD-1 therapy, enhance and prolong anti-tumor T cell responses. Despite its widespread clinical use, resistance to ICB develops in some patients, characterized by the proliferation of exhausted T cell (Tex). Here, we establish two single-cell murine hepatocellular carcinoma (HCC) models to explore regulatory network in Tex with ICB resistance. We uncover distinct T cell compositions, including both early and terminal Tex subsets, following prolonged ICB treatment, and reveal the differentiation trajectory of Tex subsets. Finally, we not only identify transcription factor Runx2 and its downstream targets as contributors to T cell exhaustion in both models, but discover ICB response correlates to Runx2 level in human tumor-infiltrating lymphocytes. These findings elucidate Runx2 regulates T cell exhaustion in response to prolonged ICB treatment, influencing ICB effICBency, and suggest potential targets for combination therapy alongside ICB in HCC.
• 🔗 查看原文

5. ⭐ GSE308675 乳酸是一种代谢-表观遗传信号，它将高强度间歇训练与以 miRNA 为中心的骨骼肌甲基化组和转录组重塑联系起来 [甲基化微珠芯片]

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolic、transcriptome、epigenetic、methylation
• 📝 描述：Contributors : Lei Zhou ; Radak ZsoltSeries Type : Methylation profiling by arrayOrganism : Mus musculusLactate, a major exercise-derived metabolite, has been proposed to couple cellular metabolism to gene regulation, yet its direct impact on skeletal muscle remains unclear. Male mice underwent six-week interventions (Control, lactate, HIIT, MCT1/2 inhibition, or HIIT+inhibition). We profiled gastrocnemius DNA methylation, mRNA-seq and miRNA-seq, and assessed signaling proteins, metabolites, and running performance. Lactate and HIIT each induced broad, site-specific remodeling of the methylome and transcriptome with substantial overlap at promoter CpGs and among DEGs. Promoter methylation changes showed weak coupling to steady-state mRNA, whereas integrative analyses revealed robust anti-directional miRNA–mRNA networks and enriched for chromatin/epigenetic regulators, identifying a lactate-driven miRNA axis as a proximate regulator of transcriptional output. At the protein level, lactate selectively increased TET2 and DNMT3A and activated PAX7, VEGF, and AKT–S6 signaling, consistent with integrative miRNA–mRNA findings. HIIT increased TET1/2 and DNMT3A with DNMT3B reduction and uniquely enhanced mitochondrial/antioxidant signaling. Blocking MCT1/2 abrogated HIIT-induced methylome and miRNA remodeling and blunted transcriptomic and protein adaptation, demonstrating that intact lactate flux is required for exercise-evoked epigenetic and transcriptomic reprogramming. Despite molecular convergence, chronic lactate did not improve running performance, indicating that lactate is necessary but not sufficient for the full physiological adaptation of training. These findings position a lactate–miRNA axis linking metabolic perturbation to epigenetic and transcriptional remodeling in skeletal muscle.
• 🔗 查看原文

6. ⭐ GSE297753 MEK抑制剂增强KRAS突变型肺癌放射治疗后的抗肿瘤免疫

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immunity、KRAS
• 📝 描述：Contributors : Yawen Zheng ; Meili SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus24 hours after the designated treatment, the LLC cells in four groups cultured in a 60 mm dish underwent two washes with PBS. Subsequently, 1 ml of TRIzol reagent was introduced. The solution was pipetted until it appeared clear, after which the mixture was transferred to an EP tube and stored at -80°C. The samples were then transported to BGI on dry ice for gene sequencing. Sequencing commenced once the samples successfully passed quality control assessments.
• 🔗 查看原文

7. ⭐ GSE313407 成年小鼠受控皮层冲击视觉空间转录组学

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、Visium、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Savannah K Kounelis-Wuillaume ; Andrew M Frank ; Camille Alba ; Gauthaman Sukumar ; Matthew D Wilkerson ; Clifton L Dalgard ; Martin L DoughtySeries Type : OtherOrganism : Mus musculusHere we investigated the topographical relationship of early transcriptional responses to a single, focal TBI in mice by controlled cortical impact (CCI). Guided by the presence of the anterior commissure (AC) in coronal sections at the rostro-caudal point of impact, we compared gene expression changes in the neocortex (CTX) and corpus callosum-external capsule (CC-EC), striatum (STR) and AC. Injury-induced gene expression changes were detected in the CTX, CC-EC and STR but not AC and were principally segregated based on cytoarchitecture, and secondarily by proximity to the site of impact. Additionally, unbiased spatial clustering revealed a positive relationship between proximity to the impact and the number of acutely differentially expressed genes within the laminar CTX. Next, we examined the effects of systemic depletion of neutrophils and monocytes on spatial gene expression changes in the injured brain.
• 🔗 查看原文

8. ⭐ GSE169182 通过单核甲基化测序研究大脑衰老的表观遗传特征 [CP-9mo-m-022]

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging、sequencing、epigenetic、methylation
• 📝 描述：Contributors : Wei Tian ; Anna Bartlett ; Jordan Altshul ; Rosa Gomez Castanon ; Joseph R Nery ; Jacinta D Lucero ; Julia K Osteen ; Huaming Chen ; M M Behrens ; Joseph R EckerSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusIllustrating aging effects on the epigenomic features of brain is critical to understand brain functional decline and neurodegeneration. Single nucleus methylation sequencing was applied to brain regions of mouse at the age of 2, 9 and 18 months. We use these data to identify the epigenomic changes with aging in mouse brains.
• 🔗 查看原文

9. ⭐ GSE313718 精准纳米疗法重塑肿瘤相关巨噬细胞以逆转胰腺癌中的免疫抑制 [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、macrophage、scRNA
• 📝 描述：Contributors : Yunching Chen ; Hsin-Mei LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive stroma rich in tumor-associated macrophages (TAMs) that limit the therapeutic efficacy. We introduce a TAM-targeted nanotherapy platform that selectively delivers either a CSF1R inhibitor or the STING agonist cGAMP to immunosuppressive TAMs. While CSF1R inhibitor–loaded nanoparticles efficiently depleted TAMs and produced moderate antitumor effects, TAM-targeted cGAMP nanoparticles reprogrammed TAMs into immune-stimulating effectors. This reprogramming normalized aberrant vasculature, alleviated desmoplasia, and enhanced infiltration and activation of cytotoxic immune cells. In combination with gemcitabine, PD-1 checkpoint blockade, or CAR-NK cell therapy, TAM-targeted STING activation provided an in situ immunostimulatory signal that markedly improved antitumor efficacy in preclinical PDAC models. Ex vivo efficacy in human PDAC tissues and a favorable safety profile show the translational potential of this TAM-targeted nanotherapy to overcome the immune desert of PDAC.
• 🔗 查看原文

10. ⭐ GSE314074 免疫基因多样性和 STING1 变异体在不同遗传祖先人群中塑造癌症免疫力

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、immunity
• 📝 描述：Contributors : Xiaowen Hu ; Jie Huang ; Zhongyi Hu ; Lin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs human populations migrated to diverse geographical regions, they encountered varying pathogens, leading to pronounced natural selection pressures on the immune system. Analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) across major geographically structured populations showed greater variation in immune-related genes than in non-immune genes, consistent with pathogen-driven selection, whereas cancer-related genes exhibited lower variation, reflecting evolutionary conservation of critical cellular functions. We prioritized nsSNPs in pattern recognition receptor genes based on population diversity and their association with type I interferon activity. Among the top-ranked variants were rs11554776, rs78233829, and rs7380824 in STING1, which demonstrated functional impacts on intrinsic cGAS-STING1-IFN signaling in cancer cells and potential influences on tumor immunity. We further conducted a genome-wide characterization of nsSNPs in immune-related genes across genetic ancestry populations and established a publicly accessible database. Our study suggests that genetic ancestry-related germline variations may influence cancer immunity and treatment, supporting their consideration in personalized medicine.
• 🔗 查看原文

💡 该来源还有 84 条内容，详见 文末

详细内容（全部6条）

1. ⭐ RoCK 和 ROI——单细胞转录组学，可对选定的转录本进行多重富集和区域特异性测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell、transcriptomics、enrichment
• 📝 描述：Enhanced targeted capture and region-specific sequencing improve single-cell RNA sequencing resolution revealing key transcripts and regions of interest across diverse cell types…
• 🔗 查看原文

2. 技术进步揭开了线粒体DNA之谜——我们的“另一个”基因组

• ✍️ 作者：未知作者
• 🏷️ 关键词：genome
• 📝 描述：Single cell RNA sequencing reveals how mitochondrial DNA mutation burden shapes metabolic flexibility and cancer growth, highlighting mtDNA as an active contributor to leukemogenesis…
• 🔗 查看原文

3. RNAConnect推出UltraMarathonRT® Direct RNA-Seq试剂盒，推进基于纳米孔的天然RNA测序技术

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：A new kit improves direct RNA sequencing on Oxford Nanopore, delivering longer reads, more isoforms, and preserved RNA modifications through gentle low-temperature reverse…
• 🔗 查看原文

4. 一项新研究揭示了泡菜如何增强免疫系统

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune
• 📝 描述：Kimchi may do far more than add flavor to meals—it could help fine-tune the human immune system. A clinical study using advanced single-cell genetic analysis found that regular kimchi consumption strengthens immune defenses while preventing harmful overreactions. Researchers observed improved activity in key immune cells, with effects varying depending on fermentation methods.
• 🔗 查看原文

5. 一项新的检测方法有望在症状出现前发现阿尔茨海默病。

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：Scientists at Northern Arizona University are developing a promising new way to detect Alzheimer’s disease earlier than ever before—by tracking how the brain uses sugar. Using tiny particles in the blood called microvesicles, researchers may soon be able to gather brain-specific information without invasive procedures. If successful, this approach could transform Alzheimer’s diagnosis, monitoring, and even prevention, much like how doctors manage heart disease today.
• 🔗 查看原文

6. 人工智能不仅能检测癌症，还能了解你的个人信息。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：AI tools designed to diagnose cancer from tissue samples are quietly learning more than just disease patterns. New research shows these systems can infer patient demographics from pathology slides, leading to biased results for certain groups. The bias stems from how the models are trained and the data they see, not just from missing samples. Researchers also demonstrated a way to significantly reduce these disparities.
• 🔗 查看原文

• GSE308673 乳酸是一种代谢-表观遗传信号，它将高强度间歇训练与以miRNA为中心的骨骼肌甲基化组和转录组重塑联系起来
• GSE293819 监测乳腺癌中免疫检查点抑制剂引起的全身免疫反应，揭示宿主反应和耐药机制
• GSE284115 髓系微环境的单细胞转录组学揭示了三阴性乳腺癌中的血管生成微环境
• GSE271589 单细胞 RNA 测序解析与糖尿病和衰老过程中黏膜伤口愈合失调相关的细胞表型
• GSE267517 探索卵巢癌中调节免疫治疗反应的肿瘤内在因素
• GSE249803 空间转录组学揭示肝脏再生过程中肝小叶的空间重塑
• GSE312098 通过双重靶向 TROP2 和 PERK 抑制 Wnt/β-catenin 信号通路克服晚期结直肠癌的 ADC 耐药性 [TROP2+GSK RNA-Seq]
• GSE313257 单核转录组学揭示创伤后应激障碍（PTSD）患者海马体中的免疫失衡
• GSE313958 Cas9 编辑和转录组的联合单细胞分析揭示了对基因表达的靶向和非靶向效应（RNA-seq）
• GSE309610 肾细胞癌中KRAS突变的临床和分子特征
• GSE309446 一项针对晚期/转移性非小细胞肺癌患者，评估西曲伐替尼联合替雷利珠单抗和多西他赛治疗获得性PD-(L)1耐药的II期临床研究
• GSE308914 小鼠心肌梗死后心脏转录组的时间动态变化
• GSE300565 MRPL37 通过调节线粒体能量代谢促进肝细胞癌进展
• GSE296212 LINE-1 基因座转录促进致癌染色质结构形成 [RNA-Seq]
• GSE295052 芍药酚在内质网应激条件下通过 CLGN/NF-κB 通路影响肝细胞癌细胞增殖和凋亡
• GSE293262 甲基苯丙胺成瘾者的全基因组DNA甲基化谱分析
• GSE292020 结直肠癌类器官驱动NK细胞中患者特异性的炎症、细胞毒性和组织驻留程序
• GSE313770 衰老雄性小鼠脑的单细胞多组学和多区域图谱
• GSE313691 T 细胞耗竭过程中 5’ TOP mRNA 的翻译下调 [RNA-Seq]
• GSE313455 运动通过骨骼肌来源的细胞外囊泡增强小胶质细胞清除斑块，从而缓解阿尔茨海默病小鼠的认知功能障碍 [RNA-Seq]
• GSE311016 通过双重靶向 TROP2 和 PERK 抑制 Wnt/β-catenin 信号通路克服晚期结直肠癌的 ADC 耐药性
• GSE309239 高维分析揭示了人类肠道单核吞噬细胞群的异质性、谱系特异性前体细胞和炎症诱导的变化
• GSE306665 女性肠道敏感性增强的细胞基础
• GSE279550 神经元 APOE4 诱导的早期海马网络过度兴奋在阿尔茨海默病发病机制中的作用
• GSE314051 序列和化学特异性定义了固有无序区域的功能图谱 [RNA-seq]
• GSE314023 膳食中特定氨基酸的缺乏会诱导不同的代谢和染色质状态
• GSE313971 抗原结合域的合理重新设计提高了CD22-CAR的体内疗效
• GSE314188 低剂量 ATG 治疗反应者在 1 型糖尿病中诱导 CD4+ T 细胞耗竭
• GSE313955 Cas9 编辑和转录组的联合单细胞分析揭示了对基因表达的靶向和非靶向效应 (rhAmpSeq)
• GSE311535 糖尿病患者人动脉粥样硬化颈动脉斑块组织的 RNA 测序
• GSE311201 抗HER2/neu TCR-T细胞的作用：转录特征、分泌组学和体内肿瘤抑制的关联
• GSE310457 脂肪组织来源的microRNA作为2型糖尿病的表观遗传调节因子[DPDR_smallSeq]
• GSE310456 脂肪组织来源的microRNA作为2型糖尿病的表观遗传调节因子[DPDR_RNASEQ]
• GSE310455 脂肪组织来源的microRNA作为2型糖尿病的表观遗传调节因子[3T3_RNASeq]
• GSE310390 脂肪组织来源的microRNA作为2型糖尿病的表观遗传调节因子
• GSE309891 SBFI抑制剂重编程前列腺癌的转录组图谱，导致细胞死亡
• GSE309799 OR7A10 GPCR 工程改造增强 CAR-NK 疗法对抗实体瘤 [scRNA-Seq]
• GSE309566 对循环 T 细胞库中病毒 CD4 T 细胞表位特异性 TCR CDR3β 库的深入探索
• GSE308723 斑马鱼短暂暴露于西酞普兰后，神经和代谢基因表达发生持续且剂量依赖性的变化
• GSE307268 小鼠实验性心肌梗死——假手术左心室组织和梗死区的RNA测序
• GSE307265 小鼠实验性心肌梗死 - 肾脏 RNA 测序
• GSE306862 用疫苗序列一致的共同共识核蛋白和血凝素进行合成DNA共免疫，只需一次免疫即可保护小鼠免受致命性流感病毒感染
• GSE306570 通过联合种系靶向免疫同时诱导多种广谱中和抗体前体
• GSE305469 应激条件下胃癌细胞的转录组分析
• GSE303388 KIAA0319 通过与阅读障碍相关的基因网络在皮层神经元成熟和突触发育中发挥关键作用
• GSE302693 双色蜡菊在发育、代谢和基因表达水平上适应磷酸盐缺乏
• GSE301349 从皮下移植到原位移植：弥合肺癌研究与人类疾病之间的差距 [小鼠]
• GSE301347 从皮下到原位：弥合肺癌研究中与人类疾病的差距 [人类]
• GSE300095 基于 PHF23 存在和氨基酸饥饿的转录组分析
• GSE300094 PHF23 的基因组结合/占位谱分析以及基于 PHF23 存在情况下 H3K27ac 的变化
• GSE300093 CRISPRi筛选鉴定自噬通量的表观遗传调控因子
• 基于PHF23存在的ATAC-seq染色质可及性分析GSE300092
• GSE299624 T3a肾细胞癌中脂肪浸润与静脉浸润的不同预后和分子特征
• GSE297941 SBFI 抑制剂重编程前列腺癌的转录组图谱，导致细胞死亡 [SBFI-1143]
• GSE297940 SBFI 抑制剂重编程前列腺癌的转录组图谱，导致细胞死亡 [SBFI-103]
• GSE296794 RNA-RNA 相互作用组方法提供了体内证据，证明 Hfq 边缘面在 sRNA-mRNA 配对中起关键作用 [RNA-seq]
• GSE296484 牛血中DNA甲基化变化与年龄和疾病的关系
• GSE296336 人类间期和中期染色体中核小体组织的差异 [RNA-Seq]
• GSE296211 LINE-1 基因座转录促进致癌染色质结构形成 [L1CaP-C]
• GSE296210 LINE-1 基因座转录促进致癌染色质结构形成 [ChIRP-seq]
• GSE293553 食管鳞状细胞癌 (ESCC) 细胞 RNA 测序：TFAP2β 过表达或其 LLPS 缺陷突变体
• GSE290729 食管鳞状细胞癌 (ESCC) 细胞过表达 TFAP2β 或其 LLPS 缺陷突变体的 ChIP-seq
• GSE289021 Ig E 介导和非 Ig E 介导的牛奶过敏婴儿的差异性 DNA 甲基化及其与获得性耐受的关系
• GSE288962 联合免疫疗法诱导干预后HIV控制
• GSE286349 IFN-γ 处理 MOLM-13 细胞可增强 HLA 基因表达
• GSE281071 m6A mRNA甲基化修饰参与纤维蛋白原合成的基因以调节小鼠肝脏再生
• GSE280902 拉丁裔患者浸润性乳腺癌新辅助化疗反应转录组元特征的鉴定
• GSE264400 人类间期和中期染色体中核小体组织的差异 [RNA-seq]
• GSE255109 RNA G-四链体(rG4)通过介导核糖体暂停加剧细胞衰老[RNA-seq]
• GSE240242 NR1D1 敲低对 Xp11.2 易位肾细胞癌细胞系 UOK109 和 UOK120 基因表达的影响
• GSE236558 小鼠三阴性乳腺癌骨转移单细胞水平的基因表达谱。
• GSE314089 揭示靶向 BDCA2 在治疗自身免疫性疾病中的两种截然不同的作用：直接抑制 BDCA2 阳性 B 细胞和通过全面抑制 I 型干扰素使促炎性单核细胞来源的巨噬细胞正常化
• GSE312599 改变的MDC1相互作用和DNA修复功能障碍导致小叶性乳腺癌对PARP抑制剂敏感
• GSE314225 贝克氏螺旋线虫感染后谱系追踪记忆性 Th2 细胞的 RNA 测序：IL-5 与 IL-13 的比较
• GSE314191：Cas9 编辑和转录组的联合单细胞分析揭示了其对基因表达的靶向和非靶向效应
• GSE314064：不同生殖能力绵羊卵巢外泌体lncRNA和mRNA表达特征及生物信息学分析
• GSE313692 T 细胞耗竭过程中 5’ TOP mRNA 的翻译下调 [Ribo-Seq]
• GSE313456 运动通过骨骼肌来源的细胞外囊泡增强小胶质细胞清除斑块，从而缓解阿尔茨海默病小鼠的认知功能障碍 [miRNA-Seq]
• GSE306194 通过发现控制肺泡上皮细胞命运的因子推进肺组织工程（AT2 scRNA-seq）
• GSE299367 缺氧激活的硬化蛋白A介导心外膜祖细胞分化为一种独特的心脏血管周围细胞类型
• GSE298395 年轻和老年肌肉产生的外泌体的 miRNA 测序
• GSE295428 太空飞行对不同年龄阶段的细胞外基质和免疫系统产生系统性影响
• GSE284663 整合元组学揭示唾液乳杆菌改善尼罗罗非鱼肠道健康的机制
• GSE284661 RNA测序，针对暴露于凡德他尼的野生型C57BL/6J小鼠的肝脏样本进行RNA测序