详细内容（前10条）

1. ⭐ GSE298107 单细胞和空间转录组学揭示紫外线照射后血管细胞协调炎症变化 [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：scRNA、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Jie An ; Rachael Bogle ; Rayan Najjar ; Lam C Tsoi ; Michelle Kahlenberg ; Ksenia Anufrieva ; Erin Theisen ; Kevin Wei ; Johann E Gudjonsson ; Keith E ElkonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo elucidate the complex effects of acute UV radiation (UVR) on the skin, we exposed shaved mouse skin to UVB and performed transcriptomic profiling of the epidermis, deep dermis and adipose tissue. Spatial transcriptomic analysis revealed the most pronounced gene expression changes in the epidermis, peaking at 24 hours post-irradiation. While CD45⁺ immune cells showed differential expression of chemokines, cytokines, and acute-phase proteins, cytokeratin⁺ epidermal cells upregulated genes related to cellular stress and damage (e.g., Usp19, Adam25), as well as structural remodeling and apoptosis (e.g., Krt18, Phlda1). Single-cell RNA sequencing (scRNA-seq) conducted 12 hours after UVR exposure identified 4,849 differentially expressed genes (DEGs), with the epidermis and endothelial cells showing the highest DEG counts. Pathway analysis of upregulated genes in the epidermis revealed enrichment in VEGF, HIPPO, complement, IL-6, and apoptosis signaling pathways. In endothelial cells, UVR induced expression of multiple chemokines and cytokines. Notably, receptor-ligand analysis highlighted endothelial cells as key targets of CXCL chemokines and complement component C3. In fibroblasts, UVR triggered upregulation of inflammatory activation markers (Osmr, Cux1) alongside genes associated with glucose metabolism (Hif1a, Pkm). Cross-species comparison of UVR-responsive DEGs between mice and humans revealed strong concordance, particularly in TGF-β and TNF-associated pathways.
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2. ⭐ GSE309517 抑制癌症干细胞免疫检查点 SOAT1 通过跨细胞 20(S)-羟基胆固醇-GPR132 通路抑制小鼠的调节性 T 细胞功能。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、T cell、pathway
• 📝 描述：Contributor : Yahui DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSOAT1 (sterol O-acyltransferase 1) serves as a cancer stem cell-specific immune checkpoint that facilitates trans-cellular signaling through the release of 20-Hydroxycholesterol (20-OHC) and subsequent activation of GPR132 on regulatory T cells (Tregs). This pathway plays a crucial role in modulating the tumor immune microenvironment and can significantly influence the balance between immune activation and suppression. In the context of cancer, SOAT1 is instrumental in regulating the cholesterol metabolism of cancer stem cells. When SOAT1 is inhibited, there is an increase in the secretion of 20-OHC by tumor cells. This oxysterol not only functions as a signaling molecule but also acts as a ligand that binds to GPR132, a G protein-coupled receptor primarily expressed on immune cells, including Tregs. This binding triggers a cascade of intracellular signaling pathways that ultimately enhances the immunosuppressive functions of Tregs. Mechanistically, the activation of GPR132 by 20-OHC leads to downstream signaling events that may involve pathways such as JAK-STAT and PKC signaling, promoting the development and survival of Tregs while enabling them to exert their immunosuppressive effects within the tumor microenvironment. This results in the downregulation of effector T cell activities and impairs the maturation and activation of dendritic cells (DCs), which are pivotal for effective anti-tumor immune responses. The presence of Tregs, particularly in elevated frequencies within tumors, can contribute to an immunosuppressive environment that protects cancer cells from immune-mediated destruction. Thus, the SOAT1-20OHC-GPR132 axis represents a critical mechanism through which cancer cells can evade immune surveillance. By controlling cholesterol metabolism through SOAT1, tumors can manipulate the availability of 20-OHC, amplifying the immunosuppressive capacity of Tregs and facilitating an environment conducive to tumor growth and progression. Targeting SOAT1 and the associated 20-OHC signaling pathway may offer a promising therapeutic strategy to neutralize Treg-mediated immunosuppression. Inhibiting SOAT1 not only disrupts the tumor’s ability to produce 20-OHC but also potentially reprograms the immune landscape, promoting a more activated and effective anti-tumor immune response. Overall, SOAT1’s dual role as a cancer stem cell-specific immune ch…
• 🔗 查看原文

3. ⭐ GSE286092 抑制癌症干细胞免疫检查点 SOAT1 通过跨细胞 20(S)-羟基胆固醇-GPR132 通路抑制小鼠的调节性 T 细胞功能。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、T cell、pathway
• 📝 描述：Contributor : Yahui DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSOAT1 (sterol O-acyltransferase 1) serves as a cancer stem cell-specific immune checkpoint that facilitates trans-cellular signaling through the release of 20-Hydroxycholesterol (20-OHC) and subsequent activation of GPR132 on regulatory T cells (Tregs). This pathway plays a crucial role in modulating the tumor immune microenvironment and can significantly influence the balance between immune activation and suppression. In the context of cancer, SOAT1 is instrumental in regulating the cholesterol metabolism of cancer stem cells. When SOAT1 is inhibited, there is an increase in the secretion of 20-OHC by tumor cells. This oxysterol not only functions as a signaling molecule but also acts as a ligand that binds to GPR132, a G protein-coupled receptor primarily expressed on immune cells, including Tregs. This binding triggers a cascade of intracellular signaling pathways that ultimately enhances the immunosuppressive functions of Tregs. Mechanistically, the activation of GPR132 by 20-OHC leads to downstream signaling events that may involve pathways such as JAK-STAT and PKC signaling, promoting the development and survival of Tregs while enabling them to exert their immunosuppressive effects within the tumor microenvironment. This results in the downregulation of effector T cell activities and impairs the maturation and activation of dendritic cells (DCs), which are pivotal for effective anti-tumor immune responses. The presence of Tregs, particularly in elevated frequencies within tumors, can contribute to an immunosuppressive environment that protects cancer cells from immune-mediated destruction. Thus, the SOAT1-20OHC-GPR132 axis represents a critical mechanism through which cancer cells can evade immune surveillance. By controlling cholesterol metabolism through SOAT1, tumors can manipulate the availability of 20-OHC, amplifying the immunosuppressive capacity of Tregs and facilitating an environment conducive to tumor growth and progression. Targeting SOAT1 and the associated 20-OHC signaling pathway may offer a promising therapeutic strategy to neutralize Treg-mediated immunosuppression. Inhibiting SOAT1 not only disrupts the tumor’s ability to produce 20-OHC but also potentially reprograms the immune landscape, promoting a more activated and effective anti-tumor immune response. Overall, SOAT1’s dual role as a cancer stem cell-specific immune ch…
• 🔗 查看原文

4. ⭐ GSE286015 抑制癌症干细胞免疫检查点 SOAT1 通过跨细胞 20(S)-羟基胆固醇-GPR132 通路抑制小鼠的调节性 T 细胞功能。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、T cell、pathway
• 📝 描述：Contributor : Yahui DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSOAT1 (sterol O-acyltransferase 1) serves as a cancer stem cell-specific immune checkpoint that facilitates trans-cellular signaling through the release of 20-Hydroxycholesterol (20-OHC) and subsequent activation of GPR132 on regulatory T cells (Tregs). This pathway plays a crucial role in modulating the tumor immune microenvironment and can significantly influence the balance between immune activation and suppression. In the context of cancer, SOAT1 is instrumental in regulating the cholesterol metabolism of cancer stem cells. When SOAT1 is inhibited, there is an increase in the secretion of 20-OHC by tumor cells. This oxysterol not only functions as a signaling molecule but also acts as a ligand that binds to GPR132, a G protein-coupled receptor primarily expressed on immune cells, including Tregs. This binding triggers a cascade of intracellular signaling pathways that ultimately enhances the immunosuppressive functions of Tregs. Mechanistically, the activation of GPR132 by 20-OHC leads to downstream signaling events that may involve pathways such as JAK-STAT and PKC signaling, promoting the development and survival of Tregs while enabling them to exert their immunosuppressive effects within the tumor microenvironment. This results in the downregulation of effector T cell activities and impairs the maturation and activation of dendritic cells (DCs), which are pivotal for effective anti-tumor immune responses. The presence of Tregs, particularly in elevated frequencies within tumors, can contribute to an immunosuppressive environment that protects cancer cells from immune-mediated destruction. Thus, the SOAT1-20OHC-GPR132 axis represents a critical mechanism through which cancer cells can evade immune surveillance. By controlling cholesterol metabolism through SOAT1, tumors can manipulate the availability of 20-OHC, amplifying the immunosuppressive capacity of Tregs and facilitating an environment conducive to tumor growth and progression. Targeting SOAT1 and the associated 20-OHC signaling pathway may offer a promising therapeutic strategy to neutralize Treg-mediated immunosuppression. Inhibiting SOAT1 not only disrupts the tumor’s ability to produce 20-OHC but also potentially reprograms the immune landscape, promoting a more activated and effective anti-tumor immune response. Overall, SOAT1’s dual role as a cancer stem cell-specific immune ch…
• 🔗 查看原文

5. ⭐ GSE298108 单细胞和空间转录组学揭示紫外线照射后血管细胞对炎症变化的调控作用 [空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Jie An ; Rachael Bogle ; Rayan Najjar ; Lam C Tsoi ; Michelle Kahlenberg ; Ksenia Anufrieva ; Erin Theisen ; Kevin Wei ; Johann E Gudjonsson ; Keith E ElkonSeries Type : OtherOrganism : Mus musculusTo elucidate the complex effects of acute UV radiation (UVR) on the skin, we exposed shaved mouse skin to UVB and performed transcriptomic profiling of the epidermis, deep dermis and adipose tissue. Spatial transcriptomic analysis revealed the most pronounced gene expression changes in the epidermis, peaking at 24 hours post-irradiation. While CD45⁺ immune cells showed differential expression of chemokines, cytokines, and acute-phase proteins, cytokeratin⁺ epidermal cells upregulated genes related to cellular stress and damage (e.g., Usp19, Adam25), as well as structural remodeling and apoptosis (e.g., Krt18, Phlda1). Single-cell RNA sequencing (scRNA-seq) conducted 12 hours after UVR exposure identified 4,849 differentially expressed genes (DEGs), with the epidermis and endothelial cells showing the highest DEG counts. Pathway analysis of upregulated genes in the epidermis revealed enrichment in VEGF, HIPPO, complement, IL-6, and apoptosis signaling pathways. In endothelial cells, UVR induced expression of multiple chemokines and cytokines. Notably, receptor-ligand analysis highlighted endothelial cells as key targets of CXCL chemokines and complement component C3. In fibroblasts, UVR triggered upregulation of inflammatory activation markers (Osmr, Cux1) alongside genes associated with glucose metabolism (Hif1a, Pkm). Cross-species comparison of UVR-responsive DEGs between mice and humans revealed strong concordance, particularly in TGF-β and TNF-associated pathways.
• 🔗 查看原文

6. ⭐ GSE298654 利用双光子激发荧光（TPEF）、质谱和RNA测序分析研究癌症治疗诱导衰老细胞的代谢特征

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、metabolic、sequencing
• 📝 描述：Contributors : Silvia Ghislanzoni ; Federica Padelli ; Alessia Bertolotti ; Antonino Belfiore ; Matteo Niero ; Arianna Bresci ; Silvia Betti ; Andrea Masella ; Dario Polli ; Luca Agnelli ; Italia BongarzoneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground. Despite major advances in cancer therapies, treatment failure remains a significant issue for a subset of patients due to therapy resistance and tumour recurrence. A key contributor to these failures is therapy-induced senescence, wherein damaged cells enter a stable cell cycle arrest while remaining metabolically active, contributing to chronic inflammation and cancer relapse. These senescent cells can promote chronic inflammation and disease relapse. However, the heterogeneous nature of senescence complicates its detection and therapeutic targeting. Methods. We employed a multimodal approach to profile metabolic alterations in senescent cancer cells. Senescent cells were induced either by doxorubicin or γ-irradiation, both widely employed strategies in anti-cancer treatment, across three human cancer cell lines: MCF7, HeLa, and TPC-1. Mitochondrial dysfunction was assessed through MitoTracker and JC-1 staining. Two-photon excitation fluorescence microscopy enabled label-free imaging of mitochondrial coenzymes NAD(P)H and FAD. Lipidomic changes were analyzed using MALDI mass spectrometry imaging following lipid extraction and matrix application. Additionally, transcriptomic profiling via RNA sequencing was performed on control, senescent, and engulfing-senescent MCF7 cells. Bioinformatic analyses included differential gene expression, gene set enrichment analysis, and pathway analysis using GO, KEGG, and Reactome databases Results. Across all models, senescent cells exhibited mitochondrial dysfunction, marked by altered NAD(P)H and FAD distribution and decreased mitochondrial membrane potential. Two-photon excited fluorescence imaging confirmed a broader intracellular redistribution of mitochondrial coenzymes. MALDI analyses revealed consistent lipid remodeling, particularly involving cardiolipin precursors such as PG(18:1/18:1) and PG(18:1/22:6). Transcriptomic profiling of senescent MCF7 cells revealed that a previously observed engulfing subpopulation is marked by enhanced oxidative metabolism and increased lipid catabolism, suggestive of an engulfing phenotype. Conclusion. Our findings delineate both conserved and divergent metabolic features across se…
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7. GSE306669 Kar4 在酿酒酵母中作为 Ste12 调节因子，促进 Ste12 与基因组范围内的特定 DNA 基序结合 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、genome
• 📝 描述：Contributors : Jason Rogers ; Amanda Yeo ; Val Meleshkevich ; Hernan Lorenzi ; Mark Rose ; Orna Cohen-FixSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeKar4 is a putative transcription factor essential for mating in the budding yeast Saccharomyces cerevisiae. Kar4 has been shown to function with Ste12, the master transcriptional regulator of the yeast mating pheromone response, to promote the transcription of a subset of Ste12 targets required for efficient mating. However, the mechanism by which Kar4 modulates Ste12 activity has remained uncertain. Here, we examine the effect of Kar4 on the mating pheromone response at the levels of transcription (RNA-seq)
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8. GSE245713 利用单细胞多组学方法对最早的心脏谱系分离进行表观遗传学刻画

• ✍️ 作者：未知作者
• 🏷️ 关键词：cardiac、epigenetic
• 📝 描述：Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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9. GSE245709 小鼠胚胎干细胞定向心脏分化不同阶段 Hand1 和 Foxf1 的 ChIP-seq 分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：cardiac、ChIP-seq
• 📝 描述：Contributors : Jingjing He ; Chengqi LinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusChIP-seq data for candidates identified from targeted screen for cardiac differentiation
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10. GSE290059 果蝇胶质瘤模型中 Ca-α1T 和 Slo 敲低的 RNA-seq

• ✍️ 作者：未知作者
• 🏷️ 关键词：glioma、RNA-seq
• 📝 描述：Contributors : Lía Alza ; Judit Herreros ; Carles Cantí ; Sergio Casas ; Andreu CasaliSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThis dataset presents transcriptomic profiles of Drosophila melanogaster glioma model to investigate the effects of Ca-α1T and Slo knockdowns on gene expression. The samples consist of dissected Drosophila heads. The glioma model used were based on the study by Read et al., 2009 (PLOS Genetics), which established a Drosophila model of glioma by co-overexpressing an activated form of dEGFR (dEGFRλ) and dp110 (dp110CAAX) in glial cells (Read et al., 2009). This work was supported by the research project ‘Programa Generación de Conocimiento PID2022-138688OB-I00’ funded by the Spanish Ministry of Science and Innovation.
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1. Vebreltinib 在 MET 扩增驱动的晚期非小细胞肺癌（KUNPENG）：一项单臂、多队列、多中心、二期临床研究

• ✍️ 作者：未知作者
• 🏷️ 关键词：T细胞、B细胞
• 📝 描述：Secret hovertext:
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2. 2020年至2023年美国劳动年龄成年人按具体职业划分的癌症死亡率：基于人口的研究

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 背景尽管高收入国家整体下降，但某些癌症类型的死亡率在工作年龄成年人中仍在上升。本研究旨在根据性别、癌症类型和具体职业在美国工作年龄成年人中统计癌症死亡率。方法2020 年至 2023 年间，20 至 64 岁成年人的癌症死亡人数（ICD-10 代码 C00–C99）数据来源于美国国家健康统计中心和国家生命统计系统提供的死亡多因死亡数据，并按性别、职业、年龄和年份分类，使用了 459 个详细的 2010 年美国人口普查职业代码和 23 个主要职业群体。按性别、年龄、年份和职业估计的人口数据来自年度美国社区调查和十年一次人口普查。按性别、职业和 22 个主要癌症部位划分的年平均癌症死亡率和 95%置信区间（CI）被统计并展示在森林地块中。发现该研究于2022年3月15日至2025年8月27日进行。在450,453例癌症死亡中，每10万美国工作年龄居民的平均年龄调整癌症死亡率为男性55.2（95%置信区间54
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3. 预防职业性癌症的重要性

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext:
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4. 皮托布替尼与伊布替尼在治疗中——初次及复发/难治性慢性淋巴细胞白血病/小淋巴细胞淋巴瘤。

• ✍️ 作者：未知作者
• 🏷️ 关键词：淋巴
• 📝 描述：Secret hovertext: 目的 吡布替尼是一种高度选择性的非共价布鲁顿酪氨酸激酶抑制剂（BTKi），在接受过共价 BTKi 的慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）患者中已显示出疗效和安全性。据我们所知，我们报告了首次随机对比吡托布鲁替尼与伊布替尼在 BTKi 未治疗 CLL/SLL 患者中，既有治疗经验（TN）患者，也包括复发/难治性（R/R）患者的结果。患者与方法 患者（N=662）被随机 1：1 分配接受吡布鲁替尼或伊布替尼。所有患者对 BTKi 都非常陌生。主要终点为独立评审委员会（IRC）对所有随机分配患者（治疗意向[ITT]）及 R/R 病患者的总体反应率（ORR）。结果 研究达到主要终点，证明 IRC-ORR 在 ITT 中对吡布鲁替尼与伊布替尼的非劣势性（NI）均具有统计学显著性（NI）（87.0% [95% CI，82.9 至 90.4]对 78.5% [95% CI，73.7 至
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1. Posit Cloud 上的 freeCount 生物信息学分析应用程序

• ✍️ 作者：未知作者
• 🏷️ 关键词：bioinformatics
• 📝 描述：One way that you can use the freeCount R Shiny applications (apps) online is through Posit Cloud, which lets you access powerful data science tools in your browser without the need for installation or complex configuration. Continue reading: freeCount Bioinformatics Analysis Apps on Posit Cloud
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1. 肠道分子展现出显著的抗糖尿病能力

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?
• 📝 描述：Researchers revealed that the microbial metabolite TMA can directly block the immune protein IRAK4, reducing inflammation and improving insulin sensitivity. The molecule counteracts damage caused by high-fat diets and even protects mice from sepsis. Since IRAK4 is a known drug target, this pathway could inspire new diabetes therapies. The study highlights how gut microbes and nutrition can work together to support metabolic health.
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2. Isoformic——一种用于转录本水平RNA测序结果解读的工作流程

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq
• 📝 描述：Isoformic improves transcript level interpretation of RNA sequencing data, revealing biologically meaningful variants linked to regulatory events and phenotypes…
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3. D3Impute——针对单细胞RNA测序数据的dropout感知判别、分布感知建模和密度引导插补

• ✍️ 作者：未知作者
• 🏷️ 关键词：scRNA
• 📝 描述：D3Impute improves single cell RNA sequencing analysis by distinguishing technical zeros from true biological signals and enhancing accuracy…
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• GSE271390 巴雷特食管和食管癌的无细胞转录组 [Illumina - 短读长]
• GSE271389 巴雷特食管和食管癌的无细胞转录组 [纳米孔长读长测序]
• GSE306827 巨噬细胞专门负责向 MAIT 细胞呈递 MR1 抗原 [RNA-seq]
• GSE306826 巨噬细胞专门负责向 MAIT 细胞呈递 MR1 抗原 [ATAC-seq]
• GSE312514 急性去神经支配的肌肉细胞外囊泡通过逆行信号传导重塑神经元线粒体代谢，从而挽救周围神经损伤
• GSE311088 CDK4驱动的酮体生成重塑组蛋白修饰以促进白血病
• GSE303070 结直肠癌空间图谱揭示了基质微环境对肿瘤分化的影响
• GSE270919 CDK4 对组蛋白修饰的生酮调控促进白血病发生 [RNA-seq]
• GSE253660 羟酰辅酶A脱氢酶的一种核同工酶抑制结直肠癌的肿瘤进展
• GSE309755 人类脑类器官 RNA 测序，用于评估性别特异性和光 FGFR 介导的对简化 5 离子 GCR 模拟的反应
• GSE309036 阿尔茨海默病患者颞叶皮层中差异表达的 miRNA 及其与 tau 病理的关系。
• GSE306791 Kar4 在酿酒酵母中作为 Ste12 的调节因子，促进 Ste12 与基因组范围内的特定 DNA 基序结合。
• GSE306667 Kar4 在酿酒酵母中作为 Ste12 调节因子，促进 Ste12 与基因组范围内的特定 DNA 基序结合 [ChIP-exo]
• GSE305266 皮质微环境驱动早期免疫组织并控制骨愈合过程中的早期破骨细胞生成
• GSE292865 ELOVL5 促进 T 细胞急性淋巴细胞白血病的进展
• GSE288604 全血转录组学表征肺部鸟分枝杆菌复合群疾病的分子表型
• GSE285936 单核 RNA 测序揭示了死后间隔对小鼠脑细胞成分和基因表达分析的影响
• GSE312906：鉴定对雌激素受体α结合及其对子宫内膜癌基因表达的影响具有独特影响的基因组特征
• GSE305933 人类胚胎干细胞衍生多激素细胞分化过程中的时间多组学基因表达数据 [RNA-seq]
• GSE298408 银屑病期间皮肤感觉神经元的单核RNA测序
• GSE271259 人类原发性肺腺癌和脑转移的 RNA 测序
• GSE311624 单核 RNA 测序揭示了 LPD 喂养的小鼠中表达 c-Met/β-catenin 癌基因的重编程肝细胞。
• GSE311027 慢性社会挫败应激后小鼠前额叶皮层的 H3K4me3 ChIP-seq 分析
• GSE310077 通过SB-HTVI对注射载体对照或c-Met/ΔN90-β-catenin的CD和LPD喂养小鼠进行批量RNA测序
• 使用载体对照组肝脏和接受 c-Met/ΔN90-β-catenin SB-HTVI 处理 2 周和 3 周的肝脏，对 GSE310076 肝脏组织进行了批量 RNA 测序。
• GSE309980 人类衰老微生理系统重现体内过程，加速抗衰老策略的评估
• GSE297347 DLX2-LAP2α 轴通过解锁染色质屏障来促进颅面再生，从而激活外胚层间充质分化 [scRNA-seq]
• GSE297346 DLX2-LAP2α 轴通过解锁染色质屏障来促进颅面再生，从而控制外胚层间充质的分化 [RNA-seq]
• GSE295479 Drp1 通过 Erk1/2-Nur77 通路调节线粒体健康并控制骨骼肌质量
• GSE280361 人类衰老微生理系统重现体内过程，加速抗衰老策略的评估
• GSE312581 新型 SLCO2B1 mRNA 亚型作为非编码 RNA，通过 FMR1 介导的蛋白质生物合成驱动癌症进展。
• GSE312333 BHB对抗原刺激的CART19细胞转录变化的影响
• GSE312324 RNA测序分析：野生型、Lao1基因敲除小鼠和Lao1/Il4i1双基因敲除小鼠在正常和DSS处理条件下的RNA测序结果
• GSE311939 MTFP1参与牛卵母细胞成熟的机制[RNA-seq]
• GSE311221 人类造血的分子和表型蓝图将增殖应激与干细胞衰老联系起来
• GSE283869 蛋白激酶A通过ALKBH5的磷酸化控制GPX4 m6A修饰来调节铁死亡
• GSE261606 Xist非编码RNA直接调控X染色体失活的逃逸[Capture Hi-C]
• GSE260483 X 失活逃逸受 Xist 非编码 RNA [甲基化] 直接调控
• GSE259399 Xist非编码RNA直接调控X染色体失活的逃逸[细胞系RNA测序]
• GSE259398 Xist非编码RNA直接调控X染色体失活的逃逸[ATAC-seq]
• GSE243327 人类造血的分子和表型蓝图将增殖应激与干细胞衰老联系起来