详细内容（前10条）

1. ⭐ GSE305308 免疫检查点阻断诱导巨噬细胞重极化，进而驱动肿瘤微环境中的T细胞活化

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immune、tumor microenvironment、macrophage
• 📝 描述：Contributors : Tina Kwok ; Jessica N LancasterSeries Type : Expression profiling by arrayOrganism : Mus musculusImmunotherapy combinations can improve patient outcomes, yet the interactions within the tumor microenvironment (TME) that drive therapeutic synergy are poorly understood. Tumor establishment drives monocyte recruitment and differentiation into tumor-associated macrophages (TAMs), which have essential roles in coordinating immune responses and are thus attractive targets for therapeutic modulation. In a murine model of combination anti-PD-1 and anti-PD-L1 checkpoint blockade, tumor control was associated with increased infiltration of CD8+ T-cells and M1-like repolarization of TAMs. Live-cell imaging of the tumor microenvironment revealed close contacts between tumor-infiltrating CD8+ T-cells and TAMs, in which the extent of the contact interfaces increased with combination immunotherapy. Treatment with anti-PD-L1 was able to increase macrophage expression of pro-inflammatory factors and phagocytic activity, suggesting a role for TAMs in reactivating CD8+ T-cells in the TME. However, co-treatment with anti-PD-1 was ultimately necessary for tumor control, indicating the need for combination targeting of the TME.
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2. ⭐ GSE309004 乳腺癌新辅助化疗耐药性的分子决定因素：基因表达和肿瘤微环境分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、tumor microenvironment、resistance
• 📝 描述：Contributors : Hedda M Guevara-Nieto ; Carlos A Orozco ; Rafael Parra Medina ; Jone Garai ; Jovanny Zabaleta ; Liliana Lopez-Kleine ; Alba L CombitaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeoadjuvant chemotherapy (NAC) is a critical component of breast cancer treatment, but the molecular mechanisms underlying resistance remain poorly understood. This study aimed to identify transcriptomic changes associated with NAC resistance across four breast cancer subtypes: Luminal A, Luminal B/HER2-positive, Luminal B/HER2-negative, and Triple-Negative Breast Cancer (TNBC). RNA-seq analysis was performed on paired pre- and post-NAC breast cancer samples from 35 non-responders. Differentially expressed genes (DEGs) were identified, and functional enrichment analyses were conducted. Protein-protein interaction (PPI) networks were constructed to identify hub genes. Tumor microenvironment (TME) infiltration was estimated using deconvolution algorithms. The results revealed distinct gene expression profiles between pre- and post-NAC samples, with FOS and NR4A1 being common DEGs across all subtypes. Enriched pathways varied among subtypes, including signal transduction, estrogen biosynthesis, extracellular matrix organization, dendritic cell activation, and B cell activation. TME analysis showed increased infiltration of specific immune cell populations after NAC, including CD4 memory T cells, regulatory T cells, neutrophils, macrophages, and mast cells, varying by subtype. These findings suggest that NAC modulates gene expression, cellular activity, and TME interactions, potentially contributing to treatment resistance. Understanding the molecular determinants of NAC resistance is crucial for developing targeted therapeutic strategies and improving outcomes for breast cancer patients.
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3. ⭐ GSE294999 肥胖驱动的炎症通过免疫抑制促进三阴性乳腺癌的进展 [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、inflammation、regex:immuno(logy|therapy|suppression)、scRNA
• 📝 描述：Contributors : Michael F Coleman ; Stephen D HurstingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculuscontrol and obese, C57BL6J mice with or without sulindac treatment were injected with E0771 cells and tumor growth was monitored
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4. ⭐ GSE272510 赖氨酸代谢重编程重塑免疫微环境并诱导肝癌免疫治疗耐受

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、metabolism、regex:immuno(logy|therapy|suppression)
• 📝 描述：Contributors : Xinlan Lu ; Yungang Xu ; Min QiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLiver cancer is one of the most common malignant tumors worldwide, and its high aggressiveness and recurrence rate pose a major challenge. Metabolic reprogramming is one of the cancer hallmarks and allows tumor cells to adapt to drastic changes, supporting their rapid growth, survival, and proliferation under various conditions. The metabolic reprogramming of several amino acids within tumors profoundly affects the function of the immune cells. Furthermore, arginine and various other amino acids are now being widely studied as potential targets for anti-tumor therapy. However, the role of lysine metabolic reprogramming in tumors remains largely unexplored. This study aims to reveal the relationship between lysine metabolism reprogramming and the prognosis of liver cancer, the tumor immune microenvironment (TIME), and responses to immunotherapy through multi-omics analysis. Combined transcriptomic and proteomic analyses revealed a significant downregulation of lysine metabolism in tumor tissues against normal tissue adjacent to the tumor from liver cancer patients. Subsequently, we constructed a lysine metabolism score (LM score) based on nine lysine metabolic genes to stratify liver cancer patients into high and low lysine metabolism subtypes. The LM score exhibited potential in predicting both survival and immunotherapy response in liver cancer. Furthermore, significant differences were observed in prognosis, clinical staging, TIME, and immunotherapy outcomes between the subtypes with low and high lysine metabolism. In the subtype of low lysine metabolism, an immunosuppressive TIME predominated, correlating with poorer patient survival and anti-tumor immune responses. In conclusion, we uncover that disturbed lysine metabolism promotes the formation of the immunosuppressive TIME, thereby inducing immunotherapy resistance and advancing liver cancer progression. This provides an effective theoretical reference for elucidating the mechanism of immunotherapy resistance in liver cancer and seeking new therapeutic strategies.
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5. ⭐ GSE270678 不同阶段的三级淋巴结构表现出不同的抗肿瘤免疫力 [空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immunity、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Zemin Zhang ; Sen GaoSeries Type : OtherOrganism : Homo sapiensThe tumour microenvironment (TME) is a focal point in cancer immunotherapy: its cellular composition and spatial organisation, especially the distribution of lymphocytes, can affect the clinical outcomes of cancer patients. In addition, the function of a cell differs depending on its spatial location and interaction with neighbouring cells. Here, by integrating single-cell transcriptomics with spatial transcriptomics, we survey how the spatial distribution of different cell types varies across diverse histological regions of gastric cancer. Notably, tertiary lymphoid structures (TLSs), a tissue architecture harbouring lymphocytes more than any other region within the TME, possess great potential in modulating anti-tumorigenic immunity by elevating an array of genes (FDCSP and CCL19) principally involved in lymphocyte recruitment and activation. Our findings advance the understanding of TLSs in contributing to anti-tumorigenic immunity in a spatially resolved context, which could be further leveraged as a predictive marker for immunotherapy response.
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6. ⭐ GSE306904 研究表明，在卵巢癌小鼠模型中，PD-1、Tim-1 3 和 Lag-3 三重免疫检查点阻断（而非单独阻断 PD-1）可增强过继性 T 细胞免疫疗法的疗效。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、T cell、regex:immuno(logy|therapy|suppression)
• 📝 描述：Contributors : Gabriel F Alencar ; Asmaa O Mohamed ; Madison G Burnett ; Samantha Jean ; Anders Nelson ; Yapeng Su ; Valentin Voillet ; Magdalia R Suarez ; Susan Ruskin ; Lam Trieu ; Jennifer L Lam ; Stefan Bekiranov ; Raphael Gottardo ; Philip D Greenberg ; Kristin G AndersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe five-year survival rate for ovarian cancer patients remains below 50%, underscoring the need for innovative therapies. One promising approach involves engineering T cells to specifically target proteins uniquely overexpressed in tumors, thereby controlling tumor growth without toxicity to healthy tissues. Mesothelin (Msln) contributes to the malignant and invasive phenotype in ovarian cancer and has limited expression in healthy cells, making it a candidate immunotherapy target. Our previous results in a mouse model of ovarian cancer demonstrated that T cells engineered to express a T cell receptor (TCR) targeting Msln (TCRMSLN) mediated therapeutic activity, delaying tumor growth and prolonging mouse survival. However, inhibitory ligands expressed in the tumor microenvironment (TME) interacted with inhibitory receptors on activated T cells, suppressing antitumor function. We hypothesized combining engineered T cells with checkpoint blockade would enhance T cell function in the TME and improve therapeutic efficacy, but administration of mono-specific antibodies targeting individual inhibitory pathways had no significant impact on T cell efficacy. By contrast, the combination of PD-1, Tim-3 and Lag-3 blockade with engineered T cells significantly improved T cell function and overall animal survival relative to treatment with antibody alone or TCRMSLN with singlet or doublet antibody combinations. Single-cell RNA sequencing revealed TCRMSLN T cells treated with the triplet antibody combination increased expression of genes involved in interferon responses and metabolic function, and reduced expression of genes associated with exhaustion. These results suggest that strategies to disrupt multiple inhibitory pathways simultaneously may be necessary for improved adoptive T cell therapy efficacy in patients.
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7. ⭐ GSE306312 周围神经损伤诱导的肿瘤相关巨噬细胞重塑促进乳腺癌的免疫逃逸

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immune
• 📝 描述：Contributors : Yongxue Jiang ; Wenfeng Zeng ; Xiaoting Deng ; Jianing Chen ; Penghan HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPeripheral nerve damage is intricately linked to the progression of various solid tumors and play a pivotal role in the tumor ecosystem. However, its effect on antitumor immunity and precise underlying mechanisms remain poorly understood. This study aimed to elucidate the effect of peripheral nerve damage and subsequent immune modulation on breast cancer progression.
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8. ⭐ GSE294944 肥胖驱动的炎症通过免疫抑制促进三阴性乳腺癌的进展

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、inflammation、regex:immuno(logy|therapy|suppression)
• 📝 描述：Contributors : Michael F Coleman ; Stephen D HurstingSeries Type : Expression profiling by arrayOrganism : Mus musculuscontrol and obese, C57BL6J mice with or without sulindac treatment were injected with E0771, metMWntlung, or metMWntliver cells and tumor growth was monitored
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9. ⭐ GSE294724：从结直肠肿瘤中分离出的新型口腔链球菌CRC211菌株的全基因组测序和分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、sequencing、genome
• 📝 描述：Contributors : Yunjie Shi ; Ling Liu ; Weiliang Hou ; Hao wangSeries Type : OtherOrganism : Mus musculusThis study provides a comprehensive genomic characterization of Streptococcus oralis CRC211, a novel bacterial strain isolated from colorectal tumor tissue, through whole-genome sequencing and comparative analysis. The high-quality assembled genome (15.03 Mb, 40.94% GC content) contains 2 prophage regions spanning 160.5 kb, which may facilitate horizontal transfer of virulence genes. Functional annotation identified 3,674 genes, with significant enrichment in metabolic pathways (amino acid and carbohydrate metabolism) and virulence factors (116 genes in VFDB), including adhesins and biofilm-associated proteins that likely promote tumor colonization. Comparative genomic analysis revealed CRC211 shares 92.29% average nucleotide identity with reference S. oralis strains, while pan-genome analysis demonstrated an open genome structure with 1,222 conserved core genes. The strain also carries 75 antimicrobial resistance genes, suggesting potential clinical relevance. Notably, the genomic profile indicates adaptations for nutrient acquisition and immune evasion in the tumor microenvironment. These findings establish CRC211 as a CRC-associated strain with distinct genomic features that may contribute to tumor progression, providing crucial insights for future investigations into its oncogenic mechanisms and potential applications in microbiota-based diagnostics or therapeutics for colorectal cancer.
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10. ⭐ GSE293361 抗癌治疗诱导的KEAP1-NRF2系统基因改变导致头颈部鳞状细胞癌对顺铂产生耐药性

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、carcinoma、resistance
• 📝 描述：Contributors : Yuki Nakayama ; Keiko Taguchi ; Masayuki YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCisplatin (CDDP) is widely used in the chemotherapy of head-and-neck squamous cell carcinoma (HNSCC), but its efficacy is limited in recurrent cases. This highlights the need for a deeper understanding of the mechanisms underlying the CDDP resistance. We hypothesized that chemoradiotherapy with CDDP may induce hyperactivation of NRF2, contributing to CDDP resistance. To investigate this, we first examined NRF2 expression in clinical HNSCC samples by immunohistochemistry and assessed the occurrence of somatic mutations in KEAP1 and NRF2 genes using public databases. We found that high NRF2 expression was associated with poorer prognosis compared to low expression. Furthermore, recurrent HNSCC cases following post-operative chemoradiotherapy exhibited higher NRF2 accumulation than their corresponding primary tumors. Database analysis also revealed occurrence of frequent mutations in KEAP1 associated with CDDP treatment. We then assessed the role of NRF2 in HNSCC malignancy utilizing seven parent (P) HNSCC cell lines and their CDDP-resistant (CR) derivatives. Of these P-CR pairs, three CR cell lines exhibited NRF2 upregulation. Two of them carried KEAP1 mutations and one carried an NRF2 mutation, both present in P and CR lines. These NRF2-high CR lines showed elevated expression of NRF2 target gene and activation of xenobiotic metabolism and reactive oxygen species pathways. Treatment with mitomycin C (MMC), known for its synthetic lethal activity against NRF2-activated cancer cells, showed strong cytotoxicity in NRF2-high CR lines. These findings indicate that the KEAP1-NRF2 system plays a critical role in the development of CDDP resistance and that MMC represents a promising therapeutic option for NRF2-high/CDDP-resistant HNSCC.
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1. ⭐ 中枢神经系统恶性肿瘤患者 CAR T 细胞的开发

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、T细胞、神经
• 📝 描述：Secret hovertext:
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2. 精准肿瘤学：2025年回顾

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext: 摘要：本文讨论了2025年精准肿瘤学取得的具体进展，我们见证了多项已知精细肿瘤药物的新适应症获批，以及针对经典通路或此前所谓不可药物靶点的新药的早期有希望数据。此外，我们观察到抗体-药物偶联物和蛋白水解靶向嵌合体的持续发展，多种基于血液的癌症早期检测方法的出现，非传统精准肿瘤生物标志物的识别，以及人工智能技术在生成精准肿瘤洞察方面的日益普及。
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1. scPER——一种利用总RNA测序数据识别肿瘤细胞亚型的计算方法

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、sequencing
• 📝 描述：Researchers introduce scPER, a machine learning method using RNA sequencing to estimate tumor cell compositions and reveal…
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2. 你的肠道正在遭受毒害吗？科学家揭示日常化学物质的隐秘影响。

• ✍️ 作者：未知作者
• 🏷️ 关键词：gut、regex:gut(-?microbiome)?
• 📝 描述：Researchers discovered that 168 common chemicals can disrupt the growth of beneficial gut bacteria, with some also promoting antibiotic resistance. Many of these substances—found in food, water, and household items—weren’t previously suspected of affecting living organisms. A new machine learning model now predicts which chemicals may harm the microbiome. The findings suggest safety testing must expand to consider gut health.
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3. 医生发现，年轻女性罹患侵袭性乳腺癌的比例比预期更高。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Younger women are being diagnosed with breast cancer more often than screening guidelines anticipate. Many of these cancers are invasive and harder to treat, especially in those under 40. After analyzing 11 years of data, researchers found that this age group makes up a steady and significant share of diagnoses. The results support a stronger push for earlier risk evaluation.
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4. 科学家发现癌细胞存活的隐藏开关

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Researchers have found a small but powerful switch inside breast cancer cells that helps them survive stressful conditions. When this switch flips, the cells activate protective programs that make them tougher and faster-growing. The finding reveals how tumors use stress to their benefit. It may open up new possibilities for therapies.
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5. 一项新研究在常见食物中发现了与癌症相关的化合物

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Scientists have found that common foods can contain hidden contaminants formed during cooking or through environmental exposure. A new testing method called QuEChERS helps identify these chemicals more quickly and with greater ease. The research showed strong accuracy and high sensitivity across multiple food samples. This streamlined approach could improve food safety checks while reducing chemical waste.
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6. 一种已有70年历史的妊娠药物，竟然揭示了其在治疗脑癌方面的一个隐藏弱点。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Researchers have solved the decades-old mystery behind how a common pregnancy drug lowers blood pressure. It turns out the medication blocks a fast-acting “oxygen alarm” inside cells. That same alarm helps brain tumors survive, meaning the drug unexpectedly weakens them, too. The discovery could inspire better treatments for both preeclampsia and brain cancer.
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• GSE290298 肝癌整合分析揭示赖氨酸代谢重编程以及具有不同免疫微环境和治疗反应的患者分层。
• GSE287023 丁酸-LncRNALy6C-RUNX3轴通过NR4A1介导的ERK1/2/MAPK通路决定肠道驻留巨噬细胞。
• GSE269680 CDK8 重塑肿瘤微环境，以抵抗靶向 KRASG12D 抑制在胰腺导管腺癌中的治疗效果（空间）
• GSE269679 CDK8 重塑肿瘤微环境，以抵抗靶向 KRASG12D 抑制在胰腺导管腺癌中的治疗效果（scRNA）
• GSE311391 长读长测序和蛋白质组学揭示多种原发性肺癌的血液转录组和蛋白质表达谱
• GSE312287 KMT5A介导的IRF3甲基化通过免疫抑制促进肿瘤进展
• GSE291699 利用纳米孔测序技术对人类癌症模型进行tRNA测序
• GSE308736 单细胞转录组分析揭示食管小细胞癌的上皮和微环境异质性
• GSE306626 AC16 细胞中 HMGN3 ChIP-seq 和敲低/未敲低 AC16 细胞中的 Bulk-RNAseq
• GSE306057 ALKBH5-IGF2BP2轴通过m6A稳定的CLSPN RNA介导前列腺癌进展和多西他赛耐药性
• GSE305604 整合 RNA-seq 和 LASSO-COX 分析揭示芍药酚在宫颈癌细胞增殖抑制和凋亡诱导中的关键靶基因
• GSE301169 PURPL 在基因表达的表观遗传调控中发挥作用 [ChIP-Seq]
• GSE298873 长链非编码RNA RAB30-DT通过增强癌细胞干性促进肝细胞癌的进展
• GSE297402 CD4⁺ T 细胞共培养后衰老和非衰老 BPH 上皮细胞的转录组分析
• GSE293543 T细胞介导的SIV向中枢神经系统扩散：单细胞转录组分析
• GSE292898 利用单细胞 RNA 测序分离和鉴定胰岛相关 CD45- MHC II 类+ 细胞。
• GSE292744 BRD4 和 MYB 抑制克服 EVI1 重排急性髓系白血病中的维奈托克耐药性
• GSE289417 年轻和老年骨髓巨核细胞祖细胞的单细胞转录组学
• GSE286926 KAT6A 乙酰化通过 AMPK 介导生长和线粒体代谢的代谢适应
• GSE285281 肿瘤浸润淋巴细胞来源的 CD8+ 克隆型浸润肿瘤组织并介导胶质母细胞瘤的肿瘤消退 [RNA-Seq]
• GSE284738 LIMCH1通过上调PDL1抑制三阴性乳腺癌的抗肿瘤免疫
• GSE284606 缺血预适应减弱了缺血再灌注条件下的心肌DNA甲基化并调节了心肌转录组
• GSE282028 多组学分析整合揭示结肠癌中新的 TRF2-miR-181a-5p-S100A10 调控轴 [ChIP-seq]
• GSE282027 多组学分析整合揭示结肠癌中新的 TRF2-miR-181a-5p-S100A10 调控轴 [RNA-seq]
• GSE268030 脂质代谢与节拍式卡培他滨和卡瑞利珠单抗治疗胃肠道癌症的疗效相关：一项探索性临床试验
• GSE240920 自噬通过调控WNT/DVL信号通路来调节神经元分化
• GSE312272 KDM6B抑制剂可调节单核细胞活化并减轻咪喹莫特（IMQ）诱导的银屑病皮肤炎症
• GSE311766 RUNX3，一种全新的NK细胞浸润生物标志物介导结直肠癌转移
• GSE299648 4-乙酰氨基蒽酚LT3通过PI3K/AKT和MAPK通路调节抑制结直肠癌的生长和转移
• GSE270680 不同阶段的三级淋巴结构表现出不同的抗肿瘤免疫力 [scRNA-seq]
• GSE270679 不同阶段的三级淋巴结构表现出不同的抗肿瘤免疫力 [bulk RNA-seq]
• GSE228185 CSNK1A1通过磷酸化ITGB5，破坏EPS15/EGFR复合物，从而降低肝细胞癌对多靶点酪氨酸激酶抑制剂的敏感性。
• GSE311517 5-甲基胞嘧啶和5-羟甲基胞嘧啶是结直肠癌早期检测的协同生物标志物
• GSE296777 哮喘和过敏基因芯片：5岁儿童口腔拭子DNA甲基化
• GSE295192 睾丸切除术诱导的小鼠前列腺细胞组成和基因表达调控的时空图谱[scRNA-seq]
• GSE289750 层粘蛋白A/C-EZH2相互作用在乳腺癌细胞上皮间质转化调控中的作用
• GSE283373 犬麻疹病毒感染原代肺泡巨噬细胞的研究揭示了病毒干扰先天免疫​​防御反应的机制
• GSE215255 对野生型和 Sucnr1 基因敲除小鼠骨髓中经 FACS 分选的造血干细胞和祖细胞 (LSK) 进行 RNA 测序
• GSE309153 RNA-seq 分析，用于 5’ isomiR 转染后的分析
• GSE309116 缺氧驱动的组蛋白修饰控制成熟眼晶状体形成的基因调控 [CUT&Run]
• GSE309107 缺氧驱动的组蛋白修饰调控成熟眼晶状体形成的基因表达
• GSE307095 RNA-seq 分析静息幼稚 B 细胞和 CD27bright 记忆 B 细胞以及体外激活的 CD27bright 记忆 B 细胞，揭示了常见变异型免疫缺陷 (CVID) 中 B 细胞活化模式的差异
• GSE305081 TET3 是一种调节因子，可作为干预心肌纤维化的靶点 [ATAC-seq]
• GSE305022 3D-ASC-Exos 作为一种新型药物载体用于胶质瘤治疗
• GSE304154 短期和长期高脂饮食下鸡的快糖酵解型和慢氧化型肌纤维的转录组分析
• GSE303510 水稻中光响应染色质可及性图谱[RNA-seq]
• GSE302977 TET3 是一种调节因子，可作为干预心肌纤维化的靶点 [RNA-seq]
• GSE302976 TET3 是一种调节因子，可作为干预心肌纤维化的靶点 [ChIP-seq]
• GSE301888 UBE2S 对结直肠癌细胞系 RKO 的影响
• GSE301166 PURPL 双向控制衰老：PURPL 缺失可使成纤维细胞恢复活力，而过表达则加速衰老 [RNA-Seq2]
• GSE301164 复制性衰老和阿霉素诱导衰老的比较分析鉴定出衰老成纤维细胞中保守的转录组特征 [RNA-Seq1]
• GSE300470 干细胞和祖细胞衍生的基因表达特征可预测骨髓纤维化患者的生存 [RNA-Seq]
• GSE297417 对良性前列腺增生模型小鼠和治疗组的前列腺组织进行批量 RNA 测序
• GSE297341 癌症治疗对肺类器官的影响作为合适的体外模型 II
• GSE297024 鱼精蛋白在体细胞中的表达会使染色质浓缩并破坏转录，但不改变DNA甲基化
• GSE296730 鱼精蛋白在体细胞中的表达会使染色质浓缩并破坏转录，但不改变DNA甲基化
• GSE296164 研究显示，骨髓和血液表现出不同的免疫重建模式，并且与移植后复发相关。
• GSE295535 Hfq 在鲍曼不动杆菌中构建了一个强大的 RNA-RNA 相互作用网络。[RNA-Seq]
• GSE295031 CAR NK细胞的产生可通过刺激NK祖细胞上的IL15受体而增强。
• GSE293219 脂肪细胞特异性 Mlkl 敲除通过增强线粒体功能减轻肥胖引起的代谢功能障碍。
• GSE291078 沙眼衣原体感染的原代宫颈内膜细胞的代谢重编程
• GSE290202 FAM49B 通过调节 MAPK 信号通路抑制卵巢癌细胞生长
• GSE289512 LINC01198 通过与 TAOK1/2 结合激活 Hippo 信号通路，刺激 IL-1β 自分泌，从而增强黑色素瘤对维莫非尼的耐药性
• GSE289136 乳酸介导的组蛋白乳酸化促进黑色素瘤血管生成
• GSE288799 小鼠晚期胚胎肾脏Kdr-FACS细胞的单核RNA测序
• GSE288442 母体产后久坐生活方式会加剧雄性小鼠摄入中等脂肪含量饮食的代谢成本
• GSE288424 CD271 通过 PI3K/Akt 和 PKCα/ERK 通路调控皮肤结构、分化和炎症
• GSE288262 B细胞特异性Wwox基因缺失促进骨髓瘤小鼠模型中浆母细胞肿瘤的发生发展和促炎特征的表达
• GSE288242 物种特异性调控复合物塑造野生番茄对坏死性病原体的定量抗性。
• GSE287898 雄激素调控的ECD过表达通过增加糖酵解促进前列腺癌的肿瘤发生
• GSE286188 全转录组整合关联分析揭示 FXTAS 中 PRKCG 相关的 GABA 能功能障碍
• GSE285723 臭氧诱导哮喘急性发作小鼠模型肺细胞的单细胞RNA测序
• GSE285283 肿瘤浸润淋巴细胞来源的 CD8+ 克隆型浸润肿瘤组织并介导胶质母细胞瘤的肿瘤消退 [WES]
• GSE285282 肿瘤浸润淋巴细胞来源的 CD8+ 克隆型浸润肿瘤组织并介导胶质母细胞瘤的肿瘤消退 [TCR]
• GSE282871 糖皮质激素受体的多聚化途径
• GSE282307 Hutchinson-Gilford早衰症中的miRNA失调：揭示miRNA与正常衰老和过早衰老之间的联系。
• GSE282029 多组学分析整合揭示了结肠癌中一种新的 TRF2-miR-181a-5p-S100A10 调控轴。
• GSE280863 研究发现，SIRT5 缺失会通过嘌呤和嘧啶代谢紊乱加速压力超负荷诱发的心力衰竭的发生发展。
• GSE280820 造血阶段表观遗传谱分析鉴定出感染后具有保守染色质改变的基因组位点
• GSE274579 RPL6 与 HMGCS1 相互作用，通过激活胆固醇生物合成来稳定肝细胞癌 II 中的 HIF-1α
• GSE274574 RPL6 与 HMGCS1 相互作用，通过激活肝细胞癌中的胆固醇生物合成来稳定 HIF-1α
• GSE273701 利用单细胞转录组学揭示虎皮鹦鹉脾脏白细胞群
• GSE253245 PACT基因敲除对LNCaP前列腺癌细胞的影响
• GSE249822 OTUD1 通过去泛素化 STAT3 下调 PD-L1 表达并促进 ccRCC 中的免疫反应
• GSE228550 通过抑制p38α逆转髓系来源抑制细胞介导的免疫抑制可增强免疫疗法的疗效
• GSE224497 通过工程改造核弹性来操控体细胞命运 [scRNA-seq]
• GSE224496 通过工程改造核弹性来操控体细胞命运 [ATAC-seq]
• GSE312139 超越β-淀粉样蛋白和tau蛋白：一种基于细胞的多变量血液检测（iCAP）用于早期阿尔茨海默病检测
• GSE305560 TP53无关致死性：通过联合泛HDAC和CDK抑制治疗急性髓系白血病
• GSE297637 STING 诱导的程序性坏死调节脑膜瘤中富含胶原蛋白的免疫抑制微环境 [RNA-seq]
• GSE295763 利用 CRISPR/Cas9 技术精确切除 NOTCH2NLC 中扩增的 GGC 重复序列以治疗神经元核内包涵体病
• GSE284354 两种转化性HFpEF小鼠模型中兴奋-收缩耦联、心肌细胞电生理和转录组的变化：病因和性别差异
• GSE283707 昼夜糖原代谢驱动肝脏蛋白质节律性分泌[体内]
• GSE283579 昼夜糖原代谢驱动肝脏蛋白质节律性分泌[体外]
• GSE271844 利用D-精氨酸增强抑制肽，以提高其结构稳定性和对肥胖的体内代谢作用
• GSE312238 利用 CHANGE-seq-BE 对碱基编辑器诱导的脱靶活性进行灵敏且无偏倚的全基因组分析 [Digenome-seq]
• GSE311868 非小细胞肺癌中线粒体双链RNA依赖性脂质重编程
• GSE306352 c-di-AMP–DasR 信号轴介导分枝杆菌的耐酸性
• GSE279970 ChIP-seq 分析肝脏缺血再灌注损伤中 LIF 信号下游的 STAT3 靶基因
• GSE260956 肝脏 GPNMB 通过与 RYK 结合加剧 NASH [RNA-Seq]