详细内容（前10条）

1. ⭐ GSE311149 CD200+ CD8 T 细胞通过精氨酸剥夺生成，激活巨噬细胞交叉呈递并改善抗肿瘤免疫[scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity、T cell、macrophage、scRNA
• 📝 描述：Contributors : Qianlong Kang ; Zedong Jiang ; Keqin Tan ; Xuelei MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusArginine is indispensable for both tumor progression and the function of immune cells, yet how arginine deprivation within the tumor microenvironment shapes anti-tumor immunity has remained unclear. In this study, we established an in vivo arginine-restriction model using a diet lacking arginine, which significantly suppressed tumor growth and activated global anti-tumor immune responses. Mechanistically, arginine deprivation triggered the integrated stress response in CD8+ T cells via the GCN2–cREL signaling axis, leading to elevated CD200 expression. These CD200+ CD8+ T cells in turn enhanced the antigen cross-presentation capacity of tumor-associated macrophages through CD200–CD200R interactions, forming a cooperative immune network that reinforced anti-tumor activity. Moreover, this arginine deprivation–induced cellular synergy improved the therapeutic efficacy of immunotherapy in colorectal cancer models. We further conducted a single-arm phase I clinical trial (NCT07038044), which demonstrated that an arginine-free diet is both feasible and safe for modulating systemic immunity in patients. Together, our findings provide a new conceptual framework for understanding the role of arginine in reshaping the tumor immune microenvironment and highlight arginine restriction as a promising and clinically translatable anti-tumor strategy.
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2. ⭐ GSE311148 CD200+ CD8 T 细胞通过精氨酸剥夺生成，激活巨噬细胞交叉呈递并改善抗肿瘤免疫[RNA-Seq 2]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity、T cell、macrophage、RNA-seq
• 📝 描述：Contributors : Qianlong Kang ; Zedong Jiang ; Keqin Tan ; Xuelei MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusArginine is indispensable for both tumor progression and the function of immune cells, yet how arginine deprivation within the tumor microenvironment shapes anti-tumor immunity has remained unclear. In this study, we established an in vivo arginine-restriction model using a diet lacking arginine, which significantly suppressed tumor growth and activated global anti-tumor immune responses. Mechanistically, arginine deprivation triggered the integrated stress response in CD8+ T cells via the GCN2–cREL signaling axis, leading to elevated CD200 expression. These CD200+ CD8+ T cells in turn enhanced the antigen cross-presentation capacity of tumor-associated macrophages through CD200–CD200R interactions, forming a cooperative immune network that reinforced anti-tumor activity. Moreover, this arginine deprivation–induced cellular synergy improved the therapeutic efficacy of immunotherapy in colorectal cancer models. We further conducted a single-arm phase I clinical trial (NCT07038044), which demonstrated that an arginine-free diet is both feasible and safe for modulating systemic immunity in patients. Together, our findings provide a new conceptual framework for understanding the role of arginine in reshaping the tumor immune microenvironment and highlight arginine restriction as a promising and clinically translatable anti-tumor strategy.
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3. ⭐ GSE311146 CD200+ CD8 T 细胞通过精氨酸剥夺生成，激活巨噬细胞交叉呈递并改善抗肿瘤免疫[RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity、T cell、macrophage、RNA-seq
• 📝 描述：Contributors : Qianlong Kang ; Zedong Jiang ; Keqin Tan ; Xuelei MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusArginine is indispensable for both tumor progression and the function of immune cells, yet how arginine deprivation within the tumor microenvironment shapes anti-tumor immunity has remained unclear. In this study, we established an in vivo arginine-restriction model using a diet lacking arginine, which significantly suppressed tumor growth and activated global anti-tumor immune responses. Mechanistically, arginine deprivation triggered the integrated stress response in CD8+ T cells via the GCN2–cREL signaling axis, leading to elevated CD200 expression. These CD200+ CD8+ T cells in turn enhanced the antigen cross-presentation capacity of tumor-associated macrophages through CD200–CD200R interactions, forming a cooperative immune network that reinforced anti-tumor activity. Moreover, this arginine deprivation–induced cellular synergy improved the therapeutic efficacy of immunotherapy in colorectal cancer models. We further conducted a single-arm phase I clinical trial (NCT07038044), which demonstrated that an arginine-free diet is both feasible and safe for modulating systemic immunity in patients. Together, our findings provide a new conceptual framework for understanding the role of arginine in reshaping the tumor immune microenvironment and highlight arginine restriction as a promising and clinically translatable anti-tumor strategy.
• 🔗 查看原文

4. ⭐ GSE311145 CD200+ CD8 T 细胞通过精氨酸剥夺生成，激活巨噬细胞交叉呈递并改善抗肿瘤免疫 [ATAC-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity、T cell、macrophage、ATAC-seq
• 📝 描述：Contributors : Qianlong Kang ; Zedong Jiang ; Keqin Tan ; Xuelei MaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusArginine is indispensable for both tumor progression and the function of immune cells, yet how arginine deprivation within the tumor microenvironment shapes anti-tumor immunity has remained unclear. In this study, we established an in vivo arginine-restriction model using a diet lacking arginine, which significantly suppressed tumor growth and activated global anti-tumor immune responses. Mechanistically, arginine deprivation triggered the integrated stress response in CD8+ T cells via the GCN2–cREL signaling axis, leading to elevated CD200 expression. These CD200+ CD8+ T cells in turn enhanced the antigen cross-presentation capacity of tumor-associated macrophages through CD200–CD200R interactions, forming a cooperative immune network that reinforced anti-tumor activity. Moreover, this arginine deprivation–induced cellular synergy improved the therapeutic efficacy of immunotherapy in colorectal cancer models. We further conducted a single-arm phase I clinical trial (NCT07038044), which demonstrated that an arginine-free diet is both feasible and safe for modulating systemic immunity in patients. Together, our findings provide a new conceptual framework for understanding the role of arginine in reshaping the tumor immune microenvironment and highlight arginine restriction as a promising and clinically translatable anti-tumor strategy.
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5. ⭐ GSE310571 双抗原狗骨DNA疫苗可诱导针对免疫抑制性口腔癌的强效抗肿瘤免疫力

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immunity、vaccine、antigen
• 📝 描述：Contributors : Grace Tan ; Natalia Savelyeva ; Chuan Wang ; Martina Meschis ; Christian OttensmeierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunotherapy has demonstrated durable responses in a subset of patients with head and neck cancer, offering potential survival benefits to those with poor prognoses and resistance to first-line treatments. Despite this, only a modest 15-20% are shown to respond. Cancer vaccines have recently demonstrated efficacy in some solid tumours including melanoma, as well as immune-cold pancreatic and liver cancer, inducing a cytotoxic T cell response and eradicating cancer cells. Our previous research identified cancer testis antigens MAGED4B and FJX1 as highly immunogenic and overexpressed in the majority of HPV-independent head-and-neck squamous cell carcinoma (HPVnegHNSCC) patients. In this study, we developed a novel DNA vaccine utilising the non-plasmid doggyboneTM (dbDNATM) platform to deliver these antigens for targeting head and neck cancer. A series of doggyboneTM vaccine prototypes targeting MAGED4B and FJX1 were generated both to optimise the backbone and to present antigens in an immunogenic form. Vaccine immunogenicity and cytotoxicity were accessed using interferon-gamma. Enzyme-Linked Immunospot (ELISpot) assay. Vaccine efficacy was evaluated in the MOC-2 oral cancer model through tumour monitoring, assessing the infiltration of CD4+, CD8+ and regulatory T cells by immunohistochemistry as well as RNAseq analysis. The optimised dual antigen dbDNA DNA vaccine significantly reduced tumour size. Furthermore, combining the vaccine with anti-PD1 therapy significantly delayed tumour growth and metastasis, thereby enhancing survival in tumour-bearing mice. Vaccination resulted in significant recruitment of CD4+ and CD8+ T cells but not regulatory T cells. IHC analysis also confirmed the ability of dbDNA™ vaccine TGL-100 OPT in shifting M2 to M1 polarisation, highlighting their therapeutic promise. Transcriptomic analysis of immune cells in the tumour indicates that vaccination promotes long term anti-tumour responses by upregulating memory T cell genes T cell factor-7 (Tcf7) and lymphoid enhancer binding factor 1 (Lef1) while suppressing PDL-1 and inhibiting anti-inflammatory cytokines such as IL-10 and IL-27. These findings suggest that our cancer vaccine effectively recruits cytotoxic T cells to immune cold tumours, minimising the host’s immune inhibitory mechanisms within…
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6. ⭐ GSE308436 骶骨脊索瘤表观遗传学、空间转录组学和免疫微环境的多模态整合研究

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Yee H Foong ; George Jour ; Garima Sinha ; Jamal Benhamida ; Nathan Aleynick ; Yanyun Li ; Travis Hollmann ; Mrinal Gounder ; Rohan Sardana ; Carla Saoud ; Max Vaynrub ; Patrick Boland ; Rami Vanguri ; Meera HameedSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensMultimodal study elucidated the complex epigenetic and immunological landscape in sacral chordomas
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7. ⭐ GSE310136 精准纳米疗法重塑肿瘤相关巨噬细胞，逆转胰腺癌中的免疫抑制。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、macrophage
• 📝 描述：Contributors : Yunching Chen ; Hsin-Mei LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive stroma rich in tumor-associated macrophages (TAMs) that limit the therapeutic efficacy. We introduce a TAM-targeted nanotherapy platform that selectively delivers either a CSF1R inhibitor or the STING agonist cGAMP to immunosuppressive TAMs. While CSF1R inhibitor–loaded nanoparticles efficiently depleted TAMs and produced moderate antitumor effects, TAM-targeted cGAMP nanoparticles reprogrammed TAMs into immune-stimulating effectors. This reprogramming normalized aberrant vasculature, alleviated desmoplasia, and enhanced infiltration and activation of cytotoxic immune cells. In combination with gemcitabine, PD-1 checkpoint blockade, or CAR-NK cell therapy, TAM-targeted STING activation provided an in situ immunostimulatory signal that markedly improved antitumor efficacy in preclinical PDAC models. Ex vivo efficacy in human PDAC tissues and a favorable safety profile show the translational potential of this TAM-targeted nanotherapy to overcome the immune desert of PDAC.
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8. ⭐ GSE306162 SPP1+巨噬细胞促进接触性过敏引起的毛发生长[空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics
• 📝 描述：Contributors : Kai-Rong Huang ; Sabrina Mai-Yi Fan ; Sung-Jan LinSeries Type : OtherOrganism : Mus musculusUsing Visium HD spatial transcriptomics and immunostaining, we mapped skin compartment dynamics during DPCP-induced allergic contact dermatitis. Dermal white adipose tissue transitioned from metabolic homeostasis to immune activation and inflammatory remodeling, accompanied by sustained lipolysis. Concurrently, CD45⁺ immune cells accumulated in the lower dermis and dWAT. These findings identify dWAT as an immune-metabolic hub orchestrating inflammatory progression and highlight spatial transcriptomics as a powerful tool for dissecting skin niche regulation.
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9. ⭐ GSE296929 E2F4/SETD1A轴介导的METTL3甲基化通过抑制内源性逆转录元件表达促进肿瘤免疫逃逸

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immune、methylation
• 📝 描述：Series Type : Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) progression and recurrence persist as major clinical challenges despite standard therapies. Emerging evidence underscores that tumor relapse arises from crosstalk between malignant cells and the immunosuppressive microenvironment, yet the role of non-histone lysine methylation in this interplay remains unclear. Here, we identify di-methylation of lysine 513 (K513) on methyltransferase-like 3 (METTL3) as a key epigenetic modification associated with CRC progression and recurrence. Mechanistically, we reveal that SETD1A catalyzes METTL3 K513 methylation, enhancing its binding affinity to S-adenosylmethionine (SAM) and augmenting RNA m⁶A deposition. Strikingly, METTL3 methylation suppresses endogenous retroelements expression, leading to impaired type I interferon responses and tumor immune evasion. We further uncover a fluorouracil-induced E2F4/SETD1A/METTL3 regulatory axis, wherein E2F4 self-regulation activates SETD1A to drive METTL3 methylation. Targeting this axis through pharmacological inhibition of E2F4 or genetic disruption of METTL3 methylation synergizes with immune checkpoint blockade (ICB), significantly suppressing tumor growth. Our findings unveil a methylation-dependent regulatory mechanism that reshapes the tumor immune microenvironment, offering a novel therapeutic strategy for CRC.
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10. ⭐ GSE276263 Epigenetic insights into fertility: involvement of immune cell methylation in dairy cows reproduction

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、epigenetic、methylation
• 📝 描述：Contributors : Lotfi Bouzeraa ; Helene Martin ; Clement Plessis ; Pascal Dufour ; Jessica C Marques ; Sydney Moore ; Ronaldo Cerri ; Marc-Andre SirardSeries Type : OtherOrganism : Bos taurusInfertility and post-partum reproductive diseases present significant clinical and economic challenges, particularly in cattle farming. Successful gestation is largely contingent upon the ability of the maternal immune system to recognize and tolerate the embryo. The role of immune cells in promoting fetal-maternal immune tolerance is critical, underlining their importance in post-partum fertility. In this context, DNA methylation in hematopoietic cells may play a pivotal role in determining the susceptibility of the animal to post-partum fertility problems. Identifying epigenetic changes linked to infertility is therefore crucial for advancing sustainable animal production. Characterizing the methylome of immune cells in relation to fertility will enable early phenotyping, setting the stage for innovative methods to detect potential subfertility in animals. In our study, whole epigenome sequencing and enzymatic methyl-seq (EM-seq) were employed to analyze the DNA methylation patterns in total blood collected from twelve Holstein cows raised on the same farm before any disease appeared. This approach helped to map the epigenetic modification profiles of genes associated with the varying fertility phenotypes observed the following year, revealing significant differences between fertile and subfertile cows. We identified 216,990 differentially methylated cytosines (DMCs), with three genes, Interferon tau-3 (IFNT3), KIAA0825, and RAS-Related Protein 2A (RAP2A), showing high significance. Additionally, 23 key genes affected by DMCs across five regions (transcription start sites-TSS shores, introns, exons, distal intergenic areas, and downstream of genes) were identified. Notably, Interferon tau-3 emerged as especially crucial due to its role in early embryonic development and the establishment of gestation in cattle, with seven DMCs in its TSS shores in subfertile cows. Similarly, the KLRA1 gene (Ly49), analogous to KIRs in humans and primarily expressed on Natural Killer (NK) cells, was highlighted for its potential impact on fertility. Past research underscored that a balance between activating and inhibiting KIR receptors is essential for embryo implantation and proper placental development. Moreover, interleukin genes, such as IL-6, IL15, IL22, IL-36G, which are vital f…
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1. 你的皮肤本身具有抗癌机制，而阳光会将其关闭。

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Scientists have uncovered how too much sunlight can flip a hidden switch inside skin cells that makes inflammation spiral out of control and increases the risk of cancer. Their research reveals that UV radiation breaks down a protective protein called YTHDF2, which normally prevents a small RNA signal from activating an immune sensor linked to dangerous inflammation. Once that protection is lost, a surprising chain reaction unfolds inside the cell, turning ordinary sun damage into a potential cancer trigger.
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2. Fructose may quietly supercharge your inflammation

• ✍️ 作者：未知作者
• 🏷️ 关键词：inflammation
• 📝 描述：Researchers found that fructose can prime immune cells to overreact to bacterial toxins. In healthy adults, fructose-sweetened drinks increased receptors that trigger inflammation. This heightened sensitivity may contribute to greater infection risk. The effects could be even more dangerous in people with metabolic diseases.
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• GSE270483 Macrophage Involvement in the Pathology of Chronic Thromboembolic Pulmonary Hypertension: Lessons from Single-Cell and Single-Nucleus RNA Sequencing
• GSE268779 比较空间转录组图谱中扰动响应区域和基因的鉴定
• GSE239497 CARD11 gain of function upregulates BCL2A1 and promotes resistance to targeted therapies combination in B-cell lymphoma [scRNA-seq]
• GSE310633 OsVAL2 过表达材料的原始 ChIP-seq 数据，使用抗 FLAG 抗体。
• GSE275484 人类胶质瘤相关巨噬细胞的一个功能亚群与恶性胶质瘤进展相关 - RNA-seq
• GSE275225 与恶性胶质瘤进展相关的人类胶质瘤相关巨噬细胞的功能亚群 [scRNA-seq]
• GSE275224 与恶性胶质瘤进展相关的人类胶质瘤相关巨噬细胞的功能亚群 [scATAC-seq]
• GSE311807 人类小胶质细胞对体内β-淀粉样蛋白、tau蛋白和阿尔茨海默病病理的混合反应存在差异[scRNA-Seq]
• GSE311534 Lamin A/C 调节脂质代谢和炎症：来自家族性部分脂肪营养不良 2 亚型 2 模型的启示
• GSE311533 层粘蛋白A/C调节脂质代谢和炎症：来自家族性部分脂肪营养不良2亚型模型的启示
• GSE311524 谷氨酰胺限制条件下转录组和蛋白质组反应解耦
• GSE311344 B16 肿瘤模型中 T 细胞的 ACT 和检查点阻断 - scRNA-seq、CITE-seq 和 TCRab [i35]
• GSE311262 利用患者来源的异种移植细胞在工程化组织模型中重现患者间结直肠癌肿瘤异质性
• GSE308942 ErbB3受体酪氨酸激酶调节小肠屏障功能和紧密连接蛋白Pmp22的表达
• GSE306583 胎盘别孕烯醇酮不足后小鼠体感皮层、海马和小脑转录组的发育轨迹
• GSE303697 单核 RNA 测序揭示了具有不同免疫背景的小鼠侧隔区细胞异质性
• GSE301537 独特的序列特征定义了炎症记忆的表观遗传持久性 [scATAC-seq]
• GSE300583 MOIRA 是果蝇时钟蛋白和基因聚集以及正常昼夜节律所必需的 [ATAC-seq]
• GSE300582 MOIRA 是果蝇时钟蛋白和基因聚集以及正常昼夜节律所必需的 [RNA-seq]
• GSE289835 ApoE-/- 和 Epn1&2-SMCiDKO/ApoE-/- 小鼠 (n=3) 主动脉的单细胞 RNA 测序
• GSE287445 发现、阐明和治疗靶向驱动细胞因子释放综合征的过度翻译通路 [RSK1_KO_RNA-seq]
• GSE287444 发现、阐明和治疗靶向驱动细胞因子释放综合征的过度翻译通路 [单核细胞核糖体测序]
• GSE287443 发现、阐明和治疗靶向驱动细胞因子释放综合征的过度翻译通路 [CRISPR_screen]
• GSE287442 发现、阐明和治疗靶向驱动细胞因子释放综合征的过度翻译通路 [BMDM_RiboTag-seq]
• GSE287441 发现、阐明和治疗靶向驱动细胞因子释放综合征的过度翻译通路 [BMDM_Ribo-seq]
• GSE287440 发现、阐明和治疗靶向驱动细胞因子释放综合征的过度翻译通路 [BCAP_KO_BMDM_Ribo-seq]
• GSE285986 异染色质保真度是淋巴瘤和其他人类癌症的治疗弱点 [ChIP-Seq]
• GSE285592 异染色质保真度是淋巴瘤和其他人类癌症的治疗弱点[RNA-seq]
• GSE285575 Syntaxin-6介导的自噬赋予肝细胞癌乐伐替尼耐药性
• GSE283882 单细胞测序揭示吸烟相关性牙周炎中上皮细胞与 CXCR6+ Treg 细胞的相互作用
• GSE282552 长读长 RNA 测序揭示精神分裂症中具有差异异构体使用的突触基因 [短读长 RNA 测序]
• GSE282551 长读长 RNA 测序揭示精神分裂症中具有差异异构体使用的突触基因 [长读长 RNA 测序]
• GSE282171 抑郁和焦虑诱导的代谢重编程通过 CBX5 乳酸化促进肝细胞癌进展：牛磺胆酸和 PHGDH 介导的铁死亡的参与
• GSE281469 IKAROS、HDAC1 和 EZH2 对白血病中异染色质形成和肿瘤抑制的调控 [Molt4_CT]
• GSE281468 Regulation of heterochromatin formation and tumor suppression in leukemia by IKAROS, HDAC1 and EZH2 [Molt4_RNA]
• GSE281327 自闭症谱系障碍中的新生结构变异破坏神经元基因的远端调控相互作用 [RNA-Seq]
• GSE281283 自闭症谱系障碍中的新生结构变异破坏神经元基因的远端调控相互作用 [Hi-C]
• GSE277238 ICAM1 mRNA通过dsRNA-ILF2/ILF3通路抑制肺癌中的翻译，其功能独立于蛋白质编码。
• GSE277143 细胞周期阻滞通过增强葡萄糖代谢和IL-2信号传导来增强CD8+ T细胞效应功能
• GSE275934 H4K16酰化修饰在代谢扰动期间微调转录反应（RNA-seq）
• GSE275933 H4K16酰化修饰在代谢扰动期间微调转录反应（ChIP-seq）
• GSE275932 H4K16酰化在代谢扰动期间微调转录反应（ATAC-seq）
• GSE274750 PMEPA1的致癌作用及其与肝细胞癌中免疫耗竭和TGF-β激活的关系
• GSE271675 前列腺癌从原发到转移扩散的肿瘤异质性动态变化
• GSE271622 肠神经元丢失对肠道细胞组成的影响
• GSE268561 研究发现，发育期暴露于甲酯磺酸盐可通过扰乱 Notch/Hes 信号通路，破坏神经元分化，从而诱导小鼠出现类似自闭症的行为缺陷。
• GSE266425 磷酸化 RB 抑制 ETS1 的转录活性，从而调节前列腺癌细胞对 CDK4/6 抑制剂的敏感性 [RNA-seq]
• GSE259251 ndufs2-/-斑马鱼模型表现出莱氏综合征的特征，包括寿命缩短、发育异常、转录组改变和代谢紊乱
• GSE249943 乳腺癌细胞能够识别并响应不同水平的孕激素，从而产生不同的表型输出 [RNA-seq]
• GSE249939 乳腺癌细胞能够识别并响应不同水平的孕激素，从而产生不同的表型输出 [ATAC-seq]
• GSE239353 CARD11 gain of function upregulates BCL2A1 and promotes resistance to targeted therapies combination in B-cell lymphoma
• GSE223746 Single-cell Transcriptome Atlas of the uroclepsia Rat urethra with LIPUS treatment
• GSE185914 Integrating multi-omics data with genome scale metabolic modeling for the analysis of Pseudomonas aeruginosa persister cells
• GSE138321 Microbial activation of intestinal TLRs is critical for the establishment of normal behavior
• GSE271330 CBLL1 (HAKAI) RNA甲基转移酶复合物组分在乳腺癌细胞（MDA-MB-231）雄激素信号传导中的作用
• GSE271326 CBLL1 (HAKAI) RNA甲基转移酶复合物成分在乳腺癌细胞 (MCF-7) 基础信号传导和雌激素信号传导中的作用
• GSE234571 METTL3:METTL14 RNA甲基转移酶调控MDA-MB-231乳腺癌细胞中的基因表达
• GSE234322 METTL3 RNA甲基转移酶抑制对乳腺癌细胞基因表达的影响
• GSE195532 METTL3 RNA甲基转移酶调控MCF-7乳腺癌细胞中的雌激素信号传导
• GSE195487 RNA甲基转移酶复合物的METTL14组分影响MCF-7乳腺癌细胞中的雌激素信号传导
• GSE284223 表皮特异性 Nampt cKO 小鼠皮肤的综合转录组分析。
• GSE310631 水稻基因 OsVAL2 过表达和敲除突变株系的原始 RNA-seq 数据。
• GSE310630 水稻基因 OsDOF3 的野生型和过表达株系的原始 RNA-seq 数据。
• GSE272216 人类胶质瘤相关巨噬细胞的一个功能亚群与恶性胶质瘤进展相关
• GSE311743 Modeling Liver Cancer Molecular and Histological Features by CRISPR Editing of Primary Porcine Hepatocytes
• GSE311543 Trithorax 通过 Ptx1 介导的 EE 特化抑制来平衡 ISC 命运决定 [RNA-seq]
• GSE311542 Trithorax 通过 Ptx1 介导的 EE 特化抑制来平衡 ISC 命运决定 [ATAC-seq]
• GSE311496 研究干燥综合征和非干燥综合征相关干眼症的结膜免疫通路
• GSE311255 用于生物监测和机制研究的RNA类别复杂转录组学
• GSE311144 通过双ParABS分区系统稳定遗传链霉菌线性质粒SCP1 [ChIP-Seq]
• GSE311079：用CM-PEG-PLGA@DOX/R848纳米颗粒处理RAW264.7细胞与PBS对照组的转录组分析
• GSE311078：CM-PEG-PLGA@DOX/R848纳米颗粒处理4T1细胞与PBS对照组的转录组分析
• GSE311038 复制性衰老模型中衰老内皮细胞及其衍生细胞外囊泡的多组学整合方法 [RNA-seq]
• GSE310979 叶酸结合蛋白诱导KB癌细胞毒性的信号传导和机制研究
• GSE310845 肠道干细胞和祖细胞在炎症性肠病中对炎症应激表现出不同的适应性反应
• GSE310735 YBX1 调节细胞稳态以预防炎症
• GSE310703 人类成纤维细胞 MRC5 细胞在 RAF 癌基因激活后的基因表达谱分析
• GSE310275 转录因子 OsWRKY36 通过调节油菜素甾醇信号传导来调控水稻叶片关节发育和叶片角度 [ChIP-Seq]
• GSE310085 萝卜硫素通过抑制PI3K/AKT/mTOR和HIF-1α通路抑制结直肠癌进展，且在缺氧条件下疗效增强
• GSE307273 年龄相关的 G-四链体积累和 DDX5 丢失塑造人类星形胶质细胞的染色质景观 [ATAC-seq]
• GSE307272 年龄相关的 G-四链体积累和 DDX5 丢失塑造人类星形胶质细胞的染色质景观 [RNA-seq]
• GSE306951 利用蜂胶提取物对绿色合成氧化锌纳米颗粒诱导斑马鱼免疫反应进行转录组分析
• GSE306591 染色质结合的 Mtf2 限制原始多能性中的胚外发育能力 [scRNA-Seq]
• GSE306510 SPP1+巨噬细胞促进接触性过敏中的毛发生长[scRNA-Seq]
• GSE306509 SPP1+巨噬细胞促进接触性超敏反应中的毛发生长[批量RNA测序]
• GSE305449 小鼠胰腺α谱系细胞的单细胞转录组分析
• GSE303631 CDCP1 和心肌纤维化在扩张型心肌病 (DCM) 小鼠模型中的作用
• GSE302326 宿主-病原体相互作用期间的组蛋白乳酸化：铜绿假单胞菌群体感应信号与宿主乳酸之间的密切和持续关系 [CUT&RUN]
• GSE302311 宿主-病原体相互作用过程中的组蛋白乳酸化：铜绿假单胞菌群体感应信号与宿主乳酸之间密切而持久的关系
• GSE301850 表皮细胞融合促进秀丽隐杆线虫从胚胎转录组向幼虫转录组的转变
• GSE300516 脑缺血小鼠模型中5-甲基胞嘧啶修饰和表达谱的转录组范围分析
• GSE300050 独特的序列特征定义了炎症记忆的表观遗传持久性
• GSE299343 批量 RNA 测序 S64F MAFA 雄性胰岛
• GSE295793 研究替代甜味剂对乳酸杆菌生长和代谢的影响及其对食源性病原体的杀菌机制
• GSE294870 Tau蛋白通过增强脂肪酸β-氧化诱导的细胞衰老来抑制胶质瘤进展
• GSE289914 一种新型食品可恢复西方饮食诱导的MASLD小鼠的异常DNA甲基化模式
• GSE289250 芍药酚通过抑制角质形成细胞的 TRPV3/NF-κB/CCL3 轴缓解特应性皮炎的皮肤炎症和瘙痒
• GSE287309 小鼠少突胶质细胞Serpina3n缺失对脑衰老的影响
• GSE286298 异染色质保真度是淋巴瘤和其他人类癌症的治疗弱点
• GSE285894 新生RNA m6A修饰参与CRPC-V16A缺氧条件下T细胞活化基因特征
• GSE285442 HU乙酰化通过HDAH介导对大肠杆菌代谢进行正反馈调控
• GSE285168 TBX5 剂量降低通过破坏心房心肌细胞身份的发育基因调控导致人类心房疾病 [scATAC-seq]
• GSE284720 RNA-seq 分析揭示了细颗粒物 (PM2.5) 中不同有机成分对人类鼻成纤维细胞的影响
• GSE284078 RNA-Seq 分析了用 SGLT2 抑制剂达格列净治疗的 Akita 小鼠和野生型对照小鼠的胰岛。
• GSE279446 单个 microRNA 靶标的去抑制导致小鼠雌性不孕 [RNA-Seq]
• GSE276336 ZEB1介导的结直肠癌HT-29细胞系上皮间质转化
• GSE274447 小鼠脑内体内空间扰动序列
• GSE274244 Arx 在发育中的中间神经元中的作用 [scRNA-seq]
• GSE274243 Arx 在发育中的中间神经元中的作用 [ChIP-seq]
• GSE273445 毒蕈碱激动剂通过钙-ATP代谢轴恢复退化的唾液腺[snRNA-Seq]
• GSE272876 利用纳米孔 tRNA 测序对 43 种不同的 RNA 修饰进行比较分析
• GSE272422 Sirt5 通过蛋白质赖氨酸丙二酰化调控软骨细胞代谢和骨关节炎发展
• GSE271303 卡波西斯肉瘤队列的整合功能基因组学分析
• GSE266938 成年肝脏肝细胞中 SWI/SNF ATPase 活性的缺失会破坏昼夜节律基因表达和肝脏中枢功能 [RNAseq]
• GSE266426 磷酸化 RB 抑制 ETS1 的转录活性，从而调节前列腺癌细胞对 CDK4/6 抑制剂的敏感性 [CUT&Tag]
• GSE261053 RNAPII 绕过阻断损伤揭示 DNA 损伤抵抗的关键见解 [PRO-seq]
• GSE260852 黏连蛋白协调 RNA 聚合酶 II 转录的多步骤过程 [ChIP-seq]
• GSE252312 基于化学分子筛选的天然人类胚胎干细胞新型培养系统[RNA-seq]
• GSE252086 心肌梗死后单核细胞命运决定的遗传定位
• GSE250411 异亮氨酰-tRNA合成酶1新突变通过稳定组织蛋白酶Z促进肺表面活性物质的沉积[scRNA-seq]
• GSE250270 异亮氨酰-tRNA 合成酶 1 的新突变通过稳定组织蛋白酶 Z 促进肺表面活性物质的沉积 [RNA-seq]
• GSE250140 肺细胞特异性驱动因子对翻译核糖体亲和纯化-RNA测序 (TRAPseq) 的比较研究
• GSE249945 乳腺癌细胞能够识别并响应不同水平的孕激素，从而产生不同的表型结果
• GSE247828 Bulk RNA-seq analysis of nilotinib resistant JURL-MK1 cells compared against parental JURL-MK1 cells.
• GSE247827 Single cell RNA-seq analysis of the effects of fluphenazine and/or nilotinib on primary CML CD34+CD38- cells
• GSE247826 Bulk RNA-seq analysis for knockdowns of dopamine receptors DRD3 or DRD4 in JURL-MK1 cells +/- TKI (nilotinib) in vitro.
• GSE242511 Reciprocal inflammatory signals establish profibrotic cross-feeding metabolism [young_old_bleo]
• GSE237235 Integrative genome-wide analysis reveals the RNA-binding motifs of yeast Pcf11 and its role in fine-tuning terminator strength
• GSE224011 Fc glyco-engineered PD-L1 antibody harnesses Fcg Receptors for increased antitumor efficacy
• GSE221069 Effects of gestational exposure to air pollution on placental methylation mark
• GSE220648 Nascent RNA-seq from in-vitro stimulated WT and Il2ra-deficient CD8 T cells
• GSE207991 High-throughput single cell RNA-sequencing of developing lens for cataract gene discovery
• GSE203198 Integrated control of mitochondrial dynamics and cancer cell stemness by σ1 receptor
• GSE196382 Defining transcripts regulated by RBBP4/p300 complex in glioblastoma [RNA-seq]
• GSE196381 Mapping chromatin landscape regulated by RBBP4/p300 complex in glioblastoma [ChIP-seq]
• GSE189447 RNA sequencing of glk1 glk2 double mutants under LD conditions at ZT16
• GSE175810 An ancestral inductive program endows neural crest cells with skeletogenic potential [scATAC-seq]
• GSE168398 De novo methylation enforces long-term lineage-specific programing of TFH and TH1 memory cells [WGBS]
• GSE160065 A facile dCAS9-M. EcoGII system for targeted DNA 6mA methylation in living cell
• GSE108449 Altas of gene expression in mice liver during liver regeneration process post 2/3 partial hepatectomy using RNA-seq