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1. ⭐ Nat Commun | 单细胞层面揭秘肺癌微环境：EGFR/KRAS 主导细胞表型，TP53 共突变促免疫抑制互作

• ✍️ 作者：单细胞天地
• 🏷️ 关键词：免疫、T细胞、NK细胞、单细胞、KRAS
• 🔗 查看原文

2. ⭐ 最新14+生信，通过单细胞分析识别HLA-DR +肿瘤细胞，并分析其对 CD8+T 细胞及预后的影响，思路新颖！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、T细胞、单细胞、生信、通路
• 📝 描述：点击查看详情
• 🔗 查看原文

3. ⭐ 最新14+热点好文，巨噬细胞胞葬驱动多胺代谢增强化疗后癌干细胞富集及耐药！生信发现现象，实验解释现象，探索机制！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：巨噬细胞、代谢、耐药、生信、富集
• 📝 描述：点击查看详情
• 🔗 查看原文

4. ⭐ 就它了！肠脑轴创新点不用愁，暨南&北医大靠肠道菌群-代谢物-炎症通路冲8.3分，思路锁定！

• ✍️ 作者：神经岛
• 🏷️ 关键词：炎症、代谢、通路、肠道
• 🔗 查看原文

5. ⭐ 最新14+生信，单细胞识别MARCO+巨噬细胞抑制CD8T，阻断MARCO增强免疫治疗疗效。干湿结合经典高分思路！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、巨噬细胞、单细胞、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

6. ⭐ 最新14+生信，单细胞识别PLAUR+中性粒细胞塑造免疫抑制微环境，抑制PLAUR 增强抗 PD1 疗效。高分文章经典思路！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、免疫微环境、单细胞、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

7. ⭐ 刚刚发表的7.5分生信，针对热点基因集，结合单细胞+机器学习+空转+多重免疫荧光。生信占百分之80实验占20。高效发文章典范！

• ✍️ 作者：东晓生物
• 🏷️ 关键词：免疫、单细胞、生信
• 🔗 查看原文

8. ⭐ 最新14+干湿结合SCI，作者鉴定出干扰素诱导的衰老 CD8T 细胞并揭示其对免疫治疗的影响。衰老虽老，但是真的火！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、衰老、T细胞
• 📝 描述：点击查看详情
• 🔗 查看原文

9. ⭐ 6+生信，基于特定基因家族进行单细胞和空转的分析，这图是真多，组图是真密啊！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：单细胞、基因组、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

10. 肝脏脂质代谢紊乱（建议收藏）

• ✍️ 作者：小李代谢
• 🏷️ 关键词：代谢
• 📝 描述：肝脏脂质代谢依赖多环节协同，其紊乱由营养过剩、酶活性失衡及炎症共同驱动，导致从脂肪变性到肝硬化的连续病变。
• 🔗 查看原文

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1. ⭐ GSE283872 先前高纤维摄入对肠系膜脂肪和肠道组织对随后高脂肪喂养的细胞反应产生影响[空间转录组学]

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、spatial transcriptomics、transcriptomics、regex:intestin(e|al)
• 📝 描述：Contributors : Zhi Peng ; Meng XieSeries Type : OtherOrganism : Mus musculusDietary modification by consuming plant-based food with high fiber content is a primary strategy to induce weight loss in obese individuals. However, long-term usage of such fiber-enriched dieting is challenging and rapid weight regain often occurs once the high-fat dietary habit resumes. Currently, how do adipose and intestinal tissues respond to a switch between high-fiber and high-fat diet remains unknown. Here, we applied C57BL/6J mice to chow diet (CD)/high-fiber diet (HfiD)-to-high-fat diet (HFD) switching paradigms and collected mesenteric white adipose tissue (mWAT), duodenum and colon tissue sections at different time points for single-nucleus profiling and spatially resolved transcriptomic analysis, respectively. We show that the progenitors and adipocytes of HfiD-fed mWAT are more sensitive to HFD-induced molecular changes. In addition, HfiD feeding prevents the subsequent HFD-induced expansion of immune-related enterocytes in duodenum and reverses the HFD-induced enterocyte-to-goblet cell conversion in colon. Moreover, HfiD-induced microbiome changes are mostly abrogated upon HFD feeding. Our results indicate that prior HfiD feeding can alter the cellular response of adipose and intestinal tissues to subsequent HFD feeding, which highlights the impact of dietary interventions with fiber-rich food for obesity treatment from a different perspective. Our data provide a spatiotemporal resource for future hypothesis-driven studies on the mechanisms of adipose and intestinal tissue plasticity in response to diet switches.
• 🔗 查看原文

2. ⭐ GSE301096 嵌合小鼠肿瘤肺中siglecf low巨噬细胞的mRNA转录组测序，这些小鼠经鼻内注射了Ad-Cre

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、sequencing、transcriptome
• 📝 描述：Contributors : Zhidong Zhang ; Dandan Lin ; Bo ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transcriptional profiling of siglecf low macrophages from tumor lungs of Tmem173fl/fl→KrasLSL-G12D/+Lkb1fl/fl (WTKL) and Tmem173fl/fl;Lyz2-Cre→KrasLSL-G12D/+Lkb1fl/fl (LYZKL) chimeric mice.
• 🔗 查看原文

3. GSE296788 肉芽肿中巨噬细胞的异质性和空间定位是结核分枝杆菌感染的非人灵长类动物早期反应的特征。

• ✍️ 作者：未知作者
• 🏷️ 关键词：macrophage、spatial
• 📝 描述：Contributors : Davide Pisu ; Persis S Sunny ; Molly L Nelson ; Beth F Junecko ; Roopa Venugopalan ; Jake H Borish ; Pauline Maiello ; Charles A Scanga ; Philana Ling Lin ; Mark A Rodgers ; David G Russell ; Joshua T Mattila ; JoAnne L FlynnSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Macaca fascicularisTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is defined by granulomas—immune aggregates that either contain or support bacterial replication. Macrophages, fundamental components of these lesions, are crucial to TB pathogenesis, yet their phenotypic and functional diversity remains incompletely understood. Here, we used single-cell RNA sequencing and immunofluorescence to profile macrophages in lung tissue and granulomas from a nonhuman primate model of early TB. We identified transcriptionally distinct subsets, including embryonic-origin tissue-resident alveolar macrophages and monocyte-derived alveolar and interstitial macrophages, each with distinct spatial localization in granulomas. Tissue-resident alveolar macrophages and a subset undergoing epithelial-to-mesenchymal transition accounted for the highest frequency of Mtb-infected cells. Infected cells exhibited differential expression of immune- and migration-associated genes compared to uninfected counterparts, suggesting Mtb either induces or exploits these pathways as a survival strategy. These findings highlight macrophage heterogeneity as a major driver of differential susceptibility to Mtb and provide insights relevant to future immunomodulatory strategies.
• 🔗 查看原文

4. GSE282411 半乳糖凝集素-9通过树突状细胞内HLA-DR结合调节CD4+ T细胞增殖

• ✍️ 作者：未知作者
• 🏷️ 关键词：T cell、HLA
• 📝 描述：Contributors : Andrea R Furones ; Guido van Mierlo ; Laia Q CanoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo initiate T cell-mediated immunity, dendritic cells (DCs) present antigen to specific T cells through the establishment of an immune synapse. Despite its critical importance, the spatiotemporal dynamics of membrane receptor organization during synapse formation in DCs have been only partly characterized. Galectins, a family of β-galactoside binding proteins, exert crucial roles in homeostasis and pathological processes but the molecular mechanisms underlying galectin function are largely unresolved. Here, we demonstrate that intracellular galectin-9 (gal9) is required for T cell activation. Murine and human DCs lacking gal9 showed impaired induction of CD4+, but not CD8+, T cell proliferation, suggesting a conserved function for gal9 in modulating DC–T cell interactions. Live-cell imaging further revealed that galectin-9-depleted DCs fail to establish stable immunological synapses with T cells, resulting in reduced T cell clustering and activation. Unbiased co-immunoprecipitation and mass spectrometry identified HLA-II as a gal9 binding partner in DCs, and we observed a marked reduction of HLA-II recruitment to the immune synapse as the underlying mechanism. Conditional gal9 knockout in DCs led to enhanced tumor growth, compared to their WT counterparts, underscoring galectin-9 role in T cell-dependent anti-tumor immunity. Collectively, this study provides the first detailed account of gal9-mediated HLA-II organization at the synaptic site of DCs, revealing a novel mechanism by which galectins orchestrate immune receptor positioning from within the cytoplasm to enhance CD4+ T cell activation.
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5. GSE281618 坏死性小肠结肠炎易感期出生后小肠转录组编目

• ✍️ 作者：未知作者
• 🏷️ 关键词：transcriptome、regex:intestin(e|al)
• 📝 描述：Contributors : Amy E. O’Connell ; Radhika Khetani ; Shannan Ho SuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the first postnatal month, the developing mouse intestine shifts from an immature to a mature intestine that will sustain the organism throughout the lifespan. Here, we surveyed the mouse intestine in C57Bl/6 mice by RNA-Seq to evaluate the changes in gene expression over time from the day of birth through 1 month of age in both the duodenum and ileum. We analyzed gene expression for changes in gene families that correlated with the periods of NEC susceptibility or resistance. We highlight that increased expression of DNA processing genes and vacuolar structure genes, tissue development and morphogenesis genes, and cell migration genes all correlated with NEC susceptibility, while increases in immunity gene sets, intracellular transport genes, ATP production, and intracellular metabolism genes correlated with NEC resistance. Using trends identified in the RNA analyses, we further evaluated expression of cellular markers and epithelial regulators, immune cell markers, and adenosine metabolism components. We confirmed key changes with qRT-PCR and immunofluorescence. In addition, we compared some findings to humans using human intestinal biopsies and organoids. This dataset can serve as a reference for other groups considering the role of single molecules or molecular families in early intestinal and postnatal development.
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6. GSE281101 RASD1 抑制 GM-CSF 信号网络以赋予免疫抑制性肿瘤微环境 [MC38]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、tumor microenvironment
• 📝 描述：Contributors : Kyu-Hye Chun ; Bo Kyung Yoon ; Mi-Young Kim ; Hyunsik Kim ; Sugyeong Jo ; Tae-Hyun Kim ; Hyeonuk Jeon ; Nahee Hwang ; Hyeonhui Kim ; Hyunki Kim ; Jae-Ho Cheong ; Sungsoon Fang ; Jae-woo KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer immunotherapy is an emerging treatment, particularly for malignant tumors; however, resistance poses a significant challenge. Using the gastric cancer stem-like subtype, known for its poor clinical outcomes, this study explores how glucocorticoid receptor (GR) signaling via the target gene RASD1 promotes tumor progression and immune evasion, positioning RASD1 as a potential target for immunotherapy. We investigated the transcriptomic features of 497 patients with gastric cancer. Syngeneic mouse models were generated using cancer cells with modulated RASD1 expression, a gene that is highly upregulated in the stem-like subtypes. These models were treated with immunotherapy and analyzed using single-cell RNA sequencing. To overcome immunotherapy resistance, GM-CSF was co-administered with anti-PD1 to improve the efficacy of RASD1-overexpressed tumors. Elevated RASD1 promotes tumor growth and resistance to anti-PD1 therapy. Immune profiling of RASD1-overexpressing tumors revealed an increase in the number of myeloid derived suppressor cells (MDSCs) and a decrease in the number of cytotoxic CD8+T cells. GM-CSF treatment reduced tumor growth and MDSC levels, which were upregulated by the downregulation of RASD1. Combined GM-CSF and anti-PD1 treatment suppressed tumor growth by increasing the number of cytotoxic CD8+GZMB+ T cells. Tumor progression driven by RASD1-induced immunosuppression highlights the need for additional treatments beyond anti-PD1 treatment. RASD1 promotes immune evasion by facilitating MDSC accumulation and skewing the tumor microenvironment toward an immunotherapy-resistant state. GM-CSF reverses the immunosuppressive effects and restores effective anti-tumor immune response.
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7. GSE281066 RASD1抑制GM-CSF信号网络以赋予免疫抑制性肿瘤微环境

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、tumor microenvironment
• 📝 描述：Contributors : Kyu-Hye Chun ; Bo Kyung Yoon ; Mi-Young Kim ; Hyunsik Kim ; Sugyeong Jo ; Tae-Hyun Kim ; Hyeonuk Jeon ; Nahee Hwang ; Hyeonhui Kim ; Hyunki Kim ; Jae-Ho Cheong ; Sungsoon Fang ; Jae-woo KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer immunotherapy is an emerging treatment, particularly for malignant tumors; however, resistance poses a significant challenge. Using the gastric cancer stem-like subtype, known for its poor clinical outcomes, this study explores how glucocorticoid receptor (GR) signaling via the target gene RASD1 promotes tumor progression and immune evasion, positioning RASD1 as a potential target for immunotherapy. We investigated the transcriptomic features of 497 patients with gastric cancer. Syngeneic mouse models were generated using cancer cells with modulated RASD1 expression, a gene that is highly upregulated in the stem-like subtypes. These models were treated with immunotherapy and analyzed using single-cell RNA sequencing. To overcome immunotherapy resistance, GM-CSF was co-administered with anti-PD1 to improve the efficacy of RASD1-overexpressed tumors. Elevated RASD1 promotes tumor growth and resistance to anti-PD1 therapy. Immune profiling of RASD1-overexpressing tumors revealed an increase in the number of myeloid derived suppressor cells (MDSCs) and a decrease in the number of cytotoxic CD8+T cells. GM-CSF treatment reduced tumor growth and MDSC levels, which were upregulated by the downregulation of RASD1. Combined GM-CSF and anti-PD1 treatment suppressed tumor growth by increasing the number of cytotoxic CD8+GZMB+ T cells. Tumor progression driven by RASD1-induced immunosuppression highlights the need for additional treatments beyond anti-PD1 treatment. RASD1 promotes immune evasion by facilitating MDSC accumulation and skewing the tumor microenvironment toward an immunotherapy-resistant state. GM-CSF reverses the immunosuppressive effects and restores effective anti-tumor immune response.
• 🔗 查看原文

8. GSE277489 囊性纤维化患者和健康对照组中人及猪单核免疫细胞的单细胞测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、sequencing
• 📝 描述：Contributors : Gianluca Santamaria ; Daniel Reichart ; Florian Jaudas ; Nikolai KlymiukSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Sus scrofaThe study aimed to compare the gene expression profiles at a single cell level in peripheral blood (human&pig), lung-derived (pig), bone marrow (pig) mononuclear cells (MNC) between subjects with cystic fibrosis (CF) and disease controls (WT).
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9. GSE255477 研究表明，cDC1s 中 Ms4a7 的表达决定了交叉呈递和抗肿瘤免疫。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immunity
• 📝 描述：Contributors : Bowen Xie ; Xiaohong Zhao ; Tian XieSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusType 1 conventional dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8+ T cells. How tumor antigens are processed for activating CD8+ T cell immunity are not well understood. Here, we found that Ms4a7 was selectively expressed in cDC1s after engulfing tumor antigens or exposed to exogenous antigens, and required for their cross-priming ability and migration to dLNs. Ms4a7-/- mice showed normal cDC1 development and turnover but failed to prime antigen-specific CD8+ T cells after infection or tumor development. In human cancers, MS4A7 specifically expressed in a subset of cDC1s which preferentially enriched in dLNs, playing a crucial role in patient survival. Our findings reveal a critical role of Ms4a7 in cDC1 migration, cross-presentation and anti-tumor CD8+ T cell responses.
• 🔗 查看原文

10. GSE249106 通过单细胞 RNA 测序解剖小鼠唾液腺上皮细胞（野生型和受辐射型）的细胞组成。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell
• 📝 描述：Contributors : Sara Viragova ; Pierangela Palmerini ; Piero DalerbaSeries Type : OtherOrganism : Mus musculusThe major salivary glands (SG) are exocrine glands responsible for the physiological production of saliva, a sero-mucinous fluid that plays a key role in the digestion and swallowing of food, the articulation of speech and the maintenance of oral hygene. Among the principal causes of SG dysfunction is radiation treatment of head-and-neck malignancies, which can cause severe damage to multiple cell-types within the SG epithelium, resulting in permanent loss of saliva production and substantial disability. The aim of this study is to analyze the cellular composition of the mouse SG epithelium using single-cell RNA-sequencing (scRNAseq) in order to: 1) gain a deeper understanding of the rich repertoire of different epithelial cell-types that coexist witin it; and 2) to elucidate whether different sub-types of epithelial cells display different radiosensitivity and are preferentially elimininated from SGs following radiotherapy. The dataset includes data from scRNAseq experiments performed on the epithelial compartment (Epcam+) of mouse adult sub-mandibular glands (C57BL/6J, female), either at baseline (wild type) or following stereotactic X-ray irradiation (30 Gy). In the specific case of wild-type mice, the dataset also includes data from a secind scRNAseq experiment performed on the basal compartment (Epcam+, Cd49f-high) of the sub-mandibular gland, which is postulated to contain a minority population of epithelial cells with stem-progenitor properties.
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1. ⭐ 衰老型 SPP1+巨噬细胞重塑肿瘤微环境，促进早期肺腺癌的进展，该肿瘤表现为混合磨碎玻璃结节。

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、衰老、巨噬细胞
• 📝 描述：Secret hovertext: 大多数持续性磨碎玻璃结节（GGNs）最终被诊断为早期肺腺癌（LUAD）。深入研究 GGNs 恶性转化的分子基础，将有助于制定预防和治疗策略，以中断早期 LUAD 的发生和进展。巨噬细胞（Macs）在免疫抑制性肿瘤微环境（TME）的形成中起着关键作用。然而，其在触发混合研磨玻璃结核（mGGN）早期 LUAD 发展中的作用尚待明确。利用对正常肺组织、磨玻璃区和固体区域的 scRNA-seq 分析，辅以多色免疫组化学（mIHC）和流式细胞术，我们发现免疫抑制性 SPP1+肺泡细胞和单细胞来源 Mac（Mo-Macs）在肿瘤周围的聚集增加，尤其强调 Mo-Macs。肿瘤边缘的这种积累可能阻碍免疫细胞进入肿瘤核心，从而促进 GGNs 的恶性转化。SPP1+ Mac 不仅表现出衰老型表现型，还具备促进肿瘤转移和血管新生的潜在能力。LUAD 组织阵列和 TCGA-LUAD 数据库的临床数据显示肿瘤 SPP1+
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2. 急诊室压力引发神经痛

• ✍️ 作者：未知作者
• 🏷️ 关键词：神经
• 📝 描述：Secret hovertext:
• 🔗 查看原文

• 发表在14.3分1区（Advanced Science）的干湿结合文章，聚焦在成纤维细胞的衰老表型，值得学习收藏，可重复！
• 刚刚发表的14+生信分析，识别MMP11+成纤维细胞进行分析和验证，本文思路新颖，值得认真学习模仿！
• CR：吉林大学团队发现，TSPAN13是让乳腺癌由“冷”肿瘤变为“热”肿瘤的关键因子
• 从确诊到死亡，曾经只有1年时间！科学家接力与“死神”竞赛，延长致命脑瘤的生存期

• GSE248397 全球转录组分析揭示鼠伤寒沙门氏菌利用硝酸盐代谢来对抗胆汁应激
• GSE219144 RNA-seq 分析了用不同条件培养基处理的 SCC7 癌细胞（来自癌细胞诱导的 TAM）的 RNA-seq 数据。
• GSE219143 RNA-seq 分析了用不同条件培养基处理的 B16F10 癌细胞（来自癌细胞诱导的 TAM）的 RNA-seq 数据。
• GSE288401 巨噬细胞中的 STING/MITA-CD38 轴支持调节性 T 细胞存活和非小细胞肺癌进展。
• GSE263586 血管内皮细胞IRE1α促进血小板反应蛋白-1 mRNA降解，并支持胰岛在代谢应激下的功能适应
• GSE311816 白鲦性别逆转过程中的转录组分析
• GSE311656 ZNF865 (BLST) 调控人类细胞衰老和 DNA 损伤 [RNA-seq]
• GSE311654 ZNF865 (BLST) 调控人类细胞衰老和 DNA 损伤 [ATAC-seq]
• GSE311564 TBX5 依赖性基因调控网络减弱与心房颤动和心力衰竭相关 [RNA-seq: Tbx5_LV_KO]
• GSE311495 TBX5 依赖基因调控网络的减少与心房颤动和心力衰竭有关 [HI-C]
• GSE311494 TBX5 依赖性基因调控网络减弱与心房颤动和心力衰竭相关 [RNA-Seq]
• GSE310798 对人类 H1 ESC 进行批量 ATAC-seq 分析，以研究在有或无 2uM 视黄酸的情况下分化为终末内胚层和前肠内胚层的情况。
• GSE308529 子宫内膜腺体分泌物诱导滋养层细胞代谢重编程和免疫调节信号传导
• GSE308116 表观遗传修饰，作为帕金森病基因治疗的独特治疗分子。
• GSE294623 CRISPR-Cas9 碱基编辑器筛选鉴定出影响临床试验中 menin 抑制剂的 MEN1 突变谱 [RNA-Seq]
• GSE283386：5-氮杂胞苷和DSS处理小鼠结肠上皮细胞的DNA甲基化分析
• GSE283223 RNA-seq 分析具有增强子缺失的黑色素瘤细胞系。
• GSE283007 先前高纤维摄入对肠系膜脂肪和肠道组织对后续高脂肪喂养的细胞反应产生影响
• GSE282707 小鼠妊娠前和妊娠期雌鼠及其后代肠道微生物群对空气污染物暴露的反应
• GSE282601 高脂饮食诱导的肥胖症中肠上皮细胞 EphB4 缺乏
• GSE282299 转录因子 AP2XII-5 缺失前后 TgHDAC3 的全基因组占位变化
• GSE281003 高血压与足细胞衰老：一项针对年轻和中年小鼠的比较研究
• GSE279837 通过 DNA 甲基化谱分析重新评估软组织肌上皮肿瘤，揭示了一组主要由融合驱动的表观遗传学特征不同的肿瘤
• GSE279270 鉴定 lncRNA-up4 通过负调控先天免疫反应增强甲型流感病毒复制
• GSE270831 大鼠海马CA1区转录组分析揭示了左右半球经验诱导基因表达的特征
• GSE256055 m6A 阅读器 IGF2BP3 通过 RNA 翻译抑制调控小鼠精子发育过程中组蛋白向鱼精蛋白的替换
• GSE256053 利用eCLIP-seq技术在小鼠睾丸中对IGF2BP3结合的RNA进行全转录组鉴定
• GSE248507 MECP2 和 MECP2T203M D30 脑类器官的 scRNA-SEQ。
• GSE248506 MECP2 和 MECP2T203M D30 脑类器官的 ATAC-SEQ。
• GSE248106 罗奎因缺陷型T细胞通过IL-17和Th17异常细胞因子产生驱动胰腺炎和肿瘤发生
• GSE231816 人类胶质瘤细胞基因表达比较：U87-MG 野生型和 CHI3L1 敲除型（克隆 1 和 2）
• GSE226831 二甲双胍通过Traf2的组蛋白乙酰化修饰促进小鼠雌性生殖干细胞增殖
• GSE225734 线粒体分裂介导一种进化上保守的针对细菌感染的先天防御反应
• GSE225050 NAT10 介导的 ac4C 修饰通过乙酰化 NR2F1 mRNA 来增强翻译效率，从而促进人类胚胎干细胞的神经外胚层分化 [RNA-seq]
• GSE198104 细胞特异性转录组用于比较细胞表面受体表达
• 水稻花序分生组织转录组分析（GSE188483）