详细内容（前10条）

1. ⭐ 文献分享–单细胞与空间转录组学揭示三级淋巴结构在胃癌中的预后功能

• ✍️ 作者：单细胞空间交响乐
• 🏷️ 关键词：淋巴、单细胞、空间转录组、空间组学、转录组
• 📝 描述：文献分享–单细胞与空间转录组学揭示三级淋巴结构在胃癌中的预后功能
• 🔗 查看原文

2. ⭐ 文献分享｜Advanced Science｜EASi-seq：单细胞微生物基因组测序技术

• ✍️ 作者：王永成Lab
• 🏷️ 关键词：微生物、测序、单细胞、基因组
• 📝 描述：微生物组具有物种多样性和遗传异质性，这主要源于核心基因组的差异以及质粒和转座子等移动遗传元件。
• 🔗 查看原文

3. ⭐ 空间组学 | CellGenomics | SpaLinker通过整合全基因组和空间测序数据识别与表型相关联的空间肿瘤微环境特征

• ✍️ 作者：BioJournal Link
• 🏷️ 关键词：肿瘤、测序、空间组学、基因组
• 🔗 查看原文

4. ⭐ Nature Aging：新型CAR-T细胞疗法，逆转并预防衰老相关肠道问题

• ✍️ 作者：生物世界
• 🏷️ 关键词：衰老、aging、T细胞、肠道
• 📝 描述：靶向uPAR的CAR-T细胞疗法
• 🔗 查看原文

5. ⭐ 8+干湿结合模板文章，结合分型和建模识别脂质代谢关键基因，进展增殖，凋亡，代谢和免疫微环境的实验验证！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、免疫微环境、代谢
• 🔗 查看原文

6. ⭐ 最新14+干湿结合SCI，作者鉴定出干扰素诱导的衰老 CD8T 细胞并揭示其对免疫治疗的影响。衰老虽老，但是真的火！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、衰老、T细胞
• 📝 描述：点击查看详情
• 🔗 查看原文

7. ⭐ 10.6分非肿瘤干湿结合生信，靶向 CD177 + 中性粒细胞减轻缺血再灌注损伤。适合动物建模测序思路！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、测序、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

8. ⭐ 各个发表的8分生信，基于铜死亡的肿瘤分型，结合WGCNA+机器学习+SCISSOR算法+单细胞+表达验证。其实一点也不难！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、单细胞、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

9. ⭐ Immunity：刘光慧、田烨等八位中外科学家共探衰老与免疫前沿

• ✍️ 作者：人体蛋白质组导航计划
• 🏷️ 关键词：免疫、immunity、衰老
• 🔗 查看原文

10. cNMF非负矩阵分解PBMC单细胞数据学习

• ✍️ 作者：单细胞天地
• 🏷️ 关键词：B细胞、单细胞
• 📝 描述：cNMF是对单细胞RNA测序数据优化的计算框架，通过共识非负矩阵分解解析基因表达程序。多层次输出体系从数学分解延伸至生物学解释，优化处理高维稀疏数据，采用共识框架确保稳定性，非负约束增强可解释性，探索复杂细胞群体功能。
• 🔗 查看原文

💡 该来源还有 24 条内容，详见 文末

详细内容（前10条）

1. ⭐ GSE310675 胰腺癌中KRAS抑制剂耐药机制的鉴定

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、resistance、KRAS
• 📝 描述：Contributor : Andrew M WatersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKRAS inhibitors (KRASi) targeting various KRAS mutations have entered clinical trials for pancreatic cancer. Despite promising preliminary clinical responses, most patients relapse due to intrinsic and acquired resistance. Thus, combination treatments are essential to extend the efficacy of KRAS-targeted therapies. To further determine genetic mechanisms of KRASi resistance, we performed KRASi-anchored CRISPR-Cas9 loss-of-function screens in KRAS G12D-, KRAS G12R-, and KRAS Q61H-mutant PDAC cell lines, using six KRASi, to identify genes, that when lost, modulate sensitivity to KRAS inhibition. We pharmacologically validated several hits from our screens, including EGFR, CK2 p110 alpha and p110 gamma, and YAP, by combining targeted inhibitors with KRASi. We determined that KRAS Q61H-mutant PDAC cell lines are intrinsically less dependent on KRAS for survival than other KRAS mutational subtypes. Further, we found that EGFR inhibitor erlotinib synergized with the RAS(ON) multi-selective inhibitor RMC-7977 in KRAS Q61H-mutant PDAC cell lines, and in cell lines with highly active EGFR, by mitigating ERK rebound activity. We also developed KRASi-resistant cell lines and observed sustained ERK MAPK dependence in the KRASi-resistant cell lines despite decreased ERK activity. Our findings enhance the understanding of KRASi intrinsic and acquired resistance and identify therapeutic vulnerabilities that can potentially be exploited for KRASi combination therapies in patients with PDAC.
• 🔗 查看原文

2. GSE311578 推进阿尔茨海默病个性化医疗：液体活检表观基因组学揭示APOE ε4连锁甲基化特征

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer、methylation
• 📝 描述：Contributor : Maite MendiorozSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensRecent studies show that patients with Alzheimer’s disease (AD) harbor specific methylation marks in the brain that, if accessible, could be used as epigenetic biomarkers. Liquid biopsy enables the study of circulating cell-free DNA (cfDNA) fragments originated from dead cells, including neurons affected by neurodegenerative processes. Here, we isolated and epigenetically characterized plasma cfDNA from 35 patients with AD and 35 cognitively healthy controls by using the Infinium® MethylationEPIC BeadChip array. Bioinformatics analysis was performed to identify differential methylation positions (DMPs) and regions (DMRs), including APOE ε4 genotype stratified analysis. Plasma pTau181 (Simoa) and cerebrospinal fluid (CSF) core biomarkers (Fujirebio) were also measured and correlated with differential methylation marks. Validation was performed with bisulfite pyrosequencing and bisulfite cloning sequencing. Epigenome-wide cfDNA analysis identified 102 DMPs associated with AD status. Most DMPs correlated with clinical cognitive and functional tests including 60% for Mini-Mental State Examination (MMSE) and 80% for Global Deterioration Scale (GDS), and with AD blood and CSF biomarkers. In silico functional analysis connected 30 DMPs to neurological processes, identifying key regulators such as SPTBN4 and APOE genes. Several DMRs were annotated to genes previously reported to harbor epigenetic brain changes in AD (HKR1, ZNF154, HOXA5, TRIM40, ATG16L2, ADAMST2) and were linked to APOE ε4 genotypes. Notably, a DMR in the HKR1 gene, previously shown to be hypermethylated in the AD hippocampus, was validated in cfDNA from an orthogonal perspective. These results support the feasibility of studying cfDNA to identify potential epigenetic biomarkers in AD. Thus, liquid biopsy could improve non-invasive AD diagnosis and aid personalized medicine by detecting epigenetic brain markers in blood.
• 🔗 查看原文

3. GSE283855 通过基于片段的发现直接靶向癌基因小眼畸形相关转录因子 (MITF) [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:onco(logy|logist|gene|genic)、RNA-seq
• 📝 描述：Contributors : Deborah Castelletti ; Fanny Mermet-Meillon ; Aurore Desplat ; Kayhan Gabriel Akyel ; Edward J Oakeley ; Ulrike Naumann ; Louise Barys ; Fei JiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite the improvement of therapeutic options for melanoma, patients with advanced metastatic disease are still in high need of durable and tolerated treatments. Analysis of clinical data from patients receiving targeted and/or immunotherapy, along with genetic and functional studies in preclinical melanoma models, show that lineage addiction to MITF is retained throughout disease progression, thus providing the rationale to pursue therapeutic inhibition of MITF. However, direct targeting of MITF or other basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors is unprecedented. Here, we report on the fragment-based discovery of high-affinity ligands for MITF. Fragment screening by NMR led to the discovery of weak binders to the kink pocket of MITF, which were optimized to sub-micromolar affinity by structure-based design enabled by crystallography and biophysics. Furthermore, NMR experiments and molecular dynamics simulations revealed a dynamic conformational exchange of the two helices in the asymmetric homodimer, which is perturbed by ligand binding. This work advances our knowledge on direct targeting of bHLH-LZ domains and sets the basis to further explore pharmacological inhibition of MITF.
• 🔗 查看原文

4. GSE280581 IDH2 突变引起的基因内表观遗传失调与 SRSF2 突变协同作用，导致关键转录调控因子的错误剪接 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、epigenetic
• 📝 描述：Contributors : Aristeidis G Telonis ; Maria E FigueroaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenes impacting DNA methylation (DNAme), like IDH2, are frequently co-mutated with splicing factors, like SRSF2, in acute myeloid leukemia (AML). These co-occurring mutations are associated with more aggressive phenotypes but the underlying molecular mechanisms remain elusive. To address this gap, we profiled wild-type, IDH2R140Q or SRSF2P95 single-mutants and IDH2R140Q/SRSF2P95 double-mutant AMLs at a deep resolution level. We find a unique set of mis-spliced genes and differentially methylated CpGs in double-mutants. Mis-spliced exons are enriched in CCNG splicing enhancers and in the corresponding DNAme changes. Using a machine-learning model, we can accurately predict exon inclusion levels from proximal CpGs. These CpGs are more likely to overlap with footprints of RNA-binding and chromatin-modifying complexes but not transcription factors. We also report unique gene expression profiles associated with each genotype; however, the differentially expressed genes do not overlap with mis-spliced transcripts. Instead, the mis-spliced genes encode for proteins that interact with the gene regulatory complexes that control the expression of these differentially expressed genes. Thus, we propose a mechanism where synergism between aberrant DNAme and splicing leads to the mis-splicing of key components in gene regulatory complexes, thus resulting in the aberrant gene expression profiles characteristic of these AMLs.
• 🔗 查看原文

5. GSE277137 单细胞RNA测序分析糖尿病对牙周炎宿主反应的影响

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、single-cell
• 📝 描述：Contributors : Bushra Alghamdi ; Min Liu ; Mi Zhou ; Michael Troka ; Michael Gonzalez ; Dana GravesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiabetes exert a disruptive immune respose process. We use single-cell RNA-sequencing (scRNA-seq) data from gingiva from normalglycemic and diabetic mice to investigate the impact of diabetes on immune cells and to understand their role in host response.
• 🔗 查看原文

6. GSE260926 人类膝关节发育的单细胞多组测序和单细胞空间高清数据

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、spatial
• 📝 描述：Contributors : G Senevirathne ; Andrew Zhu ; Divya Venkatasubramanian ; Terence D Capellini ; April M CraftSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCartilage plays a crucial role in skeletal development and function, and abnormal development contributes to genetic and age-related skeletal disease. Compromises to the integrity of joint-lining articular cartilage in particular lead to debilitating chronic degenerative diseases including osteoarthritis. To better understand how human articular cartilage develops in vivo, we jointly profiled the transcriptome and open chromatin regions in individual nuclei recovered from distal femora at 2 fetal timepoints. We used these multiomic data to predict transcription factor-based regulatory networks that are important for articular chondrocyte differentiation. We developed a human pluripotent stem cell platform for interrogating the function of predicted transcription factors during chondrocyte differentiation and identified new biological roles for CREB5. We expect new regulatory networks we uncovered using multiomic data to be important for promoting cartilage health and treating disease, and our platform to be a useful tool for studying cartilage development in vitro.
• 🔗 查看原文

7. GSE275343 持续存在的 STAT3 相关染色质构象内的协调基因表达促进肝细胞癌进展 [CHIP-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、ChIP-seq
• 📝 描述：Contributors : Sunyoung Jang ; Sumin Yoon ; Kyung H YooSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensp-STAT3 has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression; however, its role in 3D chromatin architecture and the expression of genes linked to HCC aggressiveness remains largely unexplored. Here, we elucidate the function of p-STAT3 in establishing stable regulatory regions known as FIREs, characterized by highly active interactions and the potential to alter topologically associated domains (TADs). Our results demonstrate that expression of genes located within FIREs is highly correlated, and upregulation, these genes play a crucial role in driving phenotypes, including HCC invasion and tube formation. Notably, p-STAT3-associated FIREs maintain chromatin activation despite pharmacological interventions targeting STAT3, suggesting a mechanism that failure to suppress the expression of genes associated with HCC aggressiveness leads to drug resistance. These findings provide novel insights into how the 3D genome structure associated with p-STAT3 promotes HCC progression and drug resistance, highlighting the therapeutic potential of targeting 3D chromatin dynamics in HCC.
• 🔗 查看原文

8. GSE275342 持续存在的 STAT3 相关染色质构象内的协调基因表达促进肝细胞癌进展 [RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、RNA-seq
• 📝 描述：Contributors : Sunyoung Jang ; Sumin Yoon ; Kyung H YooSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensp-STAT3 has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression; however, its role in 3D chromatin architecture and the expression of genes linked to HCC aggressiveness remains largely unexplored. Here, we elucidate the function of p-STAT3 in establishing stable regulatory regions known as FIREs, characterized by highly active interactions and the potential to alter topologically associated domains (TADs). Our results demonstrate that expression of genes located within FIREs is highly correlated, and upregulation, these genes play a crucial role in driving phenotypes, including HCC invasion and tube formation. Notably, p-STAT3-associated FIREs maintain chromatin activation despite pharmacological interventions targeting STAT3, suggesting a mechanism that failure to suppress the expression of genes associated with HCC aggressiveness leads to drug resistance. These findings provide novel insights into how the 3D genome structure associated with p-STAT3 promotes HCC progression and drug resistance, highlighting the therapeutic potential of targeting 3D chromatin dynamics in HCC.
• 🔗 查看原文

9. GSE311580 空间多组学分析揭示了MRP驱动的儿童ARDS免疫和血管功能障碍

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、spatial
• 📝 描述：Contributors : Gabrielle Antonio-Carreon ; Fernando Guimaraes ; Arutha Kulasinghe ; Ahmed MehdiSeries Type : OtherOrganism : Homo sapiensDSP RNA profling using the whole transcriptome atlas kit was performed on a cohort of ARDS and uninfected lung samples from paediatric patients.
• 🔗 查看原文

10. GSE311547 利用 CHANGE-seq-BE 对碱基编辑器诱导的脱靶活性进行灵敏且无偏倚的全基因组分析 [ABE 靶标的 gRNA 测序]

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、genome
• 📝 描述：Contributors : Varun Katta ; Yichao Li ; Shengdar TsaiSeries Type : OtherOrganism : synthetic constructTo identify potential contaminating gRNAs, we adapted a gRNA sequencing assay based on an established SMARTer smRNA sequencing technology. We evaluated five research-grade gRNAs from three synthetic gRNA manufacturer suppliers (A, B and C). We detected the presence of contaminating gRNAs in CBLB and CIITA gRNAs from supplier A (batch 1), with frequency ranging from 0.09% to 2.71%.
• 🔗 查看原文

💡 该来源还有 34 条内容，详见 文末

详细内容（全部3条）

1. 癌症青少年和年轻成人转移性复发

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 重要性 尽管治疗取得了进步，转移性复发仍是导致发病和死亡率的主要原因。关于转移性复发后发生率和存活率的实证数据仍然有限，因为癌症登记机构历来不收集复发数据。目的：估算被诊断为早期疾病青少年和青年的转移复发累计发生率（CMI），并比较诊断时与转移性疾病的生存率。设计、地点、参与者 这是一项回顾性队列研究，对象为 2006 年至 2018 年间诊断为非转移性癌症的 15 至 39 岁青少年和青年。青少年和年轻成人是从加州癌症登记处识别的，这些登记处与加州医疗服务部的住院、急诊和门诊手术接触相关联。数据分析时间为 2023 年 12 月至 2025 年 6 月。暴露 癌症类型，包括黑色素瘤、肉瘤以及乳腺癌、宫颈癌、结直肠癌、睾丸癌和甲状腺癌。主要结局和指标 转移性复发通过国际疾病分类第九版及第十版临床修订版确定，转移性疾病代码在癌症诊断后至少 6 个月或由潜在癌症死因确定。随访持续至 2020 年
• 🔗 查看原文

2. 酪氨酸激酶抑制剂中的洛拉替尼-未发现的晚期 ROS1 阳性非小细胞肺癌：一项二期非随机临床试验。

• ✍️ 作者：未知作者
• 🏷️ 关键词：激酶
• 📝 描述：Secret hovertext: 重要性 ROS1 重排较为罕见，但在晚期非小细胞肺癌（NSCLC）中是一个有吸引力的治疗靶点。克里佐替尼、恩曲替尼和雷波替尼已获美国食品药品监督管理局批准用于治疗 ROS1 阳性 NSCLC 的药物。洛拉替尼是一种脑穿透剂、第三代酪氨酸激酶抑制剂（TKI），靶向 ROS1 和 ALK;然而，其对晚期 ROS1 阳性患者的疗效和安全性尚不清楚。目的：评估洛拉替尼对晚期 ROS1 阳性非小细胞肺癌患者从未接受任何 TKI 治疗的疗效和安全性。设计、环境与参与者 该多中心第二期非随机临床试验招募了晚期 ROS1 阳性 NSCLC 患者，且未接受 TKI，东部合作肿瘤组表现状态不超过 2，且既往接受过 1 次或无铂类化疗。参与者于 2019 年 6 月至 2023 年 4 月招募，并持续跟踪至 2024 年 8 月。数据分析于 2025 年 4 月 5 日至 8 月 30 日进行。干预措施：洛拉替尼每日
• 🔗 查看原文

3. 青少年和年轻成人癌症的转移复发是早期死亡的关键驱动因素。

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext:
• 🔗 查看原文

详细内容（全部3条）

1. scKGBERT——一种用于单细胞转录组学的知识增强型基础模型

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、transcriptomics
• 📝 描述：scKGBERT combines large scale RNA sequencing data with protein interaction networks to improve biomarker discovery and cell characterization for precision medicine…
• 🔗 查看原文

2. RNA测序揭示脑蛋白OTULIN如何控制tau蛋白表达，并可能彻底改变阿尔茨海默病的治疗。

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer、RNA-seq
• 📝 描述：Researchers reveal OTULIN as a key regulator of tau production and RNA sequencing signatures in neurons, uncovering new therapeutic opportunities for Alzheimer’s disease and related tauopathies…
• 🔗 查看原文

3. Lexogen 和 Ochre Bio 推进大规模 RNA 测序技术，以加速功能基因组学和 RNA 疗法的发现。

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing、genomics
• 📝 描述：Lexogen and Ochre Bio generated large-scale functional genomics data from human hepatocytes, delivering high-fidelity RNA sequencing to advance AI-driven target…
• 🔗 查看原文

• 基因组比较分析不再复杂！gggenomes包，助你快速绘制多层次基因组图谱，秒变生信可视化高手！
• 最新11+生信，聚焦基质细胞-免疫细胞的互作网络。本文实验完美证实生信结果，干湿结合恰到好处！
• 纯生信分析的天花板！哈医大利用多组学+泛癌分析，还能融合单细胞，拿下6分SCI实至名归！
• IF=44: 7种空间组学平台,10种癌症类型,逾1400万个细胞进行跨平台整合分析
• 新免疫调节功能！苏州大学附属第四医院等单位发文：有前景的抗肿瘤治疗靶点
• 四川大学赵星/郭冰/肖雄/张菊英团队分析36万人2911种血浆蛋白，揭示五种不同共暴露模式影响心血管代谢疾病的机制
• 好思路这就水灵灵地出来了！温医大免疫细胞特异分析，小成本发高分也不难实现！
• 氨基酸代谢是真的火，干湿结合轻松发7.5分2区文章。现在下手还不晚！
• 黄芩苷-白藜芦醇自组装纳米药多通路逆转RSV肺炎
• Nat Methods | 首次系统绘制非人灵长类全身多组学衰老图谱！孔庆鹏/潘兴华团队揭秘为什么有的器官老的更快！
• 有望开启癌症治疗新纪元：林圣彩院士证实，模拟饥饿的“辟谷精”可让肝癌终身可控
• 单细胞注释太难？这篇全网最全指南让你从此不迷茫！
• 聚焦衰老，中科院刘光慧团队连获突破！
• 67分巨作，带你用爆火的代谢重编程实现弯道超车
• Cell Genom最新力作！多组学+孟德尔随机化分析，破解血清代谢物与慢性疾病的遗传关联！
• 28 样本 IF40.4！解密王红阳院士团队的单细胞创新密码
• 最新27+生信，原来只做了这些操作！
• 肝病学顶刊【Journal of Hepatology】重磅推出：胆汁酸调控Treg细胞-胆管疾病治疗新靶点
• 胡战利/董孟杰团队：首次系统描绘血糖异常进展过程中的多器官代谢网络动态重塑图谱
• Neuron：浙江中医药大学陈忠/郑艳榕团队破解「脂肪诱惑」的专属神经密码
• 这个生信思路可以学，科学问题都细化了。还能靠组学发，不需要做机制。
• 为什么只有25%的患者有效？深挖110例临床数据，终于找到了决定胃癌免疫治疗成败的“空间钥匙”！
• 巨噬细胞的常见14种功能表型，检测方法和研究思路盘点，你都知道吗？
• Cell重磅：华人学者证实，压力不仅让你掉头发，还会引发自身免疫，埋下长期脱发隐患

• GSE308805 CDCA7 促进 MET1 介导的着丝粒周围和着丝粒染色质的 CG 甲基化维持 [RNA-seq]
• GSE303706 黎巴嫩溃疡性结肠炎患者和健康对照组的肠道菌群分析：一项初步研究
• GSE290148 DNA甲基化缺失的秀丽隐杆线虫中MBD-2的基因组定位和功能[RNA-Seq]
• GSE290147 DNA甲基化缺失的秀丽隐杆线虫中MBD-2的基因组定位和功能[ChIP-Seq]
• GSE311623 RNAseq 分析了转染靶向 INPPL1 的 siRNA (siSHIP2) 和非靶向 siRNA (siCT) 的 eSCC 人类细胞系 (KYSE-410 和 KYSE-30) 的情况。
• GSE311620 RNA测序分析了经SHIP2药理抑制剂处理的eSCC人细胞系（KYSE-410）的RNA表达谱。
• GSE308255 矮牵牛花瓣身份调节因子 PhDEF 的细胞层特异性功能 [ChIP-seq]
• GSE283857 通过基于片段的发现直接靶向癌基因小眼畸形相关转录因子 (MITF)
• GSE283856 通过基于片段的发现直接靶向癌基因小眼畸形相关转录因子 (MITF) [Cut & Tag]
• GSE280562 IDH2 突变引起的基因内表观遗传失调与 SRSF2 突变协同作用，导致关键转录调控因子的错误剪接 [BiSulfite-seq]
• GSE240460 分子可塑性导致幼年型骨髓单核细胞白血病中的癌胚重编程和治疗脆弱性
• GSE235533 同种异体反应性和自身反应性汇聚，支持B细胞表位靶向
• GSE311675 SHIP2-PLK1 串扰促进食管鳞状细胞癌对双重抑制的敏感性
• 利用 CRISPR/Cas9 技术敲除 SHIP2 基因的 eSCC 人细胞系 (KYSE-410) 的 RNA 测序分析 GSE311621
• GSE307191 碱基对分辨率染色体构象捕获揭示染色质结构本质的机制性见解 [ChIP-seq]
• GSE298629 Lrig1静止干细胞群的单细胞转录组分析
• GSE289504 致病岛转录诱导域相关的细菌染色质重塑。
• GSE285035 代谢调控使酵母能够立即适应能量胁迫
• GSE281414 碱基对分辨率染色体构象捕获揭示染色质结构本质的机制见解 [ATAC-Seq]
• GSE275344 持续存在的 STAT3 相关染色质构象内的协调基因表达促进肝细胞癌进展 [HiChIP]
• GSE271136 化疗耐药细胞群的分子特征可改善儿童急性髓系白血病 (AML) 的风险分层和治疗反应预测 [pAML PDX scRNA-seq]
• GSE271134 化疗耐药细胞群的分子特征可改善儿童急性髓系白血病 (AML) 的风险分层和治疗反应预测 [pAML PDX Bulk RNA-seq]
• GSE270894 化疗耐药细胞群的分子特征可改善儿童急性髓系白血病 (pAML) 的风险分层和治疗反应预测 [pAML 患者 scRNA-seq]
• GSE270892 化疗耐药细胞群的分子特征可改善儿童急性髓系白血病 (pAML) 的风险分层和治疗反应预测 [pAML 患者批量 RNA 测序]
• GSE236265 YAP靶向TEAD4-NF-κB复合物并抑制ccRCC肿瘤生长
• GSE79936 秀丽隐杆线虫的 X 染色体交叉形成和基因组稳定性受 xnd-1 独立调控
• GSE311188 先前高纤维摄入对肠系膜脂肪和肠道组织对随后高脂肪喂养的细胞反应产生影响 [16s rRNA-seq]
• GSE311074 COPG1 是癌症进展和化疗耐药性的选择性必需调控因子：一项全面的泛癌研究
• GSE310739 鲸类单核 RNA 测序将心脏保护基因 FHL2 定位为推进猪到人心脏异种移植的靶点
• GSE308807 CDCA7 促进 MET1 介导的着丝粒周围和着丝粒染色质的 CG 甲基化维持 [BiSulfite-seq]
• GSE293406 YKT6 通过 USP7 介导的去泛素化作用稳定 β-catenin，从而促进膀胱癌进展
• GSE283329 精神分裂症患者唾液微生物群失调和代谢紊乱
• GSE282991 死后间隔估计的microRNA转录组分析
• GSE282620 DGP1家族成员通过整合两种环境信号介导水稻的大规模代谢重塑