详细内容（前10条）

1. ⭐ 7+单基因生信，2026年单基因如何发文？大量空间转录组分析必不可少！

• ✍️ 作者：东晓生物
• 🏷️ 关键词：空间转录组、基因组、转录组、生信
• 🔗 查看原文

2. ⭐ Nat Cancer | 白血病免疫逃逸机制揭示，抗体恢复T细胞攻击能力

• ✍️ 作者：图灵基因
• 🏷️ 关键词：cancer、免疫、T细胞、抗体
• 📝 描述：尽管免疫疗法取得重大进展，白血病治疗领域仍进展有限。急性髓系白血病（AML）始终能抵抗免疫治疗，这反映出我们对白血病细胞如何逃逸免疫系统攻击的认识仍不全面。Lund大学的研究人员近日揭穿了其中一种逃逸伎俩，并成功找到破解之道。
• 🔗 查看原文

3. ⭐ 不学真的血亏！ropls包，三行代码轻松搞定多变量分析，快速掌握代谢组学数据可视化！

• ✍️ 作者：云生信
• 🏷️ 关键词：代谢、代谢组、R包
• 🔗 查看原文

4. ⭐ 8+干湿结合模板文章，结合分型和建模识别脂质代谢关键基因，进展增殖，凋亡，代谢和免疫微环境的实验验证！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、免疫微环境、代谢
• 🔗 查看原文

5. ⭐ 最新14+干湿结合SCI，作者鉴定出干扰素诱导的衰老 CD8T 细胞并揭示其对免疫治疗的影响。衰老虽老，但是真的火！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、衰老、T细胞
• 📝 描述：点击查看详情
• 🔗 查看原文

6. ⭐ 10.6分非肿瘤干湿结合生信，靶向 CD177 + 中性粒细胞减轻缺血再灌注损伤。适合动物建模测序思路！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、测序、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

7. ⭐ 单细胞+空间多组学揭示癌症相关成纤维细胞的保守空间亚型与细胞邻域

• ✍️ 作者：作图丫
• 🏷️ 关键词：癌症、单细胞、空间组学
• 📝 描述：最近有小伙伴反映收不到推送，因为公众号改了推送算法，现在需要加星标，多点赞、点在看，才能准时收到推送哦。
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8. ⭐ 单细胞+空转+代谢组，公开数据集找出亮点就能发1区12分

• ✍️ 作者：生信人
• 🏷️ 关键词：代谢、代谢组、单细胞
• 🔗 查看原文

9. ⭐ Cancer Cell重磅：肿瘤竟被自己人背刺！突变引爆免疫治疗

• ✍️ 作者：生信人
• 🏷️ 关键词：肿瘤、cancer、免疫
• 📝 描述：10月16日，Cancer Cell发表了德州大学MD安德森癌症中心Padmanee Sharma教授团队的重
• 🔗 查看原文

10. ⭐ Nature免疫学综述 |这绝对是生信宝藏。T细胞新的亚群名称层出不穷，该咋注释，看看T细胞命名专家指南共识

• ✍️ 作者：生信钱同学
• 🏷️ 关键词：免疫、T细胞、生信
• 📝 描述：T细胞注释国际共识指南，绝对重点
• 🔗 查看原文

💡 该来源还有 33 条内容，详见 文末

详细内容（前10条）

1. GSE310880 靶向 MEK/ERK 通路抑制 P-糖蛋白并逆转多发性骨髓瘤的卡非佐米耐药性

• ✍️ 作者：未知作者
• 🏷️ 关键词：resistance、pathway
• 📝 描述：Contributors : Lidia Laletina ; Anastasiia Cherkasova ; Ekaterina Scherbakova ; Pavel Iamshchikov ; Natalia Koroleva ; Anna Lushnikova ; Alexey Komissarov ; Nikolay Kalitin ; Natalia MoiseevaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCarfilzomib (CFZ) is a cornerstone in the treatment of relapsed multiple myeloma (MM). However, its efficacy is limited by resistance mediated by the overexpression of the ABC-transporter P-glycoprotein (P-gp).The signaling pathways driving emergence of P-gp in MM remain unclear. To investigate this, we generated CFZ-resistant AMO-1/CFZ cells with P-gp overexpression by long-term selection. RNA sequencing of control AMO-1 and AMO-1/CFZ, sorted into two subpopulations P-gp HIGH and P-gp LOW, implicated the Ras/MEK/ERK pathway as the most likely signaling cascade involved in P-gp upregulation. We therefore evaluated two clinically used MAPK pathway inhibitors, cobimetinib and ulixertinib, for their ability to re-sensitize AMO-1/CFZ cells to CFZ. Co-administration at non-toxic concentrations enhanced sensitivity 5-fold with cobimetinib and 17-fold with ulixertinib. Analysis of combined MTT assay results, rhodamine efflux experiments, molecular docking, and western blotting revealed distinct actions. Ulixertinib primarily functions as a potent direct P-gp inhibitor. Conversely, non-toxic concentrations of cobimetinib sensitizes cells by suppressing MAPK signaling, though it also exhibits P-gp inhibition at higher concentrations. Both inhibitors at the IC₅₀ concentration reduced P-gp expression. In conclusion, combining CFZ with MAPK pathway inhibitors like cobimetinib or ulixertinib represents a promising strategy to overcome P-gp-mediated resistance in ММ.
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2. GSE309876 埃及伊蚊小RNA基因组学发现可触发RNA干扰反应的感染性病毒[RNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、genomics
• 📝 描述：Contributors : Shruti Gupta ; Rohit Sharma ; Adeline Williams ; Irma Sanchez-Vargas ; Noah Rose ; Chao Zhang ; Alexander Crosbie-Villaseca ; Margarita Kyza-Karavioti ; Zheng Zhu ; Gargi Dayama ; Andrea Gloria-Soria ; Doug Brackney ; Jessica Manning ; Sarah Wheeler ; Angela Caranci ; Trinidad Reyes ; Massamba Sylla ; Athanase Badolo ; Jewelna Akorli ; Ogechukwu Aribodor ; Diego Ayala ; Wei-Liang Liu ; Chung-Hong Chen ; Chalmers Vasquez ; Cassandra Acosta ; Alongkot Ponlawat ; Tereza Magalhaes ; Brendan Carter ; Dawn Wesson ; Darred Surin ; Meg Younger ; Andre Costa-da-Silva ; Matthew DeGennaro ; Alexander Bergman ; Louis Lambrechts ; Carolyn McBride ; Ken Olson ; Eric Calvo ; Nelson LauSeries Type : Expression profiling by high throughput sequencingOrganism : Aedes aegypti ; Aedes albopictusWe report a global survey of viral small RNAs (vsmRNAs) from >200 Aedes aegypti samples to identify many mosquito viruses that actively infect this prominent arboviral vector. Ae. aegypti viruses in the Americas were abundant, with some displaying geographical boundaries. Viruses infecting Asian Ae. aegypti were similar to those in the Americas and revealed the first wild example of dengue vsmRNAs. African Ae. aegypti displayed vsmRNAs from viruses unique to these African strains. Academic lab colonies generally lacked viruses, yet two commercial strains were deeply infected by a tombus-like virus that is related to plant viruses. Comparing matched viral long RNAs to vsmRNAs revealed viral transcripts evading the mosquito RNA interference (RNAi) pathway. By infecting mosquito cells with Ae. aegypti homogenates, we generated stably infected cell lines which produced vsmRNAs that were comparable to native mosquito vsmRNA patterns. Lastly, we demonstrate that these stably infected mosquito cells producing vsmRNAs can exert gene silencing of reporters bearing viral sequence segments, providing a potential explanation for how Ae. aegypti can tolerate the persistence of viral infections. This vsmRNA genomics approach in Ae. aegypti can add to existing vector surveillance approaches by discovering new viruses that persist in mosquito populations.
• 🔗 查看原文

3. GSE310321 丙酮酸激酶肌肉型 (PKM)-2 通过在稳态和扩增过程中调节丙酮酸氧化来促进 CD4 T 细胞存活

• ✍️ 作者：未知作者
• 🏷️ 关键词：T cell、kinase
• 📝 描述：Contributors : Jeff J Subleski ; Erika M Palmieri ; Jessica F Walls ; Steven Hsu ; Ian A Bettencourt ; Timothy R Gower ; Scott K Durum ; Daniel W McVicarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGlycolysis is an essential metabolic pathway for rapidly expanding T cells, but role of Pyruvate Kinase Muscle (PKM) 1 and 2 in regulating this process is underappreciated. Here, using a pharmacological activator and targeted deletion of PKM2 in T cells we delineated distinct functions of PKM1 and 2 in regulating CD4 T cell survival during homeostasis and expansion. Expanding PKM2-deficient CD4 T cells increased PKM1 expression with associated mitochondrial ROS-mediated cell death. Examination of T cell compartments revealed PKM2-deficient CD4 T cells were unaltered in the thymus but were significantly reduced in peripheral tissues as mice aged. The failure of PKM1 to protect CD4 T cells in the absence of PKM2 resulted in protection from T cell mediated colitis as pathogenic cell numbers were significantly reduced resulting in less severe disease compared to control cells. This study shows PKM2 is critical for CD4 T cell survival during expansion and homeostasis.
• 🔗 查看原文

4. GSE305636 单细胞定位与检查点免疫疗法反应相关的可变剪接

• ✍️ 作者：未知作者
• 🏷️ 关键词：regex:immuno(logy|therapy|suppression)、single-cell
• 📝 描述：Contributors : Jieyi Xiong ; Chen Gu ; Diether LambrechtsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEvidence suggests that alternative RNA splicing (AS) plays a critical role in tumor biology and may contribute to the generation of tumor antigens. Here, we develop a method to detect AS in short-read single-cell 5’-RNA-sequencing data, allowing us to uniquely characterize the heterogeneity and dynamic changes in AS in individual cell types within the tumor microenvironment. We identify numerous splicing events specific to either cancer cells or stromal cell types, or for triple-negative versus estrogen receptor-positive breast cancers. By correlating these splice events with expression of splicing regulators in individual cells, we also identify their potential mediators. For instance, we identify and functionally validate the Epithelial Splicing Regulatory Protein-1 (ESRP1) to drive AS in breast cancers responding to immune checkpoint blockade (ICB). Prioritization of splicing events based on their likelihood to represent tumor antigens reveals that their aggregated load also correlates with high immune activity in multiple cancers, while also predicting expansion of T-cells in breast cancers receiving ICB and prolonging long-term survival of cancer patients treated with ICB. Collectively, our method provides a framework for analyzing AS in single-cell data and defines a key role for AS in the response to ICB.
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5. GSE252237 人类小胶质细胞中与 21 三体相关的热点 CSF2RB 突变赋予对阿尔茨海默病的抵抗力 (scRNA-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer、scRNA
• 📝 描述：Contributors : Mengmeng Jin ; Ziyuan Ma ; Peng JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWhile challenging, identifying individuals displaying resilience to Alzheimer’s disease (AD) and understanding the underlying mechanism holds great promise for the development of new therapeutic interventions to effectively treat AD. Recent studies indicate that somatic mutations in hematopoietic cells may lead to both the instigation and resilience to neurodegeneration. Down syndrome (DS), or trisomy 21, is the most significant genetic risk factor for AD. Interestingly, some DS individuals show resilience to AD neuropathology and do not exhibit dementia signs. Notably, DS individuals face a heightened risk of myeloid leukemia due to somatic mutations in hematopoietic cells. Microglia dysfunction is a central mechanism in AD etiology. Here we hypothesize that somatic mutations associated with DS myeloid leukemia may impart resilience to microglia against AD. Using CRISPR-Cas9 gene editing, we introduce a DS-linked hotspot CSF2RB A455D mutation into human pluripotent stem cell (hPSC) lines derived from both DS and healthy individuals. Employing hPSC-based in vitro microglia culture and in vivo human microglia chimeric mouse brain models, we show that in response to pathological tau, the CSF2RB A455D mutation suppresses type-1 interferon signaling in both DS and control human microglia, independent of trisomy 21 genetic background. This mutation also reduces neuroinflammation and enhances phagocytic and autophagy functions, ameliorating senescent and dystrophic changes in human microglia. Furthermore, the CSF2RB A455D mutation promotes the development of a microglia subcluster with tissue repair properties. Importantly, human microglia carrying CSF2RB A455D provide protection to neuronal function, such as neurogenesis and synaptic plasticity. When co-transplanted into the same mouse brains, human microglia with CSF2RB A455D mutation phagocytize, outcompete, and gradually replace human microglia carrying the wildtype CSF2RB gene following pathological tau treatment. Our findings suggest the potential use of hPSC-derived CSF2RB A455D microglia to develop effective microglial replacement therapy for AD and other age-related neurodegenerative diseases, even without the need of depleting endogenous senescent microglia prior to cell transplantation.
• 🔗 查看原文

6. GSE252236 人类小胶质细胞中与 21 三体综合征相关的热点 CSF2RB 突变赋予其对阿尔茨海默病的抵抗力（批量 RNA 测序）

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer、RNA-seq
• 📝 描述：Contributors : Mengmeng Jin ; Ziyuan Ma ; Peng JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile challenging, identifying individuals displaying resilience to Alzheimer’s disease (AD) and understanding the underlying mechanism holds great promise for the development of new therapeutic interventions to effectively treat AD. Recent studies indicate that somatic mutations in hematopoietic cells may lead to both the instigation and resilience to neurodegeneration. Down syndrome (DS), or trisomy 21, is the most significant genetic risk factor for AD. Interestingly, some DS individuals show resilience to AD neuropathology and do not exhibit dementia signs. Notably, DS individuals face a heightened risk of myeloid leukemia due to somatic mutations in hematopoietic cells. Microglia dysfunction is a central mechanism in AD etiology. Here we hypothesize that somatic mutations associated with DS myeloid leukemia may impart resilience to microglia against AD. Using CRISPR-Cas9 gene editing, we introduce a DS-linked hotspot CSF2RB A455D mutation into human pluripotent stem cell (hPSC) lines derived from both DS and healthy individuals. Employing hPSC-based in vitro microglia culture and in vivo human microglia chimeric mouse brain models, we show that in response to pathological tau, the CSF2RB A455D mutation suppresses type-1 interferon signaling in both DS and control human microglia, independent of trisomy 21 genetic background. This mutation also reduces neuroinflammation and enhances phagocytic and autophagy functions, ameliorating senescent and dystrophic changes in human microglia. Furthermore, the CSF2RB A455D mutation promotes the development of a microglia subcluster with tissue repair properties. Importantly, human microglia carrying CSF2RB A455D provide protection to neuronal function, such as neurogenesis and synaptic plasticity. When co-transplanted into the same mouse brains, human microglia with CSF2RB A455D mutation phagocytize, outcompete, and gradually replace human microglia carrying the wildtype CSF2RB gene following pathological tau treatment. Our findings suggest the potential use of hPSC-derived CSF2RB A455D microglia to develop effective microglial replacement therapy for AD and other age-related neurodegenerative diseases, even without the need of depleting endogenous senescent microglia prior to cell transplantation.
• 🔗 查看原文

7. GSE310970 胎儿脑组织 RNA 测序，DSS 处理组或 DSS+ Gsdmd-cko 组

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe maternal mice had two genotypes: wild-type (WT) and conditional knockout of intestinal epithelial Gsdmd (Gsdmd cko). Pregnant mice were treated with DSS starting on gestational day 9.5 (GD9.5) for 4 days, and immediately afterward, the cortex of fetuses at embryonic day 13.5 (E13.5) was dissected for RNA sequencing.
• 🔗 查看原文

8. GSE310969 妊娠小鼠结肠上皮细胞测序

• ✍️ 作者：未知作者
• 🏷️ 关键词：sequencing
• 📝 描述：Contributor : Huiyang JiaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing was performed on the colorectal epithelium of pregnant mice in the normal group and the colitis group. For the colitis group, pregnant mice were treated with 2.5% DSS for 4 days starting on embryonic day 9.5 (E9.5); subsequently, CD326+ CD45- cells were sorted by flow cytometry for RNA sequencing.
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9. GSE309873 埃及伊蚊小RNA基因组学发现可触发RNA干扰反应的感染性病毒[miRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：genomics
• 📝 描述：Contributors : Shruti Gupta ; Rohit Sharma ; Adeline Williams ; Irma Sanchez-Vargas ; Noah Rose ; Chao Zhang ; Alexander Crosbie-Villaseca ; Margarita Kyza-Karavioti ; Zheng Zhu ; Gargi Dayama ; Andrea Gloria-Soria ; Doug Brackney ; Jessica Manning ; Sarah Wheeler ; Angela Caranci ; Trinidad Reyes ; Massamba Sylla ; Athanase Badolo ; Jewelna Akorli ; Ogechukwu Aribodor ; Diego Ayala ; Wei-Liang Liu ; Chung-Hong Chen ; Chalmers Vasquez ; Cassandra Acosta ; Alongkot Ponlawat ; Tereza Magalhaes ; Brendan Carter ; Dawn Wesson ; Darred Surin ; Meg Younger ; Andre Costa-da-Silva ; Matthew DeGennaro ; Alexander Bergman ; Louis Lambrechts ; Carolyn McBride ; Ken Olson ; Eric Calvo ; Nelson LauSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Aedes aegypti ; Aedes albopictusWe report a global survey of viral small RNAs (vsmRNAs) from >200 Aedes aegypti samples to identify many mosquito viruses that actively infect this prominent arboviral vector. Ae. aegypti viruses in the Americas were abundant, with some displaying geographical boundaries. Viruses infecting Asian Ae. aegypti were similar to those in the Americas and revealed the first wild example of dengue vsmRNAs. African Ae. aegypti displayed vsmRNAs from viruses unique to these African strains. Academic lab colonies generally lacked viruses, yet two commercial strains were deeply infected by a tombus-like virus that is related to plant viruses. Comparing matched viral long RNAs to vsmRNAs revealed viral transcripts evading the mosquito RNA interference (RNAi) pathway. By infecting mosquito cells with Ae. aegypti homogenates, we generated stably infected cell lines which produced vsmRNAs that were comparable to native mosquito vsmRNA patterns. Lastly, we demonstrate that these stably infected mosquito cells producing vsmRNAs can exert gene silencing of reporters bearing viral sequence segments, providing a potential explanation for how Ae. aegypti can tolerate the persistence of viral infections. This vsmRNA genomics approach in Ae. aegypti can add to existing vector surveillance approaches by discovering new viruses that persist in mosquito populations.
• 🔗 查看原文

10. GSE305595 单细胞转录组图谱揭示小鼠下颌软骨中骨骼祖细胞的层级结构和区域模式

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell
• 📝 描述：Contributors : Ikue Tosa ; Wakana Kitagawa ; Benjamin Kheyfets ; Ziyi Wang ; Hyerin Yoon ; Evan Stipano ; Mitsuaki Ono ; Mildred C EmbreeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal and synovial joint development involves distinct skeletal stem/progenitor populations. However, in neural crest-derived temporomandibular joint (TMJ), skeletal stem/progenitor lineage dynamics and ossification programs remain poorly defined. Here, we performed single-cell RNA sequencing (scRNA-seq) on mouse mandibular cartilage at embryonic day 16.5 (E16.5), postnatal day 0 (P0), and 13 weeks to construct a high-resolution atlas of skeletal stem/progenitor populations. The outer perichondrium lining the mandibular cartilage contained Lgr5⁺Pthlh⁺ cells expressing Dlx5, suggesting intramembranous ossification. In contrast, a previously uncharacterized Crabp1⁺ subpopulation within the inner perichondrium expressed Nrg1, Lsamp, Tac1, and Igfbp5, consistent with early cartilage progenitors biased toward endochondral ossification. These results reveal a spatial division of ossification modes with both intramembranous and endochondral growth and clarify the transcriptional regulation underlying TMJ development. Our findings provide a framework for understanding neural crest–derived skeletal stem/progenitor cell regulation and may inform cartilage regenerative strategies.
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1. ⭐ 癌症相关成纤维细胞通过 PGK1 介导的代谢重编程促进胃肠道间质肿瘤中的伊马替尼耐药性

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、癌症、代谢、耐药、肠道
• 📝 描述：Secret hovertext: 胃肠道间质肿瘤（GIST）是胃肠道最常见的肉瘤，主要由激活下游信号通路（包括 PI3K/AKT/mTOR）的 c-KIT 或 PDGFRA 突变驱动。虽然伊马替尼（一种一线酪氨酸激酶抑制剂 TKI）初期有效，但 20 个月内约 50%的患者出现耐药性。二线和三线 TKIs，如舒尼替尼和雷戈拉非尼，疗效有限，凸显了迫切需要解决耐药机制。此前的研究主要聚焦于耐药性的遗传驱动因素，忽视了肿瘤微环境（TME）的作用。本研究中，我们确定了癌症相关成纤维细胞（CAFs）在驱动伊马替尼耐药性中的作用。具体来说，CAFs 分泌的 TGF-β1 增强了 CCN2/Rack1 信号。CCN2/Rack1 轴激活 PI3K/AKT 信号，诱导 PGK1 的磷酸化和线粒体翻译，促进支持肿瘤存活和耐药性的代谢重编程。共培养模型和单细胞 RNA 测序揭示了不同的 CAF 亚型，并显示 CAF 分泌的 TGF-β1 增
• 🔗 查看原文

2. ⭐ 耗尽的 T 细胞对 TNFR2 的上调先于 TOX 表达，限制抗肿瘤和抗病毒免疫

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、免疫、T细胞
• 📝 描述：Secret hovertext: 目的：耗尽代表一系列程序化的 T 细胞分化状态，也是 T 细胞功能障碍的重要模式。T 细胞从前体细胞进展到终末耗尽与转录因子 TOX 的上调有关。然而，我们对调控 TOX 表达及从前体向终末耗尽转变的因素的理解仍然不完整。实验设计：采用单细胞 RNA 测序评估肿瘤浸润型人类和小鼠 CD8+ T 细胞中 TNF 受体的表达情况。利用流式细胞术评估 CD8+ T 细胞上的耗尽标志物和 TNF 受体。采用体型 RNA 测序技术证明 TNFR2 在整体耗尽谱中的作用。最后，通过 TNFR2 KO 小鼠和拮抗剂，证实了 TNFR2 对整体抗肿瘤反应的影响。结果：我们发现 TNFR2 的上调与表型标志物和功能增加一致，反映终末疲劳。TNFR2 的丧失带来了一种表达 TIM3 但 TOX 水平降低且具备前体细胞和终末耗尽细胞功能特征的新型 T 细胞群体。TIM3+ TNFR2 KO T 细胞表现出减少的耗尽转录程序和增强的
• 🔗 查看原文

3. ⭐ 靶向 SERPINB3–MAPK 轴系介导的铜管起作用耐药性增强抗肿瘤免疫疗法的反应

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、免疫、耐药
• 📝 描述：Secret hovertext: 铜管菌舌菌症是一种新发现的细胞死亡形式，与铜稳态和蛋白质脂质化密切相关。通过多组学方法，我们首先揭示 SERPINB3 赋予胰腺癌中的卵巢起作用的耐药性，并具有治疗性生物标志物的功能。机制上，SERPINB3 通过激活 MAPK 信号通路抑制 FDX1 转录，从而赋予促卵酶抗性。我们进一步证明 SERPINB3 直接与 MEK1 相互作用，阻碍其由伴侣蛋白介导的自噬降解，最终导致 MAPK 信号通路的持续激活。此外，我们发现 SERPINB3 通过上调肿瘤细胞上的 PD-L1 表达，促进胰腺癌免疫逃避。这一现象促使开发了一种三重组合策略，包括 MAPK 抑制、促成乳腺促成和αPD-1 治疗，用于高 SERPINB3 表达的胰腺癌患者。为此，我们进一步开发了一种富含铜离子和 MEK 抑制剂的金属有机框架（MOF），显著触发肿瘤特异性铜管分离并增强抗肿瘤免疫。总之，SERPINB3 作为预测性
• 🔗 查看原文

4. 单细胞谱系追踪揭示了急性骨髓性白血病中 FLT3 抑制剂的耐药特征和致敏策略

• ✍️ 作者：未知作者
• 🏷️ 关键词：耐药、单细胞
• 📝 描述：Secret hovertext: 尽管 FLT3 抑制剂显著改善了侵袭性 FLT3 突变急性髓系白血病（AML）的治疗，但耐药性的出现仍是一大挑战。在本研究中，我们应用了新开发的单细胞谱系追踪方法 ReSisTrace，识别出在 AML 中对 FLT3 抑制剂 midostaurin 和 quizartinib 具有内源性耐药或敏感且带有 FLT3-ITD 突变的细胞。对这些细胞基因表达谱的比较揭示了转录抵抗特征，包括 GSPT1 的上调。基因CRISPR-Cas9-mediated敲除导致急性髓质白细胞（AML）对奎扎替尼治疗的敏感性增加。此外，用小分子 CC-90009 靶向 GSPT1，结合 FLT3-ITD 细胞系和主要 AML 患者样本时，表现出强烈的协同效应。此外，在 FLT3-ITD 阳性 AML 患者来源异种移植（PDX）小鼠模型中，CC-90009 和喽扎替尼联合使用相比单独治疗表现出显著更高的抗肿瘤疗效
• 🔗 查看原文

5. 勘误：POLARIX 研究五年结局，比较 Pola-R-CHP 和 R-CHOP 在弥漫性大 B 细胞淋巴瘤患者中的效果

• ✍️ 作者：未知作者
• 🏷️ 关键词：淋巴、B细胞
• 📝 描述：Secret hovertext: 临床肿瘤学杂志，印刷前。
• 🔗 查看原文

6. 世卫组织为儿童友好型癌症药物制定新的全球标准

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext:
• 🔗 查看原文

7. 研究将 50 岁以下女性的超加工食品摄入与肠道息肉联系起来

• ✍️ 作者：未知作者
• 🏷️ 关键词：肠道
• 📝 描述：Secret hovertext:
• 🔗 查看原文

8. 如果运动是药丸，我们都会给癌症患者开它。但事实并非如此

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 临床肿瘤学杂志，印刷前。
• 🔗 查看原文

9. 优化慢性淋巴细胞白血病临床试验中的对照组：BRUIN-CLL-321 试验

• ✍️ 作者：未知作者
• 🏷️ 关键词：淋巴
• 📝 描述：Secret hovertext: 临床肿瘤学杂志，印刷前。
• 🔗 查看原文

10. 回复：优化慢性淋巴细胞白血病临床试验中的对照组：BRUIN-CLL-321 试验

• ✍️ 作者：未知作者
• 🏷️ 关键词：淋巴
• 📝 描述：Secret hovertext: 临床肿瘤学杂志，印刷前。
• 🔗 查看原文

详细内容（全部1条）

1. 非洲生物导体：埃塞俄比亚首个线下课程

• ✍️ 作者：未知作者
• 🏷️ 关键词：Bioconductor
• 📝 描述：Introduction Following the success of our first in-person Bioconductor course in Nairobi earlier this year, we continued building momentum across the continent with Ethiopia’s first Bioconductor workshop, held in Addis Ababa from 25–29 August 2… Continue reading: Bioconductor in Africa: Ethiopia’s First In-Person Course
• 🔗 查看原文

详细内容（全部2条）

1. 增加某种蛋白质的摄入有助于大脑抵御阿尔茨海默病。

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：Researchers discovered that raising the protein Sox9 can help the brain’s astrocytes clear out toxic plaque buildup linked to Alzheimer’s. In mouse models that already showed memory problems, activating these cells improved cognitive performance. The treatment also reduced plaque levels over time. The work points toward a natural, cell-based way to slow Alzheimer’s decline.
• 🔗 查看原文

2. 新的肥胖症发现改写了数十年来关于脂肪代谢科学的认知

• ✍️ 作者：未知作者
• 🏷️ 关键词：metabolism
• 📝 描述：Researchers have uncovered a surprising new role for the HSL protein: beyond breaking down fat, it also works inside the nucleus of fat cells to keep them functioning properly. When HSL is missing, fat tissue doesn’t expand as expected— instead, it shrinks, leading to lipodystrophy. This unexpected discovery helps explain why both obesity and fat-loss disorders share similar health risks, and it opens up fresh paths for understanding metabolic diseases at a time when obesity affects billions worldwide.
• 🔗 查看原文

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