详细内容（前10条）

1. ⭐ 宫颈癌成纤维细胞的肿瘤免疫微环境解析：基于单细胞与空间转录组学的深入探索

• ✍️ 作者：作图丫
• 🏷️ 关键词：肿瘤、免疫、免疫微环境、单细胞、空间转录组、空间组学、转录组
• 📝 描述：最近有小伙伴反映收不到推送，因为公众号改了推送算法，现在需要加星标，多点赞、点在看，才能准时收到推送哦。
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2. ⭐ 又一篇氨基酸代谢生信。本文聚焦组氨酸代谢对肿瘤免疫的抑制作用，结合实验验证。是一篇干湿结合的好文！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、免疫、代谢、代谢组、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

3. ⭐ 刚刚发表7.5分生信，聚焦新热点棕榈酰化，单细胞+无监督聚类+百种机器学习+简单验证。非肿瘤生信模板！

• ✍️ 作者：东晓生物
• 🏷️ 关键词：肿瘤、单细胞、生信、聚类
• 🔗 查看原文

4. ⭐ 单细胞转录组绘制MASH向肝癌转化免疫微环境全景图谱

• ✍️ 作者：单细胞天地
• 🏷️ 关键词：免疫、免疫微环境、单细胞、转录组
• 📝 描述：文章简介及背景介绍 单细胞测序数据简介 主要分析结果概述
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5. ⭐ CancerSCEM - 癌症单细胞表达图谱【国家生物信息中心】

• ✍️ 作者：生信菜鸟团
• 🏷️ 关键词：癌症、单细胞、生物信息、生信
• 📝 描述：癌症单细胞表达图谱（Cancer Single-cell Expression Map）（https://ng
• 🔗 查看原文

6. ⭐ IF 25+ |屠呦呦团队利用单细胞测序发现青蒿素免疫调节新机制，生信开源代码学习

• ✍️ 作者：生信钱同学
• 🏷️ 关键词：免疫、测序、单细胞、生信
• 📝 描述：好的单细胞生信代码学习
• 🔗 查看原文

7. ⭐ Nat Biomed Eng | 腾讯开发用于将单细胞转录组翻译成蛋白质组的预训练大型生成模型

• ✍️ 作者：人体蛋白质组导航计划
• 🏷️ 关键词：单细胞、转录组、蛋白质组、组蛋白
• 🔗 查看原文

8. ⭐ 聚焦氨基酸代谢热点，结合百种机器学习+单细胞+Scissor +免疫治疗+表达验证，一篇2区文章就到手了！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、代谢、单细胞
• 📝 描述：点击查看详情
• 🔗 查看原文

9. ⭐ 氨基酸代谢热度不减：最新生信发文，靶向谷氨酰胺代谢增加免疫治疗疗效！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、代谢、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

10. ⭐ Cell | 樊嘉/季彤/周俭/孙云帆/张陈平合作揭示肿瘤利用神经介导的跨器官通讯实现免疫逃逸

• ✍️ 作者：人体蛋白质组导航计划
• 🏷️ 关键词：肿瘤、免疫、神经
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💡 该来源还有 48 条内容，详见 文末

详细内容（前10条）

1. ⭐ GSE291339 CDK4/6 抑制剂 Palbociclib 克服了 Venetoclax 耐药机制，并在急性髓系白血病中优于单药治疗 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、resistance、RNA-seq
• 📝 描述：Contributors : Melissa L Stewart ; Jessica Gibbs ; Andy Kaempf ; Jeffrey W TynerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVenetoclax (ven) combined with the hypomethylating agent azacytidine (aza) is a widely used therapy for Acute Myeloid Leukemia (AML), however, most patients develop resistance. Using RNASeq, we identified loss of Ikaros (IKZF1) as a potential resistance mechanism to ven+palbo. Examination of cells with IKZF1-loss revealed upregulation of the receptor, AXL, with concordant AXL inhibitor sensitivity in AML tumors harboring IKZF1 mutations. This work suggests that the combination of ven+palbo is a potential novel therapy for AML for potential subpopulations that may benefit the most from this treatment, as well as targeting translation as a means to overcome ven resistance.
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2. ⭐ GSE271857 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (RNA-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、regex:onco(logy|logist|gene|genic)、RNA-seq
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

3. ⭐ GSE271854 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (ChIP-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、regex:onco(logy|logist|gene|genic)、ChIP-seq
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

4. GSE291338 CDK4/6 抑制剂 Palbociclib 克服了 Venetoclax 耐药机制，并在急性髓系白血病中优于单药治疗 [CRISPR 筛选]

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、resistance
• 📝 描述：Contributors : Melissa L Stewart ; Jessica Gibbs ; Daniel Bottomly ; Shannon K McWeeney ; Jeffrey W TynerSeries Type : OtherOrganism : Homo sapiensVenetoclax (ven) combined with the hypomethylating agent azacytidine (aza) is a widely used therapy for Acute Myeloid Leukemia (AML), however, most patients develop resistance. A genome-wide CRISPR screen showed that loss of genes involved in translation conferred sensitivity to ven but not ven+palbo. Accordingly, we show that increased translation occurs after AML cells are challenged with ven, and ven+palbo blocks this increase. We also found that loss of BAX, which leads to ven resistance, was overcome by combination with CDK4/6 inhibitors. Conversely, loss of RB1, a known mechanism of resistance to CDK4/6 inhibitors, was mitigated by ven+palbo. This work suggests that the combination of ven+palbo is a potential novel therapy for AML for potential subpopulations that may benefit the most from this treatment, as well as targeting translation as a means to overcome ven resistance.
• 🔗 查看原文

5. GSE271858 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、regex:onco(logy|logist|gene|genic)
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

6. GSE271856 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (PRO-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、regex:onco(logy|logist|gene|genic)
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : OtherOrganism : Homo sapiensOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

7. GSE271855 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (CLIP-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：leukemia、regex:onco(logy|logist|gene|genic)
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : OtherOrganism : Homo sapiensOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

8. GSE297256 单细胞映射揭示骨膜祖细胞和免疫微环境的年龄相关改变，这些改变会损害骨再生

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、single-cell
• 📝 描述：Contributors : Lei Zhao ; Chao WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging profoundly impacts bone homeostasis and regeneration, yet the cellular and molecular mechanisms underlying periosteal aging remain poorly understood. Using single-cell RNA sequencing, we profiled the periosteum of 3-, 9-, and 18-month-old mice, revealing age-related shifts in progenitor, neutrophil, and macrophage subpopulations. Aging reduced mesenchymal cell populations and impaired osteogenic potential, disrupting periosteal homeostasis. Periosteal progenitor subsets exhibited distinct aging trajectories: Dpt⁺ fibrous-layer cells undergoing early senescence, while Postn⁺ progenitors showed osteogenic decline. Aging also shifted immune profiles, increasing inflammatory Cd38hi macrophages and dysfunctional Nlrp3hi neutrophils, further disrupting bone homeostasis. Notably, aged progenitor cells upregulated CSF1 and CXCL signaling, driving macrophage and neutrophil infiltration, exacerbating bone loss. Our findings provide a comprehensive periosteal aging atlas, highlighting disrupted progenitor-immune crosstalk as a key driver of bone homeostasis imbalance and impaired regeneration, offering potential therapeutic targets for age-related bone disorders.
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9. GSE280833 组蛋白H4对组蛋白基因转录的细胞周期依赖性抑制

• ✍️ 作者：未知作者
• 🏷️ 关键词：histone
• 📝 描述：Contributors : Kami Ahmad ; Matt Wooten ; Brittany N Takushi ; Velinda Vidaurre ; Xin Chen ; Steven HenikoffSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogaster ; Homo sapiensIn all eukaryotes DNA replication is coupled to histone synthesis to coordinate chromatin packaging of the genome. Canonical histone genes coalesce in the nucleus into the Histone Locus Body (HLB), where gene transcription and 3’ mRNA processing occurs. Both histone gene transcription and mRNA stability are reduced when DNA replication is inhibited, implying that the Histone Locus Body senses the rate of DNA synthesis. In Drosophila melanogaster, the S-phase-induced histone genes are repeated in an ~100 copy repeat unit array, whereas in humans, these histone genes are scattered. In both organisms these genes coalesce into Histone Locus Bodies.
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10. GSE309408 比较眼转录组图谱

• ✍️ 作者：未知作者
• 🏷️ 关键词：transcriptome
• 📝 描述：Contributors : Christian Damsgaard ; Lin LinSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Anolis carolinensis ; Columba livia ; Gallus gallus ; Taeniopygia guttataThe Comparative Eye Transcriptome Atlas provides transcriptomic resources to study retinal evolution and physiology across non-mammalian vertebrates. We profiled retinas from four species using two complementary high-throughput approaches. Eight 10x Genomics Visium spatial transcriptomics datasets were generated from Anolis carolinensis (n = 2), Taeniopygia guttata (n = 4), Columba livia (n = 1), and Gallus gallus (n = 1), capturing spatially resolved gene expression with matched histology images. In parallel, six 10x Genomics Chromium Single Cell 3′ RNA-seq datasets were obtained from zebra finch (T. guttata) retinas to resolve cell-type–specific transcriptomes. Raw sequencing data (FASTQ) and processed outputs from SpaceRanger (Visium) and CellRanger (Chromium) are provided. Downstream integrated and annotated datasets can be explored interactively at https://linlab.au.dk/Damsgaard_lab/CETA/ and full Seurat objects are available on request.
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💡 该来源还有 14 条内容，详见 文末

详细内容（全部4条）

1. 评估两剂叶酸受体 α 疫苗在三阴性乳腺癌患者中的安全性和免疫原性的 II 期试验

• ✍️ 作者：未知作者
• 🏷️ 关键词：免疫、疫苗
• 📝 描述：Secret hovertext: 目的：CD4 T 细胞免疫与提高乳腺癌患者的生存率有关。我们之前报道了一项评估叶酸受体α（FRα）疫苗与环磷酰胺（CP）一起给药的 I 期试验，该试验显示出出色的安全性和免疫原性。为了简化疫苗策略以使其易于使用，我们在此报告了一项随机 II 期试验的结果，该试验评估了较低的疫苗剂量和原始剂量，在有或没有环磷酰胺预处理的情况下给药。患者和方法：完成所有全身和局部治疗的三阴性乳腺癌 （TNBC） 患者被分配接受低剂量 （825 mg） 或高剂量 （2.5 mg） 疫苗肽加 GM-CSF 在六个 4 周周期内，接种疫苗前有或没有 CP。在疫苗接种前后监测安全性并评估免疫原性。结果：共 80 例患者接种疫苗，58 例患者免疫原性可评估。疫苗接种耐受性良好，83% 的患者产生了免疫力。FRα特异性 T 细胞水平高、持久，与抗破伤风类毒素的 T 细胞水平相当。两种剂量之间的免疫力没有差异。CP 预处理也不影响免疫反应。8
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2. USP20 驱动的胆固醇代谢将炎症信号传导与胰腺癌的恶性肿瘤和基质共同进化联系起来

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、代谢
• 📝 描述：Secret hovertext: 炎症信号传导、代谢重编程和基质复杂性已成为胰腺导管腺癌 （PDAC） 的核心标志。这些程序之间的串扰可能代表同时扰乱多个肿瘤促进过程的潜在靶点。通过整合来自临床队列、患者来源的类器官和本土模型的多组学数据，我们发现 PDAC 中的肿瘤内源性炎症级联反应是甲羟戊酸途径劫持的主要调节因子，这推动了恶性进展和基质共同进化。TNFSF13B+ 肿瘤相关巨噬细胞激活肿瘤上皮细胞中的 STAT3 信号传导，导致 USP20 的转录上调。这种去泛素酶稳定了 HMGCR，以增强甲羟戊酸通量，导致胆固醇和香叶基香叶酰焦磷酸盐的产生过量。USP20 介导的代谢改变诱导的 YAP/TAZ 信号传导刺激促进肿瘤细胞增殖并触发癌症相关成纤维细胞 （CAF） 的激活。使用选择性抑制剂对 USP20 进行基因消融或药理学抑制可逆转肿瘤代谢失调，从而抑制肿瘤生长和基质结缔增生。此外，USP20 抑制与抗 PD-1/抗 CTLA-4
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3. 肿瘤相关巨噬细胞产生 PGE2 以促进 CD8+ T 细胞耗竭并驱动微卫星稳定结直肠癌对 PD-L1 阻断的耐药性

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、耐药
• 📝 描述：Secret hovertext: 免疫检查点阻断治疗对微卫星不稳定 （MSI） 结直肠癌 （CRC） 非常有效。然而，微卫星稳定 （MSS） 肿瘤对免疫治疗具有内在的耐药性。在这里，我们试图通过表征 MSS 和 MSI 肿瘤模型的免疫谱来更好地了解 CRC 中抗 PD-L1 治疗耐药的机制。虽然两种肿瘤类型都表现出瘤内 CD8+ T 细胞和 PD-L1 表达，但耗尽的 CD8+ T 细胞表型不同。在 MSS 肿瘤中，耗尽的 CD8 + T 细胞共表达 PD-1 和 TIGIT，并表现出终末耗尽特征，细胞因子分泌低，细胞毒性功能有限。相比之下，MSI 肿瘤中的 PD-1+ CD8+ T 细胞不表达 TIGIT，表现出更高的细胞因子和细胞毒性活性。有趣的是，免疫抑制性 M2 样肿瘤相关巨噬细胞（TAM）在 MSI 肿瘤中积累，并与 PD-1+ TIGIT+ CD8+ T 细胞频率呈正相关。M2 样 TAM 耗竭降低了 TIGIT
• 🔗 查看原文

4. 一种由 hsa_circ_0065394 编码的新型蛋白 cPFKFB4 可增强 PKM2 介导的葡萄糖代谢重编程，促进缺氧下胰腺癌进展

• ✍️ 作者：未知作者
• 🏷️ 关键词：代谢
• 📝 描述：Secret hovertext: 缺氧是实体瘤的标志，可引起癌症的葡萄糖代谢重编程。由环状 RNA （circRNA） 编码的肽和蛋白质被确定为肿瘤恶性进展的关键介质。尽管如此，胰腺癌 （PC） 中缺氧相关 circRNA 编码的蛋白质仍然未表征且知之甚少。使用缺氧培养系统筛选 PC 中缺氧反应性 circRNA（hsa_circ_0065394）。采用生物信息学和 RNA 免疫沉淀研究了 hsa_circ_0065394 的环化机制。利用 qRT-PCR 和原位杂交对 hsa_circ_0065394 在 PC 中的表达谱和潜在临床意义进行评估。双荧光素酶报告基因检测、质谱和蛋白质印迹鉴定出由 hsa_circ_0065394 编码的蛋白 cPFKFB4。通过体内和体外功能获得和丧失实验验证了 cPFKFB4 的生物学功能。从机制角度出发，通过质谱、免疫共沉淀、免疫荧光、PKM 剪接、RNA 免疫沉淀、蛋白质印迹和抢救实验等方法，探讨了
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详细内容（前10条）

1. RNA测序揭示了可用于改进肺外结核病诊断的免疫生物标志物

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、sequencing
• 📝 描述：RNA sequencing identifies immune biomarkers for extrapulmonary tuberculosis, revealing new molecular signatures in blood that may improve diagnosis and enable personalized treatment…
• 🔗 查看原文

2. New bacterial therapy destroys cancer without the immune system

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune
• 📝 描述：A Japanese-led research team has developed AUN, a groundbreaking immune-independent bacterial cancer therapy that uses two harmonized bacteria to destroy tumors even in patients with weakened immune systems. By leveraging the natural synergy between Proteus mirabilis and Rhodopseudomonas palustris, AUN selectively targets cancer cells, reshapes itself within tumors, and avoids harmful side effects like cytokine release syndrome.
• 🔗 查看原文

3. SPT Labtech 和 Alithea Genomics 合作，实现超灵敏单细胞转录组学工作流程的自动化

• ✍️ 作者：未知作者
• 🏷️ 关键词：single-cell、genomics
• 📝 描述：SPT Labtech, a global leader in the design and development of laboratory automation and liquid handling solutions, and Alithea Genomics, a pioneer in the field of large-scale RNA sequencing and transcriptomics, today announced a collaboration to provide an automated solution for single-cell transcriptomics. The collaboration integrates Alithea Genomics’ ultra-sensitive single-cell RNA-seq technology, MERCURIUS™ FLASH-seq, …
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4. 利用小RNA测序技术对跗库蚊进行病毒组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq
• 📝 描述：RNA sequencing reveals diverse insect-specific viruses in Culex tarsalis mosquitoes, improving understanding of viral interactions and aiding mosquito-borne disease surveillance…
• 🔗 查看原文

5. Tiny implant wipes out bladder cancer in 82% of patients

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：TAR-200, a small drug-releasing implant, wiped out tumors in most patients with high-risk bladder cancer. Its slow, consistent release of chemotherapy proved far more effective than traditional short-term treatments. The therapy may replace bladder removal surgery for many and has earned FDA Priority Review due to its impressive results.
• 🔗 查看原文

6. Clearing brain plaques isn’t enough to heal Alzheimer’s

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：Japanese researchers found that lecanemab, an amyloid-clearing drug for Alzheimer’s, does not improve the brain’s waste clearance system in the short term. This implies that nerve damage and impaired clearance occur early and are difficult to reverse. Their findings underscore that tackling amyloid alone may not be enough to restore brain function, urging a broader approach to treatment.
• 🔗 查看原文

7. Hidden weakness makes prostate cancer self-destruct

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer
• 📝 描述：Researchers have discovered that prostate cancer depends on two key enzymes, PDIA1 and PDIA5, to survive and resist therapy. When blocked, these enzymes cause the androgen receptor to collapse, killing cancer cells and enhancing the effects of drugs like enzalutamide. They also disrupt the cancer’s energy system, striking it on multiple fronts. This breakthrough could open a new path to overcoming drug resistance in advanced prostate cancer.
• 🔗 查看原文

8. Scientists find brain cells that could stop Alzheimer’s

• ✍️ 作者：未知作者
• 🏷️ 关键词：Alzheimer
• 📝 描述：Researchers have identified special immune cells in the brain that help slow Alzheimer’s. These microglia work to reduce inflammation and block the spread of harmful proteins. They appear to protect memory and brain health, offering a promising new direction for therapy.
• 🔗 查看原文

9. COVID vaccine linked to fewer infections and allergies in kids with eczema

• ✍️ 作者：未知作者
• 🏷️ 关键词：vaccine
• 📝 描述：New research suggests the COVID-19 vaccine could help children with eczema stay healthier overall. Vaccinated kids had lower rates of infections and allergies, including asthma and rhinitis, compared with unvaccinated peers. Experts believe the vaccine may help prevent allergic conditions from worsening, showing its value beyond protection from COVID-19.
• 🔗 查看原文

10. A hidden cellular cleanup trick could reverse aging

• ✍️ 作者：未知作者
• 🏷️ 关键词：aging
• 📝 描述：Researchers found that the body’s natural recycling system, the lysosome, plays a vital role in removing the protein that drives premature aging. When this system breaks down, aging speeds up. By reactivating it, scientists were able to help cells recover their youthful behavior. The discovery opens exciting possibilities for anti-aging treatments.
• 🔗 查看原文

💡 该来源还有 3 条内容，详见 文末

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