详细内容（前10条）

1. ⭐ 宫颈癌成纤维细胞的肿瘤免疫微环境解析：基于单细胞与空间转录组学的深入探索

• ✍️ 作者：作图丫
• 🏷️ 关键词：肿瘤、免疫、免疫微环境、单细胞、空间转录组、空间组学、转录组
• 📝 描述：最近有小伙伴反映收不到推送，因为公众号改了推送算法，现在需要加星标，多点赞、点在看，才能准时收到推送哦。
• 🔗 查看原文

2. ⭐ CancerSCEM - 癌症单细胞表达图谱【国家生物信息中心】

• ✍️ 作者：生信菜鸟团
• 🏷️ 关键词：癌症、cancer、单细胞、生物信息、生信
• 📝 描述：癌症单细胞表达图谱（Cancer Single-cell Expression Map）（https://ng
• 🔗 查看原文

3. ⭐ 又一篇氨基酸代谢生信。本文聚焦组氨酸代谢对肿瘤免疫的抑制作用，结合实验验证。是一篇干湿结合的好文！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、免疫、代谢、代谢组、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

4. ⭐ Nat Biomed Eng | 腾讯开发用于将单细胞转录组翻译成蛋白质组的预训练大型生成模型

• ✍️ 作者：人体蛋白质组导航计划
• 🏷️ 关键词：TME、单细胞、转录组、蛋白质组、组蛋白
• 🔗 查看原文

5. ⭐ 刚刚发表7.5分生信，聚焦新热点棕榈酰化，单细胞+无监督聚类+百种机器学习+简单验证。非肿瘤生信模板！

• ✍️ 作者：东晓生物
• 🏷️ 关键词：肿瘤、单细胞、生信、聚类
• 🔗 查看原文

6. ⭐ 单细胞转录组绘制MASH向肝癌转化免疫微环境全景图谱

• ✍️ 作者：单细胞天地
• 🏷️ 关键词：免疫、免疫微环境、单细胞、转录组
• 📝 描述：文章简介及背景介绍 单细胞测序数据简介 主要分析结果概述
• 🔗 查看原文

7. ⭐ IF 25+ |屠呦呦团队利用单细胞测序发现青蒿素免疫调节新机制，生信开源代码学习

• ✍️ 作者：生信钱同学
• 🏷️ 关键词：免疫、测序、单细胞、生信
• 📝 描述：好的单细胞生信代码学习
• 🔗 查看原文

8. ⭐ 聚焦氨基酸代谢热点，结合百种机器学习+单细胞+Scissor +免疫治疗+表达验证，一篇2区文章就到手了！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、代谢、单细胞
• 📝 描述：点击查看详情
• 🔗 查看原文

9. ⭐ 氨基酸代谢热度不减：最新生信发文，靶向谷氨酰胺代谢增加免疫治疗疗效！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：免疫、代谢、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

10. ⭐ 2025蛋白质组学大会之单细胞蛋白质组学研究

• ✍️ 作者：人体蛋白质组导航计划
• 🏷️ 关键词：单细胞、蛋白质组、组蛋白
• 🔗 查看原文

💡 该来源还有 48 条内容，详见 文末

详细内容（前10条）

1. ⭐ GSE271855 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (CLIP-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、leukemia、immune、immunity、TME、vaccine、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、Hi-C、single.cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、spatial transcriptomics、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Seurat、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : OtherOrganism : Homo sapiensOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

2. ⭐ GSE271854 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (ChIP-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、leukemia、immune、immunity、TME、vaccine、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、Hi-C、single.cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、spatial transcriptomics、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Seurat、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

3. ⭐ GSE271857 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (RNA-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、leukemia、immune、immunity、TME、vaccine、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、RNA-seq、RNAseq、DNA-seq、ATAC-seq、Hi-C、single.cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、proteome、proteomics、Seurat、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

4. ⭐ GSE271856 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy (PRO-Seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、leukemia、immune、immunity、TME、vaccine、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、RNA-seq、RNAseq、DNA-seq、ATAC-seq、Hi-C、single.cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、proteome、proteomics、Seurat、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : OtherOrganism : Homo sapiensOncogenic transcription represents a crucial event in MLL rearranged (MLLr) leukemia, yet the precise role of transcription co-activators in MLL-fusion protein-associated transcription and their contribution to leukemogenesis remain incompletely understood. Here, we demonstrate that AKAP95 is notably up-regulated in both MLLr patients and in MLL-AF9-transformed mouse bone marrow. AKAP95 proves essential for initiating mouse MLL-AF9 leukemia, exhibiting widespread DNA binding across the genome, particularly at gene promoters. Interaction with the translocated MLL1 fragment primarily occurs through phase separation mechanisms. AKAP95’s RNA-binding properties, coupled with its phase separation behavior, govern its binding to pre-mRNA and concurrent transcriptional regulation. Importantly, we engineered a peptide to disrupt its phase separation, effectively attenuating AKAP95-mediated transcriptional co-activation and inhibiting the growth of MLLr cell lines. These findings illustrate a vivid example of an RNA-binding protein orchestrating transcription and tumorigenesis via phase separation, underscoring the potential for targeting oncogenic condensation mechanisms therapeutically.
• 🔗 查看原文

5. ⭐ GSE291339 CDK4/6 抑制剂 Palbociclib 克服了 Venetoclax 耐药机制，并在急性髓系白血病中优于单药治疗 [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、leukemia、immune、immunity、TME、vaccine、cardiac、glioma、kinase、resistance、TCGA、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、single.cell、scRNA、scDNA、scATAC、spatial、Visium、genome、genomics、proteome、proteomics、bioinformatics、Bioconductor、Seurat、Scanpy、epigenome、histone、enrichment
• 📝 描述：Contributors : Melissa L Stewart ; Jessica Gibbs ; Andy Kaempf ; Jeffrey W TynerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVenetoclax (ven) combined with the hypomethylating agent azacytidine (aza) is a widely used therapy for Acute Myeloid Leukemia (AML), however, most patients develop resistance. Using RNASeq, we identified loss of Ikaros (IKZF1) as a potential resistance mechanism to ven+palbo. Examination of cells with IKZF1-loss revealed upregulation of the receptor, AXL, with concordant AXL inhibitor sensitivity in AML tumors harboring IKZF1 mutations. This work suggests that the combination of ven+palbo is a potential novel therapy for AML for potential subpopulations that may benefit the most from this treatment, as well as targeting translation as a means to overcome ven resistance.
• 🔗 查看原文

6. ⭐ GSE291338 CDK4/6 抑制剂 Palbociclib 克服了 Venetoclax 耐药机制，并在急性髓系白血病中优于单药治疗 [CRISPR 筛选]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、leukemia、immune、immunity、TME、vaccine、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、single.cell、scRNA、scDNA、scATAC、spatial、Visium、genome、genomics、proteome、proteomics、bioinformatics、Bioconductor、Seurat、Scanpy、epigenome、histone、enrichment
• 📝 描述：Contributors : Melissa L Stewart ; Jessica Gibbs ; Daniel Bottomly ; Shannon K McWeeney ; Jeffrey W TynerSeries Type : OtherOrganism : Homo sapiensVenetoclax (ven) combined with the hypomethylating agent azacytidine (aza) is a widely used therapy for Acute Myeloid Leukemia (AML), however, most patients develop resistance. A genome-wide CRISPR screen showed that loss of genes involved in translation conferred sensitivity to ven but not ven+palbo. Accordingly, we show that increased translation occurs after AML cells are challenged with ven, and ven+palbo blocks this increase. We also found that loss of BAX, which leads to ven resistance, was overcome by combination with CDK4/6 inhibitors. Conversely, loss of RB1, a known mechanism of resistance to CDK4/6 inhibitors, was mitigated by ven+palbo. This work suggests that the combination of ven+palbo is a potential novel therapy for AML for potential subpopulations that may benefit the most from this treatment, as well as targeting translation as a means to overcome ven resistance.
• 🔗 查看原文

7. ⭐ GSE271858 Phase separation mediates AKAP95 regulating oncogenic MLL-fusion driven transcription and its application in leukemia therapy

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、leukemia、immune、immunity、TME、vaccine、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、Hi-C、single.cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、proteome、proteomics、Seurat、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : Bi Shi ; Yongkun Luan ; Hao Jiang ; Wei LiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

8. ⭐ GSE255608 定制基于 CRISPR/Cas 的表观基因组编辑器以实现可编程染色质酰化和降低细胞毒性 [扰动测序]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、TME、metabolic、glioma、TCGA、DepMap、depmap、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、genome、genomics、proteome、proteomics、Scanpy、epigenetic、epigenome、methylation
• 📝 描述：Contributors : Isaac Hilton ; Jacob GoellSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensPrecisely engineering histone acylation states can inform mechanistic epigenetics and catalyze new therapeutic epigenome editing opportunities. Here, we developed engineered lysine acyltransferases that enable the deposition of acetylation and longer-chain acylations in a programmable manner using a dead Cas9 (dCas9) fusion protein. We show that targeting an engineered lysine crotonyltransferase, developed by mutagenizing the native human p300 protein, results in relatively weak levels of endogenous enhancer activation yet retains strong potency when targeted to promoters. We further identify a single mutation within the catalytic core of human p300 that preserves enzymatic activity while promoting more target-specific acetylation and substantially reducing downstream transcriptomic perturbations. Further, this novel fusion protein exhibits low cytotoxicity but maintains high levels of H3K27ac deposition, enabling markedly improved lentiviral delivery. We leveraged this enhanced delivery and improved cytotoxicity profile to perform single-cell CRISPR activation screening. Using proteomics and a panel of engineered p300 variants, we also discover acylation-specific interactions and link the cytotoxicity of the wild-type p300 core domain to altered activities among DNA repair machinery components. These new programable epigenome editing tools and insights expand our ability to perform functional genomic screens, multiplexed cell engineering, and, more broadly, understand the mechanistic role of lysine acylation in epigenetic and cellular processes.
• 🔗 查看原文

9. ⭐ GSE293813 PITX2剂量依赖性起搏细胞状态变化是窦房结功能障碍和心房心律失常易感性的基础

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、TME、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、Hi-C、scRNA、scDNA、scATAC、spatial、spatially、genome、Seurat、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : L E van der Maarel ; M R Mungroo ; O J Mulleners ; M R Rivaud ; F H Tiel Groenesteege ; L Fokkert ; C de Gier-de Vries ; K van Duijvenboden ; B Jensen ; H D Devalla ; V M ChristoffelsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensReduced spatiotemporal transcription factor levels have been shown to affect traits, organism development and disease predisposition. Here, we investigated the impact of physiologically relevant increases in transcription factor dosage, which has remained largely unexplored. Patients with genomic deletions far upstream of PITX2 present with sinus node dysfunction (SND) and atrial fibrillation. We show that delB mice, which recapitulate the deletion-driven arrhythmia in patients, ectopically express PITX2 in sinus node pacemaker cardiomyocytes (PCs) in a highly heterogeneous pattern from early embryonic development onwards. During development, delB sinus nodes form subdomains of mildly affected PC and strongly affected PCs that have lost their PC identity and switched towards an atrial cardiomyocyte-like state in a PITX2 dosage-dependent manner. Compared to heterozygous delB mice, homozygous delB mice have more PITX2+ PCs that express on average more PITX2, form proportionally larger subdomains of strongly affected PCs and have much more severe SND and atrial arrhythmia susceptibility. Ectopic expression of PITX2 in human induced pluripotent stem cell-derived PCs resulted in PITX2 dosage-dependent transcriptional changes reminiscent of those observed in the sinus node subdomains of delB mice. These results show that genetically driven ectopic expression of PITX2 in PCs causes SND and increased susceptibility for atrial arrhythmias, illustrating how spatiotemporally-defined increases in transcription factor dosage translates into developmental defects and disease predisposition.
• 🔗 查看原文

10. ⭐ GSE291752 PITX2剂量依赖性起搏细胞状态改变是窦房结功能障碍和心房心律失常易感性的基础 III

• ✍️ 作者：未知作者
• 🏷️ 关键词：carcinoma、TME、cardiac、glioma、kinase、resistance、TCGA、DepMap、depmap、Hi-C、scRNA、scDNA、scATAC、spatial、spatially、genome、Seurat、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : L E van der Maarel ; M R Mungroo ; O J Mulleners ; M R Rivaud ; F H Tiel Groenesteege ; L Fokkert ; C de Gier-de Vries ; K van Duijvenboden ; B Jensen ; H D Devalla ; V M ChristoffelsSeries Type : OtherOrganism : Mus musculusReduced spatiotemporal transcription factor levels have been shown to affect traits, organism development and disease predisposition. Here, we investigated the impact of physiologically relevant increases in transcription factor dosage, which has remained largely unexplored. Patients with genomic deletions far upstream of PITX2 present with sinus node dysfunction (SND) and atrial fibrillation. We show that delB mice, which recapitulate the deletion-driven arrhythmia in patients, ectopically express PITX2 in sinus node pacemaker cardiomyocytes (PCs) in a highly heterogeneous pattern from early embryonic development onwards. During development, delB sinus nodes form subdomains of mildly affected PC and strongly affected PCs that have lost their PC identity and switched towards an atrial cardiomyocyte-like state in a PITX2 dosage-dependent manner. Compared to heterozygous delB mice, homozygous delB mice have more PITX2+ PCs that express on average more PITX2, form proportionally larger subdomains of strongly affected PCs and have much more severe SND and atrial arrhythmia susceptibility. Ectopic expression of PITX2 in human induced pluripotent stem cell-derived PCs resulted in PITX2 dosage-dependent transcriptional changes reminiscent of those observed in the sinus node subdomains of delB mice. These results show that genetically driven ectopic expression of PITX2 in PCs causes SND and increased susceptibility for atrial arrhythmias, illustrating how spatiotemporally-defined increases in transcription factor dosage translates into developmental defects and disease predisposition.
• 🔗 查看原文

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1. 评估两剂叶酸受体 α 疫苗在三阴性乳腺癌患者中的安全性和免疫原性的 II 期试验

• ✍️ 作者：未知作者
• 🏷️ 关键词：免疫、疫苗
• 📝 描述：Secret hovertext: 目的：CD4 T 细胞免疫与提高乳腺癌患者的生存率有关。我们之前报道了一项评估叶酸受体α（FRα）疫苗与环磷酰胺（CP）一起给药的 I 期试验，该试验显示出出色的安全性和免疫原性。为了简化疫苗策略以使其易于使用，我们在此报告了一项随机 II 期试验的结果，该试验评估了较低的疫苗剂量和原始剂量，在有或没有环磷酰胺预处理的情况下给药。患者和方法：完成所有全身和局部治疗的三阴性乳腺癌 （TNBC） 患者被分配接受低剂量 （825 mg） 或高剂量 （2.5 mg） 疫苗肽加 GM-CSF 在六个 4 周周期内，接种疫苗前有或没有 CP。在疫苗接种前后监测安全性并评估免疫原性。结果：共 80 例患者接种疫苗，58 例患者免疫原性可评估。疫苗接种耐受性良好，83% 的患者产生了免疫力。FRα特异性 T 细胞水平高、持久，与抗破伤风类毒素的 T 细胞水平相当。两种剂量之间的免疫力没有差异。CP 预处理也不影响免疫反应。8
• 🔗 查看原文

2. 一种由 hsa_circ_0065394 编码的新型蛋白 cPFKFB4 可增强 PKM2 介导的葡萄糖代谢重编程，促进缺氧下胰腺癌进展

• ✍️ 作者：未知作者
• 🏷️ 关键词：代谢
• 📝 描述：Secret hovertext: 缺氧是实体瘤的标志，可引起癌症的葡萄糖代谢重编程。由环状 RNA （circRNA） 编码的肽和蛋白质被确定为肿瘤恶性进展的关键介质。尽管如此，胰腺癌 （PC） 中缺氧相关 circRNA 编码的蛋白质仍然未表征且知之甚少。使用缺氧培养系统筛选 PC 中缺氧反应性 circRNA（hsa_circ_0065394）。采用生物信息学和 RNA 免疫沉淀研究了 hsa_circ_0065394 的环化机制。利用 qRT-PCR 和原位杂交对 hsa_circ_0065394 在 PC 中的表达谱和潜在临床意义进行评估。双荧光素酶报告基因检测、质谱和蛋白质印迹鉴定出由 hsa_circ_0065394 编码的蛋白 cPFKFB4。通过体内和体外功能获得和丧失实验验证了 cPFKFB4 的生物学功能。从机制角度出发，通过质谱、免疫共沉淀、免疫荧光、PKM 剪接、RNA 免疫沉淀、蛋白质印迹和抢救实验等方法，探讨了
• 🔗 查看原文

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1. Python package development for R developers (episode 2 !)

• ✍️ 作者：未知作者
• 🏷️ 关键词：TME
• 📝 描述：In a previous article, I shared my experience as an R developer diving into Python package development! I had noted several aspects that felt less smooth than in R, or even completely missing! Thanks to feedback from the community, I’ve been abl… Continue reading: Python package development for R developers (episode 2 !)
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2. Evaluating a New Job Market Data Feed

• ✍️ 作者：未知作者
• 🏷️ 关键词：TME
• 📝 描述：I’ve recently been given early access to a service that provides data on job listings published by a wide range of companies. The dataset offers a near real-time view of hiring activity, broken down at the company level. This is a potentially valuable signal for tracking labour market trends, … Continue reading: Evaluating a New Job Market Data Feed
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详细内容（前10条）

1. ⭐ RNA测序揭示了可用于改进肺外结核病诊断的免疫生物标志物

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、immune、immunity、TME、cardiac、glioma、sequencing、RNAseq、scRNA、scDNA、scATAC、Visium、genome、genomics、Seurat、Scanpy
• 📝 描述：RNA sequencing identifies immune biomarkers for extrapulmonary tuberculosis, revealing new molecular signatures in blood that may improve diagnosis and enable personalized treatment…
• 🔗 查看原文

2. ⭐ Physicists prove the Universe isn’t a simulation after all

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、TME、scRNA、spatial、Seurat、histone
• 📝 描述：New research from UBC Okanagan mathematically demonstrates that the universe cannot be simulated. Using Gödel’s incompleteness theorem, scientists found that reality requires “non-algorithmic understanding,” something no computation can replicate. This discovery challenges the simulation hypothesis and reveals that the universe’s foundations exist beyond any algorithmic system.
• 🔗 查看原文

3. ⭐ New research finds no clear link between acetaminophen (Tylenol) and autism

• ✍️ 作者：未知作者
• 🏷️ 关键词：TME、scRNA、scDNA、scATAC、Scanpy、histone
• 📝 描述：A sweeping review of existing studies finds no solid evidence that using acetaminophen (Tylenol) during pregnancy increases the risk of autism or ADHD in children. Researchers found that previous reviews often relied on weak or biased data, and most did not properly account for genetic or environmental factors shared by families. When these factors were considered, any apparent link between acetaminophen use and neurodevelopmental disorders largely disappeared.
• 🔗 查看原文

4. ⭐ Stanford discovers an extraordinary crystal that could transform quantum tech

• ✍️ 作者：未知作者
• 🏷️ 关键词：TME、cardiac、scRNA、scDNA、scATAC、Seurat
• 📝 描述：Stanford scientists found that strontium titanate improves its performance when frozen to near absolute zero, showing extraordinary optical and mechanical behavior. Its nonlinear and piezoelectric properties make it ideal for cryogenic quantum technologies. Once overlooked, this cheap, accessible material now promises to advance lasers, computing, and space exploration alike.
• 🔗 查看原文

5. ⭐ Scientists find brain cells that could stop Alzheimer’s

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、TME、Alzheimer、scRNA、scDNA、scATAC
• 📝 描述：Researchers have identified special immune cells in the brain that help slow Alzheimer’s. These microglia work to reduce inflammation and block the spread of harmful proteins. They appear to protect memory and brain health, offering a promising new direction for therapy.
• 🔗 查看原文

6. ⭐ Tiny laser could transform medicine and quantum science

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、TME、cardiac、scRNA、scDNA、Seurat
• 📝 描述：A team at the University of Stuttgart has engineered a compact short-pulse laser that achieves up to 80% efficiency—far surpassing current models. Their new multipass design reuses light within a small crystal, combining power and precision in a palm-sized system. It opens the door to portable, cost-effective lasers for medicine, analytics, and quantum science.
• 🔗 查看原文

7. ⭐ 利用小RNA测序技术对跗库蚊进行病毒组分析

• ✍️ 作者：未知作者
• 🏷️ 关键词：TME、glioma、RNA-seq、RNAseq、Visium
• 📝 描述：RNA sequencing reveals diverse insect-specific viruses in Culex tarsalis mosquitoes, improving understanding of viral interactions and aiding mosquito-borne disease surveillance…
• 🔗 查看原文

8. ⭐ A simple DNA test could reveal the right antidepressant for you

• ✍️ 作者：未知作者
• 🏷️ 关键词：TCGA、scRNA、scDNA、Seurat、Scanpy
• 📝 描述：Millions struggle with depression and anxiety, often enduring long waits for effective treatment. Scientists in Sweden, Denmark, and Germany are developing a genetic test to predict which medications will actually work. Using polygenic risk scores, they can analyze DNA variations linked to mental health and drug response.
• 🔗 查看原文

9. ⭐ Common pesticides may cause testicular damage and lower sperm counts

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、TME、TCGA、scATAC、Seurat
• 📝 描述：A decade-long review by George Mason University researchers reveals growing evidence that neonicotinoid insecticides—the world’s most widely used class of pesticides—may harm male reproductive health. The findings, based on 21 animal studies, show consistent links between exposure and reduced sperm quality, hormonal disruption, and testicular damage.
• 🔗 查看原文

10. ⭐ After 250 years, an 18th-century mechanical volcano erupts to life

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、TME、scRNA、Seurat
• 📝 描述：An 18th-century mechanical artwork depicting Mount Vesuvius’ eruption has finally erupted — 250 years later. University of Melbourne students reconstructed Sir William Hamilton’s imaginative fusion of art and engineering using modern technology. Their re-creation glows with programmable lights and movement, reanimating history’s forgotten passion for science and spectacle.
• 🔗 查看原文

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