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1. ⭐ R语言 | 单细胞联合空间转录组学的常见分析流程~

• ✍️ 作者：作图丫
• 🏷️ 关键词：单细胞、空间转录组、空间组学、转录组
• 🔗 查看原文

2. ⭐ 院士团队刚发表在Cancer Cell，结合单细胞和空转揭示肿瘤神经浸润促癌机制。大热点不容错过！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、cancer、单细胞
• 📝 描述：点击查看详情
• 🔗 查看原文

3. 7.7分1区生信，全文32个Figure聚焦最新热点：肿瘤神经浸润。小编认证的高质量生信文章，投稿到接收仅两个多月！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

4. 48.5分，星级热点，刚发完Cancer cell又来个Nature，肿瘤神经浸润与抗 PD-1 治疗响应不佳相关！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、cancer
• 📝 描述：点击查看详情
• 🔗 查看原文

5. monocle2也可以用于bulk RNA-seq分析吗？

• ✍️ 作者：生信技能树
• 🏷️ 关键词：RNA-seq、RNAseq
• 📝 描述：100多个bulk转录组也能做拟时序吗？
• 🔗 查看原文

6. 10x Genomics：就这也能暴涨？

• ✍️ 作者：循因缉药
• 🏷️ 关键词：10x、genomics
• 📝 描述：“刺激”
• 🔗 查看原文

7. JITC：程根宏/杨衡团队揭示 EP300 调控抗肿瘤免疫反应的新机制

• ✍️ 作者：丁香学术
• 🏷️ 关键词：肿瘤、免疫
• 🔗 查看原文

8. 空间组学 | Nat.Methods | Giotto Suite：一个多尺度、技术无关的空间多组学分析生态系统

• ✍️ 作者：BioJournal Link
• 🏷️ 关键词：TME、空间组学
• 🔗 查看原文

9. 最新的33+文章，跨循环系统和组织的泛癌代谢分析，嘌呤代谢也是火起来了！

• ✍️ 作者：东晓生物
• 🏷️ 关键词：代谢
• 🔗 查看原文

10. 详解：丙酸代谢

• ✍️ 作者：小李代谢
• 🏷️ 关键词：代谢
• 📝 描述：丙酸代谢是肠道菌群与宿主之间复杂互作的重要组成部分。通过不同菌株的代谢特性及宿主的利用途径，丙酸在维持宿主健康、调节代谢和免疫功能中发挥关键作用
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1. ⭐ GSE300102 FET重排软组织肌上皮肿瘤涵盖广泛的临床病理和分子谱，其表观遗传学特征与皮肤和头颈部肌上皮肿瘤不同

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、oncology、carcinoma、immune、immunity、TME、metabolism、metabolic、metabolome、metabolomics、cardiac、glioma、resistance、TCGA、DepMap、depmap、single.cell、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、transcriptome、proteome、Bioconductor、Seurat、Scanpy、epigenetic、epigenome、histone、enrichment
• 📝 描述：Contributors : Josephine Dermawan ; Michael Michal ; Cristina AntonescuSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensDNA methylation profiling from a multi-institutional cohort of 52 fusion-positive MET cases were analyzed. Pooled clinicopathological and outcome analysis with new and published cases (total 185 and 69 cases, respectively) was performed. The MET subgroups, EWSR1::KLF15, EWSR1/FUS::KLF17, EWSR1::PBX1, EWSR1::PBX3, EWSR1/FUS::POU5F1, SS18::POU5F1, and EWSR1::ZNF444, showed significant heterogeneity in age group, site, and histology. DNA methylation analysis revealed that fusion-positive MET were epigenetically related to each other and EWSR1/FUS::NFATC2 sarcomas, but entirely distinct from the epigenetically-related PLAG1-rearranged and salivary gland MET.
• 🔗 查看原文

2. ⭐ GSE300926 综合长读长转录组分析揭示了 miR-214-3p 失调介导的胃癌细胞多层次转录改变

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、immune、immunity、TME、cardiac、glioma、resistance、TCGA、DepMap、depmap、Hi-C、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、spatial transcriptomics、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Seurat、Scanpy、epigenetic、epigenome、histone、clustering
• 📝 描述：Contributors : Ruijuan Xin ; Xiaoqin Ma ; Min Niu ; Qian Hao ; Hongliang Li ; Shengjuan HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLong-length sequencing has been widely used in cancer-related research for exploring transcriptome variations in human cancer in recent years. miR-214-3p, a microRNA, has been reported to have abnormal expression and play important regulation roles in diverse cancers. However, information about the genome-wide targets and action mechanisms of miR-214-3p in cancer cells is still limited. Here, long-read sequencing were performed to character the transcriptome variations after disturbing the expression of miR-214-3p in AGS cells, a gastric cancer cell line. The results showed that both miR-214-3p overexpression (OE) and suppression (KD) extensively increased or decreased expression level of a number of genes involved in apoptotic process and transcription at transcript level and gene level. In particular, both miR-214-3p KD and OE could increase or decrease on the expression levels of some target genes at the same direction. Moreover, miR-214-3p broadly regulated the alternative splicing of hundreds of genes with functions of cell division, cellular senescence and transcription regulation. In addition, the changes in the expression level of miR-214-3p can cause changes in the alternative polyadenylation and 3UTR lengths of the transcript. Taken together, these results indicated that miR-214-3p could mediate apoptosis by diverse modes in AGS cells, which adds to the understanding of the critical role of miR-214-3p in cancer cancer.
• 🔗 查看原文

3. ⭐ GSE308443 人类外周血单核细胞中与LPS刺激相关的可变剪接和整体转录组变化

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、immune、TME、cardiac、glioma、resistance、TCGA、DepMap、depmap、single.cell、scRNA、scDNA、scATAC、spatial、Visium、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、epigenetic、epigenome、histone
• 📝 描述：Contributors : Kord Kober ; Esther Chavez Iglesias ; Anatol SucherSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLipopolysaccharide (LPS) is a commonly used stimulant that induces an innate immune response, and serves as a model for studying inflammatory responses. Alternative splicing is key to gene expression and cell function, and is a key layer of gene regulation during disease progression and stress response. Although alternative splicing has been identified to play a role in response to LPS stimulation, a transcriptome wide ex vivo characterization of bulk PBMCs is lacking. Given the role of alternative splicing in the immune response is largely unexplored, understanding the role alternative splicing in the immune response can improve our understanding of gene regulatory processes and identify targets for treatment. The purpose of this study, using deep sequencing, is to evaluate for differential gene expression and alternative splicing associated with LPS treatment in human PBMCs.
• 🔗 查看原文

4. ⭐ GSE302606 SETD8 H4K20 单甲基转移酶的抑制限制了单纯疱疹病毒感染基因组的全局可及性 [ATAC-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、TME、metabolism、metabolic、metabolome、glioma、kinase、resistance、TCGA、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、Hi-C、scRNA、scATAC、genome、genomics、epigenome、methylation、histone、enrichment
• 📝 描述：Contributors : Jesse H Arbuckle ; Tovah E Markowitz ; Jodi L Vogel ; Thomas M KristieSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEpigenetic modulation of herpes simplex virus (HSV) immediate early (IE) genes is a critical regulatory parameter governing lytic infection, latency, and viral reactivation. Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the state of HSV-1 chromatin. As an approach to identify novel epigenetic factors that regulate the initial stage of HSV-1 infection, an epigenetic chemical probe library was screened for their impact on viral IE gene expression. This screen identified several epigenetic inhibitors that modulated IE expression. Notably, UNC0379, an inhibitor of the histone H4K20 mono-methyltransferase SETD8, potently repressed HSV-1 infection in vitro and in vivo. Furthermore, SETD8 inhibition suppressed HSV-1 reactivation in a mouse ganglia explant model. Importantly, these results correlated with enhanced heterochromatin suppression and decreased accessibility of HSV-1 chromatin. Reduced IE transcription was concomitant with disruption in recruitment of HCF-1 and RNA polymerase II (RNAPII). These results are consistent with the established roles of SETD8 in promoting chromatin accessibility through H4K20me1 deposition and regulating transcriptional elongation, suggesting that SETD8 may facilitate multiple steps in regulation of HSV-1 IE gene expression.
• 🔗 查看原文

5. ⭐ GSE275670 表征缺氧调控的少突胶质细胞前体细胞中卒中后变化，以改进卒中细胞疗法

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、TME、glioma、TCGA、DepMap、depmap、Hi-C、single.cell、scRNA、scDNA、scATAC、genome、proteome、R package、Scanpy、epigenetic、epigenome、histone
• 📝 描述：Contributors : Ken Yasuda ; Takakuni Maki ; Kazuto Tsukita ; Yasuhiro KuwataSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusOligodendrocyte precursor cells (OPCs) are traditionally known for their role in differentiating into oligodendrocytes, thereby contributing to myelination. Additionally, it has been increasingly recognized that OPCs actively modify their characteristics in response to the surrounding environment, exhibiting various other functions. However, how and when OPCs change their characteristics after acute ischemic stroke, and the contribution of these changes to post-stroke recovery, are not well understood. In this study, we aimed to transcriptionally characterize the changes in OPCs during acute ischemic stroke and develop therapies to support these changes. For this purpose, we first leveraged mouse single-cell RNA sequencing (scRNAseq) datasets to create a “middle cerebral artery occlusion (MCAO) atlas.” Crucially, we identified the distinct appearance of “angiogenic” OPCs in the subacute phase and “oligogenic” OPCs in the chronic phase after MCAO, contributing to angiogenesis and remyelination, respectively. Furthermore, we successfully induced OPCs ex vivo with similar functional characteristics to “angiogenic” OPCs through severe hypoxic preconditioning. The intravenous transplantation of these hypoxia-preconditioned OPCs more efficiently promoted post-stroke angiogenesis, reduced infarct size, and improved neurological function after MCAO compared to normally treated OPCs. Finally, we demonstrated that mild hypoxia at least partially contributes to the generation of “oligogenic” OPCs. Therefore, following acute ischemic stroke, OPCs sense oxygen levels and undergo phenotypic changes to exhibit functions required at specific times. Importantly, therapies supporting these phenotypic changes hold great promise for improving recovery from damage caused by acute ischemic stroke, for which current available treatments focus on quickly restoring blood flow.
• 🔗 查看原文

6. ⭐ GSE308968 LADA 与 1 型糖尿病免疫谱的单细胞转录组学比较

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、immune、immunity、TME、glioma、single.cell、single-cell、scRNA、scATAC、spatial、spatially、genome、genomics、transcriptome、transcriptomics、Seurat、Scanpy、epigenome
• 📝 描述：Contributor : Vadim ChechekhinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAutoimmune diabetes encompasses rapidly progressive type 1 diabetes mellitus (T1D) and indolent latent autoimmune diabetes in adults (LADA), yet the immunological drivers of this kinetic divergence remain unresolved. We performed single-cell RNA sequencing with paired T and B cell receptor profiling on over 400,000 peripheral blood mononuclear cells (PBMCs) from patients with LADA, newly diagnosed T1D, and healthy controls. PBMC composition was comparable across cohorts, indicating that qualitative rather than quantitative immune differences underlie disease heterogeneity. In T1D, pan-lineage activation of NF-kB, EGFR, MAPK, and hypoxia pathways, coupled with a TNF-centered communication hub, enhanced MHC signaling, and disrupted adhesion, promoted systemic inflammation. LADA, by contrast, exhibited global suppression of NF-kB/EGFR activity, retention of moderate JAK/STAT tone, reinforced natural killer cell inhibitory checkpoints via HLA-C-KIR2DL3/3DL1 interaction, and stabilized CD8+ T cell synapses through HLA-C-CD8 binding, collectively restraining effector activation. Single-cell V(D)J analysis revealed polyclonal, patient-unique adaptive repertoires, emphasizing the primacy of signaling context over receptor convergence. These findings define LADA and T1D as endpoints on an inflammatory-inhibitory spectrum and identify the NF-kB/EGFR-JAK/STAT gradient and HLA-C-KIR axis as potential therapeutic targets for preserving residual beta-cell function in autoimmune diabetes.
• 🔗 查看原文

7. ⭐ GSE242906 转录因子 ZNF263 启动人类胚胎干细胞的多能性丧失和早期分化

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immune、immunity、TME、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、transcriptome、transcriptomics、Seurat、Scanpy、histone、enrichment
• 📝 描述：Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

8. ⭐ GSE302607 SETD8 H4K20 单甲基转移酶的抑制限制了单纯疱疹病毒感染基因组的全局可及性 [ChIP-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：immune、TME、metabolism、metabolic、metabolome、resistance、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、Hi-C、genome、genomics、epigenome、methylation、histone
• 📝 描述：Contributors : Jesse H Arbuckle ; Tovah E Markowitz ; Jodi L Vogel ; Thomas M KristieSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEpigenetic modulation of herpes simplex virus (HSV) immediate early (IE) genes is a critical regulatory parameter governing lytic infection, latency, and viral reactivation. Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the state of HSV-1 chromatin. As an approach to identify novel epigenetic factors that regulate the initial stage of HSV-1 infection, an epigenetic chemical probe library was screened for their impact on viral IE gene expression. This screen identified several epigenetic inhibitors that modulated IE expression. Notably, UNC0379, an inhibitor of the histone H4K20 mono-methyltransferase SETD8, potently repressed HSV-1 infection in vitro and in vivo. Furthermore, SETD8 inhibition suppressed HSV-1 reactivation in a mouse ganglia explant model. Importantly, these results correlated with enhanced heterochromatin suppression and decreased accessibility of HSV-1 chromatin. Reduced IE transcription was concomitant with disruption in recruitment of HCF-1 and RNA polymerase II (RNAPII). These results are consistent with the established roles of SETD8 in promoting chromatin accessibility through H4K20me1 deposition and regulating transcriptional elongation, suggesting that SETD8 may facilitate multiple steps in regulation of HSV-1 IE gene expression.
• 🔗 查看原文

9. ⭐ GSE307083 梭鲈脑发育过程中转录因子和神经元效应器的差异活性

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、TME、glioma、TCGA、scRNA、scDNA、scATAC、Visium、genome、transcriptome、proteome、Seurat、enrichment
• 📝 描述：Contributor : Radka SymonovaSeries Type : Expression profiling by high throughput sequencingOrganism : Sander luciopercaJuvenile pikeperch (Sander lucioperca) undergo several ontogenetic shifts whose timing determines the survival of their first winter. The shift from a planktivorous phenotype to a more active predatory (piscivorous) behavior is accompanied by moving from pelagic to demersal habitat with much more stimuli and hence by potential brain functional reorganizations. During two consecutive years, we collected planktivores and piscivores, with different body sizes between the years recording distinct stages relative to the shift and analyzed their whole-brain transcriptomes framed by detailed ecological knowledge. The differential gene transcription analysis identified a distinct non-overlapping group of transcription factors (TFs) significantly upregulated in each phenotype: TFs upregulated in planktivores correspond to initial establishment of brain regions and overall architecture; TFs upregulated in piscivores correspond to the refinement of neuronal populations and the formation of specific neuronal circuits. The planktivorous phenotype independently of body size was characterized by interconnected activity of two TFs, fosab and junba. Gene set enrichment revealed extracellular matrix and collagen-related Gene Ontology terms in piscivores from both years. A highly increased activity of solute carrier (Slc) transporters was identified in the smaller-bodied piscivorous phenotype (20 members of 12 Slc families). The overall count of Slc genes transcribed in pikeperch brain was 334, which is higher than known for humans (287). The neurotranscriptomics results reflected differences in body size and matched with ecological data and survival rates. The multidimensional brain regulome indicated that the intra-phenotypic body size difference can translate into the specific gene activity of the brain in juvenile pikeperch. The period of transition to piscivory appears to be an important ontogenetic step accompanied by increased specific transcription activity.
• 🔗 查看原文

10. ⭐ GSE279266 阐明挥发性有机化合物对植物病原菌甘蔗孢子菌抑制作用的影响

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、carcinoma、TME、cardiac、glioma、TCGA、scRNA、scDNA、scATAC、Visium、genome、Seurat、Scanpy、epigenome、histone
• 📝 描述：Contributors : Mulato Aline Tieppo Nogueira ; Persinoti Gabriela Félix ; Oliveira Juliana Velasco de CastroSeries Type : Expression profiling by high throughput sequencingOrganism : Sporisorium scitamineumSugarcane holds substantial agricultural and industrial importance in Brazil and worldwide, primarily due to its use in biofuel production and for a range of biomolecules of diverse biochemical applications. The drive towards sustainable agricultural practices has fostered the interest in the exploration of bioproducts to reduce the dependence on agrochemicals. In this context, microbial volatile organic compounds (VOCs) have emerged as potential biofungicides, offering several advantages over conventional chemical treatments. This study focused on evaluating their antagonistic potential against Sporisorium scitamineum, the causative agent of sugarcane smut disease, and investigated the molecular mechanisms underlying their inhibitory effects. Two Pseudomonas bacterial strains isolated from sugarcane roots exhibited remarkable antagonistic activity against S. scitamineum. Notably, ITA P2F2 completely inhibited the growth of the phytopathogen and was identified as a novel species within the Pseudomonas genus. A total of 63 VOCs were identified from both bacterial isolates, with eight showing inhibitory activity against the phytopathogen. Transcriptomic analyses revealed significant changes in gene expression of S. scitamineum when exposed to VOCs from ITA P2F2, including the downregulation of genes involved in central metabolic pathways, such as carbohydrate metabolism and fatty acid β-oxidation, and the upregulation of genes associated with DNA repair. Potential DNA damage caused by the VOCs was further evidenced through temporal analysis using Fourier Transform Infrared (FTIR) spectroscopy. Additionally, electron microscopy analysis showed structural damage to the fungal hyphae after VOCs exposure. This multidisciplinary study is the first to investigate the inhibition of S. scitamineum using VOCs. Our findings contribute to the molecular understanding of these signaling molecules and highlight their potential as promising bioproducts to replace conventional agrochemicals in the control of sugarcane pathogens.
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1. 与 ESR1 突变转移性乳腺癌 elacestrant 结果相关的临床和基因组因素

• ✍️ 作者：未知作者
• 🏷️ 关键词：基因组
• 📝 描述：Secret hovertext: 目的：ESR1 突变介导激素受体阳性转移性乳腺癌 （MBC） 对抗雌激素治疗的耐药性。Elacestrant 是一种口服选择性雌激素受体降解剂，与标准内分泌治疗相比，ESR1 突变 MBC 的无进展生存期更高。我们评估了真实世界的 elacestrant 使用情况和与结局相关的临床基因组因素。实验设计：本研究使用 GuardantINFORM 数据库，将 >42,000 例真实世界的乳腺癌病例与测序和索赔数据联系起来。我们纳入了在 elacestrant 开始前 <6 个月（2023 年 1 月至 2024 年 3 月）检测到激活 ESR1 突变的患者。使用 Kaplan-Meier 和 Cox 回归分析估计治疗中止时间（TTD）、下一次治疗时间（TTNT）和总生存期的结果，并调整临床变量。结果：我们确定了 756 名患者（76% 既往接受过 CDK4/6 抑制剂，38% 既往接受过化疗），其中
• 🔗 查看原文

2. 衰老微环境是胰腺癌免疫排斥和转移命运的决定因素

• ✍️ 作者：未知作者
• 🏷️ 关键词：免疫
• 📝 描述：Secret hovertext: 衰老是胰腺导管腺癌 （PDAC） 风险和结果中一个关键但研究不足的决定因素。尽管与年龄有很强的流行病学关联，但传统的 PDAC 临床前模型未能捕捉到老年生物体中出现的组织病理学和基质复杂性。使用与年龄相关的同基因原位模型，我们证明了生物体衰老加速了 PDAC 的进展和转移。转录组学和分泌组分析确定了富集于老年肿瘤癌症相关成纤维细胞 （CAF） 中的保守细胞外基质基因特征，与支持免疫抑制、转移性趋性和不良预后的增强纤维化景观一致。在异慢性共植入模型中对基质老化的功能影响的直接测试表明，用年轻的 CAF 活化老化的肿瘤基质可以恢复免疫浸润并减轻老年宿主的转移。相反，老年 CAF 虽然具有免疫抑制作用，但未能增强年轻宿主的转移，这表明年轻的微环境对疾病进展施加了主导的调节控制。这些发现表明，基质年龄是 PDAC 中免疫排除和转移行为的关键调节因子。重要的是，这项工作为理解衰老如何塑造 PDAC
• 🔗 查看原文

3. 多基因组合和 pembrolizumab 覆盖率对转移性黑色素瘤患者和人群的影响

• ✍️ 作者：未知作者
• 🏷️ 关键词：基因组
• 📝 描述：Secret hovertext: 背景 靶向治疗或免疫治疗可能会为黑色素瘤患者带来增加、持久的反应。患者层面的益处是否能转化为人口健康尚不清楚。本研究旨在估计癌症控制政策对患者和人群的影响，该政策报销了加拿大不列颠哥伦比亚省转移性黑色素瘤的多基因面板检测和帕博利珠单抗。方法 这项回顾性研究检查了 2013 年至 2018 年间接受单基因或多基因检测的不列颠哥伦比亚省 721 名被诊断患有转移性黑色素瘤的成年人的人群队列。我们使用 11 种遗传算法将受政策影响的患者与历史对照进行匹配，以及 Kaplan-Meier 分析和两年医疗费用和生存时间的删失加权回归的逆概率来确定患者水平的政策影响。对于人口水平的影响，我们对每月卫生系统支出和死亡率应用了中断时间序列分析，估计了 ARIMA 和广义最小二乘泊松回归。结果 匹配队列分析（ncontrol = 154，nintervention = 154）发现患者水平平均累计成本增加 53
• 🔗 查看原文

4. 降级试验并不总是需要非劣效性——肿瘤学优越性设计降级试验的一个案例

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext: 肿瘤学降级试验最近受到越来越多的关注，因为人们越来越担心癌症患者正在接受过度治疗——更多的患者（而不是受益的患者）在病程的早期接受治疗，剂量更高，持续时间更长，频率更高。因此，重要的是要了解较少的治疗是否能让我们达到类似的结果，这种策略称为降级治疗。然而，这种降级策略的主要问题之一是可能会损害治疗效果。虽然以较小的治疗负担降级治疗本身就是一个值得的目标，因为它可以减少身体、经济和时间毒性，但降级不能以大幅影响治疗效果为代价。测试此类降级策略是否安全且不会导致不可接受的疗效妥协的最常见方法是通过非劣效性设计试验。此类试验需要更大的样本量，因此需要更多的资金和更长的完成时间。然而，降级试验不一定需要非劣效性设计。在本文中，我提出了使用优势设计来测试降级策略的案例。这将避免非劣效性设计的局限性，并使降级策略的测试更加有效。
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5. 英国可交付的国家癌症控制计划：国外的经验教训和国内纪律的必要性

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 暂无摘要
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6. 衰老相关分泌表型 （SASP） 在癌症治疗中的争议作用

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 细胞衰老以部分不可逆的细胞周期停滞为特征，通过衰老相关分泌表型 （SASP） 在癌症进展中发挥双重作用。SASP 包含多种生物活性化学物质，包括细胞因子、趋化因子、生长因子和蛋白酶，所有这些都会对肿瘤微环境 （TME） 产生重大影响。最初，SASP 可以通过吸引免疫细胞和抑制癌细胞增殖来增强肿瘤抑制，但其在 TME 的长期存在可以促进肿瘤的生长、转移和治疗耐药性。此外，治疗引起的衰老是癌症治疗的常见副作用，可导致衰老细胞和促肿瘤 SASP 增加。因此，最近的研究强调了靶向 SASP 改善癌症治疗的潜力。在治疗策略中，衰老疗法选择性地消除衰老细胞，而衰老药物降低 SASP 而没有细胞毒性，也有靶向 SASP 的联合疗法进行肿瘤治疗。因此，开发更特异性的老年人治疗药物并研究 SASP 调节的临床应用至关重要，例如使用 SASP 成分作为治疗监测和个性化医疗的生物标志物。总而言之，了解 SASP
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7. 接受癌症治疗的患者的虚弱与明显更多的不良后果有关

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 研究人员早就知道虚弱与更糟糕的癌症结果有关。一半的癌症老年人以及一些年轻癌症患者都患有虚弱，这被定义为生物储备的丧失，使人们更容易受到身体压力的影响。先前的研究表明，虚弱通常与与癌症治疗相关的毒性和死亡风险增加有关。 临床医生需要有效的筛查工具来确定哪些癌症患者有虚弱和不良预后的风险。这些信息可以帮助他们确定适合每位患者的最佳方案。 尽管存在多种衰弱筛查工具，但老年 8 （G8） 老年筛查工具是唯一一种经过评估和系统评价的预后能力工具。G8 评估八个领域：年龄、食物摄入量、活动能力、体重减轻、体重指数、处方药数量、神经心理状况和自我报告的健康状况。 在发表在《 美国国家癌症研究所杂志 》（doi：10.1093/jnci/djaf017）上的一项研究中，研究人员对 58 项研究进行了荟萃分析，综合并总结了有关衰弱评估工具与成人癌症治疗结果之间关联的当前证据患有癌症。
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详细内容（全部1条）

1. @ellis2013nz 提供的离散数据零假设下 p 值分布

• ✍️ 作者：未知作者
• 🏷️ 关键词：spatial、Seurat
• 📝 描述：Motivation A few months back in a side skirmish during the great p-curve controversy, Richard McElreath mentioned that p-values under the null hypothesis are not always uniformly distributed, as is sometimes claimed. This prompted me to check out the … Continue reading: Distribution of p-values under the null hypothesis for discrete data by @ellis2013nz
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• 10+生信，基于 Ro/e 发现不同治疗反应患者 CD8Teff 细胞比例差异。细胞丰度分析识别关键细胞目前在高分文章中很常见！
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• 克服化疗耐药性的可转化策略！徐州医科大学等单位合作发文：有前景的肺癌治疗靶点
• 刷新认知！我国博士决定命运的一次Nature发文，在肿瘤领域一战封神！提前预定诺奖！
• AI | Nature Medicine | 医学中的生成式人工智能
• 单细胞空间联合分析新贵–iStar
• Cell Report Medicine：数字病理学之新型肺癌诊断和预后算法的开发

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