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1. ⭐ 研究肠道菌群代谢物与肿瘤免疫，这篇文章凭什么发在Immunity上？

• ✍️ 作者：小张聊科研
• 🏷️ 关键词：肿瘤、免疫、immunity、代谢
• 📝 描述：研究肠道菌群代谢物与肿瘤免疫，这篇文章凭什么发在Immunity上？
• 🔗 查看原文

2. ⭐ 新思路｜非小细胞肺癌的单细胞和空间转录组学分析

• ✍️ 作者：作图丫
• 🏷️ 关键词：单细胞、空间转录组、空间组学、转录组
• 📝 描述：最近有小伙伴反映收不到推送，因为公众号改了推送算法，现在需要加星标，多点赞、点在看，才能准时收到推送哦。
• 🔗 查看原文

3. ⭐ 最新8.1分非肿瘤生信，针对PANoptosis热点进行机器学习+单细胞筛选+简单验证，全文只有4个Figure！

• ✍️ 作者：东晓生物
• 🏷️ 关键词：肿瘤、单细胞、生信
• 🔗 查看原文

4. ⭐ 最新8.5分单基因生信，泛癌+单细胞+空转+验证，多组学分析一起上分！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：单细胞、基因组、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

5. ⭐ 这篇Cell主刊关注“运动-肠道菌群-代谢物-抗肿瘤免疫”，思路清晰，证据扎实，逻辑太严谨了！

• ✍️ 作者：小张聊科研
• 🏷️ 关键词：肿瘤、免疫、代谢
• 📝 描述：这篇最新的Cell主刊关注“运动-肠道菌群-代谢物-抗肿瘤免疫”，思路清晰，证据扎实，逻辑太严谨了！
• 🔗 查看原文

6. ⭐ 国自然关注肿瘤免疫，这篇Immunity上的文章可以提供一个新角度……

• ✍️ 作者：小张聊科研
• 🏷️ 关键词：肿瘤、免疫、immunity
• 📝 描述：同样是做肿瘤免疫，这项研究凭什么发在Cell子刊Immunity上？如果改成国自然项目，你觉是是否合适？
• 🔗 查看原文

7. 肿瘤免疫新角度：引流淋巴结为何成为研究热点？

• ✍️ 作者：小张聊科研
• 🏷️ 关键词：肿瘤、免疫
• 📝 描述：肿瘤免疫新角度：引流淋巴结为何成为研究热点？
• 🔗 查看原文

8. 张耀阳团队揭示TRIM28介导的SUMO化修饰调控应激颗粒动态性的新机制 | Cell Press对话科学家

• ✍️ 作者：CellPress全科学
• 🏷️ 关键词：tumor、TME
• 📝 描述：该研究工作为解析液–液相分离相关生物过程提供了新的工具与思路。
• 🔗 查看原文

9. Nature medicine同款 | 莫兰迪配色

• ✍️ 作者：在生信的坑里挖呀挖呀挖
• 🏷️ 关键词：TME
• 📝 描述：莫兰迪配色，和科研也沾边儿的！
• 🔗 查看原文

10. 功能失调的CD8 T细胞轴的持续补充与晚期乳腺癌化学免疫治疗的反应相关

• ✍️ 作者：单细胞天地
• 🏷️ 关键词：免疫
• 📝 描述：通过整合scRNA-seq与scTCR-seq数据，高分辨率解析了化学免疫治疗在转移性三阴性乳腺癌中引发的T细胞免疫图谱重塑，揭示了从克隆增殖到谱系分化的动态应答过程。
• 🔗 查看原文

💡 该来源还有 13 条内容，详见 文末

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1. ⭐ GSE294668 脉冲式 980 nm 近红外光生物调节通过调节 Th2 细胞因子反应和炎症细胞浸润来减轻 OVA 诱导的过敏性哮喘

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、leukemia、immune、immunity、TME、metabolism、metabolic、metabolome、cardiac、glioma、resistance、TCGA、DepMap、depmap、Hi-C、single.cell、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、proteome、proteomics、Seurat、Scanpy、methylation、histone、enrichment
• 📝 描述：Contributors : Zhengyi Wu ; Shih-Chin ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPhotobiomodulation (PBM) is a non-invasive therapeutic strategy that uses specific light wavelengths to stimulate cellular processes that promote tissue repair, reduce inflammation, and alleviate pain. In this study, we evaluated the efficacy of a high-intensity 980 nm near-infrared (NIR) pulsed laser in a murine model of ovalbumin (OVA)-induced allergic asthma. In OVA-sensitized mice, typical allergic features were noted, including airway wall thickening, significant peribronchial and perivascular inflammatory cell infiltration, and compressed alveolar spaces. NIR PBM treatment markedly attenuated these histological changes. At the molecular level, PBM significantly downregulated type 2 cytokine gene expression, including IL-4, IL-5 and IL-13, in the lung tissue. Flow cytometry analyses further revealed that PBM reduced the infiltration of pulmonary eosinophils and inflammatory monocytes. Transcriptomic profiling coupled with gene set enrichment analysis (GSEA) indicated that PBM suppressed NF-κB-mediated inflammatory signaling while modulating Th2-related responses. Collectively, our findings demonstrate that high-intensity 980 nm NIR PBM effectively mitigates key features of allergic asthma in a murine model, supporting its potential as a non-pharmacological, non-invasive adjunct therapy for asthma management.
• 🔗 查看原文

2. ⭐ GSE274105 家犬启动子和增强子的转录结构以及热休克反应的快速释放 [PRO-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、leukemia、TME、cardiac、glioma、kinase、DepMap、depmap、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、genome、genomics、transcriptome、transcriptomics、proteome、Seurat、histone、enrichment
• 📝 描述：Contributors : Samu V Himanen ; Anniina VihervaaraSeries Type : OtherOrganism : Canis lupus familiarisDogs exhibit high genetic diversity due to extensive breeding, and provide a versatile model for genetics, evolution, and complex traits. While RNA synthesis and transcriptional architecture of promoters and enhancers have been extensively analyzed in human, mouse, and fly, little is known about the mechanisms that coordinate gene and enhancer transcription in dog. Here, we combine precision run-on sequencing (PRO-seq) and strand-specific mRNA-seq (mRNA-seq) to measure nascent transcription, mRNA expression and mRNA stability in golden retriever macrophage (DH82) cells. Tracking transcription at nucleotide-resolution uncovers the precise transcription start nucleotides (TSN) genome-wide, identifies the exact locations of promoters and transcribed enhancers, and quantifies transcription machineries at initiation, promoter proximal pause, gene bodies, and termination windows. Moreover, we trigger an instant transcriptional reprogramming using heat shock, and track at nucleotide-resolution, how dog cells coordinate RNA synthesis and mRNA expression across the genome. Taken together, this study describes the transcriptional landscape at nucleotide-resolution, measures RNA synthesis, mRNA expression and mRNA-stability, and identifies mechanisms of gene and enhancer reprogramming in Canis lupus familiaris.
• 🔗 查看原文

3. ⭐ GSE274106 家犬启动子和增强子的转录结构以及热休克反应的快速释放 [mRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、leukemia、TME、cardiac、glioma、kinase、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、genome、genomics、transcriptome、transcriptomics、proteome、Seurat、histone、enrichment
• 📝 描述：Contributors : Samu V Himanen ; Anniina VihervaaraSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisDogs exhibit high genetic diversity due to extensive breeding, and provide a versatile model for genetics, evolution, and complex traits. While RNA synthesis and transcriptional architecture of promoters and enhancers have been extensively analyzed in human, mouse, and fly, little is known about the mechanisms that coordinate gene and enhancer transcription in dog. Here, we combine precision run-on sequencing (PRO-seq) and strand-specific mRNA-seq (mRNA-seq) to measure nascent transcription, mRNA expression and mRNA stability in golden retriever macrophage (DH82) cells. Tracking transcription at nucleotide-resolution uncovers the precise transcription start nucleotides (TSN) genome-wide, identifies the exact locations of promoters and transcribed enhancers, and quantifies transcription machineries at initiation, promoter proximal pause, gene bodies, and termination windows. Moreover, we trigger an instant transcriptional reprogramming using heat shock, and track at nucleotide-resolution, how dog cells coordinate RNA synthesis and mRNA expression across the genome. Taken together, this study describes the transcriptional landscape at nucleotide-resolution, measures RNA synthesis, mRNA expression and mRNA-stability, and identifies mechanisms of gene and enhancer reprogramming in Canis lupus familiaris.
• 🔗 查看原文

4. ⭐ GSE270168 GAPDH 控制转录稳定性、蛋白质翻译并驱动急性髓系白血病细胞增殖 [CLIP-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、leukemia、TME、cardiac、glioma、DepMap、depmap、RNA-seq、RNAseq、DNA-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Scanpy、histone
• 📝 描述：Series Type : OtherOrganism : Homo sapiensDysregulation of RNA binding proteins (RBPs) is a hallmark in cancerous cells.In acute myeloid leukemia (AML) RBPs are key regulators of tumor proliferation. While classical RBPs have defined RNA binding domains, RNA recognition and function in AML by non-canonical RBPs (ncRBPs) remains unclear. Given the inherent complexity of targeting AML broadly, our goal was to uncover potential ncRBP candidates critical for AML survival using a CRISPR/Cas-based screening. We identified the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a pro-proliferative factor in AML cells. Based on cross-linking and immunoprecipitation (CLIP) we are defining the global targetome detecting novel RNA targets mainly located within 5’UTR including GAPDH, RPL13a, PKM and ENO1. The knockdown of GAPDH unveiled genetic pathways related to ribosome biogenesis, translation initiation, and regulation. Moreover, we were able to demonstrate a stabilizing effect through the GAPDH binding to target transcripts including its own mRNA, unveiling GAPDH’s pivotal role in cancer. The present findings provide new insights on the pathophysiological role of GAPDH in AML.
• 🔗 查看原文

5. ⭐ GSE308237 CHANGE-seq-BE 能够同时对 Cas 依赖性碱基编辑器的全基因组脱靶活性进行灵敏且无偏倚的体外分析 V

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、TME、metabolism、metabolic、metabolome、cardiac、glioma、TCGA、sequencing、Hi-C、scRNA、scDNA、scATAC、genome、proteome、Seurat、Scanpy、epigenetic、epigenome、histone、clustering
• 📝 描述：Contributors : Varun Katta ; Yichao Li ; Garret Manquen ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensTo assess genome-wide off-target activity of base editors and Cas9 nucleases identified by CHANGE-seq-BE, Digenome-seq, and CHANGE-seq, we performed hybrid capture sequencing for five therupatic loci (B2M, CBLB, CD7, CIITA, PDCD1) in human primary T-cells and PCSK9 in human hepatocytes. We observed high on-target editing for ABE, CBE, Cas9 mRNA edited cells and potential off-targets confirmed by hybrid capture sequencing. Our results demonstrate that CHANGE-seq-BE is highly sensitive than Digenome-seq to detect more bona fide off-targets with cellular activity ranging from 0.5% to 92.2%. Moreover, ABE exhibit more off-targets than Cas9 under same delivery conditions.
• 🔗 查看原文

6. ⭐ GSE307892 CHANGE-seq-BE 能够同时对 Cas 依赖性碱基编辑器的全基因组脱靶活性进行灵敏且无偏倚的体外分析 IV

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、TME、metabolism、metabolic、metabolome、cardiac、glioma、TCGA、sequencing、Hi-C、scRNA、scDNA、scATAC、genome、proteome、Seurat、Scanpy、epigenetic、epigenome、histone、clustering
• 📝 描述：Contributors : Varun Katta ; Yichao Li ; Garret Manquen ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensTo assess genome-wide off-target activity of base editors and Cas9 nucleases identified by CHANGE-seq-BE, Digenome-seq, and CHANGE-seq, we performed hybrid capture sequencing for five therupatic loci (B2M, CBLB, CD7, CIITA, PDCD1) in human primary T-cells and PCSK9 in human hepatocytes. We observed high on-target editing for ABE, CBE, Cas9 mRNA edited cells and potential off-targets confirmed by hybrid capture sequencing. Our results demonstrate that CHANGE-seq-BE is highly sensitive than Digenome-seq to detect more bona fide off-targets with cellular activity ranging from 0.5% to 92.2%. Moreover, ABE exhibit more off-targets than Cas9 under same delivery conditions.
• 🔗 查看原文

7. ⭐ GSE307740 CHANGE-seq-BE 能够同时对 Cas 依赖性碱基编辑器的全基因组脱靶活性进行灵敏且无偏倚的体外分析 III

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、TME、metabolism、metabolic、metabolome、cardiac、glioma、TCGA、sequencing、Hi-C、scRNA、scDNA、scATAC、genome、proteome、Seurat、Scanpy、epigenetic、epigenome、histone、clustering
• 📝 描述：Contributors : Cicera Lazzarotto ; Elizabeth Urbina ; GaHyun Lee ; Yichao Li ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensTo assess CHANGE-seq-BE performance, we used it to characterize ABE8e-NRCH base editor activity targeting sickle mutation (HBBS) in the HBB gene and identified additional 29 (53% more) bona fide off-targets than CIRCLE-seq. Furthermore, CHANGE-seq-BE applied for ABE8e targeting five therapeutically relevant loci (B2M, CBLB, CD7, CIITA, and PDCD1) in human primary T-cells and compared with Digenome-seq. CHANGE-seq-BE is highly sensitive and capable of detecting bona fide off-targets while requiring approximately 20-fold less sequencing reads.
• 🔗 查看原文

8. ⭐ GSE298534 CHANGE-seq-BE 能够同时对 Cas 依赖性碱基编辑器的全基因组脱靶活性进行灵敏且无偏倚的体外分析 II

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、TME、metabolism、metabolic、metabolome、cardiac、glioma、TCGA、sequencing、Hi-C、scRNA、scDNA、scATAC、genome、proteome、Seurat、Scanpy、epigenetic、epigenome、histone、clustering
• 📝 描述：Contributors : Garret Manquen ; Varun Katta ; Yichao Li ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensTo adapt and apply for cytosone base editors (CBEs), we perfomed CHANGE-seq-BE using eA3A-BE3 to target B2M, CBLB, CD7, CIITA and PDCD1 regions at different loci. CHANGE-seq-BE identified low frequency off-target editing rates ranging from 1.7% to 7.5% that are not identified by Digenome-seq further implies CHANGE-seq-BE is highly sensitive and can identify true off-targets while requiring 20-fold fewer sequencing reads.
• 🔗 查看原文

9. ⭐ GSE298465 CHANGE-seq-BE 能够同时对 Cas 依赖性碱基编辑器的全基因组脱靶活性进行灵敏且无偏倚的体外分析 I

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、TME、metabolism、metabolic、metabolome、cardiac、glioma、TCGA、sequencing、Hi-C、scRNA、scDNA、scATAC、genome、proteome、Seurat、Scanpy、epigenetic、epigenome、histone、clustering
• 📝 描述：Contributors : Garret Manquen ; Varun Katta ; Yichao Li ; Shengdar TsaiSeries Type : OtherOrganism : Homo sapiensBy CHANGE-seq-BE, we identified a total of 81 potential off-targets and confirmed 95.4% frequencies of on-target editing with no evident off-targets above the detection threshold compared to controls (rhAmp-seq, IDT).
• 🔗 查看原文

10. ⭐ GSE270169 GAPDH 控制转录本稳定性、蛋白质翻译并驱动急性髓系白血病细胞增殖 [GAPDH_KD_RNAseq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、leukemia、TME、cardiac、glioma、kinase、TCGA、DepMap、depmap、RNAseq、scRNA、scDNA、scATAC、spatial、spatially、genome、transcriptome、proteome、R package、Scanpy、histone
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulation of RNA binding proteins (RBPs) is a hallmark in cancerous cells.In acute myeloid leukemia (AML) RBPs are key regulators of tumor proliferation. While classical RBPs have defined RNA binding domains, RNA recognition and function in AML by non-canonical RBPs (ncRBPs) remains unclear. Given the inherent complexity of targeting AML broadly, our goal was to uncover potential ncRBP candidates critical for AML survival using a CRISPR/Cas-based screening. We identified the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a pro-proliferative factor in AML cells. Based on cross-linking and immunoprecipitation (CLIP) we are defining the global targetome detecting novel RNA targets mainly located within 5’UTR including GAPDH, RPL13a, PKM and ENO1. The knockdown of GAPDH unveiled genetic pathways related to ribosome biogenesis, translation initiation, and regulation. Moreover, we were able to demonstrate a stabilizing effect through the GAPDH binding to target transcripts including its own mRNA, unveiling GAPDH’s pivotal role in cancer. The present findings provide new insights on the pathophysiological role of GAPDH in AML.
• 🔗 查看原文

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1. 基于纳米颗粒的 CAR-T 细胞免疫治疗策略：挑战、影响和前景

• ✍️ 作者：未知作者
• 🏷️ 关键词：免疫
• 📝 描述：Secret hovertext: 嵌合抗原受体（CAR）-T 细胞疗法在治疗血液系统恶性肿瘤方面取得了显著进展，但其更广泛的应用面临着制造复杂性、实体瘤微环境屏障和免疫毒性等挑战。纳米颗粒 （NP） 利用其精确递送、免疫调节和多功能整合能力，为优化 CAR-T 细胞疗法提供了创新策略。本文全面阐明了 CAR-T 细胞治疗的基本框架和肿瘤学应用中的挑战。随后，系统总结了 NPs 与 CAR-T 细胞治疗的协同机制，包括优化基因修饰、增强肿瘤部位浸润、调节免疫抑制肿瘤微环境、减轻肿瘤抗原异质性、实时监测和动态控制细胞活性。最终，它强调了该领域内人工智能集成的新兴范式，同时讨论了这种联合治疗方法的相关技术障碍和未来前景。
• 🔗 查看原文

2. 分子表征为局限性尤文肉瘤患者的预后提供信息：儿童肿瘤学组的报告

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext: 临床肿瘤学杂志，印刷前。
• 🔗 查看原文

3. 髓母细胞瘤荟萃分析门户能够综合探索患者的临床和基因组数据

• ✍️ 作者：未知作者
• 🏷️ 关键词：基因组
• 📝 描述：Secret hovertext: 髓母细胞瘤是一种普遍的、高度异质性的恶性小儿脑癌。在这项研究中，我们开发了髓母细胞瘤荟萃分析门户，这是一个基于网络的数据分析和可视化平台，整合了来自三项主要临床试验（ACNS0331、ACNS0332 和 SJMB03）的 898 名患者的临床、分子和生存数据。该门户网站将临床数据与基因组突变和 DNA 甲基化组相结合，能够对肿瘤亚组和生存结果进行深入分析。该门户由 ProteinPaint 框架提供支持的用户友好型可视化工具使这些数据的动态探索和自定义分层成为可能，允许用户从各种变量中进行选择或自定义自己的变量。门户中的 Cox 回归分析工具在检查异构数据集中变量的预后影响方面表现出效用。此外，对携带 KBTBD4 突变的髓母细胞瘤及其相应甲基化组的深入研究产生了有助于改进分子分类的先导。这些用例强调了该门户网站在增强风险分层、为量身定制的治疗策略提供信息以及揭示髓母细胞瘤患者分子异质性
• 🔗 查看原文

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1. 优雅的网络套餐

• ✍️ 作者：未知作者
• 🏷️ 关键词：R package
• 📝 描述：How to join this free online event with Salix Dubois, Tan Ho and Matthias Grenié. Join us for our next Community Call, “Graceful Internet Packages,” featuring Matthias, Tan, and Salix. In this session, we’ll explore how to design and maintain R packag… Continue reading: Graceful Internet Packages
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1. ⭐ DirectRM——利用直接RNA测序技术对多种RNA修饰进行整合检测，从而揭示其间的相互作用和特征。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、immune、TME、cardiac、kinase、TCGA、sequencing、RNAseq、scRNA、scDNA、scATAC、genome、genomics、R package、Seurat
• 📝 描述：RNA sequencing with DirectRM reveals how multiple RNA modifications interact within transcripts and molecules, offering a new way to explore the complexity of the…
• 🔗 查看原文

2. ⭐ 研究揭示，压力激素通过染色质结合的RNA抑制关键脑基因的表达。

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、TME、kinase、TCGA、scRNA、scDNA、genome、Seurat、histone
• 📝 描述：RNA sequencing reveals how stress hormones trigger chromatin silencing through lncRNAs that recruit PRC2, uncovering an epigenetic pathway linking stress signaling to altered neuronal gene expression…
• 🔗 查看原文

3. 临床NGS科学主任

• ✍️ 作者：未知作者
• 🏷️ 关键词：scRNA、scDNA
• 📝 描述：Memorial Sloan Kettering is hiring a Scientific Director of Clinical NGS to advance RNA sequencing and NGS-based cancer diagnostics, enabling precise tumor profiling, non-invasive testing, and personalized treatment strategies…
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• GSE217432 对分泌脂肪酸的解脂耶氏酵母菌的比较转录组学分析揭示了细胞壁蛋白的重要性
• GSE274063 鉴定斑马鱼中控制内胚层形成和左右模式的重复SOX因子功能分化的分子基础
• GSE268442 缺血性卒中大鼠动脉内移植人神经干细胞后细胞外囊泡转录组（microRNA）
• GSE303861 生长因子FGF21通过组蛋白去乙酰化酶HDAC4维持去神经支配引起的骨骼肌萎缩中的神经肌肉接头
• GSE302582 短跑间歇训练驱动人类独特的线粒体应激反应
• GSE309046 体内抗FAP CAR-T疗法可减少代谢功能障碍相关性脂肪性肝炎中的纤维化并恢复肝脏稳态
• GSE274809 低 caspase 8 表达促进神经元祖细胞拟态和小细胞肺癌转移
• GSE274232 低 caspase 8 表达促进神经元祖细胞拟态和小细胞肺癌转移
• GSE306775 在 HAP1 MTHFD1-K56R 细胞中进行全基因组 CRISPR 敲除筛选，以鉴定赋予抗腺苷毒性的基因
• GSE299897 GW9662，一种过氧化物酶体增殖激活受体γ (PPARγ) 抑制剂，会损害斑马鱼的早期胚胎发育。
• GSE281261 钨被一种优势人类肠道微生物——黏液真杆菌（Eubacterium limosum）用于乳酸消耗和短链脂肪酸（SCFA）生成。
• GSE305038 单日活动量减少会改变次日的转录组和代谢运动反应
• GSE281233 GPC2-CAR T 细胞对原位髓母细胞瘤异种移植具有强大的临床前活性
• GSE287760 雄激素受体驱动多胺合成，从而增加患前列腺癌的风险
• GSE240493 重复行为测试和汇总指标的使用揭示了临床前啮齿动物模型中的特质焦虑
• GSE308047 凝血酶刺激的肝星状细胞中新型基因表达程序的鉴定
• GSE245166 拟南芥阳离子氨基酸转运蛋白 (CAT) 是一种对内吸性除草剂 L-膦丝菌素具有高亲和力的转运蛋白
• GSE302398 揭示PPARγ和免疫蛋白酶体在ILC2调控中的作用
• GSE296941 莱茵衣藻“野生型”菌株基础转录组的差异
• GSE270329 AINTEGUMENTA 磷酸化开关控制次级生长过程中双侧干细胞的活性
• GSE303964 丝氨酸 tRNA 竞争调控丝氨酸敏感密码子的 mRNA 翻译
• GSE237016 APOBEC3 通过 IL1A/AP-1 信号通路促进鳞状细胞分化和转移
• GSE271260 神经元前体细胞拟态驱动小细胞肺癌转移
• GSE307666 eIF3d 和 eIF3e 介导对缺氧的选择性翻译调控，这种调控可被小分子抑制。
• GSE169493 影响热带纸蜂（Polistes canadensis）成虫行为变异的因素
• GSE294234 人类死后组织样本的全基因组甲基化谱
• GSE213241 VHL突变细胞的遗传易感性研究
• 小鼠肠道 Pdgfra+ 细胞的 GSE288481 单细胞 RNA 测序
• GSE280922 博来霉素损伤小鼠肺的单细胞RNA测序分析
• GSE306269 菌株很重要：宿主反应反映了鱿鱼-弧菌共生体中的共生体起源
• GSE281841 外周动脉疾病狭窄1级与4级和5级患者的基因表达数据
• GSE250516 IAF scRNA 测序
• GSE250515 GLIS3 RNA-seq
• GSE250514 GLIS3 ChIP-seq