详细内容（前10条）

1. ⭐ 院士团队刚发表在Cancer Cell，结合单细胞和空转揭示肿瘤神经浸润促癌机制。大热点不容错过！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、cancer、单细胞
• 📝 描述：点击查看详情
• 🔗 查看原文

2. ⭐ 拒绝千篇一律！R包Ragas带你打开单细胞聚类分析及可视化的新大门

• ✍️ 作者：云生信
• 🏷️ 关键词：单细胞、R包、聚类
• 🔗 查看原文

3. 最新7.5分生信，基于生信分析识别生物力学调控相关核心基因并验证！肿瘤的硬度成为目前研究的热点之一!

• ✍️ 作者：东晓生物
• 🏷️ 关键词：肿瘤、生信
• 🔗 查看原文

4. 7.7分1区生信，全文32个Figure聚焦最新热点：肿瘤神经浸润。小编认证的高质量生信文章，投稿到接收仅两个多月！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、生信
• 📝 描述：点击查看详情
• 🔗 查看原文

5. 48.5分，星级热点，刚发完Cancer cell又来个Nature，肿瘤神经浸润与抗 PD-1 治疗响应不佳相关！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：肿瘤、cancer
• 📝 描述：点击查看详情
• 🔗 查看原文

6. 每一个单细胞umap图都带一根小皮鞭是什么鬼？

• ✍️ 作者：生信技能树
• 🏷️ 关键词：单细胞
• 📝 描述：在群里看到万能的群友分享了一篇文献，来自高分杂志SCIENCE ADVANCES，2020年发表的，文献标题为《Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis》。每一个umap图都有一根细丝一样的出现在图里面，上一次看到这么诡异的图还是这里：画出像烟花一样的单细胞umap图，原因竟然是？ 出现这种图可能是因为什么原因？ 此外，我们技能树最新一期生信入门就在11月3号开课，还没上车的可以看一看瞄一瞄，详细介绍页面可以点击：生信入门&数据挖掘线上直播课11月班，完全适合0基础小白。
• 🔗 查看原文

7. PYthon中drug2cell预测单细胞亚群与药物靶点

• ✍️ 作者：单细胞天地
• 🏷️ 关键词：单细胞
• 📝 描述：drug2cell，该工具能够整合如ChEMBL等数据库中的药物‑靶点对信息，并通过定量生物活性指标、药物类别和靶分子类别进行多级筛选。通过计算药物评分
• 🔗 查看原文

8. SATURN：跨物种的单细胞数据集整合

• ✍️ 作者：生信菜鸟团
• 🏷️ 关键词：单细胞
• 🔗 查看原文

9. 10+生信，基于 Ro/e 发现不同治疗反应患者 CD8Teff 细胞比例差异。细胞丰度分析识别关键细胞目前在高分文章中很常见！

• ✍️ 作者：生信小课堂
• 🏷️ 关键词：生信
• 📝 描述：点击查看详情
• 🔗 查看原文

10. 大佬一折腾，你学单细胞的难度又增加了，但我会救你

• ✍️ 作者：生信星球
• 🏷️ 关键词：单细胞
• 🔗 查看原文

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详细内容（前10条）

1. ⭐ GSE308045 The Peptide Genomic Therapy Increases Antibacterial Immunity and Survival in Sepsis by Reprograming the Gene Orthologs of Human Immunodeficiencies in the Spleen and Lungs

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、single.cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、metabolome、metabolomics、Seurat、Scanpy、epigenetic、epigenome、histone、enrichment、clustering
• 📝 描述：Contributors : Huan Qiao ; Jozef Zienkiewicz ; Yan Liu ; Jacek HawigerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSepsis is a life-threatening complication of infections afflicting 49 million patients worldwide with 11 million sepsis-related deaths. In the USA, this growing public health problem concerns 1.7 million adult and pediatric patients. An estimated 1 million patients with asplenia or hyposplenia are particularly vulnerable to sepsis. As the sp…
• 🔗 查看原文

2. ⭐ GSE246890 Putative indicators of thyroid hormone system disruption - a transcriptional footprint of developmental hypothyroidism in hippocampus

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、Hi-C、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Seurat、Scanpy、histone
• 📝 描述：Contributors : Louise Ramhøj ; Bertrand Evrard ; Frédéric ChalmelSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThyroid hormone (TH) system disrupting compounds can impair brain development by perturbing TH action during critical life stages. Human exposure to TH system disrupting chemicals is therefore of great concern. To better protect humans against such chemicals, sensitive test methods that can detect effects on the developing brain are critical…
• 🔗 查看原文

3. ⭐ GSE282494 The Parkinson’s disease associated LRRK2-G2019S variant restricts serine metabolism leading to microglia inflammation and dopaminergic neuron degeneration

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、carcinoma、Hi-C、scRNA、scDNA、scATAC、spatial、genome、proteome、metabolome、Seurat、epigenetic、epigenome、histone
• 📝 描述：Contributors : Henry Kurniawan ; Sarah L. Nickels ; Alise Zagare ; Elisa Zuccoli ; Enrico Glaab ; Jens C SchwambornSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA mounting body of evidence reveals that inflammation is a major hallmark in the pathophysiology of Parkinson’s disease (PD). Notably, microglia are key players in orchestrating neuroinflammatory signalling pathways in the brain. However, the molecular mechanisms underlying the microglial response…
• 🔗 查看原文

4. ⭐ GSE273803 PURE-seq Integrates FACS and PIP-seq for Single-Cell Genomics of Ultra-rare Cells

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、RNA-seq、RNAseq、ATAC-seq、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、genome、genomics、Seurat、epigenome
• 📝 描述：Contributors : Sixuan Pan ; Kai-Chun Chang ; Inés Fernández-MaestreSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWe used PURE-seq with single-cell RNA-sequencing (scRNA-seq) to study murine long-term hematopoietic stem cells (LT-HSCs) and their transcriptomes in the context of hematopoietic aging.
• 🔗 查看原文

5. ⭐ GSE287369 Novel variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、scRNA、scDNA、scATAC、spatial、Visium、genome、proteome、epigenome、histone、enrichment
• 📝 描述：Contributors : Delphine Bernard ; Kevin Uguen ; Tiffany Bergot ; Solène Chapalain ; Marie-Pier Scott-BoyerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSF3B1 is an essential and ubiquitous splicing factor that plays a pivotal role in the early steps of pre-mRNA splicing. Recurrent somatic missense mutations in SF3B1 are frequent in cancers, but no constitutional variant has been reported so far. We describe here a cohort of 26 individuals with neurodevelo…
• 🔗 查看原文

6. ⭐ GSE306105 Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、proteome、proteomics、histone
• 📝 描述：Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

7. ⭐ GSE305669 Reduced expression of UPF1 promotes tumor progression through stabilizing COX-2 mRNA in nasopharyngeal carcinoma

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、Hi-C、scRNA、scDNA、genome、genomics、proteome、Scanpy、epigenome
• 📝 描述：Contributors : Chun Wu ; Ruowen Xiao ; Rui Sun ; Shijuan MaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNonsense-mediated mRNA decay (NMD) is conserved mRNA surveillance pathway that targeted and degraded one-third of aberrant and non-aberrant cellular transcripts. Recently, growing evidences have shown that NMD pathway is implicated in multiple cancer types. However, the activity and function of NMD in nasopharyngeal carcinoma (NPC) remains unclear. He…
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8. ⭐ GSE306459 Single-cell nucleus ATAC sequencing on colorectal tumor and adjacent nonmalignant tissues

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、sequencing、single.cell、single-cell、scRNA、scDNA、scATAC、genome、Seurat
• 📝 描述：Contributors : Andrew J Lee ; Inkyung Jung ; Woong-Yang ParkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell ATAC sequencing data were collected from 24 colorectal tumor and 9 adjacent nonmalignant tissues pooled into 15 libraries. This dataset was generated to investigate the global chromatin accessibility profiles of epithelial, stromal, and immune cells in the colorectal cancer microenvironment. Information on the donors, tissues…
• 🔗 查看原文

9. ⭐ GSE299754 High-grade serous ovarian cancer induced in different sites of origin in mice exemplifies diverse features of the human disease

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、carcinoma、Hi-C、scRNA、scDNA、Visium、genome、genomics、Seurat、histone
• 📝 描述：Contributors : Ludmila Szabova ; Lucy Lu ; Melanie B Gordon ; Kristine Johnson ; Theresa M Guerin ; Laura Bassel ; Deborah B Householder ; Margalie Edouard ; Amy Ries ; Serguei Kozlov ; Keith Collins ; Wendi Custer ; Kathleen Cho ; Goli Samimi ; Robert Shoemaker ; Zoe Weaver OhlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have developed novel genetically engineered mouse models for high-grade serous carcinoma of the ovary. We compare expression prof…
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10. ⭐ GSE294472 Cooperativity between head-to-head dimerization and head-to-tail multimerization of FoxP3 transcription factor

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、Hi-C、scRNA、scDNA、scATAC、spatial、genome、proteome、Seurat
• 📝 描述：Contributors : Fangwei Leng ; Ryan Clark ; Wenxiang Zhang ; Thibault Viennet ; Haribabu Arthanari ; Xi Wang ; Sun HurSeries Type : OtherOrganism : Mus musculusFoxP3, an essential transcription factor for regulatory T cells (Tregs), forms higher-order multimers on TnG microsatellites in the genome. Although a previous study has shown that FoxP3 can form head-to-head (H-H) dimers on inverted repeats of forkhead motifs (IR-FKHM), in vivo evidence for this configuration was elusive. An unbiased FoxP…
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1. RANKL 抗体狄诺塞麦在两组复发/难治性骨肉瘤患者中的 2 期试验，儿童肿瘤学组 （COG） 的报告

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext: 背景：小鼠模型证明了 RANK 及其配体 RANKL 在骨肉瘤中的作用。这项单臂开放标签 2 期试验的主要目的是确定相对于从历史 COG 临床试验数据得出的基准，狄诺塞麦（一种 RANKL 单克隆抗体）是否能改善复发性骨肉瘤的疾病控制。患者和方法：11-49 岁且患有可测量疾病的骨骼成熟患者符合队列 1 的条件，或所有疾病部位完全手术切除的患者符合队列 2 的条件。患者每 4 周皮下注射狄诺塞麦 120 mg，并补充钙和维生素 D。队列 1 的主要终点是 RECIST 反应和 4 个月的无事件状态，队列 2 的 12 个月无事件状态。毒性、药代动力学和药效学效应是其他终点。结果：队列 1 中的 15 名患者和队列 2 中的 38 名患者符合主要终点的条件并可评估。15 名队列 1 患者中的一名在 4 个月时保持无事件。没有客观的回应。38 名队列 2 患者中有 10 名在 12 个月时无事
• 🔗 查看原文

2. 循环肿瘤 DNA 水平对参加 plasmaMATCH 试验的晚期乳腺癌患者的预后和预测影响

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext: 目的：循环肿瘤 DNA （ctDNA） 动态水平可以识别对治疗有反应的患者。我们在 plasmaMATCH 试验中评估了晚期乳腺癌患者的 ctDNA 基线水平和治疗动态，采用突变靶向治疗（队列 A-D）和三阴性乳腺癌 （TNBC） 联合使用奥拉帕尼和 ceralasertib（队列 E）。实验设计：在基线（C1D1）和治疗前的第 2 天（C2D1）采集血样。使用纠错的靶向组合（Guardant360/GuardantOMNI）对样品进行测序。循环 DNA 比值（CDR）计算为 C2D1/C1D1 的比值。CDR 和基线 ctDNA 水平与无进展生存期 （PFS） 和确认客观缓解率 （ORR） 相关。结果：167 名患者具有可评估的 C1D1-C2D1 ctDNA 结果。队列 E 的基线 ctDNA 水平与反应之间存在很强的关联;基线水平低与 PFS 较长（HR 0.33，p=0.001）和较高的
• 🔗 查看原文

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1. ¿Qué es el Índice de Gini y cómo calcularlo?

• ✍️ 作者：未知作者
• 🏷️ 关键词：scDNA
• 📝 描述：If this post is useful to you I kindly ask a minimal donation on Buy Me a Coffee. It shall be used to continue my Open Source efforts. You can send me questions for the blog using this form and subscribe to receive an email when there is a new … Continue reading: ¿Qué es el Índice de Gini y cómo calcularlo?
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1. ⭐ Single-Cell Splicing EStimation – deciphering splicing heterogeneity at single-cell resolution

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、Hi-C、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、Scanpy、epigenetic、histone
• 📝 描述：Researchers developed SCSES, a computational tool that enhances RNA sequencing data by accurately detecting alternative splicing and revealing hidden cellular diversity…
• 🔗 查看原文

2. ⭐ RNA sequencing reveals age-related changes in T cells that weaken vaccine responses

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、sequencing、RNAseq、single.cell、single-cell、scRNA、scDNA、scATAC、Seurat、histone
• 📝 描述：Researchers used single-cell RNA sequencing to reveal how aging alters T cell function, explaining weaker vaccine responses in older adults and guiding future vaccine innovations…
• 🔗 查看原文

3. ⭐ sysVI – integrating single-cell RNA-seq datasets with substantial batch effects

• ✍️ 作者：未知作者
• 🏷️ 关键词：RNA-seq、RNAseq、single.cell、single-cell、scRNA、scDNA、scATAC
• 📝 描述：Researchers at Helmholtz Munich developed sysVI, a machine learning method that improves integration of RNA sequencing data across diverse systems while preserving vital…
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• 从“基因沉默”到“基因组守护”：任捷等揭示Dicer作为分子枢纽，协调转录、复制与修复 | Cell Press论文速递

• GSE254563 Podocyte Twin in Culture: Patient-specific ex vivo Model of Genetic FSGS caused by an INF2 Mutation
• GSE304835 Transcriptomic profiling of DHA-treated human chondrocytes
• GSE263443 Gene expression profile at single cell level of CD11b+ cells from E18.5 fetal brain
• GSE289801 Effect of FBL depletion on cell morphology