详细内容（全部6条）

1. ⭐ scRNA-seq揭示病毒感染的“细胞级真相”

• ✍️ 作者：生信漫漫学
• 🏷️ 关键词：RNA-seq、RNAseq、scRNA
• 📝 描述：文章概述及研究背景 单细胞数据在病毒免疫研究中的应用
• 🔗 查看原文

2. ⭐ 单细胞测序解析骨肉瘤T细胞耗竭轨迹

• ✍️ 作者：生信漫漫学
• 🏷️ 关键词：测序、单细胞、轨迹
• 📝 描述：文献简介及研究背景 单细胞及其数据集概述 主要分析内容简介
• 🔗 查看原文

3. 文献分享｜JACS｜基于适体测序的单细胞高通量多组学定量分析

• ✍️ 作者：杨朝勇课题组
• 🏷️ 关键词：测序、单细胞
• 📝 描述：文献分享｜JACS｜基于适体测序的单细胞高通量多组学定量分析
• 🔗 查看原文

4. 课题组工作 ｜ Adv. Sci. ｜ 高度有序的DNA框架界面实现高效酶促寡核苷酸合成

• ✍️ 作者：杨朝勇课题组
• 🏷️ 关键词：scDNA
• 🔗 查看原文

5. 单细胞细胞类型与细胞状态

• ✍️ 作者：生信漫漫学
• 🏷️ 关键词：单细胞
• 📝 描述：细胞类型与细胞状态 如何定义细胞状态 时间序列单细胞数据分析
• 🔗 查看原文

6. 宏基因组组装必备软件清单

• ✍️ 作者：生信漫漫学
• 🏷️ 关键词：基因组
• 📝 描述：宏基因组组装软件概述 软件安装及简单介绍
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详细内容（前10条）

1. ⭐ GSE309698 Transcriptomic Profiling of Bronchial Epithelium Reveals Dysregulated Interferon and Inflammatory Responses to Rhinovirus in Exacerbation-Prone Pediatric Asthma [RNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、lymphoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、Hi-C、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Seurat、epigenetic、epigenome、methylation、histone、enrichment
• 📝 描述：Contributors : Basilin Benson ; Jason S. Debley ; Matthew C. AltmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHost factors influencing susceptibility to rhinovirus-induced asthma exacerbations remain poorly characterized. Using organotypic bronchial epithelial cultures from well-characterized children with asthma and healthy children, this study investigated viral load kinetics and resultant host responses by bulk and single-cell transcriptomics and ta…
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2. ⭐ GSE309311 Transcriptomic Profiling of Bronchial Epithelium Reveals Dysregulated Interferon and Inflammatory Responses to Rhinovirus in Exacerbation-Prone Pediatric Asthma [scRNA-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、lymphoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、Hi-C、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Seurat、epigenetic、epigenome、methylation、histone、enrichment
• 📝 描述：Contributors : Naresh Doni Jayavelu ; Jason S. Debley ; Matthew C AltmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHost factors influencing susceptibility to rhinovirus-induced asthma exacerbations remain poorly characterized. Using organotypic bronchial epithelial cultures from well-characterized children with asthma and healthy children, this study investigated viral load kinetics and resultant host responses by bulk and single-cell transcriptomics a…
• 🔗 查看原文

3. ⭐ GSE309705 Transcriptomic Profiling of Bronchial Epithelium Reveals Dysregulated Interferon and Inflammatory Responses to Rhinovirus in Exacerbation-Prone Pediatric Asthma

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、lymphoma、Hi-C、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、transcriptome、transcriptomics、proteome、proteomics、Seurat、epigenetic、epigenome、methylation、histone、enrichment
• 📝 描述：Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• 🔗 查看原文

4. ⭐ GSE307469 Bulk RNA sequencing for gene expression profiling of iPSC-derived liver sinusoidal endothelial cells treated with Antithymocyte globulin compared with normal rabbit IgG

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、lymphoma、sequencing、RNAseq、single.cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、proteome、Bioconductor、Seurat、epigenetic、epigenome、histone、pathway、enrichment、clustering
• 📝 描述：Contributors : Shuntaro Kawamura ; Yosuke Yoneyama ; Norikazu Saiki ; Takanori TakebeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAntithymocyte globulin (ATG) is a widely used immunosuppressive agent, yet its off-target vascular effects remain a clinical challenge in part due to a lack of relevant human models. To elucidate the effects of ATG on liver sinusoidal endothelial cells, we performed bulk RNA-seq analysis of iPSC-derived liver sinusoidal endoth…
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5. ⭐ GSE297393 Single-cell RNA sequencing reveals distinct senotypes and a quiescence-senescence continuum at the transcriptome level following chemotherapy

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、oncology、carcinoma、sequencing、RNAseq、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、transcriptome、Seurat、Scanpy、pathway、enrichment、clustering
• 📝 描述：Contributors : Brianna Fernandez ; Victor Passanisi ; Humza M Ashraf ; Sabrina L SpencerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensQuiescence (reversible cell-cycle arrest) and senescence (irreversible arrest) are challenging to distinguish due to a lack of specific biomarkers, yet both arise simultaneously after chemotherapy. While senescence suppresses tumors by limiting proliferation and recruiting the immune system, quiescent cancer cells evade fut…
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6. ⭐ GSE295949 Augmenting AMPA receptor signaling following spinal cord injury increases ependymal-derived stem/progenitor cell (epNSPC) migration and promotes functional recovery

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、oncology、carcinoma、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、transcriptome、proteome、Seurat、Scanpy、epigenetic、epigenome、clustering、trajectory
• 📝 描述：Contributors : Laureen D Hachem ; Homeira Moradi Chameh ; Gustavo Balbinot ; Andrea J Mothe ; Alain Pacis ; Rui Tong Geng Li ; Taufik Valiante ; Wei Lu ; Charles H Tator ; Michael G FehlingsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUsing lineage tracing in adult mice, we demonstrate that pharmacological blockade of AMPARs reduces epNSPC proliferation and migration after cervical SCI. Similarly, knocking out AMPAR subunits in Foxj1+ ependymal cells and…
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7. ⭐ GSE246071 Quantitative transcriptome N6-methyladenosine profiling reveals the mechanism of far-red regulated anthocyanin homeostasis in Arabidopsis

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、sequencing、Hi-C、scRNA、scDNA、scATAC、spatial、Visium、genome、genomics、transcriptome、transcriptomics、proteome、Seurat、Scanpy、epigenome、methylation、histone、enrichment
• 📝 描述：Contributors : Shun Liu ; Bochen Jiang ; Mengjie Chen ; Chuan HeSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaN6-methyladenosine (m6A) is the most abundant messenger RNA modification in higher eukaryotes. Functional studies of the RNA m6A modification in plants have been limited by mapping individual m6A-modified sites in whole transcriptomes. In this study, we introduce the method m6A-selective allyl chemical labeling and sequencing (m6A-SAC-seq…
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8. ⭐ GSE267292 DNA cytosine methylation suppresses meiotic recombination at the sex-determining region (H3K27ac ChIP-seq)

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、Hi-C、scRNA、scDNA、scATAC、genome、genomics、proteome、proteomics、Seurat、methylation、histone、clustering
• 📝 描述：Contributors : Tong Ge ; Xiuqi GuiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Chlamydomonas reinhardtiiIn sexual organisms, random meiotic recombination between homologous chromosomes is vital to maximize genetic variation among offspring. The sex-determining region (SDR), however, does not undergo recombination, as required for the maintenance of distinct alleles. The contribution of epigenetic versus genetic mechanisms to suppress recombination in S…
• 🔗 查看原文

9. ⭐ GSE246671 Gene expression of hippocampus from 17-month-old wildtype mice with sham/400 mGy X-ray irradiation treatment and 17-month-old 3xTg-AD mice with sham/400 mGy X-ray irradiation treatment.

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、oncology、carcinoma、Hi-C、scRNA、scDNA、scATAC、10x、spatial、genome、genomics、proteome、proteomics、Seurat、Scanpy、epigenome、methylation、histone、pathway、enrichment
• 📝 描述：Contributors : Chi H Ma ; Yi J Xu ; Tan Wu ; Xin WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrent study aimed to identify the 400 mGy X-ray irradiation-induced unique gene expression changes in the hippocampus of the 17-month-old 3xTg-AD mice.
• 🔗 查看原文

10. ⭐ GSE244622 Single-cell transcriptome sequencing provides insight into multiple chemotherapy resistance in a patient with refractory DLBCL: a case report

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、sequencing、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、Visium、genome、genomics、transcriptome、transcriptomics、Seurat、Scanpy、epigenetic、epigenome、enrichment
• 📝 描述：Contributors : Zhao Kewei ; Zhang LilingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRelapsed and refractory diffuse large B-cell lymphoma (DLBCL) is associated with poor prognosis. As such, a comprehensive analysis of intratumoral components, intratumoral heterogeneity, and the immune microenvironment is essential to elucidate the mechanisms driving the progression of DLBCL and to develop new therapeutics.
• 🔗 查看原文

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1. ⭐ 集成的单核和空间转录组学阐明了幕上室管膜瘤的异质性和缺氧驱动的组织。

• ✍️ 作者：未知作者
• 🏷️ 关键词：空间转录组、空间组学、转录组
• 📝 描述：Secret hovertext: 幕上室管膜瘤通常是危及生命的脑肿瘤，其特征是显着的分子异质性。缺氧导致了这种异质性，但这种关系的程度和性质仍不清楚。这给有效的治疗策略带来了挑战，需要对潜在生物学有更全面和详细的了解。在这项研究中，我们采用单核 （n = 63） 和空间 （n = 30） 转录组学来描绘幕上室管膜瘤的细胞和空间景观。表征该实体的转录共识程序揭示了两个以前未描述的程序，它们与细胞外基质的重塑和 ZFTA 融合身份有关。这些程序与非常不利的结果有关，并且是 ZFTA 融合阳性肿瘤所独有的。开发一套对混合点转录组敏感的空间评分算法能够确定缺氧作为空间组织潜在驱动因素的作用。再加上程序之间推断的重复空间关联，这为高阶架构的广义模型提供了信息。该模型的功能和空间定义区域显示出明显的免疫存在，其中缺氧区最高。这些结果提供了对幕上室管膜瘤的分子异质性和空间组织的见解，这可能有助于开发未来有针对性的治疗方法。
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2. 在通往罗马的道路上：定义精准肿瘤学中的组织-液体一致性。

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤、通路
• 📝 描述：Secret hovertext: 越来越多的证据已将液体活检确立为一种有前途的非侵入性基因组分析平台。在本评论中，我们以多中心、随机 II 期 ROME 试验的结果为基础，探讨了组织液分析一致性在改善个性化癌症治疗和生存结果方面的挑战和机遇。
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3. 始终遵守身体活动指南和消化系统癌症风险和死亡率

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 重要性越来越多的证据表明，体育锻炼可以预防消化系统癌症 （DSC）。然而，持续达到身体活动指南（≥7.5 代谢当量任务（MET）小时/周）是否与较低的 DSC 风险相关，或者是否需要更高的水平，目前尚不清楚。目的 探讨体力活动与 DSC 风险和死亡率的关系，重点关注长期执行推荐水平的最佳量和长期一致性。设计、设置和参与者 这项基于人群的队列研究包括来自 3 个大型美国前瞻性队列的数据：卫生专业人员随访研究，1988-2020 年;护士健康研究，1988-2021 年;和护士健康研究 II，1991-2021 年。数据分析于 2024 年 10 月至 2025 年 5 月期间进行。参与者是基线时没有癌症和心血管疾病的男性和女性。暴露 使用两年一次的经过验证的问卷评估休闲时间身体活动的总水平，并以每周 MET 小时数表示。一致性计算为达到推荐水平（≥7.5 MET 小时/周）的随访年数百分比。主要结局和措施
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4. 微卫星稳定结直肠癌靶向治疗后获得性高肿瘤突变负荷和免疫治疗活性

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext: 目的：与微卫星不稳定性高 （MSI-H） CRC 相比，微卫星稳定 （MSS） 结直肠癌 （CRC） 突变很少，并且对免疫检查点阻断 （ICB） 不敏感。用靶向药物治疗的 CRC 在进展过程中通常会获得大量基因组改变。我们询问靶向治疗是否可用于在 MSS CRC 中产生高肿瘤突变负荷 （TMB） 并使这些肿瘤对 ICB 敏感。患者和方法：在接受靶向治疗的 MSS 转移性 CRC 患者中，我们评估了肿瘤发展为高 TMB 的患者的基线和进展 TMB 以及对 ICB 的反应。我们确定了在获得性高 TMB 病例中与紧急基因组改变相关的改变类型、突变特征、新抗原性和克隆性。结果：26 例病例中，9 例进展时 TMB 升高。其中三名患者接受了 ICB，但均无反应。在 TMB 高病例中，我们没有发现肿瘤浸润淋巴细胞的诱导或程序性死亡配体 1 表达。获得性基因组改变主要由单核苷酸变异组成，富集了单碱基取代
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5. 人工智能在癌症中的应用、挑战和未来展望

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 人工智能 （AI） 正在迅速彻底改变肿瘤学研究的格局和个性化临床干预的进步。三个相互关联的领域的进展，包括训练人工智能模型的方法和算法的开发、专业计算硬件的发展以及成像、基因组学和临床信息等大量癌症数据的访问增加，已经融合在一起，导致人工智能在癌症研究中的新应用前景广阔。人工智能应用根据特定的癌症类型和临床领域进行系统组织，包括生物学机制的阐明和预测、临床数据中模式的识别和利用以改善患者预后，以及揭示流行病学、行为和现实世界数据集中固有的复杂性。当以道德和科学严谨的方式应用时，这些人工智能驱动的方法有望加速癌症研究的进展，并最终促进改善所有人群的健康结果。我们回顾了展示人工智能在肿瘤学中整合的例子，重点介绍了深度学习巧妙地解决了曾经被认为无法克服的挑战的案例，同时还讨论了为促进这些技术的更广泛采用而必须克服的障碍。
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6. I 型干扰素信号传导对癌症的背景依赖性影响

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext: 长期以来，I 型干扰素 （IFN） 一直被认为是分子机制的关键组成部分，该分子机制首先对多细胞真核生物中的病毒感染做出反应。最近，I 型干扰素信号传导也已成为自然发展的肿瘤以及对（免疫）治疗有反应的肿瘤的微环境中的常见过程。在这种情况下，稳健、急性但最终解决的 I 型干扰素反应似乎通过多种机制支持自然和治疗驱动的癌症免疫监测，包括恶性细胞阻止其增殖并经历凋亡细胞死亡的累积倾向，以及对 CD8+ 细胞毒性 T 淋巴细胞 （CTL）、自然杀伤 （NK） 细胞的广泛免疫刺激作用， 树突状细胞 （DC） 和肿瘤相关巨噬细胞 （TAM）。相反，微弱、惰性和最终无法解决的 I 型干扰素反应实际上促进了肿瘤进展，不仅通过促进恶性细胞的干性（这与转移性播散和治疗耐药性增加有关），而且还有利于建立高度免疫抑制的淋巴和髓系肿瘤微环境。在这里，我们对 I 型干扰素信号传导对癌症进展和治疗反应的背景依赖性影响进行
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7. 肿瘤浸润淋巴细胞疗法在基因工程时代成熟

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext:
• 🔗 查看原文

8. 不利组织学和临床 M 期的序贯组合定义了高危神经母细胞瘤：儿童肿瘤学组的一份报告

• ✍️ 作者：未知作者
• 🏷️ 关键词：肿瘤
• 📝 描述：Secret hovertext: 目的：从历史上看，神经母细胞瘤风险分层以临床分期为起点，随后依次增加其他预后因素。本研究采用另一种方法从国际神经母细胞瘤病理学分类 （INPC） 开始定义神经母细胞瘤患者风险组。实验设计：以前用于开发儿童肿瘤学组修订神经母细胞瘤风险分类 （RNRC） 系统的神经母细胞瘤患者队列通过生存树回归分析重新分析，从 INPC 开始区分有利的组织学和不利的组织学类别。由此产生的两个分支首先由国际神经母细胞瘤风险组分期系统 （INRGSS） 进一步划分，然后依次按其他预后因素划分。结果：这种新的分层系统，即 INPC-风险分组 （INPC-RG），比 RNRC 系统更简单，消除了不必要的决策树并区分了四个风险组（第 I 组至第 IV 组）。INPC-RG 仅使用 INPC（不利组织学）和 INRGSS（M 期），定义了具有高度侵袭性的 IV 组肿瘤的患者，其 5 年无事件生存期（EFS）低于 RNRC
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9. 一线 sacituzumab govitecan 可延长 TNBC 的 PFS

• ✍️ 作者：未知作者
• 🏷️ 关键词：scATAC
• 📝 描述：Secret hovertext:
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10. 超越基础：在医疗补助扩张的基础上实现癌症公平。

• ✍️ 作者：未知作者
• 🏷️ 关键词：癌症
• 📝 描述：Secret hovertext:
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1. ⭐ Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、sequencing、RNA-seq、RNAseq、ATAC-seq、Hi-C、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、spatially、transcriptome、transcriptomics、bioinformatics、R package、Scanpy、pathway
• 📝 描述：RNA sequencing technologies reveal how gene expression varies across tissues and individual cells, offering new insights into biology through advanced bioinformatics and computational…
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2. ⭐ MultiGATE – integrative analysis and regulatory inference in spatial multi-omics data via graph representation learning

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、single.cell、scRNA、scDNA、scATAC、spatial、Visium、genome、genomics、Seurat、clustering
• 📝 描述：RNA sequencing combined with spatial multi-omics and AI-driven analysis enables deeper insights into transcriptional regulation and cellular organization within tissues…
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• GSE279944 Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes [Mnase-Seq]
• GSE246670 Gene expression of hippocampus from 9-month-old wildtype mice with sham/400 mGy X-ray irradiation treatment and 9-month-old 3xTg-AD mice with sham/400 mGy X-ray irradiation treatment
• GSE244783 Comprehensive Mapping of Transcriptionally-active Enhancers During Murine Cardiogenesis at Single Cell Resolution
• GSE298225 Transcriptomic profiling of cardiac lymphatic endothelial cells in autoimmune myocarditis
• GSE291412 Hepatic Transcriptomic Responses in Pregnant and Non-pregnant Rats Exposed to HFPO-DA: Analyses to Inform the Role of Maternal Effects on Neonatal Toxicity
• GSE250389 Transcriptomic analyses of mouse livers from an 18-month oral carcinogenicity study of HFPO-DA with a 9-month chronic toxicity phase
• GSE303009 Phenotypically Anchored Transcriptomics of Diverse Agrichemicals Revealed Congruent Pathways and Unique Gene Expression Signatures
• GSE288749 Senescence of tumor-specific Non-Classic Monocytes Facilitates Immune Suppression and Prostate Cancer Progression through Tumor and Host Immune Interactions
• GSE282291 Exercise Training-induced Extracellular miR-136-3p Modulates Glucose Uptake and Myogenesis through Targeting of NRDC in Human Skeletal Muscle
• GSE279908 Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes [RNA-Seq]
• GSE309638 Laser fixed-point timing and quantitatively induce venous thrombosis in zebrafish as a general model system to address the essential initial inflammation cytokines
• GSE281816 A Novel Microprotein, MUCP1, Mediates Succinate Transport and Promotes Colorectal Cancer Progression by Modulating Glutamine Metabolism
• GSE280881 Rapid Disease Progression of Myelodysplastic Syndrome is Reflected in Transcriptomic and Functional Abnormalities of Bone Marrow MSCs
• GSE246719 Comprehensive bioinformatics analysis reveals the hub genes and pathways in a mouse model of Pierpont Syndrome
• GSE307622 Western Diet-induced Visceral Adipose Tissue Inflammation Promotes Alzheimer’s Disease Pathology via Microglial Activation in a Mouse Model
• GSE294468 Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell
• GSE278554 Early transcriptional responses post-recanalization in a mouse model of middle cerebral artery occlusion
• GSE300419 Photobiomodulation mitigates LPS-induced astrocyte neuroinflammation via the STAT5A/SOCS3 axis
• GSE298822 G9a Epigenetically Suppresses CXCL10 Expression and Inhibits Anti-tumor Immunity in Hepatocellular Carcinoma
• GSE280115 Circadian Reprogramming by Timed Sodium Intake Reveals Transcriptional Pathways of Daily Salt Handling in the Colon.
• GSE246320 EGR1 induction compromises the therapeutic efficacy of BET depletion in triple-negative breast cancer (ChIP-Seq)
• GSE246319 EGR1 induction compromises the therapeutic efficacy of BET depletion in triple-negative breast cancer (RNA-Seq)
• GSE236051 Dual transcriptomics of host-pathogen interaction of neonatal sepsis/meningitis causing isolate Cronobacter turicensis z3032 with zebrafish larvae
• GSE307004 Stability and Progressive Differentiation of Tfr cells are intrinsically and extrinsically controlled by Tfh programs [TCR-seq]
• GSE262594 Multi-omics of Sex-Based Differences in Nephrotoxic Serum Nephritis [scATAC-seq]
• GSE256325 Gene expression changes in postnatal mouse brain Neural Stem Cells differentiated in the presence of platelets.
• GSE263421 Bruceine A protects nuclear receptor 4A1 from ubiquitin-degradation to alleviate mesangial proliferative glomerulonephritis
• GSE244443 A human-specific microRNA controls the timing of excitatory synaptogenesis (time course smallRNA)
• GSE306845 Accute and repeated DSS exposure induce distinct immune responses with differential relevance to human Ulcerative Colitis
• GSE295414 SMD2 reads pseudouridines to regulate mRNA splicing and promote tumorigenesis [RNA-Seq]
• GSE294560 Bulk RNAseq profiling of Streptococcus pneumoniae EF3030 and Influenza A virus (A/California/07/2009(H1N1)) mono/coinfection in the mouse lungs.
• GSE278799 Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model
• GSE303160 Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes
• GSE262692 Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells
• GSE306221 Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells
• GSE301252 A widely-occurring family of pore-forming effectors broadens the impact of the Serratia Type VI secretion system
• GSE280730 Oligoastrocytoma consisting of IDH-mutant 1p/19q-codeleted oligodendroglioma and IDH-wildtype astrocytoma
• GSE269653 Identification of strong constitutive promoters in Burkholderia to activate natural product production in Gram-negative bacteria
• GSE253978 Training-induced exosomal miR-136-3p modulates mitochondrial functions by targeting NRDC in human skeletal muscle.
• GSE252789 Multi-omics based dynamic molecular changes characterization in EV-A71-infected mice elucidating potential therapeutic targets
• GSE234880 Ruxolitinib improves hematopoietic regeneration by retrieving mesenchymal stromal cell function in aGVHD
• GSE217660 Glioma immune microenvironment associated with malignant transformed cells Transcriptome sequencing
• GSE244440 A human-specific microRNA controls the timing of excitatory synaptogenesis (time course ribozero)
• GSE307468 Bulk RNA sequencing for gene expression profiling of iPSC-derived liver sinusoidal endothelial cells and arterial endothelial cells
• GSE295415 SMD2 reads pseudouridines to regulate mRNA splicing and promote tumorigenesis [RIP-Seq]
• GSE280633 The function and mechanisms of hsa_circCDKN2B-AS_012 on tumor suppression of Colorectal cancer
• GSE278690 Phenotypic impact of individual conserved neuronal microexons and their regulators in zebrafish
• GSE278292 Nuclear body reorganization by the viral RNA kaposin promotes Kaposi-sarcoma associated herpesvirus gene expression
• GSE262595 Multi-omics of Sex-Based Differences in Nephrotoxic Serum Nephritis [scRNA-seq]
• GSE201566 Differential autophagy responses in macrophages in chronic inflammatory gastrointestinal disorders
• GSE287559 Winter temperature affects fatty acid composition and gene expression, but not fat content and survival in a northern population of a range-expanding spider
• GSE280321 USP13 dictates RAN turnover and vulnerability to ferroptosis in diffused large B cell lymphoma (DLBCL)
• GSE277398 Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen-spreading and elimination of antigen-negative tumor variants
• GSE276264 Comparison of the transcriptome of KP4 controls or resistant to Folfirinox after 96h of treatment with Vehicule or Folfirinox
• GSE265832 Ex vivo–expanded human regulatory T cells enhance cholesterol efflux and PON1 expression in oxLDL-exposed macrophages
• GSE260601 A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects
• GSE254670 Obesity modifies cell fate plasticity of Pdgfrα-expressing adipocyte progenitors to promote an aberrant mammary microenvironment
• GSE238265 An IL-17-Ly6G+Polymorphonuclear Neutrophil (PMN) axis limits protective host responses against tuberculosis.
• GSE280446 Transcriptional alteration in the treatment of MDA-MB-231 cells using SFN and/or ZA
• GSE280172 Effect of NUDT21 knockdown on gene expression in MUTZ-1 and SKM-1 myelodysplastic syndrome cells
• GSE280046 Transcriptome sequencing of THP1 cells infected with Brucella
• GSE267157 Effect of HIPK3 depletion in tamoxifen-resistant EGFR-overexpressing MCF7 breast cancer cells
• GSE131468 Next Generation Sequencing Facilitates Quantitative Analysis of Erysiphe pisi infected resistant and susceptible garden pea genotypes
• GSE306818 Stability and Progressive Differentiation of Tfr cells are intrinsically and extrinsically controlled by Tfh programs
• GSE291404 Deficiency of the Collagen Endocytic Receptor MRC2 Accelerates Mouse Lung Fibroblast Proliferation
• GSE291115 Transcriptomic responses in zebrafish ovary to PNX and receptor agonists
• GSE286568 Comparison of gene expression in HeLa cells after treatment with IFN-b, IFN-g, or VPgEMCV.
• GSE280708 Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling
• GSE278345 A plastidial lipoyl synthase LIP1p plays a crucial role in phosphate homeostasis in Arabidopsis.
• GSE267542 Tumor intrinsic METTL5 induces immune resistance in ovarian cancer by suppressing ferroptosis
• GSE244441 A human-specific microRNA controls the timing of excitatory synaptogenesis (pLNA dataset)
• GSE230140 Transcriptome-wide off target examining of AIM systems.
• GSE289915 Comparing Transcriptomes of human Alpha Beta and Gamma Delta T cells
• GSE289913 Transcriptome analysis of γδT cells with/without PERK knockdown
• GSE222584 Single cell sequencing revealed cell heterogeneity in rice infected with RRSV and RGSV
• GSE244444 A human-specific microRNA controls the timing of excitatory synaptogenesis
• GSE308622 Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension III
• GSE308621 Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension II
• GSE308620 Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension
• GSE308226 RBMXL3 binds a wide range of RNA molecules in human TCam-2 cells (eCLIP data)
• GSE305182 Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases
• GSE281563 Oxidative phosphorylation in kidney-resident macrophages of type 2 diabetic kidney disease
• GSE280044 RNA-seq analysis of NK-92 cells expressing Vaccinia virus (VACV) poxin (encoded by the B2R gene)
• GSE276990 TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma
• GSE307200 tRF-394 has the potential to be a RNA-based therapy for H. pylori-infected gastric cancer
• GSE274855 APOBR is downregulated in EBV+ tonsils of children with obstructive sleep-disordered breathing
• GSE278823 liver isolated single cell RNAseq v2
• GSE278822 liver isolated single cell RNAseq v1
• GSE270115 SGSS05-NS3 as a potent SETD8 inhibitor that activates p53 pathway in Neuroblastoma
• GSE248157 Thiolutin is a direct inhibitor of RNA Polymerase II
• GSE216922 ChIP-Seq of MYC in MCF-7 cells with EPIC1 knockdown or overexpression.
• GSE308336 PFOA impairs host immune response in viral infection
• GSE298532 IsomiR Utility in ALS Prognostication (ALS)
• GSE289345 Highly multiplexed mRNA quantitation with CRISPR-Cas13
• GSE307456 IsomiR Utility in ALS Prognostication [control]
• GSE278824 miR_122 Knockout mice
• GSE278821 whole liver RNAseq
• GSE244047 Effect of naringin in mouse lymph nodes

• 大规模 T 细胞受体库分析揭示了用于诊断不确定肺结节的肿瘤特异性信号。
• ABBV-303 是一种针对表达 c-Met 的肿瘤的自然杀伤细胞接合剂。