详细内容（前10条）

1. ⭐ GSE289018 Comparative Single Cell RNA Sequencing of Notch2 and RBPJ-deficient mononuclear phagocyte cells and myeloid progenitors from the spleen and bone marrow

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、lymphoma、sequencing、RNAseq、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、proteome、metabolome、Seurat、Scanpy、epigenetic、epigenome、histone、enrichment、trajectory
• 📝 描述：Contributors : Jaba Gamrekelashvili ; Florian P LimbourgSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMononuclear phagocytes and their myeloid progenitors are critical in various homeostatic processes as well as immune responses. We employed single-cell RNA sequencing to investigate myeloid progenitors and mononuclear phagocytic cell subsets, including monocytes, splenic red pulp macrophages and dendritic cells in the spleen and in the bone marrow, with a…
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2. ⭐ GSE309097 Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis.

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、leukemia、Hi-C、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、proteome、proteomics、Seurat、Scanpy、methylation、histone、enrichment、clustering
• 📝 描述：Contributors : Johann E Gudjonsson ; Lam C TsoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGeneralized pustular psoriasis (GPP) is a severe subtype of psoriasis characterized by epidermal neutrophil infiltration, often presenting as acute, potentially life-threatening flares. However, the characterization of the immune micro-environment in GPP lesions remains largely unknown. Here, we used single-cell RNA profiling to interrogate the transcriptomes of 6…
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3. ⭐ GSE291317 The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [scRNA-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、spatially、genome、genomics、transcriptome、transcriptomics、Scanpy、histone、enrichment
• 📝 描述：Contributors : Joseph Léger ; Eva Artano ; Delphine Coulais ; Naomie Belletoise ; Fadhloun Raoudha ; Devin Kenney ; Avinash Bhandoola ; Christelle HarlySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHelper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced expression of NF…
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4. ⭐ GSE291316 The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [RNA-seq - Tox]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、spatially、genome、transcriptome、Seurat、Scanpy、histone、enrichment
• 📝 描述：Contributors : Joseph Léger ; Eva Artano ; Delphine Coulais ; Naomie Belletoise ; Fadhloun Raoudha ; Devin Kenney ; Avinash Bhandoola ; Christelle HarlySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHelper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced expression of NF…
• 🔗 查看原文

5. ⭐ GSE291076 The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [RNA-seq - Il7rLT]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、spatially、genome、transcriptome、Seurat、Scanpy、histone、enrichment
• 📝 描述：Contributors : Joseph Léger ; Eva Artano ; Delphine Coulais ; Naomie Belletoise ; Fadhloun Raoudha ; Devin Kenney ; Avinash Bhandoola ; Christelle HarlySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHelper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced expression of NF…
• 🔗 查看原文

6. ⭐ GSE291075 The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [RNA-seq - ex vivo, Nfil3]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、10x、spatial、spatially、genome、transcriptome、Scanpy、histone、enrichment
• 📝 描述：Contributors : Joseph Léger ; Eva Artano ; Delphine Coulais ; Naomie Belletoise ; Fadhloun Raoudha ; Devin Kenney ; Avinash Bhandoola ; Christelle HarlySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHelper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced expression of NF…
• 🔗 查看原文

7. ⭐ GSE305511 DNA Methylation Profiles Predicting Response to Anti-PD-1-based Treatment in Patients with Advanced Gastric Cancer [Targeted Bisulfite-Seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：cancer、RNA-seq、RNAseq、DNA-seq、ATAC-seq、Hi-C、scRNA、scDNA、scATAC、spatial、genome、genomics、proteome、proteomics、epigenetic、epigenome、methylation、histone
• 📝 描述：Contributors : Wei Tang ; Zhixiong WangSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensImmunotherapy has shown promise in treating gastric cancer, but predicting patient response remains challenging. In this study, DNA methylation levels at 20 specific CpG probes were measured in 69 tumor samples using targeted bisulfite sequencing (TBS). These CpG probes, previously identified as highly predictive of treatment response, were used to construct and validate…
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8. ⭐ GSE291319 The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [DNase-seq]

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、carcinoma、RNA-seq、RNAseq、DNA-seq、ChIP-seq、ATAC-seq、scRNA、scDNA、scATAC、spatial、spatially、genome、transcriptome、Scanpy、histone、enrichment
• 📝 描述：Contributors : Joseph Léger ; Eva Artano ; Delphine Coulais ; Naomie Belletoise ; Fadhloun Raoudha ; Devin Kenney ; Avinash Bhandoola ; Christelle HarlySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHelper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced ex…
• 🔗 查看原文

9. ⭐ GSE300531 A Single-cell Transcriptomic Profiling Reveals the Effects of Chronic House Dust Mite Exposure on the Murine Lung Microenvironment

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、single.cell、single-cell、scRNA、scATAC、Visium、genome、genomics、transcriptome、transcriptomics、proteome、epigenetic、epigenome、histone、enrichment、clustering
• 📝 描述：Contributors : Han Chang ; Chanond A Nasamran ; Scott Herdman ; Maripat Corr ; Kathleen M Fisch ; Nicholas Webster ; Eyal Raz ; Samuel BertinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHouse dust mite (HDM) is a common environmental aeroallergen linked to the development of allergic airway inflammation and asthma. While the effects of acute HDM exposure on T helper 2 (Th2)-driven allergic responses and pulmonary eosinophilia are well established in muri…
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10. ⭐ GSE290358 ZEB1, a novel Junctional Adhesion Molecule A regulator, impacts sensitivity of pancreatic cancer-associated fibroblasts to oncolytic reovirus

• ✍️ 作者：未知作者
• 🏷️ 关键词：tumor、cancer、oncology、Hi-C、single.cell、single-cell、scRNA、scDNA、scATAC、spatial、spatially、Visium、genome、genomics、Seurat、Scanpy、histone
• 📝 描述：Contributors : Dam Nicole ; Harryvan Tom J. ; Dang Hao ; Ioannidis Gavriil ; Schmierer Bernhard ; Haawinkels Lukas J.A.C. ; Kemp VeraSeries Type : OtherOrganism : Homo sapiensOncolytic virus (OV) therapy is a promising treatment for various tumors. However, in pancreatic ductal adenocarcinoma (PDAC), the high abundance of cancer-associated fibroblasts (CAFs) can limit OV therapy efficacy by impairing viral spread and anti-tumor immunity. We have previously shown that oncolytic reovirus infection…
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1. ⭐ Of course, someone has to write imperative code to build reproducible data science pipelines. It doesn’t have to be you.

• ✍️ 作者：未知作者
• 🏷️ 关键词：scRNA、scDNA、scATAC、spatial、Seurat、Scanpy、histone
• 📝 描述：Last time I quickly introduced my latest package, {rixpress}, but I think that to really understand what {rixpress} brings to the table, one needs to solve the same problem without it. And incidentally, I think that this exercise also show… Continue reading: Of course, someone has to write imperative code to build reproducible data science pipelines. It doesn’t have to be you.
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详细内容（全部2条）

1. ⭐ Matching gene expression to metabolite production in single plant cells

• ✍️ 作者：未知作者
• 🏷️ 关键词：single.cell、genome、genomics、histone
• 📝 描述：Researchers combined single-cell RNA sequencing with mass spectrometry to analyze gene expression and metabolite profiles in the same plant cell, offering new insights into…
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2. P-body-seq permits comprehensive profiling of P-body contents

• ✍️ 作者：未知作者
• 🏷️ 关键词：Hi-C
• 📝 描述：Researchers used RNA sequencing to show how RNA condensates called P-bodies control stem cell fate by storing untranslated RNAs that guide developmental decisions across vertebrate species..
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• GSE308109 Comparative transcriptomics as a key to understanding the adaptation mechanisms of Baikal sculpins to the deep-water habitat
• GSE309549 Transcriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms [KO_RNAseq]
• GSE309548 Transcriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms [Human_RNAseq]
• GSE296122 Complex DNA Structural Variant on Chromosome 2 in a Pediatric Patient with Development Delay and Congenital Malformation
• GSE272716 mTORC1 controls ILC2 activation and allergic lung inflammation through NMUR1-mediated neuronal regulation [WT-KO ILC2s RNA-seq]
• GSE295844 Circadian regulator REV-ERBα is a master regulator of tumor lineage plasticity and an effective therapeutic target [ChIP-Seq]
• GSE287517 Chemical reprogramming of fibroblasts into functional retinal pigment epithelium cells (scRNA-seq)
• GSE287516 Chemical reprogramming of fibroblasts into functional retinal pigment epithelium cells (RNA-seq)
• GSE268044 StealTHY: enabling CRISPR-Cas9 screens in immunocompetent hosts to expose concealed metastatic regulators [single-end]
• GSE276674 Vascular regeneration with adenovirally reprogrammed endothelial cells and their long-term neovascularization effects
• GSE306157 Distinct miRNA profiles in human amniotic tissue and its vesicular and non-vesicular secretome
• GSE295843 Circadian regulator REV-ERBα is a master regulator of tumor lineage plasticity and an effective therapeutic target. [ATAC-Seq]
• GSE295834 Circadian regulator REV-ERBα is a master regulator of tumor lineage plasticity and an effective therapeutic target [RNA-Seq]
• GSE231432 HSC-derived exosomal miR-122- 5p inhibits EMT and fibrosis of intrahepatic biliary epithelial cells to alleviate primary biliary cholangitis
• GSE305240 DNA Methylation Profiles Predicting Response to Anti-PD-1-based Treatment in Patients with Advanced Gastric Cancer
• GSE290046 PolyA RNA seq of human glioblastoma cells treated with a pool of 11 miRNAs in vitro and in vivo (orthotopic tumors in mice)
• GSE268588 StealTHY: enabling CRISPR-Cas9 screens in immunocompetent hosts to expose concealed metastatic regulators [CRISPR]
• GSE268045 StealTHY: enabling CRISPR-Cas9 screens in immunocompetent hosts to expose concealed metastatic regulators [paired-end]
• GSE291321 The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [CUT&RUN]
• GSE291077 The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors
• GSE245593 Trastuzumab Priming on aggregate formation, Intracellular signaling, and the Tumor Microenvironment​
• GSE309535 Transcriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms
• GSE300862 Protein Kinase Cι dictates tumor trajectory, cell state plasticity and immune surveillance in lung adenocarcinoma
• GSE304666 Transcriptomic profiling of meningiomas reveals SMARCB1 mutation-driven immunosuppression via IL-17/CSF1 axis
• GSE237171 To investigate role of bile acids in modulating regulatory T cell phenotype under cholestatic conditions
• GSE296766 A Y-linked duplication of anti-Mullerian hormone is the sex determination gene in threespine stickleback
• GSE287785 Chemical reprogramming of fibroblasts into functional retinal pigment epithelium cells (cut&tag)
• GSE286875 Improved spike-in normalization clarifies the relationship between active histone modifications and transcription
• GSE272521 mTORC1 controls ILC2 activation and allergic lung inflammation through NMUR1-mediated neuronal regulation
• GSE308392 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [dRNH ChIP-seq]
• GSE302208 Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation [Neuron SmartSeq2]
• GSE302051 Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation [10xPerturbSeq]
• GSE279715 CD94 deficiency or blockade unleashes the anti-tumor immunity in mice and humanized murine models
• GSE278847 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [H2AX ChIP-seq]
• GSE278840 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [Ago1 ChIP-seq]
• GSE278836 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [GLOE-seq]
• GSE308593 Loss of Twist impairs tentacle development and induces epithelial neoplasia in the sea anemone Nematostella vectensis
• GSE301963 Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation [10xGermfree]
• GSE298454 In Vivo Imaging Reveals Exosome-Mediated Intercellular Communication in Lens Development
• GSE280677 Transcriptomic profile of IL-10-producing B cells (B10) in response to IL-2 signal in vitro
• GSE278849 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [sRNA-seq]
• GSE278843 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [Ago1-RIP-seq]
• GSE278839 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [RNA-seq]
• GSE278837 Transcription-Replication Conflict Resolution by Nuclear RNA Interference [PRO-seq]
• GSE297273 Imaginal discs produce neuropeptide-like precursor 1 to alleviate ER stress in response to warm temperatures
• GSE278850 Transcription-Replication Conflict Resolution by Nuclear RNA Interference
• GSE261899 v-ATPase-mediated buffering of mitochondrial dysfunction
• GSE290047 small RNA seq of patient-derived glioma cells (GBM1,GBM2, GG3)
• GSE283429 Changes in Muscularis Macrophage Populations in Diabetes
• GSE279858 Gene expression profile on dermal fibroblasts treated with melanocortin compounds